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Benschop, H.P. (author), van den Berg, G.R. (author), van Hooidonk, C. (author), de Jong, L.P.A. (author), Kientz, C.E. (author), Berends, F. (author), Kepner, L.A. (author), Meeter, E. (author), Visser, R.P.L.S. (author), Medisch Biologisch Laboratorium TNO (author)Three new nonquaternary oximes have been evaluated with respect to their antidotal activities against organophosphate poisoning. The oximes 1,2,3-thiadiazole-5-carboxaldoxime (1, pKa = 7.6), 2-methyl-1,3,4-thiadiazole-5-carboxaldoxime (2, pKa = 8.4), and 3-methyl-1,2,4-thiadiazole-5-carboxaldoxime (3, pKa = 7.0) were prepared in yields of 56, 24...article 1979
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Kluft, C. (author), Trumpi-Kalshoven, M.M. (author), Jie, A.F.H. (author), Veldhuyzen-Stolk, E.C. (author), Gaubius instituut TNO (author)Fibrinolytic studies in euglobulin fractions of Fletcher trait plasma (deficient in prekallikrein) revealed reduced activities as compared to normal plasma. A quantitative assay for total plasminogen activator plus proactivator in plasma showed that the amount in Fletcher trait patients is about half of normal (normal = ?? 100 blood activator...article 1979
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van der Schans, G.P. (author), Medisch Biologisch Laboratorium TNO (author)The induction of single- and double-strand breaks in DNA by γ-rays has been measured. The maximum number of nucleotide paris (a) between two independently induced single-strand breaks in opposite strands of the DNA which cannot prevent the occurrence of a double-strand break was found to amount to about 16. This value did not differ...article 1978
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Hollander, C.F. (author), Instituut voor experimentele gerontologie TNO (author)The main goal of experimental aging research is to understand the mechanisms of aging in order to rationally approach the health problems of the aged as well as to increase the quality of life in this phase of human existence. Animal models are needed to obtain this goal. It is outlined that the approach of biomedical research on aging should be...article 1978
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Radiobiologisch Instituut TNO (author), Maat, B. (author)Recent data on extrapulmonary colony formation after heparin administration are inconclusive. A systemic study of this topic was undertaken with 4 experimental tumour systems and 2 distinct periods of reduced clotting capacity in rats and mice. I.v. injection of various numbers of tumour cells into i.p. heparinized animals leads to: Significant...article 1978
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Kruysse, A. (author), Feron, V.J. (author), Immel, H.R. (author), Centraal instituut voor voedingsonderzoek TNO (author)The inhalation toxicity of peroxyacetyl nitrate (PAN) was examined in acute (single exposure), subacute (4-wk repeated exposure) and subchronic (13-wk repeated exposure) studies in rats. The 4-hr LC50 was found to be 95 ppm. In the 4-wk study rats were exposed to 0, 0.9, 4.1 or 11.8 ppm PAN vapor for 6 hr/day, 5 days/wk. Exposure to 11.8 ppm...article 1977
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van Hemmen, J.J. (author), Meuling, W.J.A. (author), Medisch Biologisch Laboratorium TNO (author)E. coli cells are inactivated by the products of the reaction between dialuric acid and oxygen, of which the primary product is superoxide. The rate of inactivation is decreased by superoxide dismutase, by catalase, and by EDTA, whereas it is increased by addition of cupric ions or hydrogen peroxide. It is concluded that a toxic product is...article 1977
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Davidse, L.C. (author), Flach, W. (author), Centrum voor Plantenfysiologisch Onderzoek Nationale Raad voor Landbouwkundig Onderzoek TNO (author)Chemicals/CAS: benomyl, 17804-35-2; carbon 14, 14762-75-5; colchicine, 64-86-8; fuberidazole, 3878-19-1; griseofulvin, 126-07-8; mebendazole, 31431-39-7; melatonin, 73-31-4; nocodazole, 31430-18-9; parbendazole, 14255-87-9; podophyllotoxin, 518-28-5; tiabendazole, 148-79-8; vinblastine, 865-21-4; Benzimidazoles; Carbamates; Colchicine, 64-86-8;...article 1977
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de Mik, G. (author), de Groot, I. (author), Medisch Biologisch Laboratorium TNO Chemisch Laboratorium TNO (author)The mechanisms of inactivation of aerosolized bacteriophage phiX174 in atmospheres containing ozone, cyclohexene, or ozonized cyclohexene were studied by using 32P-labelled phage. The inactivation of the aerosolized phage in clean air or in air containing cyclohexene is due to damage of the protein coat since the deoxyribonucleic acid (DNA)...article 1977
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Bleichrodt, J.F. (author), Roos, A.L.M. (author), Roos Verheij, W.S.D. (author), Medisch Biologisch Laboratorium TNO (author)Amber mutants of bacteriophage T7 are reverted by γ-rays to pseudo wild-type particles, i.e. particles able to propagate in a suppressorless host. The yield of revertants is much higher when the phage is irradiated in the presence of oxygen than when irradiated anoxically. Under particular gas conditions the efficiency of mutation induction...article 1977
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van Velsen, F.L. (author), Nickolson, V.J. (author), Medisch Biologisch Laboratorium TNO Medisch Fysisch Instituut TNO (author)The effects of the myotonic agent, 9-anthroic acid (ANCA), and the acetylcholinesterase (AChE) inhibitor, soman, on the isolated phrenic nerve-diaphragm preparation of the rat were studied. ANCA induced after-contractions which followed the twitches evoked by either direct or indirect stimulation. In the intermittently stimulated muscle the...article 1977
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Polak, R.L. (author), Molenaar, P.C. (author), van Gelder, M. (author), Medisch Biologisch Laboratorium RVO-TNO (author)The uptake of [14C]choline was studied in cortical slices from rat brain after their incubation in a Krebs-Henseleit medium containing either 4.7 mM-KCl (low K), 25 mM-KCl (high K) or 25 mM-KCl without calcium (Ca free, high K). With 0.84 μM-[14C]choline in the medium the uptake per gram of tissue was 0.62 nmol after incubation in low K medium,...article 1977
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- Lohman, P.H.M. (author), Reynolds, R. (author), Paterson, M.C. (author), Medisch Biologisch Laboratorium TNO (author) article 1977
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de Mik, G. (author), de Groot, I. (author), Gerbrandy, J.L.F. (author), Medisch Biologisch Laboratorium TNO Chemisch Laboratorium TNO (author)The effects of ozone and ozonized olefins on aerosol survival of bacteriophage phiX174 were studied. The ozone concentrations used were between 0 and 110 parts/109, giving decay rates up to 0.03 min-1. The olefins used were trans 2 butene and cyclohexene in concentrations of 500 parts/109 and 2.4 parts/106, respectively. Olefins alone have no...article 1977
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Kluft, C. (author), Jenks, R.L. (author), Astrup, T. (author), Gaubius instituut TNO (author)The authors studied the production of fibrinolytic activity in Hageman trait plasma, and conclude that the development of activator activity in euglobulin fractions is delayed, particularly in the Hageman trait plasma, by the presence of C1 inactivator, an inhibitor whose effect can be abolished by the synthetic compound flufenamic acid. Using...article 1977
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de Mik, G. (author), de Groot, I. (author), Medisch Biologisch Laboratorium TNO (author)Using the microthread technique the survival of Escherichia coli MRE 162 in open air was measured in different parts of The Netherlands. The presence of bactericidal compounds (open air factor=OAF) could be demonstrated on several days and quantitated in relative units of OAF concentration. In the absence of ozone the OAF concentration was...article 1977
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Gaubius instituut TNO (author), van Gent, C.M. (author), van der Voort, H.A. (author), de Bruyn, A.M. (author), Klein, F. (author)Two enzymatic methods for the determination of cholesterol in serum have been modified for automatic use. These methods utilize the colour reactions according to Kageyama or Trinder to measure the hydrogen peroxide resulting from the enzymatic reaction. The procedures have been compared with the classical methods according to Abell and to Huang....article 1977
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Veldhuisen, G. (author), Bacchetti, S. (author), van der Valk, M.J. (author), Medisch Biologisch Laboratorium TNO (author)Chemicals/CAS: DNA, Viralarticle 1976
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Davidse, L.C. (author), Werkgroep voor Inwendige Therapie van Plantenziekten TNO (author)Methyl benzimidazol 2 yl carbamate was metabolized by Aspergillus nidulans mycelium to two metabolites, one of which was identified as methyl 5 hydroxybenzimidazol 2 yl carbamate. This compound was further converted to a second metabolite which was not identified. Conversion rate was highest when the culture medium was depleted of nutrients....article 1976
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Hoppe, H.H. (author), Kerkenaar, A. (author), Kaars Sypesteyn, A. (author), Organisch Chemisch Instituut TNO (author)3 Phenylindole is an antimicrobial compound active towards many fungi and gram positive bacteria. At 5 μg/ml it inhibits growth of Aspergillus niger. Higher concentrations (50 μg/ml) also suppress spore germination; they do not kill the fungus. Dry weight of the fungus still increases for 1 or 2 days after fungicide treatment. The toxicant has...article 1976