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Koppert, P.W. (author), Huijsmans, C.M.G. (author), Nieuwenhuizen, W. (author), Gaubius instituut TNO (author)Spleen cells of BALB/c mice, immunized with fragments Y of normal human fibrinogen, were fused with P3 x 63 Ag 8653 myeloma cells. A clone was found which produces monoclonal antibodies (Mab-Y18) of the IgM?? type. Mab-Y18 is immunoreactive with normal human fibrinogen, and its fragments X, Y, N-terminal disulphide knot, A??-chain, and A??...article 1985
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Prins Maurits Laboratorium TNO (author), Leeuw, M.W. (author), Rooijers, A.J.T. (author), van der Steen, A.C. (author)Emission spectroscopy is used to monitor the emission of decompositon products of primary explosives after initiation with an excimer laser pulse. Using a gated optical multichannel analyser spectra can be obtained in the microsecond time domain. These spectra provide detailed information about the decomposition reactions in the first stage of...conference paper 1985
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Bemelmans, J.M.H. (author), den Braber, H.J.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Marinated herring from the Baltic Sea was found to have an offensive odor and taste described as iodine-like and phenolic. Fat isolated from herring was found to contain this taint. The volatiles were isolated from the fat, using a molecular distillation and were subsequently fractionated by gas chromatography. A fraction containing the taint...conference paper 1983
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- Instituut CIVO-Toxicologie en voeding TNO Instituut voor Wiskunde, Informatieverwerking en Statistiek TNO (author), van Dokkum, W. (author), Pikaar, N.A. (author), Thissen, J.T.N.M. (author) article 1983
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Nieuwenhuizen, W. (author), Voskuilen, M. (author), Hermans, J. (author), Gaubius instituut TNO (author)The present study was undertaken as a step to delineate further the localization of the calcium-binding sites in fibrinogen and to assess the anticlotting properties of fibrinogen degradation products. To this purpose, fragments Y were prepared by plasmin digestion of human fibrinogen in the presence of added Ca2+, and purified. We found that,...article 1982
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- Tollenaar, F.D. (author), Centraal Instituut voor Voedingsonderzoek TNO (author) article 1982
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Verheijen, J.H. (author), Nieuwenhuizen, W. (author), Wijngaards, G. (author), Gaubius instituut TNO (author)Tissue activator-mediated plasminogen activation is potentiated both by fibrin and by some soluble fibrin(ogen) fragments. The potentiating effect of the different fragments decreases in the order fibrin monomer > D-dimer > Y > D EGTA > Dcate > X. Fibrinogen and the fragments Ecate, E EGTA and E fibrin have almost no effect. The existence of a...article 1982
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- Centraal Instituut voor Voedingsonderzoek TNO (author), van Dokkum, W. (author), Wesstra, A. (author), Schippers, F.A. (author) article 1982
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Stitz, L. (author), Kreeftenberg, J.G. (author), Loggen, H.G. (author), Balner, H. (author), Primatencentrum TNO (author)62 Rhesus monkeys were tested at different times after vaccinia virus infection for virus-specific induction of lymphocyte proliferation in vitro or antibody production in vivo. No association was found between identifiable RhLA-controlled antigens and the strength of the cellular proliferative and/or humoral response. Chemicals/CAS: Antibodies,...article 1981
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Nieuwenhuizen, W. (author), Vermond, A. (author), Haverkate, F. (author), Gaubius instituut TNO (author)Experiments have been carried out with fibrinogen and with purified degradation products of fibrinogen and fibrin which demonstrate that the structure of D fragments obtained after prolonged plasmin digestion is influenced by several factors in the media. The previously described protective effect of calcium ions on the ??-chain carboxy...article 1981
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Wijsman, J.A. (author), Hilwig, G.N.G. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Es wurde untersucht, ob die Analyse von Glycerinäthern — eine in sehr geringer Menge im Unverseifbaren von Schweine‐und Rindsfett vorkommende Gruppe von Verbindungen — Perspektiven bei der Reinheitsbestimmung dieser Fette bietet. Dazu wurden eine “Mikro”‐Isolation und ein “Mikro”‐Analysenverfahren entwickelt, wobei die Möglichkeit besteht, die...article 1981
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Nieuwenhuizen, W. (author), Gravesen, M. (author), Gaubius instituut TNO (author)Early plasmin degradation products (X fragments) of human fibrinogen were prepared in the presence of calcium-ions or EGTA, and purified on Sepharose 6B-CL. X fragments were characterized with respect to amino-terminal amino acids, polypeptide-chain composition, anticlotting properties and calcium-binding. Amino-terminal amino acids were alanine...article 1981
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Steeneken, H.J.M. (author), Houtgast, T. (author), Instituut voor Zintuigfysiologie TNO (author)A physical method for measuring the quality of speech‐transmission channels has been developed. Essentially, the method represents an extension of the Articulation Index (AI) concept, which was developed mainly to account for distortions in the frequency domain (noise, bandpass‐limiting). The underlying concept of the present approach, based on...article 1980
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Centraal Instituut voor Voedingsonderzoek TNO (author), Olsman, W.J. (author)Soy protein is the vegetable protein that is most frequently used in meat products. Accordingly, detection and determination procedures have mainly been focused on soy proteins. Cereal proteins received far less attention analytically, let alone the less conventional vegetable proteins. Every method published has only a limited applicability,...article 1979
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von Lossonczy, T.O. (author), Ruiter, A. (author), Bronsgeest-Schoute, H.C. (author), van Gent, C.M. (author), Hermus, R.J.J. (author)A cross-over study was done with 19 male and 23 female volunteers living in a monastery and a convent, respectively. The effect of a fat fish (mackerel) diet on the blood serum lipid composition was studied. As the normal diet of these volunteers was of the lacto-ovo-vegetarian type, a control diet in which the fish was replaced by full-fat...article 1978
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- Leegwater, D.C. (author) article 1978
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Gaubius instituut TNO (author), van Ruijven-Vermeer, I.A.M. (author), Nieuwenhuizen, W. (author), Nooijen, W.J. (author)The authors studied the binding of Ca to rat fibrinogen and plasmic fibrin(ogen) degradation products by means of equilibrium dialysis with special reference to the protective effect of Ca2+ in the plasmic degradation of fibrinogen. Direct binding studies demonstrate that rat fibrinogen and the plasmic degradation products D(cate) and D-dimer...article 1978
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Olsman, W.J. (author), van Leeuwen, C.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)An improved procedure for the determination of protein-bound nitrite (PBN) in meat products, based on Mirna's method, is described. The results obtained with this modification are significantly higher, and have a lower variation coefficient, than those provided by the old procedure. This is demonstrated by comparison of the analytical results....article 1977
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- Centraal Instituut voor Voedingsonderzoek TNO (author), Nicolas, E. (author) book 1977
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de Vos, R.H. (author), ten Noever de Brauw, M.C. (author), Olthof, P.D.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Pentachloronitrobenzene (PCNB, also known as Quintozene, Terraclor) is used as a soil fungicide in greenhouses, mainly for the control of Rhizoctonia and Botrytis in lettuce. During an examination (by gas liquid chromatography) of a number of soil samples from greenhouses, not only a PCNB peak was found in the chromatograms, but also several...article 1974