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(Cost-)effectiveness of a personalized multidisciplinary eHealth intervention for knee arthroplasty patients to enhance return to activities of daily life, work and sports - rationale and protocol of the multicentre ACTIVE randomized controlled trial

Straat, C. (author), Maarleveld, J.M. (author), Smit, D.J.M. (author), Visch, L, (author), Hulsegge, G. (author), Huirne, J.A.F. (author), van Dongen, J.M. (author), van Geenen, R.C. (author), Kerkhoff, G.M.M.J. (author), Anema, J.R. (author), Coenen, P. (author), Kuijer, P.P.F.M. (author)

Background: With the worldwide rising obesity epidemic and the aging population, it is essential to deliver (cost-)effective care that results in enhanced societal participation among knee arthroplasty patients. The purpose of this study is to describe the development, content, and protocol of our (cost-)effectiveness study that assesses a...

article 2023

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Evaluating biomass ash properties as influenced by feedstock and thermal conversion technology towards cement clinker production with a lower carbon footprint

Tosti, L. (author), van Zomeren, A. (author), Pels, J.R. (author), Comans, R.N.J. (author)

Purpose: This study evaluates the potential of biomass ash as raw clinker material and the influence of biomass feedstock and thermal conversion technology on biomass ash properties. Methods: A set of criteria for biomass feedstock and ash properties (i.e. CaO/SiO2 ratio and burnability) are established. A large dataset was collected and the...

article 2021

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Product platform replacement: Impact of performance objectives, innovation speed, and competition

van den Broeke, M. (author), Devoldere, B.P.E. (author), Creemers, S. (author), Boute, R. (author)

article 2021

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Development of a Personalized m/eHealth Algorithm for the Resumption of Activities of Daily Life Including Work and Sport after Total and Unicompartmental Knee Arthroplasty: A Multidisciplinary Delphi Study

Straat, A.C. (author), Coenen, P. (author), Smit, D.J.M. (author), Hulsegge, G. (author), Bouwsma, E.V.A. (author), Huirne, J.A. (author), van Geenen, R.G. (author), Janssen, R.P.A. (author), Boymans, T.A.E.J. (author), Kerkhoffs, G.M. (author), Anema, J.R. (author), Kuijer, P.P.E.M. (author)

Evidence for recommendations concerning the resumption of activities of daily life, including work and sport, after knee arthroplasty is lacking. Therefore, recommendations vary considerably between hospitals and healthcare professionals. We aimed to obtain multidisciplinary consensus for such recommendations. Using a Delphi procedure, we...

article 2020

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Development of a Risk Stratification Model for Delayed Inpatient Recovery of Physical Activities in Patients Undergoing Total Hip Replacement

Elings, J. (author), van der Sluis, G. (author), Goldbohm, R.A. (author), Galindo Garre, F. (author), de Gast, A. (author), Hoogeboom, T. (author), van Meeteren, N.L.U. (author)

Study Design Prospective cohort design using data derived from usual care. Background It is important that patients are able to function independently as soon as possible after total hip replacement. However, the speed of regaining activities differs significantly. Objectives To develop a risk stratification model (RSM) to predict delayed...

article 2016

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Online corrosion monitoring in a postcombustion CO2 capture pilot plant and its relation to solvent degradation and ammonia emissions

Khakharia, P. (author), Mertens, J. (author), Huizinga, A. (author), de Vroey, S. (author), Sanchez Fernandez, E. (author), Srinivasan, S. (author), Vlugt, T.J.H. (author), Goetheer, E.L.V. (author)

Corrosion in amine treating plants is known to cause integrity failures, plant shutdown, costly repairs, and so forth. The use of an amine treatment system for postcombustion CO2 capture brings additional challenges in terms of the flue gas quality, flue gas composition, operating conditions, scale of operation, and so forth. These differences...

article 2015

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Risk factors for delayed inpatient functional recovery after total knee arthroplasty

Hoogeboom, T.J. (author), van Meeteren, N.L.U. (author), Schank, K. (author), Kim, R.H. (author), Miner, T. (author), Stevens-Lapsley, J.E. (author)

Purpose. To determine the predictive value of surgery-related variables for delayed inpatient functional recovery (i.e., ≥3 days to reach functional independence) after TKA. Method. 193 consecutive people undergoing TKA were included in this prospective cohort study. Inpatient functional recovery was measured daily using the Iowa Level of...

article 2015

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What augmented physical activity and empowerment can bring to patients receiving total knee replacement: content, implementation, and comparative effectiveness of a new function-tailored care pathway in a routine care setting

van der Sluis, G. (author), Goldbohm, R.A. (author), Bimmel, R. (author), Galindo Garre, F. (author), Eling, J. (author), Hoogeboom, T.J. (author), van Meeteren, N.L.U. (author)

Background. In the routine setting of the 20-bed orthopaedic ward of a regional hospital in Netherlands, we developed, implemented, and evaluated a new, function-tailored perioperative care pathway for patients receiving total knee replacement (TKR), aimed at faster functional recovery by reduction of inactivity and stimulation of self-efficacy...

article 2015

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Regulatory acceptance and use of 3R models for pharmaceuticals and chemicals: Expert opinions on the state of affairs and the way forward

Schiffelers, M.J.W.A. (author), Blaauboer, B.J. (author), Bakker, W.E. (author), Beken, S. (author), Hendriksen, C.F.M. (author), Koeter, H. (author), Krul, C.A.M. (author)

Pharmaceuticals and chemicals are subjected to regulatory safety testing accounting for approximately 25% of laboratory animal use in Europe. This testing meets various objections and has led to the development of a range of 3R models to Replace, Reduce or Refine the animal models. However, these models must overcome many barriers before being...

article 2014

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Monounsaturated and Saturated, but Not n-6 Polyunsaturated Fatty Acids Decrease Cartilage Destruction under Inflammatory Conditions: A Preliminary Study

Bastiaansen-Jenniskens, Y.M. (author), Siawash, M. (author), van de Lest, C.H.A. (author), Verhaar, J.A.N. (author), Kloppenburg, M. (author), Zuurmond, A.M. (author), Stojanovic-Susulic, V. (author), van Osch, G.J.V.M. (author), Clockaerts, S. (author)

Purpose: Osteoarthritis (OA) is associated with obesity in which altered fatty acid levels have been observed. We investigated whether the most common fatty acids in synovial fluid influence cartilage deterioration in OA. Design: Cartilage was obtained from OA patients undergoing total knee arthroplasty. Chondrocytes or cartilage explants were...

article 2013

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In end stage osteoarthritis, cartilage tissue pentosidine levels are inversely related to parameters of cartilage damage

Vos, P.A.J.M. (author), Mastbergen, S.C. (author), Huisman, A.M. (author), de Boer, T.N. (author), de Groot, J. (author), Polak, A.A. (author), Lafeber, F.P.J.G. (author)

Objectives: Age is the most prominent predisposition for development of osteoarthritis (OA). Age-related changes of articular cartilage are likely to play a role. Advanced glycation endproducts (AGEs) accumulate in cartilage matrix with increasing age and adversely affect the biomechanical properties of the cartilage matrix and influence...

article 2012

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Preoperative home-based physical therapy versus usual care to improve functional health of frail older adults scheduled for elective total hip arthroplasty: A pilot randomized controlled trial

Oosting, E. (author), Jans, M.P. (author), Dronkers, J.J. (author), Naber, R.H. (author), Dronkers-Landman, C.M. (author), Appelman-De Vries, S.M. (author), van Meeteren, N.L. (author)

Preoperative home-based physical therapy versus usual care to improve functional health of frail older adults scheduled for elective total hip arthroplasty: a pilot randomized controlled trial. Objective: To investigate the feasibility and preliminary effectiveness of a home-based intensive exercise program to improve physical health of frail...

article 2012

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Implementation challenges for designing Integrated In Vitro Testing Strategies (ITS) aiming at reducing and replacing animal experimentation

de Wever, B. (author), Fuchs, H.W. (author), Gaca, M. (author), Krul, C.A.M. (author), Mikulowski, S. (author), Poth, A. (author), Roggen, E.L. (author), Vilà, M.R. (author)

At the IVTIP (In Vitro Testing Industrial Platform) meeting of November 26th 2009 entitled 'Toxicology in the 21st century ('21C') - working our way towards a visionary reality' all delegates endorsed the emerging concept of the '21C' vision as the way forward to enable a thorough, reliable and systematic approach to future toxicity testing...

article 2012

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Toxicology in the 21st century - Working our way towards a visionary reality

Berg, N. (author), de Wever, B. (author), Fuchs, H.W. (author), Gaca, M. (author), Krul, C.A.M. (author), Roggen, E.L. (author)

In November 2009 the In Vitro Testing Industrial Platform (IVTIP) organized a meeting entitled '. Toxicology in the 21st century - working our way towards a visionary reality'. Participating delegates included scientists, key opinion leaders, developers and users of 3Rs-related tests and testing strategies. This paper summarizes the discussions...

article 2011

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Evaluation of research activities and research needs to increase the impact and applicability of alternative testing strategies in risk assessment practice

Punt, A. (author), Schiffelers, M.J.W.A. (author), Jean Horbach, G. (author), van de Sandt, J.J.M. (author), Groothuis, G.M.M. (author), Rietjens, I.M.C.M. (author), Blaauboer, B.J. (author)

The present paper aims at identifying strategies to increase the impact and applicability of alternative testing strategies in risk assessment. To this end, a quantitative and qualitative literature evaluation was performed on (a) current research efforts in the development of in vitro methods aiming for alternatives to animal testing, (b) the...

article 2011

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Reproducibility and validity of the Dutch translation of the de Morton Mobility Index (DEMMI) used by physiotherapists in older patients with knee or Hip osteoarthritis

Jans, M.P. (author), Slootweg, V.C. (author), Boot, C.R. (author), de Morton, N.A. (author), van der Sluis, G. (author), van Meeteren, N.L. (author)

Objective: To examine the reproducibility, construct validity, and unidimensionality of the Dutch translation of the de Morton Mobility Index (DEMMI), a performance-based measure of mobility for older patients. Design: Cross-sectional study. Setting: Rehabilitation center (reproducibility study) and hospital (validity study). Participants:...

article 2011

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Cardiovascular risk markers during treatment with estradiol and trimegestone or dydrogesterone

Hellgren, M. (author), Conard, J. (author), Norris, L. (author), Kluft, C. (author), TNO Kwaliteit van Leven (author)

Objective: To study cardiovascular risk markers in women taking estradiol/trimegestone or estradiol/dydrogesterone. Design: Multicenter, randomized, prospective, double-blind study of 184 healthy post-menopausal women randomized to 6 cycles of either estradiol (2 mg) + trimegestone (0.5 mg) (T-group) or estradiol (2 mg) + dydrogesterone (10 mg) ...

article 2009

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The impact of waiting for total joint replacement on pain and functional status: A systematic review

Hoogeboom, T.J. (author), van den Ende, C.H.M. (author), van der Sluis, G. (author), Elings, J. (author), Dronkers, J.J. (author), Aiken, A.B. (author), van Meeteren, N.L.U. (author), TNO Kwaliteit van Leven (author)

Objective: To systematically describe changes in pain and functioning in patients with osteoarthritis (OA) awaiting total joint replacement (TJR), and to assess determinants of this change. Methods: MEDLINE®, EMBASE, CINAHL® and Cochrane Database were searched through June 2008. The reference lists of eligible publications were reviewed. Studies...

article 2009

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Implementation of a shared care guideline on the lumbosacral radicular syndrome: effects on unnecessary referrals, waiting time and costs

TNO Preventie en Gezondheid (author), Fleuren, M.A.H. (author), Dusseldorp, E. (author), van den Akker-van Marle, M.E. (author), van den Bergh-Verhappen, S. (author), Wildschut, J. (author), Vlek, H. (author), Wijkel, D. (author)

Conference abstract of the 9th Annuale Integrated Care Conference, Vienna, Austria, 3-6 November 2009.

article 2009

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Effects of non-oral postmenopausal hormone therapy on markers of cardiovascular risk: A systematic review

Hemelaar, M. (author), van der Mooren, M.J. (author), Rad, M. (author), Kluft, C. (author), Kenemans, P. (author), TNO Kwaliteit van Leven (author)

Objective: To review the effects of non-oral administration of postmenopausal hormone therapy (HT) on risk markers for atherosclerotic and venous thromboembolic disease.Non-oral postmenopausal HT appears not to increase venous thromboembolic risk, whereas the effect on coronary heart disease risk is less clear. Design: Systematic review of...

article 2008