- document
-
Detmar, S.B. (author), Hosli, E.J. (author), Chorus, A.M.J. (author), van Beekum, T. (author), Vogels, T. (author), Mourad-Baars, P.E.C. (author), Engelberts, A.C. (author), Groothuis - Oudshoorn, C.G.M. (author), Verrips, G.H.W. (author)Introduction: This paper describes the development and initial psychometric evaluation of the Handicap Scale for Children (HSC). This questionnaire is based on the London Handicap Scale (LHS), a valid and reliable utility instrument for measuring social participation in adults. Methods: A multidisciplinary research group was involved in...article 2005
- document
-
van den Hauwe, O. (author), Campbell, K. (author), Crooks, S.R.H. (author), Schilt, R. (author), van Peteghem, C.H. (author), TNO Kwaliteit van Leven (author)Within the framework of a European Union (EU) research project entitled "Food Safety Screening: Synthetic Glucocorticoids (QLK1-1999-00122)," an international interlaboratory ring test was organized to compare and evaluate different liquid chromatography/mass spectrometry (LC/MS) confirmatory methods that are applied in European monitoring...article 2005
- document
-
Boonzaaijer, G. (author), Bobeldijk, I. (author), van Osenbruggen, W.A. (author), TNO Kwaliteit van Leven (author)A reliable method for the determination of patulin in apple juice, apple puree and apples was developed using two clean-up steps and high performance liquid chromatography and diode array (HPLC-DAD) analysis. Baseline separation from hydroxymethyl furfural (HMF) was obtained. The performance characteristics of the method were determined at four...article 2005
- document
-
Rasmussen, B. (author), Gerretsen, E. (author), TNO Industrie en Techniek (author)ISO 140 is the basic series of standards in Building Acoustics and consists of several parts relating to laboratory and field measurements. The standards were originally prepared by ISO/TC43/SC2 WGs in the early sixties and since then updated and implemented as European standards through CEN/TC126. The ISO 140 series now consists of more than 10...conference paper 2005
- document
-
van Wendel de Joode, B. (author), van Hemmen, J.J. (author), Meijster, T. (author), Major, V. (author), London, L. (author), Kromhout, H. (author), TNO Kwaliteit van Leven (author)Valid and reliable semi-quantitative dermal exposure assessment methods for epidemiological research and for occupational hygiene practice, applicable for different chemical agents, are practically nonexistent. The aim of this study was to assess the reliability of a recently developed semi-quantitative dermal exposure assessment method (DREAM)...article 2005
- document
-
van der Werf, M.J. (author), Jellema, R.H. (author), Hankemeier, T. (author), TNO Kwaliteit van Leven (author)Microbial production strains are currently improved using a combination of random and targeted approaches. In the case of a targeted approach, potential bottlenecks, feed-back inhibition, and side-routes are removed, and other processes of interest are targeted by overexpressing or knocking-out the gene(s) of interest. To date, the selection of...article 2005
- document
-
Bobeldijk, I. (author), Boonzaaijer, G. (author), Spies-Faber, E.J. (author), Vaes, W.H.J. (author), TNO Kwaliteit van Leven (author)Reversed-phase liquid chromatography and detection with atmospheric pressure chemical ionisation tandem mass spectrometry was used for the determination of kava extracts in herbal mixtures. One percent of kava extract can be detected, corresponding to approximately 0.05-0.2 mg/g of the individual kava lactones kavain, dihydrokavain, yangonin,...article 2005
- document
- Netzeva, T.I. (author), Worth, A.P. (author), Aldenberg, T. (author), Benigni, R. (author), Cronin, M.T.D. (author), Gramatica, P. (author), Jaworska, J.S. (author), Kahn, S. (author), Klopman, G. (author), Marchant, C.A. (author), Myatt, G. (author), Nikolova-Jeliazkova, N. (author), Patlewicz, G.Y. (author), Perkins, R. (author), Roberts, D.W. (author), Schultz, T.W. (author), Stanton, D.T. (author), van de Sandt, J.J.M. (author), Tong, W. (author), Veith, G. (author), Yang, C. (author), TNO Kwaliteit van Leven (author) article 2005
- document
-
Pires, N.M.M. (author), van der Hoeven, B.L. (author), de Vries, M.R. (author), Havekes, L.M. (author), van Vlijmen, B.J. (author), Hennink, W.E. (author), Quax, P.H.A. (author), Jukema, J.W. (author), TNO Kwaliteit van Leven (author)The introduction of drug-eluting stents (DES) to prevent in-stent restenosis is one of the major advances in interventional cardiology. Currently many types of DES are under evaluation for effectiveness and safety, a time-consuming and difficult procedure in humans. An animal model that allows rapid evaluation of the present and upcoming...article 2005
- document
-
Lina, B.A.R. (author), Woutersen, R.A. (author), Bruijntjes, J.P. (author), van Benthem, J. (author), van den Berg, J.A.H. (author), Monbaliu, J. (author), Thoolen, B.J.J.M. (author), Beems, R.B. (author), van Kreijl, C.F. (author), TNO Voeding (author)As part of the international evaluation program coordinated by ILSI/HESI, the potential of DNA repair deficient Xpa-/- mice and the double knockout Xpa-/-.p53+/- mice for short term carcinogenicity assays was evaluated. For comparison also wild-type C57BL/6 mice (WT) were included in these studies. Four test compounds were administered to groups...article 2004
- document
- Gennari, A. (author), van den Berghe, C. (author), Casati, S. (author), Castell, J. (author), Clemedson, C. (author), Coecke, S. (author), Colombo, A. (author), Curren, R. (author), Dal Negro, G. (author), Goldberg, A. (author), Gosmore, C. (author), Hartung, T. (author), Langezaal, I. (author), Lessigiarska, I. (author), Maas, W. (author), Mangelsdorf, I. (author), Parchment, R. (author), Prieto, P. (author), Sintes, J.R. (author), Ryan, M. (author), Schmuck, G. (author), Stitzel, K. (author), Stokes, W. (author), Vericat, J.A. (author), Gribaldo, L. (author), TNO Voeding (author) article 2004
- document
-
Germolec, D.R. (author), Kashon, M. (author), Nyska, A. (author), Kuper, C.F. (author), Portier, C. (author), Kommineni, C. (author), Johnson, K.A. (author), Luster, M.I. (author), TNO Voeding (author)The accuracy of extended histopathology to detect immunotoxic chemicals in female B6C3F1 mice was evaluated under the auspices of the National Toxicology Program (NTP). A workgroup was formed consisting of four pathologists who conducted extended histopathological evaluation of lymphoid tissues obtained from a subset of NTP toxicology studies,...article 2004
- document
-
Raat, H. (author), Bonsel, G.J. (author), Hoogeveen, W.C. (author), Essink-Bot, M.L. (author), Gemke, R.J.B.J. (author), Krabbe, P.F.M. (author), Moll, H.A. (author), Suijlekom van-Smit, L.W.A. (author), Verrips, E. (author), TNO Preventie en Gezondheid (author)To establish the generalizability (external validity) of the Health Utilities Index Mark 3 (HUI3) as a single-summary score generic outcome measure in numerous countries/subgroups (including children), repeated studies of community preferences should be performed in various settings. In performing multiple HUI3 studies, a mailed questionnaire...article 2004
- document
-
Degenhardt, C.E.A.M. (author), Pleijsier, K. (author), van der Schans, M.J. (author), Langenberg, J.P. (author), Preston, K.E. (author), Solano, M.I. (author), Maggio, V.L. (author), Barr, J.R. (author), Prins Maurits Laboratorium TNO (author)One of the most appropriate biomarkers for the verification of organophosphorus nerve agent exposure is the conjugate of the nerve agent to butyrylcholinesterase (BuChE). The phosphyl moiety of the nerve agent can be released from the BuChE enzyme by incubation with fluoride ions, after which the resulting organophosphonofluoridate can be...article 2004
- document
-
van Wijngaarden, S.J. (author), Bronkhorst, A.W. (author), Houtgast, T. (author), Steeneken, H.J.M. (author), TNO Technische Menskunde (author)While the Speech Transmission Index ~STI! is widely applied for prediction of speech intelligibility in room acoustics and telecommunication engineering, it is unclear how to interpret STI values when non-native talkers or listeners are involved. Based on subjectively measured psychometric functions for sentence intelligibility in noise, for...article 2004
- document
-
Heinrich, J. (author), Blatter, B.M. (author), Bongers, P.M. (author)Aim: To compare two different methods for assessment of postural load and duration of computer use in office workers. Methods: The study population existed of 87 computer workers. Questionnaire data about exposure were compared with exposures measured by a standardised or objective method. Measuring true exposure to postural load consisted of an...article 2004
- document
-
van de Sandt, J.J.M. (author), van Burgsteden, J.A. (author), Cage, S. (author), Carmichael, P.L. (author), Dick, I. (author), Kenyon, S. (author), Korinth, G. (author), Larese, F. (author), Limasset, J.C. (author), Maas, W.J.M. (author), Montomoli, L. (author), Nielsen, J.B. (author), Payan, J.-P. (author), Robinson, E. (author), Sartorelli, P. (author), Schaller, K.H. (author), Wilkinson, S.C. (author), Williams, F.M. (author), TNO Voeding (author)To obtain better insight into the robustness of in vitro percutaneous absorption methodology, the intra- and inter-laboratory variation in this type of study was investigated in 10 European laboratories. To this purpose, the in vitro absorption of three compounds through human skin (9 laboratories) and rat skin (1 laboratory) was determined. The...article 2004
- document
-
Role of bacterial virulence proteins in Agrobacterium-mediated transformation of Aspergillus awamoriMichielse, C.B. (author), Ram, A.F.J. (author), Hooykaas, P.J.J. (author), van den Hondel, C.A.M.J.J. (author), TNO Voeding (author)The Agrobacterium-mediated transformation of Aspergillus awamori was optimized using defined co-cultivation conditions, which resulted in a reproducible and efficient transformation system. Optimal co-cultivation conditions were used to study the role of Agrobacterium tumefaciens virulence proteins in T-DNA transfer. This study revealed that...article 2004
- document
-
Zagers, N.P.A. (author), van Norren, D. (author)We measured the amplitude of the directional component of the bleached fundus reflectance, the so-called optical Stiles-Crawford effect, as a function of wavelength. The directional reflectance originates from within the outer segments of the photoreceptors. Thus only two anterior absorbers are of importance: Macular pigment and the crystalline...article 2004
- document
-
Germolec, D.R. (author), Nyska, A. (author), Kashon, M. (author), Kuper, C.F. (author), Portier, C. (author), Kommineni, C. (author), Johnson, K.A. (author), Luster, M.I. (author), TNO Voeding (author)There has been considerable interest in the use of expanded histopathology as a primary screen for immunotoxicity assessment. To determine the utility of a semiquantitative histopathology approach for examining specific structural and architectural changes in lymphoid tissues, a validation effort was initiated. This study addresses the...article 2004