- document
-
Guzik, P. (author), Piskorski, J. (author), Krauze, T. (author), Schneider, R. (author), Wesseling, K.H. (author), Wykrȩtowicz, A. (author), Wysocki, H. (author), TNO Biomedical Instrumentation (author)Aim: To analyze the correlation of the Poincaré plot descriptors of RR intervals with standard measures of heart rate variability (HRV) and spontaneous baroreflex sensitivity (BRS). A physiological model of changing respiratory rates from 6 to 15 breaths/min provided a wide range of RR intervals for analysis. Material and methods: Beat-to-beat...article 2007
- document
-
TNO Kwaliteit van Leven (author), Bongaerts, B.W.C. (author), de Goeij, A.F.P.M. (author), de Vogel, S. (author), van den Brandt, P.A. (author), Goldbohm, R.A. (author), Weijenberg, M.P. (author)High alcohol consumption is related to colorectal cancer (CRC). Our objective was to study associations between alcohol consumption and risk of CRC according to characteristics of aetiological pathways: the chromosomal instability (CIN) and the microsatellite instability (MIN) pathway. We classified CIN+ tumours (tumours with either a truncating...article 2007
- document
-
TNO Kwaliteit van Leven (author), Rist, L. (author), Mueller, A. (author), Barthel, C. (author), Snijders, B. (author), Jansen, M. (author), Simões-Wüst, A.P. (author), Huber, M. (author), Kummeling, I. (author), von Mandach, U. (author), Steinhart, H. (author), Thijs, C. (author)The aim of the present study was to find out whether the incorporation of organic dairy and meat products in the maternal diet affects the contents of the conjugated linoleic acid isomers (CLA) and trans-vaccenic acid (TVA) in human breast milk. To this purpose, milk samples from 312 breastfeeding mothers participating in the KOALA Birth Cohort...article 2007
- document
-
TNO Kwaliteit van Leven TNO Voeding (author), van den Brandt, P.A. (author), Smits, K.M. (author), Goldbohm, R.A. (author), Weijenberg, M.P. (author)Energy-adjusted magnesium intake was nonsignificantly inversely related to risk of colorectal cancer (n=2328) in the Netherlands Cohort Study on Diet and Cancer that started in 1986 (n=58 279 men and 62 573 women). Statistically significant inverse trends in risk were observed in overweight subjects for colon and proximal colon cancer across...article 2007
- document
-
TNO Kwaliteit van Leven (author), Alkemade, F.E. (author), de Gittenberger-Groot, A.C. (author), Schiel, A.E. (author), van Munsteren, J.C. (author), Hogers, B. (author), van Vliet, L.S.J. (author), Poelmann, R.E. (author), Havekes, L.M. (author), van Dijk, K.W. (author), de Ruiter, M.C. (author)OBJECTIVE - Maternal hypercholesterolemia is associated with a higher incidence and faster progression of atherosclerotic lesions in neonatal offspring. We aimed to determine whether an in utero environment exposing a fetus to maternal hypercholesterolemia and associated risk factors can prime the murine vessel wall to accelerated development of...article 2007
- document
-
de Lange, M. (author), de Geus, E.J.C. (author), Kluft, C. (author), Meijer, P. (author), van Doornen, L.J.P. (author), Boomsma, D.I. (author), Snieder, H. (author), TNO Kwaliteit van Leven (author)Differences in genetic influence on death from CHD between males and females have been reported. Haemostatic factors have consistently been associated with risk for coronary heart disease (CHD), but sex differences in genetic architecture have not been studied. This study in middle-aged twins investigates whether there are sex differences in...article 2006
- document
-
Wilkinson, S.C. (author), Maas, W.J.M. (author), Nielsen, J.B. (author), Greaves, L.C. (author), van de Sandt, J.J.M. (author), Williams, F.M. (author), TNO Kwaliteit van Leven TNO Voeding (author)Objectives: To determine the effect of skin thickness on the percutaneous penetration and distribution of test compounds with varying physicochemical properties using in vitro systems. Studies were carried out in accordance with OECD guidelines on skin absorption tests. Methods: Percutaneous penetration of caffeine (log P -0.01), testosterone ...article 2006
- document
-
Schaafsma, G. (author), TNO Kwaliteit van Leven (author)The increasing prevalence in many countries of people with overweight and obesity is undoubtedly one of the biggest threats to public health. Dietary proteins, because of their positive effects on satiation/ satiety, may help to reduce energy intake and promote a healthy body composition with less body fat. Several mechanisms have been put...article 2006
- document
-
Zeegers, M.P. (author), Selen, R.F.M. (author), Kleinjans, J.C.S. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)Objectives: N-nitroso compounds, endogenously formed from nitrate-derived nitrite, are suspected to be important bladder carcinogens. However, the association between nitrate exposure from food or drinking water and bladder cancer has not been substantially investigated in epidemiologic studies. Methods: We evaluated the associations between...article 2006
- document
-
Gao, K. (author), Xu, A. (author), Krul, C.A.M. (author), Venema, K. (author), Liu, Y. (author), Niu, Y. (author), Lu, J. (author), Bensoussan, L. (author), Seeram, N.P. (author), Heber, D. (author), Henning, S.M. (author), TNO Kwaliteit van Leven (author)Dietary flavonoids are poorly absorbed from the gastrointestinal tract. Colonic bacteria convert flavonoids into smaller phenolic acids (PA), which can be absorbed into the circulation and may contribute to the chemopreventive activity of the parent compounds. The purpose of our study was to determine whether flavonoids from green and black tea ...article 2006
- document
-
Koushik, A. (author), Hunter, D.J. (author), Spiegelman, D. (author), Anderson, K.E. (author), Buring, J.E. (author), Freudenheim, J.L. (author), Goldbohm, R.A. (author), Hankinson, S.E. (author), Larsson, S.C. (author), Leitzmann, M. (author), Marshall, J.R. (author), McCullough, M.L. (author), Miller, A.B. (author), Rodriguez, C. (author), Rohan, T.E. (author), Ross, J.A. (author), Schatzkin, A. (author), Schouten, L.J. (author), Willett, W.C. (author), Wolk, A. (author), Zhang, S.M. (author), Smith-Warner, S.A. (author), TNO Kwaliteit van Leven (author)Carotenoids, found in fruits and vegetables, have the potential to protect against cancer because of their properties, including their functions as precursors to vitamin A and as antioxidants. We examined the associations between intakes of α-carotene, β-carotene, β-cryptoxanthin, lutein/zeaxanthin and lycopene and the risk of invasive...article 2006
- document
-
A pooled analysis of 12 cohort studies of dietary fat, cholesterol and egg intake and ovarian cancerGenkinger, J.M. (author), Hunter, D.J. (author), Spiegelman, D. (author), Anderson, K.E. (author), Beeson, W.L. (author), Buring, J.E. (author), Colditz, G.A. (author), Fraser, G.E. (author), Freudenheim, J.L. (author), Goldbohm, R.A. (author), Hankinson, S.E. (author), Koenig, K.L. (author), Larsson, S.C. (author), Leitzmann, M. (author), McCullough, M.L. (author), Miller, A.B. (author), Rodriguez, C. (author), Rohan, T.E. (author), Ross, J.A. (author), Schatzkin, A. (author), Schouten, L.J. (author), Smit, E. (author), Willett, W.C. (author), Wolk, A. (author), Zeleniuch-Jacquotte, A. (author), Zhang, S.M. (author), Smith-Warner, S.A. (author), TNO Kwaliteit van Leven TNO Voeding (author)Fat and cholesterol are theorized to promote ovarian carcinogenesis by increasing circulating estrogen levels. Although case-control studies have reported positive associations between total and saturated fat intake and ovarian cancer risk, two cohort studies have observed null associations. Dietary cholesterol and eggs have been positively...article 2006
- document
-
Genkinger, J.M. (author), Hunter, D.J. (author), Spiegelman, D. (author), Anderson, K.E. (author), Arslan, A. (author), Beeson, W.L. (author), Buring, J.E. (author), Fraser, G.E. (author), Freudenheim, J.L. (author), Goldbohm, R.A. (author), Hankinson, S.E. (author), Jacobs Jr., D.R. (author), Koushik, A. (author), Lacey Jr., J.V. (author), Larsson, S.C. (author), Leitzmann, M. (author), McCullough, M.L. (author), Miller, A.B. (author), Rodriguez, C. (author), Rohan, T.E. (author), Scheuten, L.J. (author), Shore, R. (author), Smit, E. (author), Wolk, A. (author), Zhang, S.M. (author), Smith-Warner, S.A. (author), TNO Kwaliteit van Leven (author)Background: Dairy foods and their constituents (lactose and calcium) have been hypothesized to promote ovarian carcinogenesis. Although case-control studies have reported conflicting results for dairy foods and lactose, several cohort studies have shown positive associations between skim milk, lactose, and ovarian cancer. Methods: A pooled...article 2006
- document
-
Dihal, A.A. (author), Woutersen, R.A. (author), Ommen, B.v. (author), Rietjens, I.M.C.M. (author), Stierum, R.H. (author), TNO Kwaliteit van Leven (author)The effect of the dietary flavonoid quercetin was investigated on proliferation and differentiation of the human colon cancer cell line Caco-2. Confluent Caco-2 monolayers exposed to quercetin showed a biphasic effect on cell proliferation and a decrease in cell differentiation (0.001<P<0.05). During differentiation Caco-2 cells formed 5 phase...article 2006
- document
-
McKee, R.H. (author), Lammers, J.H.C.M. (author), Hoogendijk, E.M.G. (author), Emmen, H.H. (author), Muijser, H. (author), Barsotti, D.A. (author), Owen, D.E. (author), Kulig, B.M. (author), TNO Kwaliteit van Leven (author)As a preliminary step to evaluating the acute neurobehavioral effects of hydrocarbon solvents and to establish a working model for extrapolating animal test data to humans, joint neurobehavioral/toxicokinetic studies were conducted which involved administering ethanol to rats and volunteers. The specific objectives of the present studies were to...article 2006
- document
-
Kistemaker, J.A. (author), den Hartog, E.A. (author), Daanen, H.A.M. (author), TNO Defensie en Veiligheid (author)The SensorTouch thermometer performs an infrared measurement of the skin temperature above the Superficial Temporal Artery (STA). This study evaluates the validity and the accuracy of the SensorTouch thermometer. Two experiments were performed in which the body temperature was measured with a rectal sensor, with an oesophageal sensor and with...article 2006
- document
-
Schaafsma, G. (author), TNO Kwaliteit van Leven (author)Loss of muscle mass as a consequence of changes in protein metabolism during periods of catabolic stress is a serious complication in a variety of conditions. These conditions are weight loss programs, sarcopenia in the elderly and several clinical states. It appears from many studies that improved protein nutrition by ingestion of high-quality...article 2006
- document
-
TNO Kwaliteit van Leven (author), Steenvoorden, M.M.C. (author), Huizinga, T.W.J. (author), Verzijl, N. (author), Bank, R.A. (author), Ronday, H.K. (author), Luning, H.A.F. (author), Lafeber, F.P.J.G. (author), Toes, R.E.M. (author), de Groot, J. (author)Objective. The major risk factor for osteoarthritis (OA) is aging, but the mechanisms underlying this risk are only partly understood. Age-related accumulation of advanced glycation end products (AGEs) could be one of these mechanisms. We undertook this study to investigate the role of the receptor for AGEs (RAGE) in mediating the cellular...article 2006
- document
-
Hoeksma, M. (author), van Rijn, M. (author), Verkerk, P.H. (author), Bosch, A.M. (author), Mulder, M.F. (author), de Klerk, J.B.C. (author), de Koning, T.J. (author), Rubio-Gozalbo, E. (author), de Vries, M. (author), Sauer, P.J.J. (author), van Spronsen, F.J. (author), TNO Preventie en Gezondheid (author)In a previous study, Dutch children with phenylketonuria (PKU) were found to be slightly shorter than their healthy counterparts. In the literature, it has been hypothesized that a higher protein intake is necessary to optimize growth in PKU patients. The study aimed to investigate whether protein intake (total, natural and protein substitute)...article 2005
- document
-
Delsing, D.J.M. (author), Post, S.M. (author), Groenendijk, M. (author), Solaas, K. (author), van der Boom, H. (author), van Duyvenvoorde, W. (author), de Wit, E.C.M. (author), Bloks, V.W. (author), Kuipers, F. (author), Havekes, L.M. (author), Princen, H.M.G. (author), TNO Kwaliteit van Leven (author)The present study was designed to investigate the lipid-lowering properties and mechanisms of action of a new HMG-CoA reductase inhibitor, rosuvastatin, in female ApoE*3-Leiden transgenic mice. Mice received a high fat/cholesterol (HFC) diet containing either rosuvastatin (O [control], 0.00125%, 0.0025%, or 0.005% [w/w]) or 0.05% (w/w)...article 2005