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Creyghton, Y. (author), Illiberi, A. (author), Mione, M. (author), van Boekel, W. (author), Debernardi, N. (author), Seitz, M. (author), van den Bruele, F. (author), Poodt, P. (author), Roozeboom, F. (author)Atomic layer deposition by means of spatial separation of reactive gases is emerging as an industrial manufacturing technology. Integration of non-thermal plasma in spatial ALD machines will further expand the process window towards lower operation temperatures and specific materials requiring radicals (O, N, H, OH, NH etc.). Plasma sources with...conference paper 2016
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Cnubben, N.H.P. (author), Tel, S.L. (author), Hemmes, M.A. (author), Langenkamp-Brand, A. (author), Grossouw, D. (author), Jansen, H.T. (author), de Bie, B.T.H.J. (author)Background: Worldwide obesity has nearly doubled since 1980 and is a leading risk for global deaths, profoundly affecting morbidity, mortality, health-care costs, and professional and personal quality of life. Treatment of obesity and its consequences include lifestyle intervention, pharmacotherapy, and bariatric surgery. Polyglucosamines have...article 2016
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- Princen, H.M.G. (author), Pouwer, M.G. (author), Pieterman, E.J. (author) article 2016
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Brust, H. (author), Koeberg, M. (author), van der Heijden, A. (author), Wiarda, W. (author), Mügler, I. (author), Schrader, M. (author), Vivo-Truyols, G. (author), Schoenmakers, P. (author), van Asten, A. (author)Ammonium nitrate (AN) is frequently encountered in explosives in forensic casework. It is widely available as fertilizer and easy to implement in explosive devices, for example by mixing it with a fuel. Forensic profiling methods to determine whether material found on a crime scene and material retrieved from a suspect arise from the same source...article 2015
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Ripken, D. (author), van der Wielen, N. (author), van der Meulen, J. (author), Schuurman, T. (author), Witkamp, R.F. (author), Hendriks, H.F.J. (author), Koopmans, S.J. (author)The vagal nerve and gut hormones CCK and GLP-1 play important roles in the control of food intake. However, it is not clear to what extent CCK and GLP-1 increase satiation by stimulating receptors located on abdominal vagal nerve endings or via receptors located elsewhere. This study aimed to further explore the relative contribution of the...article 2015
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Garner, C.R. (author), Park, K.B. (author), French, N.S. (author), Earnshaw, C. (author), Schipani, A. (author), Selby, A.M. (author), Byrne, L. (author), Siner, S. (author), Crawley, F.P. (author), Vaes, W.H.J. (author), van Duijn, E. (author), de ligt, R. (author), Varendi, H. (author), Lass, J. (author), Grynkiewicz, G. (author), Maruszak, W. (author), Turner, M.A. (author)Aims The aims of the study were to compare [14C]-paracetamol ([14C]-PARA) paediatric pharmacokinetics (PK) after administration mixed in a therapeutic dose or an isolated microdose and to develop further and validate accelerator mass spectrometry (AMS) bioanalysis in the 0-2 year old age group. Methods [14C]-PARA concentrations in 10-15 μl...article 2015
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Eelderink, C. (author), Noort, M.W.J. (author), Sozer, N. (author), Koehorst, M. (author), Holst, J.J. (author), Deacon, C.F. (author), Rehfeld, J.F. (author), Poutanen, K. (author), Vonk, R.J. (author), Oudhuis, L. (author), Priebe, M.G. (author)Postprandial high glucose and insulin responses after starchy food consumption, associated with an increased risk of developing several metabolic diseases, could possibly be improved by altering food structure. We investigated the influence of a compact food structure; different wheat products with a similar composition were created using...article 2015
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Berbeé, J.F.P. (author), Boon, M.R. (author), Khedoe, P.P.S.J. (author), Bartelt, A. (author), Schlein, C. (author), Worthmann, A. (author), Kooijman, S. (author), Hoeke, G. (author), Mol, I.M. (author), John, C. (author), Jung, C. (author), Vazirpanah, N. (author), Brouwers, L.P.J. (author), Gordts, P.L.S.M. (author), Esko, J.D. (author), Hiemstra, P.S. (author), Havekes, L.M. (author), Scheja, L. (author), Heeren, J. (author), Rensen, P.C.N. (author)Brown adipose tissue (BAT) combusts high amounts of fatty acids, thereby lowering plasma triglyceride levels and reducing obesity. However, the precise role of BAT in plasma cholesterol metabolism and atherosclerosis development remains unclear. Here we show that BAT activation by b3-adrenergic receptor stimulation protects from atherosclerosis...article 2015
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Peng, X.B. (author), Hirsch, M. (author), Köppen, M. (author), Fellinger, J. (author), Bykov, V. (author), Schauer, F. (author), Vliegenthart, W.A. (author)A 10 channels interferometer will be used in the Wendelstein 7-X (W7-X) for plasma density control and density profile tracking with laser beams passing through the plasma. Due to complex shape of non-planar modular coils and divertor structure, there are no large poloidally opposite ports on the plasma vessel (PV). Therefore 10 in-vessel Corner...article 2014
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van Mierlo, G.J.D. (author), Cnubben, N.H.P. (author), Wouters, D. (author), Wolbink, G.J. (author), Hart, M.H.L. (author), Rispens, T. (author), Ganderup, N.C. (author), Kuper, C.F. (author), Aarden, L. (author), Penninks, A.H. (author)Immunogenicity is a major issue of concern for monoclonal antibodies used in human diseases and is by default mainly determined in non-human primates (NHP), as target molecules are considered most similar in NHP compared to human. In this manuscript the predictive value of immunogenicity testing in minipigs for human safety is evaluated, as the...article 2014
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Van Assche, F.J.H. (author), Unnikrishnan, S. (author), Michels, J.J. (author), van Mol, A.M.B. (author), van de Weijer, P. (author), van de Sanden, M.C.M. (author), Creatore, M. (author)We report on a low substrate temperature (110°C) remote microwave plasma-enhanced chemical vapor deposition (PECVD) process of silicon nitride barrier layers against moisture permeation for organic light emitting diodes (OLEDs) and other moisture sensitive devices such as organic photovoltaic cells (OPVs). Specifically, the influence of the SiH4...article 2014
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High-throughput processes for industrially scalable deposition of zinc oxide at atmospheric pressureIlliberi, A. (author), Grob, F. (author), Kniknie, B. (author), Frijters, C. (author), van Deelen, J. (author), Poodt, P. (author), Beckers, E.H.A. (author), Bolt, P.J. (author)ZnO films have been grown on a moving glass substrate by high temperature (480 0C) chemical vapour deposition (CVD) and low temperature (200 0C) plasma enhanced CVD (PE-CVD) process at atmospheric pressure. Deposition rates above 7 nm/s have been achieved for substrate speeds from 20 to 500 mm/min. The conductivity of the films is enhanced by Al...article 2014
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Peters, R.J.B. (author), van Bemmel, G. (author), Herrera-Rivera, Z. (author), Helsper, H.P.F.G. (author), Marvin, H.J.P. (author), Weigel, S. (author), Tromp, P.C. (author), Oomen, A.G. (author), Rietveld, A.G. (author), Bouwmeester, H. (author)Titanium dioxide (TiO2) is a common food additive used to enhance the white color, brightness, and sometimes flavor of a variety of food products. In this study 7 food grade TiO2 materials (E171), 24 food products, and 3 personal care products were investigated for their TiO 2 content and the number-based size distribution of TiO2 particles...article 2014
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van den Bruele, F.J. (author), Smets, M.M.H. (author), Illiberi, A. (author), Creyghton, Y.L.M. (author), Buskens, P.J.P. (author), Roozeboom, F. (author), Poodt, P.W.G. (author)The authors have investigated the growth of thin silver films using a unique combination of atmospheric process elements: spatial atomic layer deposition and an atmospheric pressure surface dielectric barrier discharge plasma source. Silver films were grown on top of Si substrates with good purity as revealed by resistivity values as low as 18μΩ...article 2014
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van Duijn, E. (author), Sandman, H. (author), Grossouw, D. (author), Mocking, J.A.J. (author), Coulier, L. (author), Vaes, W.H.J. (author)The increasing role of accelerator mass spectrometry (AMS) in biomedical research necessitates modernization of the traditional sample handling process. AMS was originally developed and used for carbon dating, therefore focusing on a very high precision but with a comparably low sample throughput. Here, we describe the combination of automated...article 2014
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Niittynen, J. (author), Abbel, R. (author), Mäntysalo, M. (author), Perelaer, J. (author), Schubert, U.S. (author), Lupo, D. (author)In this contribution several alternative sintering methods are compared to traditional thermal sintering as high temperature and long process time of thermal sintering are increasing the costs of inkjet-printing and preventing the use of this technology in large scale manufacturing. Alternative sintering techniques are evaluated based on the...article 2014
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Koster, N.B. (author), Geluk, C.P.E.C. (author), Versloot, T.W. (author), Janssen, J.P.B. (author), Fleming, Y. (author), Wirtz, T. (author)We report on our investigation of dry cleaning of reticles with a microwave induced hydrogen plasma on dummy reticles. The dummy reticles were manufactured with 70 nm ALD grown TaN on a Ru surface and test structures were patterned with lines and spaces ranging between 250 and 400 nm. After processing the test structures were contaminated with e...conference paper 2014
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Mooij, M.G. (author), van Duijn, E. (author), Knibbe, C.A.J. (author), Windhorst, A.D. (author), Hendrikse, N.H. (author), Vaes, W.H.J. (author), Spaans, E. (author), Fabriek, B.O. (author), Sandman, H. (author), Grossouw, D. (author), Hanff, L.M. (author), Janssen, P.J.J.M. (author), Koch, B.C.P. (author), Tibboel, D. (author), de Wildt, S.N. (author)Results: Ten infants (aged 0.1–83.1 months) were included; one was excluded as he vomited shortly after administration. In nine patients, [14C]AAP and metabolites in blood samples were detectable at expected concentrations: median (range) maximum concentration (Cmax) [14C]AAP 1.68 (0.75–4.76) ng/L, [14C]AAP-Glu 0.88 (0.34–1.55) ng/L, and [14C...article 2014
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Guilhem, D. (author), Argouarch, A. (author), Bernard, J.M. (author), Bouquey, F. (author), Colas, L. (author), Delpech, L. (author), Durodié, F. (author), Ekedahl, A. (author), Helvoirt, J. (author), Hillairet, J. (author), Joffrin, E. (author), Litaudon, X. (author), Magne, R. (author), Milanesio, D. (author), Moerel, J. (author), Mollard, P. (author), Wittebol, E. (author), Achard, J. (author), Armitano, A. (author), Berger-By, G. (author), Charabot, N. (author), Goniche, M. (author), Jacquot, J. (author), Lombard, G. (author), Prou, M. (author), Traisnel-Corbel, E. (author), Volpe, R. (author), Vulliez, K. (author)This year TORE-SUPRA celebrated its 25 years of operation. During this long time a number of technologies have been developed [1]. First of all it was mandatory to develop reliable superconducting magnets at ∼ - 4 K, with superfluid helium as efficient coolant. For the production of steady state discharge, 3 types of Radio Frequency (RF)...conference paper 2013
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Balvers, M.G.J. (author), Wortelboer, H.M. (author), Witkamp, R.F. (author), Verhoeckx, K.C.M. (author)The origin of N-acyl ethanolamides (NAEs) in plasma is not well understood, and it is possible that NAEs are present in plasma in esterified form. To test this hypothesis, a new and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the quantification of arachidonoyl ethanolamide, 2...article 2013