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TNO Defensie en Veiligheid (author), Krump, H. (author), Šimor, M. (author), Hudec, I. (author), Jaššo, M. (author), Luyt, A.S. (author)In this work, the adhesion strength between poly(ethylene terephthalate) (PET) fibres and styrene-butadiene rubber (SBR) was studied. The effects of atmospheric plasma treatment, used to increase adhesion strength between PET fibres and the rubber matrix, were investigated and compared. It was confirmed that lubricants on the fibres caused a...article 2005
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Bovenschen, N. (author), van Dijk, K.W. (author), Havekes, L.M. (author), Mertens, K. (author), van Vlijmen, B.J.M. (author), Gaubius Instituut TNO (author)Low-density lipoprotein receptor-related protein (LRP) contributes to factor VIII (FVIII) catabolism in vivo. Besides LRP, FVIII also interacts with very low-density lipoprotein receptor (VLDLR) in vitro. We investigated the physiological role of VLDLR in FVIII catabolism, using knockout mouse models for VLDLR and LRP, alone and in combination....article 2004
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Degenhardt, C.E.A.M. (author), Pleijsier, K. (author), van der Schans, M.J. (author), Langenberg, J.P. (author), Preston, K.E. (author), Solano, M.I. (author), Maggio, V.L. (author), Barr, J.R. (author), Prins Maurits Laboratorium TNO (author)One of the most appropriate biomarkers for the verification of organophosphorus nerve agent exposure is the conjugate of the nerve agent to butyrylcholinesterase (BuChE). The phosphyl moiety of the nerve agent can be released from the BuChE enzyme by incubation with fluoride ions, after which the resulting organophosphonofluoridate can be...article 2004
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Davidov, E. (author), Clish, C.B. (author), Oresic, M. (author), Meys, M. (author), Stochaj, W. (author), Snell, P. (author), Lavine, G. (author), Londo, T.R. (author), Adourian, A. (author), Zhang, X. (author), Johnston, M. (author), Morel, N. (author), Marple, E.W. (author), Plasterer, T.N. (author), Neumann, E. (author), Verheij, E. (author), Vogels, J.T.W.E. (author), Havekes, L.M. (author), van der Greef, J. (author), Naylor, S. (author), TNO Preventie en Gezondheid (author)Multitiered quantitative analysis of biological systems is rapidly becoming the desired approach to study hierarchical functional interactions between proteins and metabolites. We describe here a novel systematic approach to analyze organisms with complex metabolic regulatory networks. By using precise analytical methods to measure biochemical...article 2004
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Jansen, M.C.J.F. (author), van Kappel, A.L. (author), Ocké, M.C. (author), van 't Veer, P. (author), Boshuizen, H.C. (author), Riboli, E. (author), Bueno-de-Mesquita, H.B. (author), TNO Voeding (author)Objective: Fruit and vegetable intake is inversely associated with cancer risk in many epidemiological studies. Accurate assessment of consumption of these foods is difficult, and biomarkers of intake would overcome several drawbacks of currently used dietary assessment methods. Therefore, we investigated the relation between plasma carotenoids...article 2004
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Rijken, D.C. (author), Barrett-Bergshoeff, M.M. (author), Jie, A.F.H. (author), Criscuoli, M. (author), Sakharov, D.V. (author), Gaubius Instituut TNO (author)Amediplase (K2tu-PA) is a hybrid plasminogen activator, consisting of the kringle 2 domain of alteplase and the protease domain of urokinase. The objective of this study was to determine the in vitro clot penetration of amediplase in relation to its fibrin binding and to compare the properties with those of alteplase. The clot lysis activity of...article 2004
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van Schoonbeek, K. (author), Feijge, M.A.H. (author), Paquay, M. (author), Rosing, J. (author), Saris, W. (author), Kluft, C. (author), Giesen, P.L.A. (author), Maat, M.P.M.de (author), Heemskerk, J.W.M. (author), TNO Preventie en Gezondheid (author)Objective-The beneficial effect of dietary fish oil, rich in omega-3 polyunsaturated fatty acids (PUFAs), on cardiovascular disease is multifactorial and may partly rely on their anticoagulant action. We studied how fish oil intake influenced thrombin generation in plasma and which factors were involved herein. Methods and Results-Twenty-five...article 2004
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TNO Preventie en Gezondheid (author), Gervois, P. (author), Kleemann, R. (author), Pilon, A. (author), Percevault, F. (author), Koenig, W. (author), Staels, B. (author), Kooistra, T. (author)The peroxisome proliferator-activated receptor alpha (PPARalpha), which is highly expressed in liver, plays key roles in lipid metabolism and inflammation. Interleukin-6 (IL-6) is the principal inducer of acute phase response (APR) gene expression. In the present study, we demonstrate that chronic treatment with the PPARalpha agonist fenofibrate...article 2004
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TNO Preventie en Gezondheid (author), Mandard, S. (author), Zandbergen, F. (author), Nguan, S.T. (author), Escher, P. (author), Patsouris, D. (author), Koenig, W. (author), Kleemann, R. (author), Bakker, A. (author), Veenman, F. (author), Wahli, W. (author), Müller, M. (author), Kersten, S. (author)The fasting-induced adipose factor (FIAF, ANGPTL4, PGAR, HFARP) was previously identified as a novel adipocytokine that was up-regulated by fasting, by peroxisome proliferator-activated receptor agonists, and by hypoxia. To further characterize FIAF, we studied regulation of FIAF mRNA and protein in liver and adipose cell lines as well as in...article 2004
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Gaubius Instituut TNO (author), Goudriaan, J.R. (author), Espirito Santo, S.M.S. (author), Voshol, P.J. (author), Teusink, B. (author), van Dijk, K.W. (author), van Vlijmen, B.J.M. (author), Romijn, J.A. (author), Havekes, L.M. (author), Rensen, P.C.N. (author)The VLDL receptor (VLDLr) is involved in tissue delivery of VLDL-triglyceride (TG)-derived FFA by facilitating the expression of lipoprotein lipase (LPL). However, vldlr-/- mice do not show altered plasma lipoprotein levels, despite reduced LPL expression. Because LPL activity is crucial in postprandial lipid metabolism, we investigated whether...article 2004
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Willems, F.P.T. (author), Creyghton, Y. (author), van Gulijk, C. (author), Oonk, H. (author), Maisuls, S. (author), TNO Wegtransportmiddelen (author)Plasma-assisted PM removal is examined in a packed-bed plasma system. This study focuses on the effect of plasma power, space velocity and exhaust gas composition on PM filtration. Experiments are done on an engine dynamometer with a VW 1.2l TDI engine. During these experiments, the airflow is throttled so large smoke levels are realized. Then,...conference paper 2003
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Vogt, M.H.J. (author), Lopatinskaya, L. (author), Smits, M. (author), Polman, C.H. (author), Nagelkerken, L. (author), TNO Preventie en Gezondheid (author)In the search for proteins that might play a role in the pathogenesis of multiple sclerosis (MS), osteopontin (OPN) has been identified as the most prominent cytokine-encoding gene expressed within MS lesions. Here, we report significantly increased OPN protein levels in plasma of relapsing-remitting MS patients. In contrast, OPN protein levels...article 2003
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TNO Voeding (author), Vente-Spreeuwenberg, M.A.M. (author), Verdonk, J.M.A.J. (author), Verstegen, M.W.A. (author), Beynen, A.C. (author)The present study was designed to evaluate the differential effects of dietary glucose, lactose and starch on small-intestinal morphology, organ weights, pH of chyme and haptoglobin levels in blood plasma of weaned piglets. It was hypothesised that lactose consumption would ameliorate the weaning-induced decrease in gut integrity. A total of...article 2003
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Meijer, P. (author), Verbruggen, H.W. (author), de Weerd, B. (author), den Dool, E.J. (author), van Oerle, R. (author), Gaubius Instituut TNO (author)The comparability of test results for protein S between laboratories is hampered by a high inter-laboratory variability. The effect of the use and type of common reference plasma on the inter-laboratory variability of the total and free protein S measurement was evaluated. The results of 10 plasma samples measured against a centrally distributed...article 2002
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Löffler, J. (author), Groenen, R. (author), Linden, J.L. (author), van de Sanden, M.C.M. (author), Schropp, R.E.I. (author), Technisch Physische Dienst TNO - TH (author)Natively textured ZnO layers deposited by the expanding thermal plasma CVD technique between 150 and 350°C at a deposition rate between 0.65 and 0.75 nm/s have been investigated with respect to their suitability as front electrode material for amorphous silicon pin solar cells in comparison to reference SnO2:F (Asahi U-type). At higher substrate...article 2001
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Löffler, J. (author), Schropp, R.E.I. (author), Groenen, Ft. (author), Van De Sanden, M.C.M. (author), Linden, J.L. (author), Technisch Physische Dienst TNO - TH (author)Natively textured ZnO layers for the application as front electrode material in amorphous silicon pin solar cells have been deposited by Expanding Thermal Plasma Chemical Vapor Deposition. Films deposited in the temperature regime from 150 to 350°C at a rate between 0.65 and 0.75 nm/s have been characterteed with respect to their optical,...conference paper 2000
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Sakharov, D.V. (author), Hekkenberg, R.T. (author), Rijken, D.C. (author), Gaubius Instituut TNO (author)High-frequency ultrasound has been shown to accelerate enzymatic fibrinolysis. One of the supposed mechanisms of this effect is the enhancement of mass transport by acoustic streaming, i.e., ultrasound-induced macroscopic flow around the clot. In this study, which is aimed at further elucidating the mechanisms of the acceleration of fibrinolysis...article 2000
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Banine, V.Y. (author), Benschop, J.P.H. (author), Werij, H.G.C. (author), Technisch Physische Dienst TNO - TH (author)The source is one of the critical factors for the success of Extreme Ultraviolet Lithography (EUVL). Various possibilities to generate EUV radiation exist. The Laser Produced Plasma (LPP), the Synchrotron Wiggler and the gas discharge sources (Z-pinch, Plasma Focus and Capillary discharge) all have the potential to be used for EUV Lithography....article 2000
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Groenen, R. (author), van de Sanden, M.C.M. (author), Löffler, J. (author), Schropp, R.E.I. (author), Linden, J.L. (author), Technisch Physische Dienst TNO - TH (author)A new method for low temperature deposition of surface textured ZnO is presented utilizing an expanding thermal plasma created by a cascaded arc. Films have been deposited at 150-350°C at a rate of typically 0.65-0.75 nm/s, exhibiting low sheet resistance (> 10 Ω/□), high transmittance (>80%) and a rough surface texture. Surface roughness...conference paper 2000
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TNO Milieu, Energie en Procesinnovatie (author), Wang, C. (author), Zhu, W. (author), Wang, Z. (author), Guicherit, R. (author)Atmospheric particulate matter (APM) was collected in Delft, in the western part of the Netherlands, on micro-quartz glass fibre filters from July to September, 1997. The concentrations of rare earth elements (REE) and 9 other metals (Cd, Pb, Fe, V, Ti, Mg, Ca, Na and Al) in the APM were determined by Inductively Coupled Plasma Mass Spectrometry...article 2000