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Hogervorst, M.A. (author), van Damme, W.J.M. (author), TNO Defensie en Veiligheid (author)Purpose. The purpose of our study was to develop a tool to visualize the limitations posed by visual impairments in detecting small and low-contrast elements in natural images. This visualization tool incorporates existing models of several aspects of visual perception, such as the band-limited contrast model of Peli (J Opt Soc Am A 1996;13:1131...article 2008
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Post, M.W.M. (author), de Witte, L.P. (author), Reichrath, E. (author), Verdonschot, M.M. (author), Wijlhuizen, G.J. (author), Perenboom, R.J.M. (author), TNO Kwaliteit van Leven (author)Objective: IMPACT-S is the screener part of the ICF Measure of Participation and ACTivities questionnaire. IMPACT-S consists of 33 items in 9 scales, reflecting the 9 activity and participation chapters of the International Classification of Functioning, Disability and Health (ICF). The reliability and validity of IMPACT-S as an independent...article 2008
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Damsten, M.C. (author), Commandeur, J.N.M. (author), Fidder, A. (author), Hulst, A.G. (author), Touw, D. (author), Noort, D. (author), Vermeulen, N.P.E. (author), TNO Defensie en Veiligheid (author)Covalent binding of reactive electrophilic intermediates to proteins is considered to play an important role in the processes leading to adverse drug reactions and idiosyncratic drug reactions. Consequently, both for the discovery and the development of new drugs, there is a great interest in sensitive methodologies that enable the detection of...article 2007
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Mol, H.G.J. (author), Rooseboom, A. (author), van Dam, R. (author), Roding, M. (author), Arondeus, K. (author), Sunarto, S. (author), TNO Kwaliteit van Leven (author)The ethyl acetate-based multi-residue method for determination of pesticide residues in produce has been modified for gas chromatographic (GC) analysis by implementation of dispersive solid-phase extraction (using primary-secondary amine and graphitized carbon black) and large-volume (20 μL) injection. The same extract, before clean-up and after...article 2007
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Nielen, M.W.F. (author), van Engelen, M.C. (author), Zuiderent, R. (author), Ramaker, R. (author), TNO Kwaliteit van Leven (author)An emerging trend is recognised in hormone and veterinary drug residue analysis from liquid chromatography tandem mass spectrometry (LC/MS/MS) based screening and confirmation towards accurate mass alternatives such as LC coupled with time-of-flight (TOF), Fourier transform ion cyclotron resonance (FTICR) or Fourier transform orbitrap (FT...article 2007
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Reijneveld, S.A. (author), Spijker, J. (author), Dijkshoorn, H. (author), TNO Kwaliteit van Leven (author)Background and Objective: We examined the reliability and validity of self-reported limitations encountered in the activities of daily living (ADL) as measure of functional performance, for Turkish, Moroccan, and indigenous Dutch elderly in the Netherlands. Methods: We obtained data on self-reported ADL measured by Katz' ADL index and on five...article 2007
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van der Greef, J. (author), Martin, S. (author), Juhasz, P. (author), Adourian, A. (author), Plasterer, T. (author), Verheij, E.R. (author), McBurney, R.N. (author), TNO Kwaliteit van Leven (author)Systems biology has developed in recent years from a technology-driven enterprise to a new strategic tool in Life Sciences, particularly for innovative drug discovery and drug development. Combining the ultimate in systems phenotyping with in-depth investigations of biomolecular mechanisms will enable a revolution in our understanding of disease...article 2007
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- Bouvier D'Yvoire, M. (author), Prieto, P. (author), Blaauboer, B.J. (author), Bois, F.Y. (author), Boobis, A. (author), Brochot, C. (author), Coecke, S. (author), Freidig, A. (author), Gundert-Remy, U. (author), Hartung, T. (author), Jacobs, M.N. (author), Lavé, T. (author), Leahy, D.E. (author), Lennernäs, H. (author), Loizou, G.D. (author), Meek, B. (author), Pease, C. (author), Rowland, M. (author), Spendiff, M. (author), Yang, J. (author), Zeilmaker, M. (author), TNO Kwaliteit van Leven (author) article 2007
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Kamphorst, J.J. (author), van der Heijden, R. (author), de Groot, J. (author), Lafeber, F.P.J.G. (author), Reijmers, T.H. (author), van El, B. (author), Tjaden, U.R. (author), van der Greef, J. (author), Hankemeier, T. (author), TNO Kwaliteit van Leven (author)Synovial fluid potentially contains markers for early diagnosis and disease progression in degenerative joint diseases such as osteoarthritis. Here, a method is described for profiling endogenous peptides in human synovial fluid, using ultrafiltration, solid-phase extraction, nanoscale liquid chromatography, and high-resolution mass spectrometry...article 2007
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Freidig, A.P. (author), Dekkers, S. (author), Verwei, M. (author), Zvinavashe, E. (author), Bessems, J.G.M. (author), van de Sandt, J.J.M. (author), TNO Kwaliteit van Leven (author)Future EU legislations enforce a fast hazard and risk assessment of thousands of existing chemicals. If conducted by means of present data requirements, this assessment will use a huge number of test animals and will be neither cost nor time effective. The purpose of the current research was to develop methods to increase the acceptability of in...article 2007
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Guzik, P. (author), Piskorski, J. (author), Krauze, T. (author), Schneider, R. (author), Wesseling, K.H. (author), Wykrȩtowicz, A. (author), Wysocki, H. (author), TNO Biomedical Instrumentation (author)Aim: To analyze the correlation of the Poincaré plot descriptors of RR intervals with standard measures of heart rate variability (HRV) and spontaneous baroreflex sensitivity (BRS). A physiological model of changing respiratory rates from 6 to 15 breaths/min provided a wide range of RR intervals for analysis. Material and methods: Beat-to-beat...article 2007
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Wieringa, F.P. (author), Mastik, F. (author), Boks, R.H. (author), Visscher, A. (author), Bogers, A. (author), van der Steen, A.F.W. (author), TNO Industrie en Techniek (author)Feasibility of pulse oxigraphy is examined using an in- vitro phantom, perfused with human blood by a heart- lung machine. 29 different oxygen saturation levels, measured with our experimental camera and a clinical pulse oximeter, were matched against laboratory blood gas analysis. Discrete transfer functions between measurements & laboratory...conference paper 2007
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Testing the structural and cross-cultural validity of the KIDSCREEN-27 quality of life questionnaireRobitail, S. (author), Ravens-Sieberer, U. (author), Simeoni, M.C. (author), Rajmil, L. (author), Bruil, J. (author), Power, M. (author), Duer, W. (author), Cloetta, B. (author), Czemy, L. (author), Mazur, J. (author), Czimbalmos, A. (author), Tountas, Y. (author), Hagquist, C. (author), Kilroe, J. (author), Auquier, P. (author), Fuerth, K. (author), Czerny, L. (author), Erhart, M. (author), Nickel, J. (author), Kurth, B.-M. (author), Gosch, A. (author), Von Rüden, U. (author), Dimitrakakis, C. (author), Aszman, A. (author), Flannery, E. (author), Detmar, S. (author), Veripps, E. (author), Mierzejeswka, E. (author), Berra, S. (author), Tebé, C. (author), Herdman, M. (author), Alonso, J. (author), Abel, T. (author), Bisegger, C. (author), Farley, C. (author), Atherton, C. (author), Phillips, K. (author), TNO Kwaliteit van Leven (author)Objectives: The aim of this study is to assess the structural and cross-cultural validity of the KIDSCREEN-27 questionnaire. Methods: The 27-item version of the KIDSCREEN instrument was derived from a longer 52-item version and was administered to young people aged 8-18 years in 13 European countries in a cross-sectional survey. Structural and...article 2007
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Theoretical feasibility of suppressing offensive sports chants by means of delayed feedback of soundvan Wijngaarden, S.J. (author), van Balken, J.A. (author)A novel approach for disrupting offensive chants at sporting events is proposed, based on attacking synchronization between individuals. Since timing is crucial for coordination between chanters, disruption of timing is expected to be effective against undesired chants. Delayed auditory feedback is known to disrupt timing in individual sound...article 2007
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Robitail, S. (author), Simeoni, M.-C. (author), Erhart, M. (author), Ravens-Sieberer, U. (author), Bruil, J. (author), Auquier, P. (author), TNO Preventie en Gezondheid (author)Purpose: The KIDSCREEN project aims to develop a European cross-cultural generic self-administered Health-Related Quality of Life (HRQoL) instrument for children and adolescents. Proxy measures HRQoL should be a useful and practical alternative to assess children's HRQoL. The KIDSCREEN pilot study involved 3988 children and 2526 child-proxy...article 2006
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Pieterse, B. (author), Jellema, R.H. (author), van der Werf, M.J. (author), TNO Kwaliteit van Leven (author)Messenger RNA levels change on a minutes scale due to both degradation and de novo transcription. Consequently, alterations in the transcript profiles that are not representative for the condition of interest are easily introduced during sample harvesting and work-up. In order to avoid these unwanted changes we have validated a - 45°C methanol...article 2006
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Papp, Z. (author), den Ouden, F. (author), Netten, B.D. (author), Zoutendijk, A.M. (author), TNO Industrie en Techniek (author)Important application domains of multi-agent systems require agent interactions in physical environments (e.g. mobile robotics, intelligent transportation systems, etc.). Sensing and sensory data interpretation play ever increasing role because sensing becomes the primary way of collecting information about the environment. In the most...conference paper 2006
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Goldbohm, R.A. (author), Tielemans, E.L.J.P. (author), Heederik, D. (author), Rubingh, C.M. (author), Dekkers, S. (author), Willems, M.I. (author), Dinant Kroese, E. (author), TNO Kwaliteit van Leven (author)It is generally recognized that human, epidemiological data, if available, are preferred as the starting point for quantitative risk analysis above the use of data from animal studies. Although methods to obtain proper risk estimates from epidemiological data are available, several impediments prevent their widespread application. These...article 2006
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- Prinsen, M.K. (author), TNO Kwaliteit van Leven (author) article 2006
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Coulier, L. (author), Bas, R. (author), Jespersen, S. (author), Verheij, E. (author), van der Werf, M.J. (author), Hankemeier, T. (author), TNO Kwaliteit van Leven TNO Voeding (author)We have developed an analytical method, consisting of ion-pair liquid chromatography coupled to electrospray ionization mass spectrometry (IP-LC-ESI-MS), for the simultaneous quantitative analysis of several key classes of polar metabolites, like nucleotides, coenzyme A esters, sugar nucleotides, and sugar bisphosphates. The use of the ion-pair...article 2006