Visceral fat accumulation is an important determinant of PAI-1 levels in young, nonobese men and women: Modulation by cross-sex hormone administration

Increased plasminogen activator inhibitor type-1 (PAI-1) levels, leading to impaired fibrinolysis, are associated with increased visceral fat in middle-aged and obese subjects. It is unknown, however, whether this association is independent of other disturbances clustered in the insulin resistance syndrome. We analyzed this association in young,...

New aspects of blood collection and handling procedures for the assessment of t-PA and PAI-1 variables after the introduction of acid blood collection

Blood collection and handling procedures for t-PA activity have thusfar been rather strict and have restrained the use in clinical practice. We evaluated simplifications in the procedures for specifically the use of Stabilyte® vacutainers with respect to time before centrifugation of blood, storage of plasma, times of inversion of the collection...

Constitutive synthesis of tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor type 1 (PAI-1): Conditions and therapeutic targets

In the population at large and in individual normal volunteers, baseline molar concentratios of t-PA and PAI-1 in plasma show a strong correlation. Evidence is summarized that insulin resistance is a prominent cause of interindividual variation, next to possible contributions of vascular inflammation and steroid hormones. In healthy volunteers,...