Searched for: subject:"urine"
(1 - 20 of 73)

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Oerlemans, A. (author), Verscheijden, L.F.M. (author), Mol, J.G.J. (author), Vermeulen, R.C.H. (author), Westerhout, J. (author), Roeleveld, N. (author), Russel, F.G.M. (author), Scheepers, P.T.J. (author)
Tebuconazole (TEB) is a widely used triazole fungicide, but the toxicokinetics of its human metabolites are not fully described. For proper interpretation of biological monitoring data, knowledge on the metabolism and elimination of the compound is required. A human volunteer study was performed with the aim to describe the time courses of...
article 2019
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Fu, J. (author), Schoeman, J.C. (author), Harms, A.C. (author), van Wietmarschen, H.A. (author), Vreeken, R.J. (author), Berger, R. (author), Cuppen, B.V.J. (author), Lafeber, F.P.J.G. (author), van der Greef, J. (author), Hankemeier, T. (author)
Oxidised lipids, covering enzymatic and auto-oxidation-synthesised mediators, are important signalling metabolites in inflammation while also providing a readout for oxidative stress, both of which are prominent physiological processes in a plethora of diseases. Excretion of these metabolites via urine is enhanced through the phase-II...
article 2016
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Tsikas, D. (author), Pham, V.V. (author), Suchy, M.T. (author), van de Ree, M.A. (author), Huisman, M.V. (author), Frölich, J.C. (author), Princen, H.M.G. (author)
The present study describes the effects of atorvastatin on whole body synthesis of nitric oxide (NO), prostacyclin (PGI2), and thromboxane A2 (TxA2), on oxidative stress and nitrite/nitrate-related renal carbonic anhydrase (CA) activity in patients with type 2 diabetes mellitus (T2DM). A double-blind, randomized, placebo-controlled parallel...
article 2015
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Saccenti, E. (author), Tenori, L. (author), Verbruggen, P. (author), Timmerman, M.E. (author), Bouwman, J. (author), van der Greef, J. (author), Luchinat, C. (author), Smilde, A.K. (author)
Background: Metabolomics has attracted the interest of the medical community for its potential in predicting early derangements from a healthy to a diseased metabolic phenotype. One key issue is the diversity observed in metabolic profiles of different healthy individuals, commonly attributed to the variation of intrinsic (such as (epi)genetic...
article 2014
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Beltman, M. (author), Kamphuis, M. (author)
article 2013
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Snijder, C.A. (author), Heederik, D. (author), Pierik, F.H. (author), Hofman, A. (author), Jaddoe, V.W. (author), Koch, H.M. (author), Longnecker, M.P. (author), Burdorf, A. (author)
Background: Prenatal exposure to bisphenol A (BPA) has been associated with adverse birth outcomes, but findings of previous studies have been inconsistent. Objective: We investigated the relation of prenatal BPA exposure with intrauterine growth and evaluated the effect of the number of measurements per subject on observed associations. Methods...
article 2013
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van der Kloet, F.M. (author), Tempels, F.W.A. (author), Ismail, N. (author), van der Heijden, R. (author), Kasper, P.T. (author), Rojas-Cherto, M. (author), van Doorn, R. (author), Spijksma, G. (author), Koek, M. (author), van der Greef, J. (author), Mäkinen, V.P. (author), Forsblom, C. (author), Holthöfer, H. (author), Groop, P.H. (author), Reijmers, T.H. (author), Hankemeier, T. (author)
Diabetic kidney disease (DKD) is a devastating complication that affects an estimated third of patients with type 1 diabetes mellitus (DM). There is no cure once the disease is diagnosed, but early treatment at a sub-clinical stage can prevent or at least halt the progression. DKD is clinically diagnosed as abnormally high urinary albumin...
article 2012
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Beltman, M. (author), Deurloo, J.A. (author), van Leerdam, F.J.M. (author), Wierenga-van der Hoeven, C.J. (author), Bulk-Bunschoten, A.M.W. (author), Kamphuis, M. (author)
Continence problems can occur during childhood. This guideline is for the Dutch Youth Health Care (JGZ) and gives recommendations for the prevention, early detection and treatment of these problems. As a preventative measure advices for potty training should be started in children aged 18-24 months. If incontinence is present, it is important to...
article 2012
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Kamphuis, M. (author), van Leerdam, F.J.M. (author), Wierenga-van der Hoeven, C.J. (author), Bulk-Bunschoten, A.W.W. (author), Deurloo, J.A. (author), Beltman, M. (author)
De JGZ kan voorlichting geven over zindelijkheid aan ouders en kinderen en zindelijkheidsproblemen signaleren en begeleiden. Doel van deze richtlijn is het uniform, tijdig en correct signaleren, verwijzen en begeleiden van kinderen met zindelijkheidsproblemen door de JGZ. Ook kan de JGZ een rol spelen in de voorlichting aan de omgeving van het...
report 2011
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Kramer, A.J.W. (author), Broerse, A. (author), Kamphuis, M. (author), TNO Kwaliteit van Leven (author)
report 2010
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van den Heuvel, E.G.H.M. (author), Muijs, T. (author), Brouns, F. (author), Hendriks, H.F.J. (author), TNO Kwaliteit van Leven (author)
Consumption of fructo-oligosaccharides (FOS) has been shown to improve mineral absorption in the short term, but no long-term effects were studied in girls with a low calcium intake. Therefore, we hypothesized that short- and long-term consumption of short-chain FOS (sc-FOS) improves calcium and magnesium absorption in girls with a low habitual...
article 2009
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Bobeldijk, I. (author), Hekman, M. (author), van der Vries de- Weij, J. (author), Coulier, L. (author), Ramaker, R. (author), Kleemann, R. (author), Kooistra, T. (author), Rubingh, C. (author), Freidig, A. (author), Verheij, E. (author), TNO Kwaliteit van Leven (author)
We report a sensitive, generic method for quantitative profiling of bile acids and other endogenous metabolites in small quantities of various biological fluids and tissues. The method is based on a straightforward sample preparation, separation by reversed-phase high performance liquid-chromatography mass spectrometry (HPLC-MS) and electrospray...
article 2008
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Chanteranne, B. (author), Branca, F. (author), Kardinaal, A. (author), Wahala, K. (author), Braesco, V. (author), Ladroite, P. (author), Brouns, F. (author), Coxam, V. (author), TNO Kwaliteit van Leven (author)
The estrogenic effects of soy isoflavones (IF) on symptoms of menopause are of particular interest. The aim of the present study was to improve compliance of IF in two IF-enriched foods providing the same IF circulating levels in postmenopausal women. Forty-two healthy postmenopausal women (mean age: 53.28 years) were recruited for a randomized,...
article 2008
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van Doorn, M. (author), Vogels, J. (author), Tas, A. (author), van Hoogdalem, E.J. (author), Burggraaf, J. (author), Cohen, A. (author), van der Greef, J. (author), TNO Kwaliteit van Leven (author)
Aims: To explore the usefulness of metabolomics as a method to obtain a broad array of biomarkers for the pharmacological effects of rosiglitazone (RSG) in plasma and urine samples from patients with type 2 diabetes mellitus (T2DM) and healthy volunteers (HVs). Additionally, we explored the differences in metabolite concentrations between T2DM...
article 2007
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Schoonen, W.G.E.J. (author), Kloks, C.P.A.M. (author), Ploemen, J.P.H.T.M. (author), Horbach, G.J. (author), Smit, M.J. (author), Zandberg, P. (author), Mellema, J.R. (author), van Zuylen, C.T. (author), Tas, A.C. (author), van Nesselrooij, J.H.J. (author), Vogels, J.T.W.E. (author), TNO Kwaliteit van Leven (author)
1H nuclear magnetic resonance (NMR) spectroscopy of rat urine in combination with pattern recognition analysis was evaluated for early noninvasive detection of toxicity of investigational chemical entities. Bromobenzene (B) and paracetamol (P) were administered at five single oral dosages between 2 and 500 mg/kg and between 6 and 1800 mg/kg,...
article 2007
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Huls, M. (author), Kramers, C. (author), Levtchenko, E.N. (author), Wilmer, M.J.G. (author), Dijkman, H.B.P.M. (author), Kluijtmans, L.A.J. (author), van der Hoorn, J.W.A. (author), Russel, F.G.M. (author), Masereeuw, R. (author), TNO Kwaliteit van Leven (author)
The multidrug resistance gene 1 product, P-glycoprotein (P-gp), is expressed in several excretory organs, including the apical membrane of proximal tubules. After inducing acute renal failure, P-gp expression is upregulated and this might be a protective function by pumping out toxicants and harmful products of oxidative stress. We characterized...
article 2007
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Schoonen, W.G.E.J. (author), Kloks, C.P.A.M. (author), Ploemen, J.-P.H.T.M. (author), Smit, M.J. (author), Zandberg, P. (author), Horbach, G.J. (author), Mellema, J.-R. (author), van Zuylen, C.T. (author), Tas, A.C. (author), van Nesselrooij, J.H.J. (author), Vogels, J.T.W.E. (author), TNO Kwaliteit van Leven (author)
A procedure of nuclear magnetic resonance (NMR) urinalysis using pattern recognition is proposed for early detection of toxicity of investigational compounds in rats. The method is applied to detect toxicity upon administration of 13 toxic reference compounds and one nontoxic control compound (mianserine) in rats. The toxic compounds are...
article 2007
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Hunter, D.J. (author), LaValley, M. (author), Li, J. (author), Zhang, Y. (author), Bauer, D. (author), Nevitt, M. (author), Guermazi, A. (author), de Groot, J. (author), Sakkee, N. (author), Gale, D. (author), Felson, D.T. (author), TNO Kwaliteit van Leven (author)
Objective: Age-related changes in articular cartilage are likely to play a role in the etiology of osteoarthritis (OA). One of the major changes in the extracellular matrix of cartilage is the age-related accumulation of advanced glycation end products (AGEs). Pentosidine, an AGE crosslink, is one of the few characterized AGEs and is considered...
article 2007
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Schaafsma, G. (author), TNO Kwaliteit van Leven (author)
The increasing prevalence in many countries of people with overweight and obesity is undoubtedly one of the biggest threats to public health. Dietary proteins, because of their positive effects on satiation/ satiety, may help to reduce energy intake and promote a healthy body composition with less body fat. Several mechanisms have been put...
article 2006
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Vermeulen, M. (author), van den Berg, R. (author), Freidig, A.P. (author), van Bladeren, P.J. (author), Vaes, W.H.J. (author), TNO Kwaliteit van Leven (author)
A high intake of cruciferous vegetables is associated with a reduced risk of cancer and cardiovascular diseases. This protective effect has been linked to isothiocyanates, enzymatic hydrolysis products of glucosinolates. In this study, the metabolic fate of glucosinolates and isothiocyanates after ingestion of 19 different cruciferous vegetables...
article 2006
Searched for: subject:"urine"
(1 - 20 of 73)

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