Searched for: subject%3A%22partition%255C%2Bcoefficient%22
(1 - 15 of 15)
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Smedes, F. (author), Rusina, T.P. (author), Beeltje, H. (author), Mayer, P. (author)
Polymers are increasingly used for passive sampling of neutral hydrophobic organic substances (HOC) in environmental media including water, air, soil, sediment and even biological tissue. The equilibrium concentration of HOC in the polymer can be measured and then converted into equilibrium concentrations in other (defined) media, which however...
article 2017
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Buist, H.E. (author), de Wit-Bos, L. (author), Bouwman, T. (author), Vaes, W.H.J. (author)
Quantitative Property Property Relationships (QPPRs) for human and rat blood:air partition coefficients (PBAs) have been derived, based on vapour pressure (Log(VP)), the octanol:water partition coefficient (Log(K_OW)) and molecular weight (MW), using partial least squares multilinear modelling. These parameters are all included in the standard...
article 2012
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Buist, H.E. (author), van Burgsteden, J.A. (author), Freidig, A.P. (author), Maas, W.J.M. (author), van de Sandt, J.J.M. (author), TNO Kwaliteit van Leven (author)
Most QSARs for dermal absorption predict the permeability coefficient, K<sub>p</sub>, of a molecule, which is valid for infinite dose conditions. In practice, dermal exposure mostly occurs under finite dose conditions. Therefore, a simple model to predict finite dose dermal absorption from infinite dose data (K<sub>p</sub> and lag time) and the...
article 2010
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Punt, A. (author), Freidig, A.P. (author), Delatour, T. (author), Scholz, G. (author), Boersma, M.G. (author), Schilter, B. (author), van Bladeren, P.J. (author), Rietjens, I.M.C.M. (author), TNO Kwaliteit van Leven (author)
The present study defines a physiologically based biokinetic (PBBK) model for the alkenylbenzene estragole in rat based on in vitro metabolic parameters determined using relevant tissue fractions, in silico derived partition coefficients, and physiological parameters derived from the literature. The model consists of eight compartments including...
article 2008
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Hissink, A.M. (author), Krüse, J. (author), Kulig, B.M. (author), Verwei, M. (author), Muijser, H. (author), Salmon, F. (author), Leenheers, L.H. (author), Owen, D.E. (author), Lammers, J.H.C.M. (author), Freidig, A.P. (author), McKee, R.H. (author), TNO Kwaliteit van Leven (author)
As part of a project designed to develop a framework for extrapolating acute central nervous system (CNS) effects of hydrocarbon solvents in animals to humans, experimental studies were conducted in rats and human volunteers in which acute CNS effects were measured and toxicokinetic data were collected. A complex hydrocarbon solvent, white...
article 2007
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Sweeney, R.E. (author), Langenberg, J.P. (author), Maxwell, D.M. (author), TNO Defensie en Veiligheid (author)
A physiologically based pharmacokinetic (PB/PK) model has been developed in advanced computer simulation language (ACSL) to describe blood and tissue concentration-time profiles of the C(±)P(-) stereoisomers of soman after inhalation, subcutaneous and intravenous exposures at low (0.8-1.0 × LD50), medium (2-3 × LD50) and high (6 × LD50) levels...
article 2006
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Zvinavashe, E. (author), Murk, A.J. (author), Vervoort, J. (author), Soffers, A.E.M.F. (author), Freidig, A. (author), Rietjens, I.M.C.M. (author), TNO Kwaliteit van Leven (author)
Fifteen experimental literature data sets on the acute toxicity of substituted nitrobenzenes to algae (Scenedesmus obliquus, Chlorella pyrenoidosa, C. vulgaris), daphnids (Daphnia magna, D. carinata), fish (Cyprinus carpio, Poecilia reticulata), protozoa (Tetrahymena pyriformis), bacteria (Phosphobacterium phosphoreum), and yeast (Saccharomyces...
article 2006
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Hendriks, A.J. (author), Maas-Diepeveen, J.L.M. (author), Heugens, E.H.W. (author), van Straalen, N.M. (author), TNO Kwaliteit van Leven (author)
Most of the thousands of substances and species that are of concern for environmental management will not be investigated empirically at ecologically relevant levels because of financial, practical, and ethical constraints. To allow risk assessment for these less well-known categories, we have developed a mechanistic model with classical...
article 2005
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Ploemen, J.P.H.T.M. (author), Kelder, J. (author), Hafmans, T. (author), van de Sandt, H. (author), van Burgsteden, J.A. (author), Salemink, P.J.M. (author), van Esch, E. (author), TNO Voeding (author)
Several cationic amphiphilic compounds are known to induce phospholipidosis, a condition primarily characterized by excessive accumulation of phospholipids in different cell types, giving the affected cells a finely foamy appearance. Excessive storage of lamellar membranous intralysosomal inclusion bodies is the hallmark for phospholipidosis on...
article 2004
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den Boer, M. (author), Voshol, P.J. (author), Kuipers, F. (author), Havekes, L.M. (author), Romijn, J.A. (author), TNO Preventie en Gezondheid (author)
Epidemiological studies in humans, as well as experimental studies in animal models, have shown an association between visceral obesity and dyslipidemia, insulin resistance, and type 2 diabetes mellitus. Recently, attention has been focused on the excessive accumulation of triglycerides (TG) in the liver as part of this syndrome. In this review,...
article 2004
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TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author), Werlen, C. (author), Jaspers, M.C.M. (author), van der Meer, J.R. (author)
Genetically constructed microbial biosensors for measuring organic pollutants are mostly applied in aqueous samples. Unfortunately, the detection limit of most biosensors is insufficient to detect pollutants at low but environmentally relevant concentrations. However, organic pollutants with low levels of water solubility often have significant...
article 2004
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Artola-Garicano, E. (author), Sinnige, T.L. (author), van Holsteijn, I. (author), Vaes, W.H.J. (author), Hermens, J.L.M. (author)
In the current study, the bioconcentration behavior and acute toxicity of two polycyclic musks, Tonalide® 7-acetyl-1,1,3,4,4,6,-hexamethyl-1,2,3,4,-tetrahydronaphthalene (AHTN) and Galaxolide® 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexa-methyl-cyclopenta[γ]-2- benzopyran (HHCB), were studied in two benthic organisms. Polycyclic musks are frequently...
article 2003
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Artola-Garicano, E. (author), Borkent, I. (author), Damen, K. (author), Jager, T. (author), Vaes, W.H.J. (author)
In the current study, a new method is introduced with which the rate-limiting factor of biodegradation processes of hydrophobic chemicals in organic and aqueous systems can be determined. The novelty of this approach lies in the combination of a free concentration-based kinetic model with measurements of both free and total concentrations in...
article 2003
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Mayer, P. (author), Vaes, W.H.J. (author), Wijnker, F. (author), Legierse, K.C.H.M. (author), Kraaij, R.H. (author), Tolls, J. (author), Hermens, J.L.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Polymer coated glass fibers were applied as disposable samplers to measure dissolved concentrations of persistent and bioaccumulative pollutants (PBPs) in sediment porewater. The method is called matrix solid-phase microextraction (matrix-SPME), because it utilizes the entire sediment matrix as a reservoir for an equilibrium extraction: A glass...
article 2000
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TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author), Hissink, A.M. (author), van Ommen, B. (author), Krüse, J. (author), van Bladeren, P.J. (author)
A physiologically based pharmacokinetic (PB-PK) model was developed for 1,2-dichlorobenzene (1,2-DCB) for the rat. This model was adjusted for the human situation, using human in vitro parameters, including a V(max) and K(m) determined with human microsomes. For comparison, the V(max) and K(m) values from the rat were scaled allometrically to...
article 1997
Searched for: subject%3A%22partition%255C%2Bcoefficient%22
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