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Alleleyn, A.M.E. (author), van Avesaat, M. (author), Ripken, D. (author), Bleiel, S.B. (author), Keszthelyi, D. (author), Wilms, E. (author), Troost, F.J. (author), Hendriks, H.F.J. (author), Masclee, A.A.M. (author)Activation of the intestinal brake by infusing nutrients into the distal small intestine with catheters inhibits food intake and enhances satiety. Encapsulation of macronutrients, which protects against digestion in the proximal gastrointestinal tract, can be a non-invasive alternative to activate this brake. In this study, we investigate the...article 2018
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Pasman, W.J. (author), Hendriks, H.F.J. (author), Minekus, M.M. (author), de Ligt, R.A.F. (author), Scholtes-Timmerman, M.J. (author), Clabbers, N.D.S. (author), Leonards, N.M. (author), Johnson, J. (author), Bellmann, S. (author)Background: Appetite regulating properties of foods are usually investigated under laboratory conditions, whereas in real life, foods are consumed under at home conditions. The objective of this study was to compare the acute effects of breakfasts when tested in a laboratory condition and in an at home condition. Appetite regulating properties...article 2018
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Ripken, D. (author), van Avesaat, M. (author), Troost, F.J. (author), Masclee, A.A. (author), Witkamp, R.F. (author), Hendriks, H.F. (author)Background. Activation of the ileal brake by casein induces satiety signals and reduces energy intake. However, adverse effects of intraileal casein administration have not been studied before. These adverse effects may include impaired amino acid digestion, absorption and immune activation. Objective. To investigate the effects of intraileal...article 2017
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van Ommen, B. (author), van den Broek, T. (author), de Hoogh, I. (author), van Erk, M. (author), van Someren, E. (author), Rouhani-Rankouhi, T. (author), Anthony, J.C. (author), Hogenelst, K. (author), Pasman, W. (author), Boorsma, A. (author), Wopereis, S. (author)Personalized nutrition is fast becoming a reality due to a number of technological, scientific, and societal developments that complement and extend current public health nutrition recommendations. Personalized nutrition tailors dietary recommendations to specific biological requirements on the basis of a person’s health status and goals. The...article 2017
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Krishnan, S. (author), Hendriks, H.F.J. (author), Hartvigsen, M.L. (author), de Graaf, A.A. (author)Background: An artificial neural network approach was chosen to model the outcome of the complex signaling pathways in the gastro-intestinal tract and other peripheral organs that eventually produce the satiety feeling in the brain upon feeding. Methods: A multilayer feed-forward neural network was trained with sets of experimental data relating...article 2016
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van Avesaat, M. (author), Troost, F.J. (author), Ripken, D. (author), Peters, J. (author), Hendriks, H.F.J. (author), Masclee, A.A.M. (author)Background: Taste receptors are expressed not only in taste buds but also in the gastrointestinal tract. It has been hypothesized that these receptors may play a role in satiety and food intake. Objective: This study investigated the effect of intraduodenal tastant infusions (bitter, sweet, and umami) on food intake, hunger and fullness,...article 2015
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Lukovac, S. (author), Belzer, C. (author), Pellis, L. (author), Keijser, B.J. (author), de Vos, W.M. (author), Montijn, R.C. (author), Roeselers, G. (author)The gut microbiota is essential for numerous aspects of human health. However, the underlying mechanisms of many host-microbiota interactions remain unclear. The aim of this study was to characterize effects of the microbiota on host epithelium using a novel ex vivo model based on mouse ileal organoids. We have explored the transcriptional...article 2014
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Helbig, A. (author), Silletti, E. (author), van Aken, G.A. (author), Oosterveld, A. (author), Minekus, M. (author), Hamer, R.J. (author), Gruppen, H. (author)This study investigated the effect of gastric passage of protein stabilized emulsions, i.e., whey protein isolate (WPI) and lysozyme, under dynamic in vitro conditions on both the gastric and intestinal lipolysis. Emulsions were prepared at neutral pH to enable an opposite surface charge. Experiments were performed in a multi-compartmental...article 2013
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Voortman, T. (author), Hendriks, H.F.J. (author), Witkamp, R.F. (author), Wortelboer, H.M. (author)Gastrointestinal (GI) peptide hormones play an important role in short-term regulation of food intake and blood glucose levels. Modulating their release is of potential relevance for weight management and possibly diabetes. As currently available models are hard to extrapolate to the human situation, the use of porcine intestinal tissue,...article 2012
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Hogenkamp, P.S. (author), Mars, M. (author), Stafleu, A. (author), de Graaf, C. (author)Food intake and a food’s expected satiating effect initially rely on sensory attributes. People will learn about the food’s satiating capacity by exposure. We investigated whether repeated consumption changed the expected satiety effects and intake of iso-energetic liquid and semi-solid foods. In a randomised cross-over study, participants (n =...article 2012
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Hogenkamp, P.S. (author), Stafleu, A. (author), Mars, M. (author), de Graaf, C. (author)Background:People learn about a food's satiating capacity by exposure and consequently adjust their energy intake.Objective:To investigate the effect of energy density and texture on subsequent energy intake adjustments during repeated consumption.Design:In a randomized crossover design, participants (n=27, age: 21±2.4 years, body mass index: 22...article 2012
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Boelsma, E. (author), Brink, E.J. (author), Stafleu, A. (author), Hendriks, H.F.J. (author), TNO Kwaliteit van Leven (author)The general feeling of wellness after food consumption may play an important role in regulating food intake. This exploratory study aimed at identifying and evaluating measures of such postprandial wellness, tentatively defined as subjective appreciation of life after food intake. The study had a randomized cross-over, double blind design....article 2010
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Hogenkamp, P.S. (author), Mars, M. (author), Stafleu, A. (author), de Graaf, C. (author), TNO Kwaliteit van Leven (author)Background: An important question in the regulation of energy intake is whether dietary learning of energy content depends on the food's characteristics, such as texture. Texture might affect the duration of sensory exposure and eating rate. Objective: The objective was to investigate whether a long sensory exposure, due to differences in means...article 2010
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Mars, M. (author), Hogenkamp, P.S. (author), Gosses, A.M. (author), Stafleu, A. (author), de Graaf, C. (author), TNO Kwaliteit van Leven (author)A higher viscosity of a food leads to a longer orosensory stimulation. This may facilitate the learned association between sensory signals and metabolic consequences. In the current study we investigated the effect of viscosity on learned satiation. In two intervention groups a low viscosity (LV) yogurt (n = 24) and a high viscosity (HV) yogurt ...article 2009
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- Zijlstra, N. (author), de Wijk, R.A. (author), Mars, M. (author), Stafleu, A. (author), de Graaf, C. (author), TNO Kwaliteit van Leven (author) article 2009
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Harthoorn, L.F. (author), Brattinga, C. (author), van Kekem, K. (author), Neyraud, E. (author), Dransfield, E. (author), TNO Kwaliteit van Leven (author)Human saliva contains numerous salivary components that are fundamental for a healthy oral environment and the oral processing of foods. To study a possible differential influence of orosensory stimulation and metabolic activation on salivary composition, human parotid salivary flow, pH, A280, and α-amylase activity were measured before, during...article 2009
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Hamer, H.M. (author), Jonkers, D. (author), Venema, K. (author), Vanhoutvin, S. (author), Troost, F.J. (author), Brummer, R.J. (author)Background: Butyrate, a short-chain fatty acid, is a main end-product of intestinal microbial fermentation of mainly dietary fibre. Butyrate is an important energy source for intestinal epithelial cells and plays a role in the maintenance of colonic homeostasis. Aim: To provide an overview on the present knowledge of the bioactivity of butyrate,...article 2008
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de Wijk, R.A. (author), Zijlstra, N. (author), Mars, M. (author), de Graaf, C. (author), Prinz, J.F. (author), TNO Kwaliteit van Leven (author)Two studies investigated the effect of a food's viscosity on bite size, bite effort and food intake using a standardized protocol in which subjects sipped through a straw every 20 s for a period of 15 min from one of two products, a chocolate-flavored dairy drink and a chocolate-flavored dairy semi-solid, matched for energy density. In the first...article 2008
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TNO Kwaliteit van Leven (author), Pasman, W.J. (author), Heimerikx, J. (author), Rubingh, C.M. (author), van den Berg, R. (author), O'Shea, M. (author), Gambelli, L. (author), Hendriks, H.F.J. (author), Einerhand, A.W.C. (author), Scott, C. (author), Keizer, H.G. (author), Mennen, L.I. (author)Appetite suppressants may be one strategy in the fight against obesity. This study evaluated whether Korean pine nut free fatty acids (FFA) and triglycerides (TG) work as an appetite suppressant. Korean pine nut FFA were evaluated in STC-1 cell culture for their ability to increase cholecystokinin (CCK-8) secretion vs. several other dietary...article 2008
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Schaafsma, G. (author), TNO Kwaliteit van Leven (author)The increasing prevalence in many countries of people with overweight and obesity is undoubtedly one of the biggest threats to public health. Dietary proteins, because of their positive effects on satiation/ satiety, may help to reduce energy intake and promote a healthy body composition with less body fat. Several mechanisms have been put...article 2006
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