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Kong, H. (author), Wang, M. (author), Venema, K. (author), Maathuis, A. (author), van der Heijden, R. (author), van der Greef, J. (author), Xu, G. (author), Hankemeier, T. (author), TNO Kwaliteit van Leven (author)A high-performance liquid chromatography-high resolution Fourier transform ion cyclotron resonance mass spectrometry (HPLC-FTICR-MS) method was developed to investigate the metabolism of ginsenosides in in vitro models of the gastro-intestinal tract. The metabolites were identified by high-resolution tandem mass spectrometry. Degradation and...article 2009
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Wang, J. (author), van der Heijden, R. (author), Spijksma, G. (author), Reijmers, T. (author), Wang, M. (author), Xu, G. (author), Hankemeier, T. (author), van der Greef, J. (author), TNO Kwaliteit van Leven (author)A matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS) method was developed for the high throughput and robust qualitative profiling of alkaloids in Fuzi-the processed lateral roots of the Chinese herbal medicine Aconitum carmichaeli Debx (A. carmichaeli). After optimization, powdered roots - without any further sample...article 2009
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de Vries, S.I. (author), van Hirtum, H.W.J.E.M. (author), Bakker, I. (author), Hopman-Rock, M. (author), Hirasing, R.A. (author), van Mechelen, W. (author), TNO Kwaliteit van Leven (author)Purpose: To review recently published studies on the reproducibility, validity, and feasibility of motion sensors used to assess physical activity in healthy children and adolescents (2-18 yr). Methods: On October 2004, a systematic literature search in PubMed, EMBASE, and PsycINFO was performed. This search has been updated on October 2007. In...article 2009
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Comprehensive analysis of the metabolome of Pseudomonas putida S12 grown on different carbon sourcesvan der Werf, M.J. (author), Overkamp, K.M. (author), Muilwijk, B. (author), Koek, M.M. (author), van der Werff van der - Vat, B.J.C. (author), Jellema, R.H. (author), Coulier, L. (author), Hankemeier, T. (author), TNO Kwaliteit van Leven (author)Metabolomics is an emerging, powerful, functional genomics technology that involves the comparative non-targeted analysis of the complete set of metabolites in an organism. We have set-up a robust quantitative metabolomics platform that allows the analysis of 'snapshot' metabolomes. In this study, we have applied this platform for the...article 2008
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Ploeg, J. (author), Hendriks, F.M. (author), Schouten, N.J. (author), TNO Industrie en Techniek (author)Recently, the developments in the field of ADA systems shifted from comfort oriented systems to safety oriented systems. Consequently, the complexity of testing those systems increased. This leads to a demand for reproducible, efficient and safe testing methods for ADA systems in general, and pre-crash systems in particular. A method for pre...conference paper 2008
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Bobeldijk, I. (author), Hekman, M. (author), van der Vries de- Weij, J. (author), Coulier, L. (author), Ramaker, R. (author), Kleemann, R. (author), Kooistra, T. (author), Rubingh, C. (author), Freidig, A. (author), Verheij, E. (author), TNO Kwaliteit van Leven (author)We report a sensitive, generic method for quantitative profiling of bile acids and other endogenous metabolites in small quantities of various biological fluids and tissues. The method is based on a straightforward sample preparation, separation by reversed-phase high performance liquid-chromatography mass spectrometry (HPLC-MS) and electrospray...article 2008
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Hu, C. (author), van Dommelen, J. (author), van der Heijden, R. (author), Spijksma, G. (author), Reijmers, T.H. (author), Wang, M. (author), Slee, E. (author), Lu, X. (author), Xu, G. (author), van der Greef, J. (author), Hankemeier, T. (author), TNO Kwaliteit van Leven (author)A reversed-phase liquid chromatography-linear ion trap-Fourier transform ion cyclotron resonance-mass spectrometry method was developed for the profiling of lipids in human and mouse plasma. With the use of a fused-core C<sub>8</sub> column and a binary gradient, more than 160 lipids belonging to eight different classes were detected in a single...article 2008
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IJmker, S. (author), Mikkers, J. (author), Blatter, B.M. (author), van der Beek, A.J. (author), van Mechelen, W. (author), Bongers, P.M. (author), TNO Kwaliteit van Leven (author)Introduction: "Ergonomic" questionnaires are widely used in epidemiological field studies to study the association between workstation characteristics, work posture and musculoskeletal disorders among office workers. Findings have been inconsistent regarding the putative adverse effect of work postures. Underestimation of the true association...article 2008
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Kruizinga, A.G. (author), Briggs, D. (author), Crevel, R.W.R. (author), Knulst, A.C. (author), Bosch, L.M.C.v.d. (author), Houben, G.F. (author), TNO Kwaliteit van Leven (author), KvL (author)Previously, TNO developed a probabilistic model to predict the likelihood of an allergic reaction, resulting in a quantitative assessment of the risk associated with unintended exposure to food allergens. The likelihood is estimated by including in the model the proportion of the population who is allergic, the proportion consuming the food and...article 2008
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Wesselink, J.M. (author), Berkhoff, A.P. (author), TNO Industrie en Techniek (author)In this paper, real-time results are given for broadband multichannel active noise control using the regularized modified filtered-error algorithm. As compared to the standard filtered-error algorithm, the improved convergence rate and stability of the algorithm are obtained by using an inner-outer factorization of the transfer path between the...article 2008
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Kaptein, S. (author), Jansen, D.E.M.C. (author), Vogels, A.G.C. (author), Reijneveld, S.A. (author), TNO Kwaliteit van Leven (author)Background: The assessment of mental health problems in children with intellectual disability (ID) mostly occurs by filling out long questionnaires that are not always validated for children without ID. The aim of this study is to assess the differences in mental health problems between children with ID and without ID, using a short...article 2008
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Fischer, H.R. (author), TNO Industrie en Techniek (author)Micro-thermal analysis (μTATM) is a technique in which thermal analysis is performed on surfaces of test specimens on a small (ca. 2×2 μm) scale. Like any thermal analysis technique, interpretation of results benefits from accurate temperature information and knowledge of the precision of the resultant measurement. However, temperature...article 2008
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Terband, H. (author), Drullman, R. (author), TNO Defensie en Veiligheid (author)A procedure was developed for the automated measurement of the speech reception threshold in stationary noise (SRTn), which can be administered by the subjects themselves using a computer. The procedure was based on the SRTn test for Dutch developed by Plomp and Mimpen [(1979). Improving the reliability of testing the speech reception threshold...article 2008
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van den Berg, J.F. (author), van Rooij, F.J.A. (author), Vos, H. (author), Tulen, J.H.M. (author), Hofman, A. (author), Miedema, H.M.E. (author), Neven, A.K. (author), Tiemeier, H. (author), TNO Bouw (author)Sleep duration is an important concept in epidemiological studies. It characterizes a night's sleep or a person's sleep pattern, and is associated with numerous health outcomes. In most large studies, sleep duration is assessed with questionnaires or sleep diaries. As an alternative, actigraphy may be used, as it objectively measures sleep...article 2008
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Spaan, S. (author), Schinkel, J. (author), Wouters, I.M. (author), Preller, L. (author), Tielemans, E. (author), Nij, E.T. (author), Heederik, D. (author), TNO Kwaliteit van Leven (author)Objectives: Workers in many industries are exposed to endotoxins, which may cause adverse health effects. In exposure assessment, information about exposure variability is essential. However, variability in exposure has rarely been investigated for biological agents and more specifically for endotoxin. Therefore, variance components and...article 2008
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Tomaso, H. (author), Jacobs, D. (author), Eickhoff, M. (author), Scholz, H.C. (author), al Dahouk, S. (author), Kattar, M.M. (author), Reischl, U. (author), Plicka, H. (author), Strand Olsen, J. (author), Nikkari, S. (author), Matero, P. (author), Beuret, C. (author), Ciammaruconi, A. (author), Lista, F. (author), Gala, J.-L. (author), Broll, H. (author), Appel, B. (author), Sellek Cano, R.E. (author), Ybarra de Villavicencio, M.D.C. (author), Broekhuijsen, M.P. (author), Indra, A. (author), Petersen, R. (author), Neubauer, H. (author)Background: Yersinia pestis (Y. pestis) is a zoonotic bacterium mainly circulating among rodents and their fleas. Transmission to humans can cause bubonic, pneumonic or septicemic plague with a high case-fatality rate. Therefore, rapid and reliable diagnostic tools are crucial. The objective of this study was to assess the inter-laboratory...article 2008
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Hoogendoorn, R.J.W. (author), Helder, M.N. (author), Kroeze, R.J. (author), Bank, R.A. (author), Smit, T.H. (author), Wuisman, P.I.J.M. (author), TNO Kwaliteit van Leven (author)STUDY DESIGN. Twelve goats were chemically degenerated and the development of the degenerative signs was followed for 26 weeks to evaluate the progression of the induced degeneration. The results were also compared with a previous study to determine the reproducibility. OBJECTIVES. The purpose of this study was determine whether this...article 2008
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- Kromhout, H. (author), van Wendel-de Joode, B. (author), van Hemmen, J. (author), TNO Kwaliteit van Leven (author) article 2008
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Bobeldijk, I. (author), Karlsson, D. (author), Pronk, A. (author), Gonsalves, J. (author), Hekman, M. (author), van de Lagemaat, D. (author), Preller, L. (author), Heederik, D. (author), Skarping, G. (author), TNO Kwaliteit van Leven (author)An adapted method for the quantitative determination of isocyanates in air was implemented and validated in-house. The method was based on air sampling using an impinger flask containing di-n-butylamine (DBA) in toluene and a glass fibre filter in series. The DBA derivatives were determined using liquid chromatography and tandem mass...article 2008
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Ravens-Sieberer, U. (author), Gosch, A. (author), Rajmil, L. (author), Erhart, M. (author), Bruil, J. (author), Power, M. (author), Duer, W. (author), Auquier, P. (author), Cloetta, B. (author), Czemy, L. (author), Mazur, J. (author), Czimbalmos, A. (author), Tountas, Y. (author), Hagquist, C. (author), Kilroe, J. (author), Fuerth, K. (author), Simeoni, M.-C. (author), Robitail, S. (author), Nickel, J. (author), Kurth, B.M. (author), von Rüden, U. (author), Dimitrakakis, C. (author), Aszman, A. (author), Keenaghan, C. (author), Detmar, S. (author), Veripps, E. (author), Mierzejeswka, E. (author), Berra, S. (author), Tebé, C. (author), Herdman, M. (author), Alonso, J. (author), Abel, T. (author), Bisegger, C. (author), Farley, C. (author), Atherton, C. (author), Phillips, K. (author), TNO Kwaliteit van Leven (author)Objective: This study assesses the reliability and validity of the European KIDSCREEN-52 generic health-related quality of life (HRQoL) questionnaire for children and adolescents. Research Design: The KIDSCREEN-52, which measures HRQoL in 10 dimensions, was administered to a representative sample of 22,827 children and adolescents (8 to 18 years...article 2008