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Kong, H. (author), Wang, M. (author), Venema, K. (author), Maathuis, A. (author), van der Heijden, R. (author), van der Greef, J. (author), Xu, G. (author), Hankemeier, T. (author), TNO Kwaliteit van Leven (author)A high-performance liquid chromatography-high resolution Fourier transform ion cyclotron resonance mass spectrometry (HPLC-FTICR-MS) method was developed to investigate the metabolism of ginsenosides in in vitro models of the gastro-intestinal tract. The metabolites were identified by high-resolution tandem mass spectrometry. Degradation and...article 2009
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Wang, J. (author), van der Heijden, R. (author), Spijksma, G. (author), Reijmers, T. (author), Wang, M. (author), Xu, G. (author), Hankemeier, T. (author), van der Greef, J. (author), TNO Kwaliteit van Leven (author)A matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS) method was developed for the high throughput and robust qualitative profiling of alkaloids in Fuzi-the processed lateral roots of the Chinese herbal medicine Aconitum carmichaeli Debx (A. carmichaeli). After optimization, powdered roots - without any further sample...article 2009
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TNO Industrie en Techniek (author), Laan, E.C. (author), Ahlers, B. (author), Westrenen, W.V. (author), Heiligers, J. (author), Wielders, A. (author)Moon4You is a project led by the Dutch Organisation for Applied Scientific Research TNO, with partners from industry and universities in the Netherlands that aims to provide a combined Raman/LIBS instrument as scientific payload for lunar exploration missions. It is the first time that Raman spectroscopy and LIBS (Laser Induced Breakdown...conference paper 2009
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Bobeldijk, I. (author), Hekman, M. (author), van der Vries de- Weij, J. (author), Coulier, L. (author), Ramaker, R. (author), Kleemann, R. (author), Kooistra, T. (author), Rubingh, C. (author), Freidig, A. (author), Verheij, E. (author), TNO Kwaliteit van Leven (author)We report a sensitive, generic method for quantitative profiling of bile acids and other endogenous metabolites in small quantities of various biological fluids and tissues. The method is based on a straightforward sample preparation, separation by reversed-phase high performance liquid-chromatography mass spectrometry (HPLC-MS) and electrospray...article 2008
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Hill, M.K. (author), Brooks, B.J. (author), Norris, S.J. (author), Smith, M.H. (author), Brooks, I.M. (author), de Leeuw, G. (author), TNO Defensie en Veiligheid (author)The Compact Lightweight Aerosol Spectrometer Probe (CLASP) is an optical particle spectrometer capable of measuring size-resolved particle concentrations in 16 user-defined size bins spanning diameters in the range 0.24 < D < 18.5 μm at a rate of 10 Hz. The combination of its compact nature and lightweight and robust build allows for deployment...article 2008
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Bobeldijk, I. (author), Karlsson, D. (author), Pronk, A. (author), Gonsalves, J. (author), Hekman, M. (author), van de Lagemaat, D. (author), Preller, L. (author), Heederik, D. (author), Skarping, G. (author), TNO Kwaliteit van Leven (author)An adapted method for the quantitative determination of isocyanates in air was implemented and validated in-house. The method was based on air sampling using an impinger flask containing di-n-butylamine (DBA) in toluene and a glass fibre filter in series. The DBA derivatives were determined using liquid chromatography and tandem mass...article 2008
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- TNO Industrie en Techniek (author), Ahlers, B. (author), Hutchinson, I. (author), Inley, R. (author) article 2008
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Bazalgette Courrèges-Lacoste, G. (author), Ahlers, B. (author), Pérez, F.R. (author), TNO Industrie en Techniek (author)Among the different instruments that have been pre-selected to be on-board the Pasteur payload on ExoMars is the Raman/laser induced breakdown spectroscopy (LIBS) instrument. Raman spectroscopy and LIBS will be integrated into a single instrument sharing many hardware commonalities. An international team under the lead of TNO has been gathered...article 2007
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Schoonen, W.G.E.J. (author), Kloks, C.P.A.M. (author), Ploemen, J.P.H.T.M. (author), Horbach, G.J. (author), Smit, M.J. (author), Zandberg, P. (author), Mellema, J.R. (author), van Zuylen, C.T. (author), Tas, A.C. (author), van Nesselrooij, J.H.J. (author), Vogels, J.T.W.E. (author), TNO Kwaliteit van Leven (author)1H nuclear magnetic resonance (NMR) spectroscopy of rat urine in combination with pattern recognition analysis was evaluated for early noninvasive detection of toxicity of investigational chemical entities. Bromobenzene (B) and paracetamol (P) were administered at five single oral dosages between 2 and 500 mg/kg and between 6 and 1800 mg/kg,...article 2007
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Technisch Physische Dienst TNO - TH (author), Leijtens, J.A.P. (author), Hoegaerts, C.L.G. (author), Barros, J. (author), de Vries, J. (author)The microbolometer spectrometer breadboard MIBS is a prism spectrometer that uses an uncooled microbolometer detector array and has been designed for the ESA EarthCARE mission. In order to demonstrate its feasibility a breadboard has been build, and tests have been performed that show good correlation between predicted and achieved results....conference paper 2007
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Noort, D. (author), Fidder, A. (author), van der Schans, M.J. (author), Hulst, A.G. (author), TNO Defensie en Veiligheid (author)We present a generic mass spectrometric method to verify exposure to organophosphates, based on the chemical conversion of the phosphylated peptides obtained after pepsin digestion of human butyrylcholinesterase (HuBuChE) to a common precursor peptide. After exposure of plasma to various organophosphates (nerve agents, pesticides), HuBuChE was...article 2006
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Lichtenberg, G. (author), Kleipool, Q. (author), Krijger, J.M. (author), van Soest, G. (author), van Hees, R. (author), Tilstra, L.G. (author), Acarreta, J.R. (author), Aben, I. (author), Ahlers, B. (author), Bovensmann, H. (author), Chance, K. (author), Gloudemans, A.M.S. (author), Hoogeveen, R.W.M. (author), Jongma, R.T.N. (author), Noël, S. (author), Piters, A. (author), Schrijver, H. (author), Schrijvers, C. (author), Sioris, C.E. (author), Skupin, J. (author), Slijkhuis, S. (author), Stammes, P. (author), Wuttke, M. (author), TNO Industrie en Techniek (author)The calibration of SCIAMACHY was thoroughly checked since the instrument was launched on-board ENVISAT in February 2002. While SCIAMACHY's functional performance is excellent since launch, a number of technical difficulties have appeared, that required adjustments to the calibration. The problems can be separated into three types: (1) Those...article 2006
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Levelt, P.F. (author), van den Oord, G.H.J. (author), Dobber, M.R. (author), Mälkki, A. (author), Visser, H. (author), de Vries, J. (author), Stammes, P. (author), Lundell, J.O.V. (author), Saari, H. (author), TNO Industrie en Techniek (author)The Ozone Monitoring Instrument (OMI) flies on the National Aeronautics and Space Adminsitration's Earth Observing System Aura satellite launched in July 2004. OMI is a ultraviolet/visible (UV/VIS) nadir solar backscatter spectrometer, which provides nearly global coverage in one day with a spatial resolution of 13 km × 24 km. Trace gases...article 2006
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König, R. (author), Hildebrandt, D. (author), Hübner, T. (author), Klinkhamer, J.F.F. (author), Moddemeijer, K. (author), Vliegenthart, W.A. (author), TNO Industrie en Techniek (author)The stellarator W7-X will be capable of running in a quasicontinuous operating mode with 10 MW of electron cyclotron heating (ECRH) heating for 30 min, the duration only being limited by the capacity of the available cooling reservoir. The integrated ten discrete water cooled divertor modules need to be closely monitored by ten high resolution...article 2006
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TNO Defensie en Veiligheid (author), Reid, J.S. (author), Brooks, B. (author), Crahan, K.K. (author), de Leeuw, G. (author), Reid, E.A. (author), Anderson, F.D. (author), Hegg, D.A. (author), Eck, T.F. (author), O'Neill, N. (author)In August/September of 2001, the R/P FLIP and CIRPAS Twin Otter research aircraft were deployed to the eastern coast of Oahu, Hawaii, as part of the Rough Evaporation Duct (RED) experiment. Goals included the study of the air/sea exchange, turbulence, and sea-salt aerosol particle characteristics at the subtropical marine Pacific site. Here we...article 2006
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TNO Industrie en Techniek (author), van Brug, H. (author), Bazalgette Courrèges-Lacoste, G.A.F. (author), Otter, G.C.J. (author), Groote Schaarsberg, J.J.M. (author), Delwart, S. (author), Del Bello, U. (author)This paper reports the activities performed in the framework of the ESA contract 18432/04/NL/AR: Enhancement of diffusers BSDF Accuracy. This study was conducted to investigate properties of various diffusers. Diffusers are widely used in space instruments as part of the on-board absolute calibration. Knowledge of the behavior of the diffuser is...conference paper 2006
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TNO Industrie en Techniek (author), Levelt, P.F. (author), van den Oord, G.H.J. (author), Dobber, M.R. (author), Eskes, H. (author), van Weele, M. (author), Veefkind, J.P. (author), van Oss, R. (author), Aben, I. (author), Jongma, R.T. (author), Landgraf, J. (author), de Vries, J. (author), Visser, H. (author)TROPOMI (Tropospheric Ozone-Monitoring Instrument) is a five-channel UV-VIS-NIR-SWIR non-scanning nadir viewing imaging spectrometer that combines a wide swath (114°) with high spatial resolution (10 × 10 km 2). The instrument heritage consists of GOME on ERS-2, SCIAMACHY on Envisat and, especially, OMI on EOS-Aura. TROPOMI has even smaller...conference paper 2006
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TNO Industrie en Techniek (author), Leijtens, J.A.P. (author), de Goeij, B.T.G. (author), Boslooper, E.C. (author)MIBS is a spectrometer operating in the thermal infrared wavelength region, designed in frame of the phase A study for the ESA EarthCARE mission as part of the multispectral Imaging instrument MSI, which uses a 2D microbolometer array detector in stead of the more common MCT detectors. Utilization of a microbolometer and using an integrated...conference paper 2006
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TNO Industrie en Techniek (author), Jongma, R.T. (author), Gloudemans, A.M.S. (author), Hoogeveen, R.W.M. (author), Aben, I. (author), de Vries, J. (author), Escudero-Sanz, I. (author), van den Oord, G. (author), Levelt, P.F. (author)In preparation for future atmospheric space missions a consortium of Dutch organizations is performing design studies on a nadir viewing grating-based imaging spectrometer using OMI and SCIAMACHY heritage. The spectrometer measures selected species (O3, NO2, HCHO, H2O, SO 2, aerosols (optical depth, type and absorption index), CO and CH4) with...conference paper 2006
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Kusmierczyk-Michulec, J. (author), de Leeuw, G. (author), TNO Defensie en Veiligheid (author)An algorithm for the retrieval of the aerosol optical thickness over land and over water from SCIAMACHY (SCanning Imaging Absorption SpectroMeter for Atmospheric ChartographY) is presented. Because calibrated data are not yet available for the SCIAMACHY channels used by the algorithm, the concepts were tested with GOME (Global Ozone Monitoring...conference paper 2005