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Rhodes, S. (author), Beale, S. (author), Wilkinson, J. (author), van Veldhoven, K. (author), Basinas, J. (author), Mueller, W. (author), Oude Hengel, K.M. (author), Burdorf, A. (author), Peters, S. (author), Stokholm, Z.A. (author), Schlünssen, V. (author), Kolstad, H. (author), Pronk, A. (author), Pearce, N. (author), Hayward, A. (author), van Tongeren, M. (author)Objective: This study aimed to assess whether workplace exposures as estimated via a COVID-19 job exposure matrix (JEM) are associated with SARS-CoV-2 in the UK. Methods: Data on 244 470 participants were available from the Office for National Statistics Coronavirus Infection Survey (CIS) and 16 801 participants from the Virus Watch Cohort,...article 2022
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Spini, G. (author), Mancini, E. (author), Attema, T. (author), Abspoel, M. (author), de Gier, J. (author), Fehr, S. (author), Veugen, T. (author), van Heesch, M. (author), Worm, D. (author), de Luca, A. (author), Cramer, R. (author), Sloot, P.M.A. (author)BackgroundHIV treatment prescription is a complex process. Clinical decision support systems (CDSS) are a category of health information technologies that can assist clinicians to choose optimal treatments based on clinical trials and expert knowledge. The usability of some CDSSs for HIV treatment would be significantly improved by using the...article 2022
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Bourgonje, A.R. (author), Offringa, A.K. (author), van Eijk, L.E. (author), Abdulle, A.E. (author), Hillebrands, J.L. (author), van der Voort, P.H.J. (author), van Goor, H. (author), van Hezik, E.J. (author)Significance: Hydrogen sulfide (H2S) is one of the three main gasotransmitters that are endogenously produced in humans and are protective against oxidative stress. Recent findings from studies focusing on coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), shifted our attention to a...article 2021
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Offringa, A. (author), Montijn, R. (author), Singh, S. (author), Paul, M. (author), Pinto, Y.M. (author), Pinto-Sietsma, S.J. (author)The SARS-CoV-2 pandemic is a healthcare crisis caused by insufficient knowledge applicable to effectively combat the virus. Therefore, different scientific discovery strategies need to be connected, to generate a rational treatment which can be made available as rapidly as possible. This relies on a solid theoretical understanding of the...article 2020
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van Eijk, M. (author), Hillaire, M.L.B. (author), Rimmelzwaan, G.F. (author), Rynkiewicz, M.J. (author), White, M.R. (author), Hartshorn, K.L. (author), Hessing, M. (author), Koolmees, P.A. (author), Tersteeg, M.H. (author), van Es, M.H. (author), Meijerhof, T. (author), Huckriede, A. (author), Haagsman, H.P. (author)Innate immunity is critical in the early containment of influenza A virus (IAV) infection and surfactant protein D (SP-D) plays a crucial role in innate defense against IAV in the lungs. Multivalent lectin-mediated interactions of SP-D with IAVs result in viral aggregation, reduced epithelial infection, and enhanced IAV clearance by phagocytic...article 2019
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Harris, C.M. (author), Thomas, L. (author), Falcone, E.A. (author), Hildebrand, J. (author), Houser, D. (author), Kvadsheim, P.H. (author), Lam, F.P.A. (author), Miller, P.J.O. (author), Moretti, D.J. (author), Read, A.J. (author), Slabbekoorn, H. (author), Southall, B.L. (author), Tyack, P.L. (author), Wartzok, D. (author), Janik, V.M. (author)Marine mammals may be negatively affected by anthropogenic noise. Behavioural response studies (BRS) aim to establish a relationship between noise exposure conditions (dose) from a potential stressor and associated behavioural responses of animals. A recent series of BRS have focused on the effects of naval sonar sounds on cetaceans. Here, we...article 2018
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Remels, A.H.V. (author), Derks, W.J.A. (author), Cillero-Pastor, B. (author), Verhees, K.J.P. (author), Kelders, M.C. (author), Heggermont, W. (author), Carai, P. (author), Summer, G. (author), Ellis, S.R. (author), de Theije, C.C. (author), Heeren, R.M.A. (author), Heymans, S. (author), Papageorgiou, A.P. (author), van Bilsen, M. (author)Acute viral myocarditis (VM), characterised by leukocyte infiltration and dysfunction of the heart, is an important cause of sudden cardiac death in young adults. Unfortunately, to date, the pathological mechanisms underlying cardiac failure in VM remain incompletely understood. In the current study, we investigated if acute VM leads to cardiac...article 2018
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Mevissen, F.E.F. (author), van Empelen, P. (author), Watzeels, A. (author), van Duin, G. (author), Meijer, S. (author), van Lieshout, S. (author), Kok, G. (author)This paper describes the development of a Dutch online programme called Long Live Love+ focusing on positive, coercion-free relationships, contraception use, and the prevention of STIs, using the Intervention Mapping (IM) approach. All six steps of the approach were followed. Step 1 confirmed the need for a sexual health programme targeting...article 2018
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Rapid and generic identification of influenza A and other respiratory viruses with mass spectrometryMajchrzykiewicz-Koehorst, J.A. (author), Heikens, E. (author), Trip, H. (author), Hulst, A.G. (author), de Jong, A.L. (author), Viveen, M.C. (author), Sedee, N.J.A. (author), van der Plas, J. (author), Coenjaerts, F.E.J. (author), Paauw, A. (author)The rapid identification of existing and emerging respiratory viruses is crucial in combating outbreaks and epidemics. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is a rapid and reliable identification method in bacterial diagnostics, but has not been used in virological diagnostics. Mass...article 2015
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Borgdorff, H. (author), Tsivtsivadze, E. (author), Verhelst, R. (author), Marzorati, M. (author), Jurriaans, S. (author), Ndayisaba, G.F. (author), Schuren, F.H. (author), van de Wijgert, J.H.H.M. (author)Cervicovaginal microbiota not dominated by lactobacilli may facilitate transmission of HIV and other sexually transmitted infections (STIs), as well as miscarriages, preterm births and sepsis in pregnant women. However, little is known about the exact nature of the microbiological changes that cause these adverse outcomes. In this study,...article 2014
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Majchrzykiewicz-Koehorst, J.A. (author), Heikens, E. (author), Trip, H. (author), Hulst, A.G. (author), de Jong, A.L. (author), Viveen, M.C. (author), Sedee, N.J.A. (author), van der Plas, J. (author), Coenjaerts, F.E.J. (author), Paauw, A. (author)Tested respiratory viruses: influenza A virus, respiratory syncytial virus (RSV) and human metapneumovirus (hMPV), were successfully identified directly from crude cell cultures using liquid chromatography-tandem MS (LC-MS/MS). The identification was preceded with the simple, generic and fast sample preparation method. The determined...conference paper 2014
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Bereszczak, J.Z. (author), Havlik, M. (author), Weiss, V.U. (author), Marchetti-Deschmann, M. (author), van Duijn, E. (author), Watts, N.R. (author), Wingfield, P.T. (author), Allmaier, G. (author), Steven, A.C. (author), Heck, A.J.R. (author)The capsid of hepatitis B virus (HBV) is a major viral antigen and important diagnostic indicator. HBV capsids have prominent protrusions ('spikes') on their surface and are unique in having either T = 3 or T = 4 icosahedral symmetry. Mouse monoclonal and also human polyclonal antibodies bind either near the spike apices (historically the 'α...article 2014
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van Keulen, H.M. (author), Otten, W. (author), Ruiter, R.A.C. (author), van Steenbergen, J. (author), Paulussen, T.W.G.M. (author), Fekkes, M. (author), Paulussen, T.W.G.M. (author)Onderzoeken welke factoren deelname aan de HPV-vaccinatie bepaalden in 2009 en 2010. Opzet Retrospectief dwarsdoorsnede-onderzoek. Methode Uit een telepanel werden aselecte steekproeven getrokken van Nederlandse meisjes die in 2009 en 2010 werden opgeroepen voor de HPV-vaccinatie, evenals hun moeders. Gegevens werden verzameld via een online...article 2013
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Zhang, X. (author), Paulssen, H. (author)The Gulf of California, which forms part of the Pacific-North American plate boundary, is an ideal place to investigate upper mantle dynamics in a continental rifting area. With 19 seismic stations located around the gulf, the NARS-Baja experiment (2002-2008) was designed to image its crustal and mantle structure. Here we present results of a...article 2012
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Kälin, S. (author), Amstutz, B. (author), Gastaldelli, M. (author), Wolfrum, N. (author), Boucke, K. (author), Havenga, M. (author), DiGennaro, F. (author), Liska, N. (author), Hemmi, S. (author), Greber, U.F. (author), TNO Kwaliteit van Leven (author)Human adenovirus serotype 35 (HAdV-35; here referred to as Ad35) causes kidney and urinary tract infections and infects respiratory organs of immunocompromised individuals. Unlike other adenoviruses, Ad35 has a low seroprevalence, which makes Ad35-based vectors promising candidates for gene therapy. Ad35 utilizes CD46 and integrins as receptors...article 2010
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Treijtel, N. (author), Eijkeren, J.C.H.v. (author), Nijmeijer, S. (author), van der Greef de - Sandt, I.C.J. (author), Freidig, A.P. (author), TNO Kwaliteit van Leven (author)The metabolism and active transport of ritonavir and saquinavir were studied using sandwich-cultured rat hepatoyctes and rat liver microsomes. For ritonavir four comparable metabolites were observed in the sandwich-culture and in microsomes. For saquinavir eight metabolites were observed in sandwich-culture and 14 different metabolites in...article 2009
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Parker, A.L. (author), Waddington, S.N. (author), Buckley, S.M.K. (author), Custers, J. (author), Havenga, M.J.E. (author), van Rooijen, N. (author), Goudsmit, J. (author), McVey, J.H. (author), Nicklin, S.A. (author), Baker, A.H. (author), TNO Kwaliteit van Leven (author)The deployment of adenovirus serotype 5 (Ad5)-based vectors is hampered by preexisting immunity. When such vectors are delivered intravenously, hepatocyte transduction is mediated by the hexon-coagulation factor X (FX) interaction. Here, we demonstrate that human sera efficiently block FX-mediated cellular binding and transduction of Ad5-based...article 2009
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van Mieghem, P. (author), Omic, J. (author), Kooij, R.E. (author), TNO Informatie- en Communicatietechnologie (author)The influence of the network characteristics on the virus spread is analyzed in a new-the N-intertwined Markov chain-model, whose only approximation lies in the application of mean field theory. The mean field approximation is quantified in detail. The N-intertwined model has been compared with the exact 2N-state Markov model and with previously...article 2009
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van der Laan, J.W. (author), Forster, R. (author), Ledwith, B. (author), Gruber, M. (author), Gould, S. (author), Segal, L. (author), Penninks, A. (author), TNO Kwaliteit van Leven (author)Vaccine research and development is a heterogeneous and intensely active area, encompassing the development of many different kinds of novel preventive and therapeutic vaccines (eg, against infectious, allergic, and autoimmune diseases, cancer, etc). Included in this is the development of different types of vaccines (eg, DNA vaccines, novel...article 2009
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Liu, J. (author), O'Brien, K.L. (author), Lynch, D.M. (author), Simmons, N.L. (author), La Porte, A. (author), Riggs, A.M. (author), Abbink, P. (author), Coffey, R.T. (author), Grandpre, L.E. (author), Seaman, M.S. (author), Landucci, G. (author), Forthal, D.N. (author), Montefiori, D.C. (author), Carville, A. (author), Mansfield, K.G. (author), Havenga, M.J. (author), Pau, M.G. (author), Goudsmit, J. (author), Barouch, D.H. (author), TNO Kwaliteit van Leven (author)A recombinant adenovirus serotype 5 (rAd5) vector-based vaccine for HIV-1 has recently failed in a phase 2b efficacy study in humans. Consistent with these results, preclinical studies have demonstrated that rAd5 vectors expressing simian immunodeficiency virus (SIV) Gag failed to reduce peak or setpoint viral loads after SIV challenge of rhesus...article 2009