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Huls, M. (author), Kramers, C. (author), Levtchenko, E.N. (author), Wilmer, M.J.G. (author), Dijkman, H.B.P.M. (author), Kluijtmans, L.A.J. (author), van der Hoorn, J.W.A. (author), Russel, F.G.M. (author), Masereeuw, R. (author), TNO Kwaliteit van Leven (author)The multidrug resistance gene 1 product, P-glycoprotein (P-gp), is expressed in several excretory organs, including the apical membrane of proximal tubules. After inducing acute renal failure, P-gp expression is upregulated and this might be a protective function by pumping out toxicants and harmful products of oxidative stress. We characterized...article 2007
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Gauthier, E. (author), Roche, H. (author), Thomas, E. (author), Droineau, S. (author), Bertrand, B. (author), Migozzi, J.B. (author), Vliegenthart, W.A. (author), Dague, L. (author), Andrew, P. (author), Tiscornia, T. (author), Sands, D. (author), TNO Industrie en Techniek (author)Control of the plasma-wall interaction during transient events will be a critical issue in ITER. A new ITER-like wide-angle infrared and visible diagnostic, allowing to observe plasma wall interaction in the main chamber, has been installed on JET. The design and the manufacture of the diagnostic and the test results are presented. ELM...article 2007
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Smulders, Y.M. (author), Smith, D.E.C. (author), Kok, R.M. (author), Teerlink, T. (author), Gellekink, H. (author), Vaes, W.H.J. (author), Stehouwer, C.D.A. (author), Jakobs, C. (author), TNO Kwaliteit van Leven (author)Background: Red blood cells (RBCs) represent a storage pool for folate. In contrast to plasma, RBC folate can appear in different biochemical isoforms. So far, only the methylenetetrahydrofolate reductase (MTHFR) 677 TT genotype has been identified as a determinant of RBC folate vitamer distribution. Objective: The purpose of this study is to...article 2007
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Henneman, P. (author), Schaap, F.G. (author), Havekes, L.M. (author), Rensen, P.C.N. (author), Frants, R.R. (author), van Tol, A. (author), Hattori, H. (author), Smelt, A.H.M. (author), van Dijk, K.W. (author), TNO Kwaliteit van Leven (author)Objective: The recently discovered apoAV is hypothesized to affect triglyceride metabolism by stimulating the lipolysis of triglycerides in VLDL and chylomicrons. We set out to determine the association between increased serum TG levels, plasma apoAV levels, and polymorphism of the APOA5 gene, with specific emphasis on the APOA5 S19W variation....article 2007
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Buscher, B.A.P. (author), Gerritsen, H. (author), van Schöll, I. (author), Cnubben, N.H.P. (author), Brüll, L.P. (author), TNO Kwaliteit van Leven (author)An LC-MS/MS method has been developed for the quantitative determination of a protein drug (Tenecteplase; MW 58,777 Da) in rat plasma. The protein was digested with trypsin without prior clean-up of the plasma sample, without the use of a label nor internal standard. A limited validation was performed to assess the linearity, the sensitivity and...article 2007
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van Vliet, P. (author), Mooijaart, S.P. (author), de Craen, A.J.M. (author), Rensen, P.C.N. (author), van Heemst, D. (author), Westendorp, R.G.J. (author), TNO Kwaliteit van Leven (author)Recently, high plasma apoE levels have been shown to be related to increased cardiovascular mortality, independent of APOE genotype. Here we studied the association of plasma apoE levels with risk of stroke. Within the Leiden 85-plus Study, a prospective population-based study of 561 subjects aged 85 years, we measured plasma apoE level and...bookPart 2007
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TNO Defensie en Veiligheid (author), Marino, E. (author), Huijser, T. (author), Creyghton, Y.L.M. (author), van der Heijden, A.E.D.M. (author)Metals and metal oxides are well-known catalysts in many applications. TNO investigates metal and metal oxide nanoparticles as catalysts in rocket and gun propellants. Using nanosize particles allows to tune the curing, mechanical or ballistic properties of the propellant, but to avoid undesired chemical side-reactions a coating of these...conference paper 2007
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TNO Kwaliteit van Leven (author), Guimarães, A.H.C. (author), Laurens, N. (author), Weijers, E.M. (author), Koolwijk, P. (author), van Hinsbergh, V.W.M. (author), Rijken, D.C. (author)OBJECTIVE - Besides having a key role in fibrinolysis, the plasminogen system has been implicated in cell migration and angiogenesis. A common mechanism is the binding of plasminogen to carboxy-terminal lysine residues in partially degraded fibrin or on cellular surfaces. Here we examined the involvement of thrombin activatable fibrinolysis...article 2007
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Nohynek, G.J. (author), Meuling, W.J.A. (author), Vaes, W.H.J. (author), Lawrence, R.S. (author), Shapiro, S. (author), Schulte, S. (author), Steiling, W. (author), Bausch, J. (author), Gerber, E. (author), Sasa, H. (author), Nau, H. (author), TNO Kwaliteit van Leven (author)Background: Vitamin A is widely used in cosmetic preparations. Given that oral Vitamin A and its metabolites present a potential reproductive risk, the present study investigated the effect of topical Vitamin A on human endogenous plasma levels of Vitamin A and its metabolites. Methods: Two groups of 14 female volunteers of child-bearing age...article 2006
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Noort, D. (author), Fidder, A. (author), van der Schans, M.J. (author), Hulst, A.G. (author), TNO Defensie en Veiligheid (author)We present a generic mass spectrometric method to verify exposure to organophosphates, based on the chemical conversion of the phosphylated peptides obtained after pepsin digestion of human butyrylcholinesterase (HuBuChE) to a common precursor peptide. After exposure of plasma to various organophosphates (nerve agents, pesticides), HuBuChE was...article 2006
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Westerterp, M. (author), van der Hoogt, C.C. (author), de Haan, W. (author), Offerman, E.H. (author), Dallinga-Thie, G.M. (author), Jukema, J.W. (author), Havekes, L.M. (author), Rensen, P.C.N. (author), TNO Kwaliteit van Leven (author)OBJECTIVE - The role of cholesteryl ester transfer protein (CETP) in the development of atherosclerosis is still undergoing debate. Therefore, we evaluated the effect of human CETP expression on atherosclerosis in APOE*3-Leiden (E3L) mice with a humanized lipoprotein profile. METHODS AND RESULTS - E3L mice were crossbred with human CETP...article 2006
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von Hellermann, M. (author), Jaspers, R. (author), Biel, W. (author), Litnovsky, A. (author), Neubauer, O. (author), Pap, M. (author), Hawkes, N.C. (author), Marren, C. (author), Walton, B. (author), Kaschuck, Y. (author), Serov, V. (author), Tugarinov, S. (author), Vliegenthart, W.A. (author), Moddemeijer, K. (author), Walker, C. (author), Ingesson, C. (author), TNO Industrie en Techniek (author)A status report is given on recent joint activities on the ITER CXRS and BES diagnostic package. Expected measurement performances are reviewed as well as comprehensive discussions are led on an integral approach to the implementation of Core and Edge CXRS observation periscopes. The "first mirror" location, its operational temperature,...article 2006
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König, R. (author), Hildebrandt, D. (author), Hübner, T. (author), Klinkhamer, J.F.F. (author), Moddemeijer, K. (author), Vliegenthart, W.A. (author), TNO Industrie en Techniek (author)The stellarator W7-X will be capable of running in a quasicontinuous operating mode with 10 MW of electron cyclotron heating (ECRH) heating for 30 min, the duration only being limited by the capacity of the available cooling reservoir. The integrated ten discrete water cooled divertor modules need to be closely monitored by ten high resolution...article 2006
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Duivenvoorden, I. (author), Voshol, P.J. (author), Rensen, P.C.N. (author), van Duyvenvoorde, W. (author), Romijn, J.A. (author), Emeis, J.J. (author), Havekes, L.M. (author), Nieuwenhuizen, W.F. (author), TNO Kwaliteit van Leven (author)Background: The prevalence of dyslipidemia and obesity resulting from excess energy intake and physical inactivity is increasing. The liver plays a pivotal role in systemic lipid homeostasis. Effective, natural dietary interventions that lower plasma lipids and promote liver health are needed. Objective: Our goal was to determine the effect of...article 2006
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Rensen, P.C.N. (author), Havekes, L.M. (author), TNO Kwaliteit van Leven (author)Chemicals / CAS: 2 methylpropanethioic acid s [2 [1 (2 ethylbutyl)cyclohexylcarboxamido]phenyl] ester, 211513-37-0; atorvastatin, 134523-00-5, 134523-03-8; nicotinic acid, 54-86-4, 59-67-6; torcetrapib, 262352-17-0; Carrier Proteins; CETP protein, human; Cholesterol Ester Transfer Proteins; Cholesterol Esters; Cholesterol, HDL; Glycoproteins;...article 2006
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Bijlsma, S. (author), Bobeldijk, I. (author), Verheij, E.R. (author), Ramaker, R. (author), Kochhar, S. (author), Macdonald, I.A. (author), van Ommen, B. (author), Smilde, A.K. (author), TNO Kwaliteit van Leven (author)A large metabolomics study was performed on 600 plasma samples taken at four time points before and after a single intake of a high fat test meal by obese and lean subjects. All samples were analyzed by a liquid chromatography-mass spectrometry (LC-MS) lipidomic method for metabolic profiling. A pragmatic approach combining several well...article 2006
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Keijzer-Veen, M.G. (author), Finken, M.J.J. (author), Nauta, J. (author), Dekker, F.W. (author), Hille, E.T.M. (author), Frölich, M. (author), Wit, J.M. (author), van der Heijden, A.J. (author), TNO Kwaliteit van Leven (author)Objective. To determine whether intrauterine growth restriction (IUGR) is a predisposing factor for high blood pressure (BP) in 19-year-olds who were born (very) preterm. Methods. A prospective follow-up study was conducted at age 19 in individuals who born preterm in the Netherlands in 1983. Systolic, diastolic, and mean BP values and plasma...article 2005
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- Coecke, S. (author), Blaauboer, B.J. (author), Elaut, G. (author), Freeman, S. (author), Freidig, A. (author), Gensmantel, N. (author), Hoet, P. (author), Kapoulas, V.M. (author), Ladstetter, B. (author), Langley, G. (author), Leahy, D. (author), Mannens, G. (author), Meneguz, A. (author), Monshouwer, M. (author), Nemery, B. (author), Pelkonen, O. (author), Pfaller, W. (author), Prieto, P. (author), Proctor, N. (author), Rogiers, V. (author), Rostami-Hodjegan, A. (author), Sabbioni, E. (author), Steiling, W. (author), van de Sandt, J.J.M. (author), TNO Kwaliteit van Leven (author) article 2005
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TNO Kwaliteit van Leven (author), Verschuur, M. (author), Jong, M.de (author), Felida, L. (author), Maat, M.P.M.de (author), Vos, H.L. (author)An elevated plasma fibrinogen level is an independent risk factor for cardiovascular disease. Therefore, an understanding of the regulation of fibrinogen expression is important. Inflammation and genetic variation of the fibrinogen beta gene regulate plasma fibrinogen levels, and there are indications that inflammation and genetic variation...article 2005
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TNO Defensie en Veiligheid (author), Krump, H. (author), Šimor, M. (author), Hudec, I. (author), Jaššo, M. (author), Luyt, A.S. (author)In this work, the adhesion strength between poly(ethylene terephthalate) (PET) fibres and styrene-butadiene rubber (SBR) was studied. The effects of atmospheric plasma treatment, used to increase adhesion strength between PET fibres and the rubber matrix, were investigated and compared. It was confirmed that lubricants on the fibres caused a...article 2005