Searched for: subject%3A%22pH%22
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Tosti, L. (author), van Zomeren, A. (author), Pels, J.R. (author), Dijkstra, J.J. (author), Comans, R.N.J. (author)
The pH-dependent availability and leaching of major and trace elements was investigated for a wide range of biomass ash from different fuels and conversion technologies. A technical and environmental assessment of selected biomass ash for application in soil or cement mortars was performed, using both the total content and leaching of elements....
article 2019
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Keulen, A. (author), van Zomeren, A. (author), Dijkstra, J.J. (author)
This study explores the leaching of oxyanionic metalloid species (As, Mo, Se, V and Cr) from alkali activated slag-fly ash materials (AAM), dependent on various mixture parameters i.e., activator molarity, slag-fly ash precursor/binder compositions, liquid to binder ratio, curing time and strength. The analyses focusses on the leaching of...
article 2018
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Niessink, R.J.M. (author)
public lecture 2018
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Erpelinck, S. (author), Meijers, T. (author), Ariga, K. (author)
Membrane embedded transporter proteins play an important role in the absorption, distribution and excretion of many drugs. A reliable prediction of human pharmacokinetics of (new) drugs based on PBPK modeling is highly dependent on accurate determination of the absolute protein expression levels of these transmembrane transporter proteins.
other 2017
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Dusinska, M. (author), Boland, S. (author), Saunders, M. (author), Juillerat-Jeanneret, L. (author), Tran, L. (author), Pojana, G. (author), Marcomini, A. (author), Volkovova, K. (author), Tulinska, J. (author), Knudsen, L.E. (author), Gombau, L. (author), Whelan, M. (author), Collins, A.R. (author), Marano, F. (author), Housiadas, C. (author), Bilanicova, D. (author), Halamoda Kenzaoui, B. (author), Correia Carreira, S. (author), Magdolenova, Z. (author), Fjellsbo, L.M. (author), Huk, A. (author), Handy, R. (author), Walker, L. (author), Barancokova, M. (author), Bartonova, A. (author), Burello, E. (author), Castell, J. (author), Cowie, H. (author), Drlickova, M. (author), Guadagnini, R. (author), Harris, G. (author), Harju, M. (author), Heimstad, E.S. (author), Hurbankova, M. (author), Kazimirova, A. (author), Kovacikova, Z. (author), Kuricova, M. (author), Liskova, A. (author), Milcamps, A. (author), Neubauerova, E. (author), Palosaari, T. (author), Papazafiri, P. (author), Pilou, M. (author), Poulsen, M.S. (author), Ross, B. (author), Runden-Pran, E. (author), Sebekova, K. (author), Staruchova, M. (author), Vallotto, D. (author), Worth, A. (author)
In spite of recent advances in describing the health outcomes of exposure to nanoparticles (NPs), it still remains unclear how exactly NPs interact with their cellular targets. Size, surface, mass, geometry, and composition may all play a beneficial role as well as causing toxicity. Concerns of scientists, politicians and the public about...
article 2015
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Zune, Q. (author), Delepierre, A. (author), Gofflot, S. (author), Bauwens, J. (author), Twizere, J.C. (author), Punt, P.J. (author), Francis, F. (author), Toye, D. (author), Bawin, T. (author), Delvigne, F. (author)
Fungal biofilm is known to promote the excretion of secondary metabolites in accordance with solid-staterelated physiological mechanisms. This work is based on the comparative analysis of classical submerged fermentation with a fungal biofilmreactor for the production of a Gla::green fluorescent protein (GFP) fusion protein by Aspergillus oryzae...
article 2015
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Reus, A.A. (author), Maas, W.J.M. (author), Jansen, H.T. (author), Constant, S. (author), Staal, Y.C.M. (author), van Triel, J.J. (author), Kuper, C.F. (author)
The respiratory route is an important portal for human exposure to a large variety of substances. Consequently, there is an urgent need for realistic in vitro strategies for evaluation of the absorption of airborne substances with regard to safety and efficacy assessment. The present study investigated feasibility of a 3D human airway epithelial...
article 2014
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van Soestbergen, M. (author), Baukh, V. (author), Erich, S.J.F. (author), Huinink, H.P. (author), Adan, O.C.G. (author)
Carcinogenic chromates are phased out as corrosion inhibitors in organic coatings, and are replaced by benign alternatives. Cerium-based compounds are excellent corrosion inhibitors in an aqueous environment. However, whether they are effective as corrosion inhibitor in an organic coating also depends on their interaction with the coating matrix...
article 2014
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Kostewicz, E.S. (author), Abrahamsson, B. (author), Brewster, M. (author), Brouwers, J. (author), Butler, J. (author), Carlert, S. (author), Dickinson, P.A. (author), Dressman, J. (author), Holm, R. (author), Klein, S. (author), Mann, J. (author), McAllister, M. (author), Minekus, M. (author), Muenster, U. (author), Müllertz, A. (author), Verwei, M. (author), Vertzoni, M. (author), Weitschies, W. (author), Augustijns, P. (author)
Accurate prediction of the in vivo biopharmaceutical performance of oral drug formulations is critical to efficient drug development. Traditionally, in vitro evaluation of oral drug formulations has focused on disintegration and dissolution testing for quality control (QC) purposes. The connection with in vivo biopharmaceutical performance has...
article 2014
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Minekus, M. (author), Alminger, M. (author), Alvito, P. (author), Ballance, S. (author), Bohn, T. (author), Bourlieu, C. (author), Carrière, F. (author), Boutrou, R. (author), Corredig, M. (author), Dupont, D. (author), Dufour, C. (author), Egger, L. (author), Golding, M. (author), Karakaya, S. (author), Kirkhus, B. (author), Le Feunteun, S. (author), Lesmes, U. (author), MacIerzanka, A. (author), MacKie, A. (author), Marze, S. (author), McClements, D.J. (author), Ménard, O. (author), Recio, I. (author), Santos, C.N. (author), Singh, R.P. (author), Vegarud, G.E. (author), Wickham, M.S.J. (author), Weitschies, W. (author), Brodkorb, A. (author)
Simulated gastro-intestinal digestion is widely employed in many fields of food and nutritional sciences, as conducting human trials are often costly, resource intensive, and ethically disputable. As a consequence, in vitro alternatives that determine endpoints such as the bioaccessibility of nutrients and non-nutrients or the digestibility of...
article 2014
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van Loo-Bouwman, C.A. (author), Naber, T.H.J. (author), Minekus, M. (author), van Breemen, R.B. (author), Hulshof, P.J.M. (author), Schaafsma, G. (author)
Since the food matrix determines β-carotene availability for intestinal absorption, food matrix effects on the bioaccessibility of β-carotene from two diets were investigated in vitro and compared with in vivo data. The "mixed diet" consisted of β-carotene-rich vegetables, and the "oil diet" contained β-carotene-low vegetables with supplemental...
article 2014
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Reimer, R.A. (author), Maathuis, A.J.H. (author), Venema, K. (author), Lyon, M.R. (author), Gahler, R.J. (author), Wood, S. (author)
Many of the health benefits associated with dietary fiber are attributed to their fermentation by microbiota and production of short chain fatty acids (SCFA). The aim of this study was to investigate the fermentability of the functional fiber PolyGlyopleX® (PGX®) in vitro. A validated dynamic, computer-controlled in vitro system simulating the...
article 2014
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Martinez, R.C.R. (author), Cardarelli, H.R. (author), Borst, W. (author), Albrecht, S. (author), Schols, H. (author), Gutiérrez, O.P. (author), Maathuis, A.J.H. (author), de Melo Franco, B.D.G. (author), de Martinis, E.C.P. (author), Zoetendal, E.G. (author), Venema, K. (author), Saad, S.M.I. (author), Smidt, H. (author)
A validated in vitro model of the large intestine (TIM-2), set up with human or pig faeces, was used to evaluate the impact of potentially probiotic Lactobacillus amylovorus DSM 16698, administered alone (i), in the presence of prebiotic galactooligosaccharides (GOS) (ii), and co-administered with probiotic Bifidobacterium animalis ssp. lactis...
article 2013
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Hendriks, H.F.J. (author)
In this paper, the nutrigenomics approach is discussed as a research tool to study the physiological effects of nutrition and consequently how nutrition affects health and disease (endpoints). Nutrigenomics is the study of the effects of foods and food constituents on gene expression; the analyses include analysis of mRNA, proteins and...
article 2013
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Helbig, A. (author), Silletti, E. (author), van Aken, G.A. (author), Oosterveld, A. (author), Minekus, M. (author), Hamer, R.J. (author), Gruppen, H. (author)
This study investigated the effect of gastric passage of protein stabilized emulsions, i.e., whey protein isolate (WPI) and lysozyme, under dynamic in vitro conditions on both the gastric and intestinal lipolysis. Emulsions were prepared at neutral pH to enable an opposite surface charge. Experiments were performed in a multi-compartmental...
article 2013
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Balvers, M.G.J. (author), Wortelboer, H.M. (author), Witkamp, R.F. (author), Verhoeckx, K.C.M. (author)
The origin of N-acyl ethanolamides (NAEs) in plasma is not well understood, and it is possible that NAEs are present in plasma in esterified form. To test this hypothesis, a new and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the quantification of arachidonoyl ethanolamide, 2...
article 2013
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Roeselers, G. (author), Ponomarenko, M. (author), Lukovac, S. (author), Wortelboer, H.M. (author)
It is increasingly apparent that the microbial ecosystems in the mammalian gastrointestinal tract play an intricate role in health and disease. There is a growing interest in the development of targeted strategies for modulating health through the modification of these microbiota. Ecologists are faced with the challenge of understanding the...
article 2013
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van de Steeg, E. (author), Greupink, R. (author), Schreurs, M. (author), Nooijen, I.H.G. (author), Verhoeck, K.C.M. (author), Hanemaaijer, R. (author), Ripken, D. (author), Monshouwer, M. (author), Vlaming, M.L.H. (author), DeGroot, J. (author), Verwei, M. (author), Russel, F.G.M. (author), Huisman, M.T. (author), Wortelboer, H.M. (author)
Organic anion-transporting polypeptide 1B1 (OATP1B1) is an important hepatic uptake transporter, of which the polymorphic variant OATP1B1*15 (Asn130Asp and Val174Ala) has been associated with decreased transport activity. Rosuvastatin is an OATP1B1 substrate and often concomitantly prescribed with oral antidiabetics in the clinic. The aim of...
article 2013
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Schrieks, I.C. (author), van Berg, R. (author), Sierksma, A. (author), Beulens, J.W.J. (author), Vaes, W.H.J. (author), Hendriks, N.F.J. (author)
Aims: To evaluate the effect of acute and chronic consumption of red wine or de-alcoholized red wine with a similar antioxidant capacity on plasma total antioxidant capacity (TEAC), nuclear factor-κB (NF-κB) activity and F2-isoprostanes (8-iso-PGF2α) in healthy men. Methods: Nineteen healthy men with an increased waist circumference (≥94 cm) and...
article 2013
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Bereszczak, J.Z. (author), Rose, R.J. (author), van Duijn, E. (author), Watts, N.R. (author), Wingfield, P.T. (author), Steven, A.C. (author), Heck, A.J.R. (author)
Infection of humans by hepatitis B virus (HBV) induces the copious production of antibodies directed against the capsid protein (Cp). A large variety of anticapsid antibodies have been identified that differ in their epitopes. These data, and the status of the capsid as a major clinical antigen, motivate studies to achieve a more detailed...
article 2013
Searched for: subject%3A%22pH%22
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