Searched for: subject%3A%22toluene%22
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Hulst, A.G. (author), Verstappen, D.R.W. (author), van der Riet-van Oeveren, D. (author), Vermeulen, N.P.E. (author), Noort, D. (author)
In the current paper we show that exposure of human callus to isocyanates leads to covalent modifications within keratin proteins. Mass spectrometric analyses of pronase digests of keratin isolated from exposed callus show that both mono- and di-adducts (for di-isocyanates) are predominantly formed on the ε-amino group of lysine. In addition,...
article 2015
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Wijte, D. (author), van Baar, B.L.M. (author), Heck, A.J.R. (author), Altelaar, A.F.M. (author)
To enhance target production from biocatalysts, it is necessary to thoroughly understand the molecular mechanisms involved in production, degradation, and, importantly, adaptation to the required environment. One such bacterium with high potential for biocatalysis is the solvent-tolerant bacteria Pseudomonas putida S12, which, among others, is...
article 2011
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Craciun, N.I. (author), Wildeman, J. (author), Blom, P.W.M. (author), TNO Industrie en Techniek (author)
We report on the synthesis and electrical characterization of polyfluorene-triarylamine-based hole transport layers (HTLs). The solubility of the HTL can be tuned by adjustment of the chemical structure without loss of the charge transport properties. Double-layer polymer light-emitting diodes are constructed with an HTL that is not soluble in...
article 2010
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de Jong, W.H. (author), Arts, J.H.E. (author), de Klerk, A. (author), Schijf, M.A. (author), Ezendam, J. (author), Kuper, C.F. (author), van Loveren, H. (author), TNO Kwaliteit van Leven (author)
There are currently no validated animal models that can identify low molecular weight (LMW) respiratory sensitizers. The Local Lymph Node Assay (LLNA) is a validated animal model developed to detect contact sensitizers using skin exposure, but all LMW respiratory sensitizers tested so far were also positive in this assay. Discrimination between...
article 2009
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Volkers, R.J.M. (author), Ballerstedt, H. (author), Ruijssenaars, H. (author), de Bont, J.A.M. (author), de Winde, J.H. (author), Wery, J. (author), TNO Kwaliteit van Leven (author)
Pseudomonas putida S12 is well known for its remarkable solvent tolerance. Transcriptomics analysis of this bacterium grown in toluene-containing chemostats revealed the differential expression of 253 genes. As expected, the genes encoding one of the major solvent tolerance mechanisms, the solvent efflux pump SrpABC and its regulatory genes...
article 2009
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Bobeldijk, I. (author), Karlsson, D. (author), Pronk, A. (author), Gonsalves, J. (author), Hekman, M. (author), van de Lagemaat, D. (author), Preller, L. (author), Heederik, D. (author), Skarping, G. (author), TNO Kwaliteit van Leven (author)
An adapted method for the quantitative determination of isocyanates in air was implemented and validated in-house. The method was based on air sampling using an impinger flask containing di-n-butylamine (DBA) in toluene and a glass fibre filter in series. The DBA derivatives were determined using liquid chromatography and tandem mass...
article 2008
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TNO Kwaliteit van Leven (author), Prenafeta-Boldú, F.X. (author), Illa, J. (author), van Groenestijn, J.W. (author), Flotats, X. (author)
The biodegradation of toluene was studied in two lab-scale air biofilters operated in parallel, packed respectively with perlite granules (PEG) and polyurethane foam cubes (PUC) and inoculated with the same toluene-degrading fungus. Differences on the material pore size, from micrometres in PEG to millimetres in PUC, were responsible for...
article 2008
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Penkett, S.A. (author), Burgess, R.A. (author), Coe, H. (author), Coll, I. (author), Hov, O. (author), Lindskog, A. (author), Schmidbauer, N. (author), Solberg, S. (author), Roemer, M. (author), Thijsse, T. (author), Beck, J. (author), Reeves, C.E. (author), TNO Bouw en Ondergrond (author)
The nitrate radical (NO3) was first measured in the atmosphere in the 1970s and suggestions were made that it could play a major role in oxidising many unsaturated hydrocarbons, such as those emitted from the biosphere. Analysis of the hydrocarbon mix over the North Atlantic Ocean suggested subsequently that the influence of NO3 radical...
article 2007
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Volkers, R.J.M. (author), de Jong, A.L. (author), Hulst, A.G. (author), van Baar, B.L.M. (author), de Bont, J.A.M. (author), Wery, J. (author), TNO Kwaliteit van Leven TNO Defensie en Veiligheid (author)
The aim of this study was to assess the cellular response of the solvent-tolerant Pseudomonas putida S12 to toluene as the single effector. Proteomic analysis (two-dimensional difference-in-gel-electrophoresis) was used to assess the response of P. putida S12 cultured in chemostats. This approach ensures constant growth conditions, both in the...
article 2006
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Arts, J.H.E. (author), Mommers, C. (author), de Heer, C. (author), TNO Kwaliteit van Leven (author)
A literature study was performed to evaluate dose-response relationships and no-effect levels for sensitization and elicitation in skin- and respiratory allergy. With respect to the skin, dose-response relationships and no-effect levels were found for both intradermal and topical induction, as well as for intradermal and topical elicitation of...
article 2006
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Pronk, A. (author), Yu, F. (author), Vlaanderen, J. (author), Tielemans, E. (author), Preller, L. (author), Bobeldijk, I. (author), Deddens, J.A. (author), Latza, U. (author), Baur, X. (author), Heederik, D. (author), TNO Kwaliteit van Leven (author)
Objectives: To study inhalation and dermal exposure to hexamethylene diisocyanate (HDI) and its oligomers as well as personal protection equipment (PPE) use during task performance in conjunction with urinary hexamethylene diamine (HDA) in car body repair shop workers and industrial spray painters. Methods: Personal task based inhalation samples...
article 2006
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Lammers, J.H.C.M. (author), Meuling, W.J.A. (author), Muijser, H. (author), Freidig, A.P. (author), Bessems, J.G.M. (author), TNO Kwaliteit van Leven (author)
The health risks of inhalation exposure to volatile organic solvents may not only depend on the total external dose, but also on the pattern of exposure. It has been suggested that exposure to regularly occurring peak concentrations may have a stronger impact on the brain than constant exposure at the same average level. Recent animal...
article 2005
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Lammers, J.H.C.M. (author), van Asperen, J. (author), de Groot, D. (author), Rijcken, W.R.P. (author), TNO Kwaliteit van Leven (author)
The toxicity of exposure by inhalation to organic solvents may not only be related to the total external dose, but also to the pattern of exposure. In this study the impact of the exposure scenario on the behavioural effects of the model solvent toluene in rats was investigated. Rats were exposed for 7.5 h to either a constant concentration or...
article 2005
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van Wendel de Joode, B. (author), Tielemans, E. (author), Vermeulen, R. (author), Wegh, H. (author), Kromhout, H. (author), TNO Kwaliteit van Leven (author)
Charcoal cloth pads have been used to assess volatile chemicals on the skin in a laboratory setting; however, they have not yet been applied to measure dermal exposure in occupational settings. This study aimed at evaluating whether charcoal pads can be used to assess dermal exposure to benzene and toluene in workers of a petrochemical plant....
article 2005
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van Asperen, J. (author), Rijcken, W.R.P. (author), Lammers, J.H.C.M. (author), TNO Voeding (author)
The toxicity of inhalatory exposure to organic solvents may not only be related to the total external dose, but also to the pattern of exposure. In this study physiologically based toxicokinetic (PBTK) modelling has been used to study the impact of the exposure scenario on the toxicokinetics and the behavioural effects of the model solvent...
article 2003
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Meuleman, E.E.B. (author), Willemsen, J.H.A. (author), Mulder, M.H.V. (author), Strathmann, H. (author)
Various types of ethylene-propylene-diene terpolymers (EPDM) and crosslinking procedures have been investigated with pervaporation, vapor sorption, liquid sorption and gas permeation experiments. The EPDM parameters that have been changed are ethylene content, molecular weight, choice of third monomer, type of branching and various crosslinking...
article 2001
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de Wolf, J.M. (author), van den Beld, C.M.B. (author), Gennart, J.-Ph. (author), Riley, A.J. (author), Urbanus, J. (author)
A review of reports on the occurrence of some hydrocarbons in food in relation to the sales location, with emphasis on petrol station shops, covers the principal selected hydrocarbons, i.e., volatile components of gasoline, e.g., benzene, pentane, hexane, toluene, MTBE, and xylene; relevance of gasoline sales to the levels of the selected...
report 2000
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Sinke, A.J.C. (author), Dury, O. (author), Zobrist, J. (author), TNO Milieu, Energie en Procesinnovatie (author)
The development of the redox conditions has been studied in an initially aerobic column filled with quartz sand coated with ferrihydrite and subjected to a fluctuating water table. The purpose of this study was to evaluate the effect of water table fluctuations on the redox dynamics and the fate of selected organic pollutants. The column that...
article 1998
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van Lune, F.S. (author), Nijssen, L.M. (author), Linssen, J.P.H. (author), Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author)
Absorption aspects of flavours and chemicals are important quality criteria when plastic bottles are reused or recycled. In the present study absorption of methanol and toluene by polyester-based bottles (PET and PEN) was studied at different temperatures in the range 20-40°C for a period of 16 weeks with two different ways of exposure: one...
article 1997
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Muijser, H. (author), Geuskens, R.B.M. (author), Hooisma, J. (author), Emmen, H.H. (author), Kulig, B.M. (author), TNO Voeding (author)
Carpet layers and age-matched controls were investigated both at the beginning of a working day and at the end with four subtests of a neuropsychological test battery (NES2). Exposure to toluene, cyclohexane, ethyl acetate, and heptane was measured with personal air sampling methods. One group of carpet layers used water-based adhesives (WBA) on...
article 1996
Searched for: subject%3A%22toluene%22
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