Constitutive synthesis of tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor type 1 (PAI-1): Conditions and therapeutic targets

In the population at large and in individual normal volunteers, baseline molar concentratios of t-PA and PAI-1 in plasma show a strong correlation. Evidence is summarized that insulin resistance is a prominent cause of interindividual variation, next to possible contributions of vascular inflammation and steroid hormones. In healthy volunteers,...