Searched for: subject%3A%22validation%255C%2Bstudy%22
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Westbeek, S. (author), Remmers, J.J.C. (author), van Dommelen, J.A.W. (author), Maalderink, H.H. (author), Geers, M.G.D. (author)
In photopolymerization-based additive manufacturing a complex interplay exists between the vat photopolymerization process characteristics and the (photo-active) resin’s material properties, which governs the trajectory from the input target geometry to the resulting true geometry of a printed component. Particularly for fine featured geometries...
article 2021
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Reisinger, K. (author), Blatz, V. (author), Brinkmann, J. (author), Downs, T.R. (author), Fischer, A. (author), Henkler, F. (author), Hoffmann, S. (author), Krul, C. (author), Liebsch, M. (author), Luch, A. (author), Pirow, R. (author), Reus, A.A. (author), Schulz, M. (author), Pfuhler, S. (author)
Recently revised OECD Testing Guidelines highlight the importance of considering the first site-of-contact when investigating the genotoxic hazard. Thus far, only in vivo approaches are available to address the dermal route of exposure. The 3D Skin Comet and Reconstructed Skin Micronucleus (RSMN) assays intend to close this gap in the in vitro...
article 2018
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Kang, N. (author), Brinkman, W.P. (author), Birna Van Riemsdijk, M. (author), Neerincx, M. (author)
Expressive virtual audiences are used in scientific research, psychotherapy, and training. To create an expressive virtual audience, developers need to know how specific audience behaviors are associated with certain characteristics of an audience, such as attitude, and how well people can recognize these characteristics. To examine this, four...
article 2016
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van Loon, K. (author), Breteler, M.J.M. (author), van Wolfwinkel, L. (author), Rheineck Leyssius, A.T. (author), Kossen, A.S. (author), Kalkman, C.J. (author), van Zaane, B. (author), Peelen, L.M. (author)
Altered respiratory rate is one of the first symptoms of medical conditions that require timely intervention, e.g., sepsis or opioid-induced respiratory depression. To facilitate continuous respiratory rate monitoring on general hospital wards a contactless, non-invasive, prototype monitor was developed using frequency modulated continuous wave...
article 2016
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Groothuis-Oudshoorn, C.G.M. (author), Chorus, A.M.J. (author), Verrips, G.H.W. (author), Detmar, S.B. (author)
BACKGROUND: The London Handicap Scale (LHS) was found to be a valid and reliable scale for measuring participation restrictions in adults. OBJECTIVE: This paper describes the development and assesses the construct-related validity of a Dutch version of the London Handicap Scale (DLHS). METHODS: The DLHS was tested in 798 adults (mean age: 50.7...
article 2015
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Celis-Morales, C. (author), Livingstone, K.M. (author), Woolhead, C. (author), Forster, H. (author), O’Donovan, C.B. (author), Macready, A.L. (author), Fallaize, R. (author), Marsaux, C.F.M. (author), Tsirigoti, L. (author), Efstathopoulou, E. (author), Moschonis, G. (author), Navas-Carretero, S. (author), San-Cristobal, R. (author), Kolossa, S. (author), Klein, U.L. (author), Hallmann, J. (author), Godlewska, M. (author), Surwiłło, A. (author), Drevon, C.A. (author), Bouwman, J. (author), Grimaldi, K. (author), Parnell, L.D. (author), Manios, Y. (author), Traczyk, I. (author), Gibney, E.R. (author), Brennan, L. (author), Walsh, M.C. (author), Lovegrove, J.A. (author), Martinez, J.A. (author), Daniel, H. (author), Saris, W.H.M. (author), Gibney, M. (author), Mathers, J.C. (author)
In e-health intervention studies, there are concerns about the reliability of internet-based, self-reported (SR) data and about the potential for identity fraud. This study introduced and tested a novel procedure for assessing the validity of internet-based, SR identity and validated anthropometric and demographic data via measurements performed...
article 2015
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Jónasdóttir, H.S. (author), Ioan-Facsinay, A. (author), Kwekkeboom, J. (author), Brouwers, H. (author), Zuurmond, A.M. (author), Toes, R. (author), Deelder, A.M. (author), Giera, M. (author)
Here we present an advanced platform for the analysis of specialized pro-resolving mediators (SPM), including a set of pro-inflammatory lipids and respective biochemical pathway markers. The platform is characterized by a largely simplified sample preparation protocol, employing methanol protein-precipitation instead of solid phase extraction....
article 2014
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de Hollander, E.L. (author), Zwart, L. (author), de Vries, S.I. (author), Wendel-Vos, W. (author)
Objective: To examine whether the "Short QUestionnaire to ASsess Health-enhancing physical activity" (SQUASH) and the "Injuries and Physical Activity in the Netherlands" questionnaire ("Ongevallen en Bewegen in Nederland," OBiN) were valid in assessing adherence to physical activity (PA) guidelines. Study Design and Setting: Participants (N =...
article 2012
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Koek, M.M. (author), Jellema, R.H. (author), van der Greef, J. (author), Tas, A.C. (author), Hankemeier, T. (author)
Metabolomics involves the unbiased quantitative and qualitative analysis of the complete set of metabolites present in cells, body fluids and tissues (the metabolome). By analyzing differences between metabolomes using biostatistics (multivariate data analysis; pattern recognition), metabolites relevant to a specific phenotypic characteristic...
article 2011
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Schinkel, J. (author), Fransman, W. (author), Heussen, H. (author), Kromhout, H. (author), Marquart, H. (author), Tielemans, E. (author), TNO Kwaliteit van Leven (author)
Objectives: For regulatory risk assessment under REACH a tiered approach is proposed in which the first tier models should provide a conservative exposure estimate that can discriminate between scenarios which are of concern and those which are not. The Stoffenmanager is mentioned as a first tier approach in the REACH guidance. In an attempt to...
article 2010
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van Zon, A.T. (author), Roy Chowdhury, K. (author), TNO Defensie en Veiligheid (author)
In this study, a regional scale gravity data set has been inverted to infer the structure (topography) of the top of the basement underlying sub-horizontal strata. We apply our method to this real data set for further proof of concept, validation and benchmarking against results from an earlier forward modelling done elsewhere.Our aim is to...
article 2010
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de Vries, S.I. (author), van Hirtum, H.W.J.E.M. (author), Bakker, I. (author), Hopman-Rock, M. (author), Hirasing, R.A. (author), van Mechelen, W. (author), TNO Kwaliteit van Leven (author)
Purpose: To review recently published studies on the reproducibility, validity, and feasibility of motion sensors used to assess physical activity in healthy children and adolescents (2-18 yr). Methods: On October 2004, a systematic literature search in PubMed, EMBASE, and PsycINFO was performed. This search has been updated on October 2007. In...
article 2009
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Bottini, A.A. (author), Alepee, N. (author), Phillips, B. (author), Gribaldo, L. (author), de Silva, O. (author), Hartung, T. (author), Hendriksen, C. (author), Kuil, J. (author), Pazos, P. (author), Rhein, C. (author), Schiffelers, M.-J. (author), Stokes, W. (author), Theobald, A. (author), Vidal, J.-M. (author), van de Sandt, H. (author), Breier, S. (author), Sintes, J.R. (author), Blaauboer, B. (author), TNO Kwaliteit van Leven (author)
article 2008
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van Dommelen, P. (author), Schuller, A. (author), Detmar, S. (author), van den Berg, B. (author), Groothuis-Oudshoorn, K. (author), TNO Kwaliteit van Leven (author)
Objective: To establish a model that estimates a preference-based measure (valuation) of social participation for children between 8 and 18 years of age from the Handicap Scale for Children (HSC), a validated questionnaire for children with a chronic illness. Methods: Vignettes of the HSC classification system were valued by a representative...
article 2008
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Post, M.W.M. (author), de Witte, L.P. (author), Reichrath, E. (author), Verdonschot, M.M. (author), Wijlhuizen, G.J. (author), Perenboom, R.J.M. (author), TNO Kwaliteit van Leven (author)
Objective: IMPACT-S is the screener part of the ICF Measure of Participation and ACTivities questionnaire. IMPACT-S consists of 33 items in 9 scales, reflecting the 9 activity and participation chapters of the International Classification of Functioning, Disability and Health (ICF). The reliability and validity of IMPACT-S as an independent...
article 2008
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Hissink, A.M. (author), Krüse, J. (author), Kulig, B.M. (author), Verwei, M. (author), Muijser, H. (author), Salmon, F. (author), Leenheers, L.H. (author), Owen, D.E. (author), Lammers, J.H.C.M. (author), Freidig, A.P. (author), McKee, R.H. (author), TNO Kwaliteit van Leven (author)
As part of a project designed to develop a framework for extrapolating acute central nervous system (CNS) effects of hydrocarbon solvents in animals to humans, experimental studies were conducted in rats and human volunteers in which acute CNS effects were measured and toxicokinetic data were collected. A complex hydrocarbon solvent, white...
article 2007
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Kerkdijk, H. (author), Mol, H.G.J. (author), van der Nagel, B. (author), TNO Kwaliteit van Leven (author)
A new concept for cleanup, based on volume overloading of the cleanup column, has been developed for on-line coupling of gel permeation chromatography (GPC), solid-phase extraction (SPE), or both, to gas chromatography (GC). The principle is outlined and the applicability demonstrated by the determination of pesticide residues in food matrixes...
article 2007
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Kamphorst, J.J. (author), van der Heijden, R. (author), de Groot, J. (author), Lafeber, F.P.J.G. (author), Reijmers, T.H. (author), van El, B. (author), Tjaden, U.R. (author), van der Greef, J. (author), Hankemeier, T. (author), TNO Kwaliteit van Leven (author)
Synovial fluid potentially contains markers for early diagnosis and disease progression in degenerative joint diseases such as osteoarthritis. Here, a method is described for profiling endogenous peptides in human synovial fluid, using ultrafiltration, solid-phase extraction, nanoscale liquid chromatography, and high-resolution mass spectrometry...
article 2007
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Molag, M.L. (author), de Vries, J.H.M. (author), Ocké, M.C. (author), Dagnelie, P.C. (author), van den Brandt, P.A. (author), Jansen, M.C.J.F. (author), van Staveren, W.A. (author), van 't Veer, P. (author), TNO Kwaliteit van Leven (author)
The authors investigated the role of food frequency questionnaire (FFQ) design, including length, use of portion-size questions, and FFQ origin, in ranking subjects according to their nutrient intake. They also studied the ability of the FFQ to detect differences in energy intake between subgroups and to assess energy and protein intake. In a...
article 2007
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Freidig, A.P. (author), Dekkers, S. (author), Verwei, M. (author), Zvinavashe, E. (author), Bessems, J.G.M. (author), van de Sandt, J.J.M. (author), TNO Kwaliteit van Leven (author)
Future EU legislations enforce a fast hazard and risk assessment of thousands of existing chemicals. If conducted by means of present data requirements, this assessment will use a huge number of test animals and will be neither cost nor time effective. The purpose of the current research was to develop methods to increase the acceptability of in...
article 2007
Searched for: subject%3A%22validation%255C%2Bstudy%22
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