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Koning, J. (author), Jaspers, R. (author), Doornink, J. (author), Ouwehand, B. (author), Klinkhamer, J.F.F. (author), Snijders, B. (author), Sadakov, S. (author), Heemskerk, C. (author), TNO Industrie en Techniek (author)Already in the early phase of a design for ITER, the maintenance aspects should be taken into account, since they might have serious implications. This paper presents the arguments in support of the case for the maintainability of the design, notably if this maintenance is to be performed by advanced remote methods. This structure is compliant...article 2009
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- van der Heijden, A.E.D.M. (author), Creyghton, Y.L.M. (author), van de Peppel, R.J.E. (author), Abadjieva, E. (author), TNO Defensie en Veiligheid (author) conference paper 2009
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Ronden, D. (author), de Baar, M. (author), van den Berg, M. (author), Bongers, W. (author), Chavan, R. (author), Graswinckel, M. (author), Hannink, M. (author), Houkema, M. (author), de Vreede, F. (author), TNO Industrie en Techniek (author)The design of a remote steering (RS) variant of the electron cyclotron heating (ECH) upper port launcher (UPL) for neo-classical tearing mode (NTM) stabilization in ITER is being finalised. The RS variant is the fall-back option for the reference design, which is a front steering (FS) UPL. This paper presents the changes made in the design of...article 2009
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Bongers, W.A. (author), Goede, A.P.H. (author), Westerhof, E. (author), Oosterbeek, J.W. (author), Doelman, N.J. (author), Schüller, F.C. (author), de Baar, M.R. (author), Kasparek, W. (author), Wubie, W. (author), Wagner, D. (author), Stober, J. (author), Team, T. (author), TNO Industrie en Techniek (author)Neoclassical tearing modes (NTMs) deteriorate highpressure tokamak plasma confinement and can be suppressed by electron cyclotron current drive (ECCD). In order to obtain efficient suppression, the ECCD power needs to be deposited at the center of an NTM magnetic island. To enhance efficiency, this power also needs to be synchronized in phase...article 2009
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Konuk, A.R. (author), Aarts, R.G.K.M. (author), Huis in 't Veld, A.J. (author), TNO Industrie en Techniek (author)Optical emissions from the laser welding process can be obtained relatively easy in real-time. Such emissions come from the melt pool, keyhole, or plume during welding. Therefore it is very beneficial to establish a clear relation between characteristics of these emissions and the resulting weld quality or the ocurrence of welding defects for...conference paper 2009
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Sadakov, S. (author), Baross, T. (author), Biel, W. (author), Borsuk, V. (author), Hawkes, N. (author), von Hellermann, M. (author), Gille, P. (author), Kiss, G. (author), Koning, J. (author), Knaup, M. (author), Klinkhamer, J.F.F. (author), Krasikov, Yu. (author), Litnovsky, A. (author), Neubauer, O. (author), Panin, A. (author), TNO Industrie en Techniek (author)A plug for the ITER core charge exchange recombination spectroscopy (core CXRS) is located in the upper port 3. It transfers the light emitted by interaction of plasma ions with the diagnostic neutral beam (DNB). The plug consists of a main shell, a shielding cassette and a retractable tube. The tube carries the first mirror (M1) with a shutter...article 2009
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Kong, H. (author), Wang, M. (author), Venema, K. (author), Maathuis, A. (author), van der Heijden, R. (author), van der Greef, J. (author), Xu, G. (author), Hankemeier, T. (author), TNO Kwaliteit van Leven (author)A high-performance liquid chromatography-high resolution Fourier transform ion cyclotron resonance mass spectrometry (HPLC-FTICR-MS) method was developed to investigate the metabolism of ginsenosides in in vitro models of the gastro-intestinal tract. The metabolites were identified by high-resolution tandem mass spectrometry. Degradation and...article 2009
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Hellebrekers, B.W.J. (author), Trimbos-Kemper, T.C.M. (author), Boesten, L. (author), Jansen, F.W. (author), Kolkman, W. (author), Trimbos, J.B. (author), Press, R.R. (author), van Poelgeest, M.I.E. (author), Emeis, S.J. (author), Kooistra, T. (author), TNO Kwaliteit van Leven (author)Objective: To identify predictors of postsurgical adhesion formation in peritoneal fluid and plasma, and assess efficacy and safety of reteplase (recombinant plasminogen activator [r-PA]). Design: Prospective randomized study. Setting: University Medical Center. Patient(s): Twenty-six abdominal myomectomy patients with early second-look...article 2009
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van Deelen, J. (author), van Mol, A.M.B. (author), Poodt, P.W.G. (author), Grob, F. (author), Spee, C.I.M.A. (author), TNO Industrie en Techniek (author)For the past decade TNO has been involved in the research and development of atmospheric pressure CVD (APCVD) and plasma enhanced CVD (PECVD) processes for deposition of transparent conductive oxides (TCO), such as tin oxide and zinc oxide. The use of atmospheric deposition processes allows for large scale roll to roll manufacturing, and is...conference paper 2009
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Peter, M. (author), Furthner, F. (author), Deen, J. (author), de Laat, W.J.M. (author), Meinders, E.R. (author), TNO Industrie en Techniek (author)In this paper the challenges of patterning electrodes with separations in the micron and sub-micron range onto thin polyethylene naphthalate foils for use in biochips are discussed. It was found that it was necessary to improve the adhesion of the metal electrodes to the foil by using plasma treatment and/or an adhesion layer, and a quantitative...article 2009
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Cordeiro, A.L. (author), Nitschke, M. (author), Janke, A. (author), Helbig, R. (author), D'Souza, F. (author), Donnelly, G.T. (author), Willemsen, P.R. (author), Werner, C. (author), TNO Industrie en Techniek (author)Fluorinated surface groups were introduced into poly(dimethylsiloxane) (PDMS) coatings by plasma treatment using a low pressure radio frequency discharge operated with tetrafluoromethane. Substrates were placed in a remote position downstream the discharge. Discharge power and treatment time were tuned to alter the chemical composition of the...article 2009
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Geert Heidema, A. (author), Thissen, U. (author), Boer, J.M.A. (author), Bouwman, F.G. (author), Feskens, E.J.M. (author), Mariman, E.C.M. (author), TNO Kwaliteit van Leven (author)In this study, we applied the multivariate statistical tool Partial Least Squares (PLS) to analyze the relative importance of 83 plasma proteins in relation to coronary heart disease (CHD) mortality and the intermediate end points body mass index, HDL-cholesterol and total cholesterol. From a Dutch monitoring project for cardiovascular disease...article 2009
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TNO Industrie en Techniek (author), Ivan, M.G. (author), Vaney, J.B. (author), Verhaart, D. (author), Meinders, E.R. (author)A computer-controlled laser beam recorder with a wavelength of 405 nm has been employed for patterning the deposited resist with feature sizes varying from a few hundreds of nanometers to tens of micrometers. Four inch silicon templates for hot embossing source/ drain electrodes and metallic circuit for a disposable biosensor were obtained. SEM...conference paper 2009
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Lindeman, J.H.N. (author), Abdul-Hussien, H. (author), Schaapherder, A.F.M. (author), van Bockel, J.H. (author), von der Thüsen, J.H. (author), Roelen, D.L. (author), Kleemann, R. (author)Inflammation plays a key role in the pathogenesis of an AAA (abdominal aortic aneurysm); however, the nature of the inflammatory factors and cellular response(s) involved in AAA growth is controversial. In the present study, we set out to determine the aortic levels of inflammatory cytokines in relation to downstream inflammatory transcription...article 2008
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Bobeldijk, I. (author), Hekman, M. (author), van der Vries de- Weij, J. (author), Coulier, L. (author), Ramaker, R. (author), Kleemann, R. (author), Kooistra, T. (author), Rubingh, C. (author), Freidig, A. (author), Verheij, E. (author), TNO Kwaliteit van Leven (author)We report a sensitive, generic method for quantitative profiling of bile acids and other endogenous metabolites in small quantities of various biological fluids and tissues. The method is based on a straightforward sample preparation, separation by reversed-phase high performance liquid-chromatography mass spectrometry (HPLC-MS) and electrospray...article 2008
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Rijken, D.C. (author), Hoegee-de Nobel, E. (author), Jie, A.F.H. (author), Atsma, D.E. (author), Schalij, M.J. (author), Nieuwenhuizen, W. (author), TNO Kwaliteit van Leven (author)Background: The development of global tests for the fibrinolytic capacity in blood is hampered by the low base-line fibrinolytic activity in blood, by the involvement of both plasmatic components and blood cells in the fibrinolytic system and by the loss of fibrinolytic activity as a result of the action of plasminogen activator inhibitor-1 (PAI...article 2008
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van der Hoorn, J.W.A. (author), de Haan, W. (author), Berbée, J.P.P. (author), Havekes, L.M. (author), Jukema, J.W. (author), Rensen, P.C. (author), Princen, H.M.G. (author), TNO Kwaliteit van Leven (author)Objective - Niacin potently decreases plasma triglycerides and LDL-cholesterol. In addition, niacin is the most potent HDL-cholesterol- increasing drug used in the clinic. In the present study, we aimed at elucidation of the mechanism underlying its HDL-raising effect. Methods and Results - InAPOE*3Leiden transgenic mice expressing the human...article 2008
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van Assche, F.J.H. (author), Rooms, H.C.A. (author), Young, E.W.A. (author), Michels, J. (author), van Mol, A.M.B. (author), Rietjens, G. (author), van de Weijer, P. (author), Bouten, P. (author), TNO Industrie en Techniek (author)Within the Holst centre a transparent barrier on foil has been under development which is based on low-temperature plasma deposited silicon nitride films as intrinsic moisture barrier, stacked with planarization layers to spatially separate defects in these films. OLED lifetime testing and water vapor transmission rate measurements using a Ca...conference paper 2008
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- Hu, L. (author), Bovenschen, N. (author), Havekes, L.M. (author), van Vlijmen, B.J.M. (author), Tamsma, J.T. (author), TNO Kwaliteit van Leven (author) article 2007
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van Doorn, M. (author), Vogels, J. (author), Tas, A. (author), van Hoogdalem, E.J. (author), Burggraaf, J. (author), Cohen, A. (author), van der Greef, J. (author), TNO Kwaliteit van Leven (author)Aims: To explore the usefulness of metabolomics as a method to obtain a broad array of biomarkers for the pharmacological effects of rosiglitazone (RSG) in plasma and urine samples from patients with type 2 diabetes mellitus (T2DM) and healthy volunteers (HVs). Additionally, we explored the differences in metabolite concentrations between T2DM...article 2007