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Kartaram, S. (author), Mensink, M. (author), Teunis, M. (author), Schoen, E. (author), Witte, G. (author), Janssen Duijghuijsen, L. (author), Verschuren, M. (author), Mohrmann, K. (author), M'Rabet, L. (author), Knipping, K. (author), Wittink, H. (author), van Helvoort, A. (author), Garssen, J. (author), Witkamp, R. (author), Pieters, R. (author), van Norren, K. (author)Background & aims: Plasma citrulline concentration is considered to be a marker for enterocyte metabolic mass and to reflect its reduction as may occur during intestinal dysfunction. Strenuous exercise can act as a stressor to induce small intestinal injury. Our previous studies suggest that this comprises the intestinal ability to produce...article 2019
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Boon, M.R. (author), Kooijman, S. (author), van Dam, A.D. (author), Pelgrom, L.R. (author), Berbée, J.F.P. (author), Visseren, C.A.R. (author), van Aggele, R.C. (author), van den Hoek, A.M. (author), Sips, H.C.M. (author), Lombès, M. (author), Havekes, L.M. (author), Tamsma, J.T. (author), Guigas, B. (author), Meijer, O.C. (author), Jukema, J.W. (author), Rensen, P.C.N. (author)The endocannabinoid system is an important player in energy metabolism by regulating appetite, lipolysis, and energy expenditure. Chronic blockade of the cannabinoid 1 receptor (CB1R) leads to long-term maintenance of weight loss and reduction of dyslipidemia in experimental and human obesity. The molecular mechanism by which CB1R blockade...article 2014
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Daanen, H.A.M. (author), van Ling, S. (author), Tan, T.K. (author)Background: It has been shown that endurance performance after one night of sleep deprivation is not compromised despite the feeling of fatigue and that, in contrast, performance in the heat deteriorates even though people may feel good. However, it is essentially unknown how the estimation of performance capabilities relate to actual...article 2013
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Slootmaker, S.M. (author), Chin A Paw, M.J.M. (author), Schuit, A.J. (author), van Mechelen, W. (author), Koppes, L.L.J. (author), TNO Kwaliteit van Leven (author)The purpose of this study was to examine the concurrent validity of the Personal Activity Monitor (PAM) accelerometer relative to the Actigraph accelerometer using oxygen consumption as a reference, and to assess the test-retest reliability of the PAM. Thirty-two fit, normal weight adults (aged 21-54) performed two activities, treadmill walking...article 2009
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van Dieën, J.H. (author), Putten, E.P. (author), Kingma, I. (author), de Looze, M.P. (author), TNO Kwaliteit van Leven (author)This study was designed to determine whether trunk extensor fatigue occurs during low-level activity and whether this is associated with a drop in muscle tissue oxygenation. Electromyography (EMG) feedback was used to impose constant activity in a part of the trunk extensor muscles. We hypothesized that electromyographic manifestations of...article 2009
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TNO Kwaliteit van Leven (author), Madsen, L. (author), Pedersen, L.M. (author), Liaset, B. (author), Ma, T. (author), Petersen, R.K. (author), van den Berg, S. (author), Pan, J. (author), Müller-Decker, K.M. (author), Dülsner, E.D. (author), Kleemann, R. (author), Kooistra, T. (author), Døskeland, S.O. (author), Kristiansen, K. (author)The effect of n-6 polyunsaturated fatty acids (n-6 PUFAs) on adipogenesis and obesity is controversial. Using in vitro cell culture models, we show that n-6 PUFAs was pro-adipogenic under conditions with base-line levels of cAMP, but anti-adipogenic when the levels of cAMP were elevated. The anti-adipogenic action of n-6 PUFAs was dependent on a...article 2008
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Gaubius Instituut TNO (author), van den Hoek, A.M. (author), Heijboer, A.C. (author), Voshol, P.J. (author), Havekes, L.M. (author), Romijn, J.A. (author), Corssmit, E.P.M. (author), Pijl, H. (author)PYY3-36 is a gut-derived hormone acting on hypothalamic nuclei to inhibit food intake. We recently showed that PYY3-36 acutely reinforces insulin action on glucose disposal in mice. We aimed to evaluate effects of PYY3-36 on energy metabolism and the impact of chronic PYY3-36 treatment on insulin sensitivity. Mice received a single injection of...article 2007
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Vuyk, J. (author), van den Bos, J. (author), Terhell, K. (author), de Bos, R. (author), Vletter, A. (author), Valk, P. (author), van Beuzekom, M. (author), van Kleef, J. (author), Dahan, A. (author), TNO Technische Menskunde (author)Acute mountain sickness is thought to be triggered by cerebral hypoxemia and be prevented by acetazolamide (Actz). The effect of Actz on cerebral oxygenation at altitude remains unknown. In 16 members of the 2005 Dutch Cho Oyu (8201 m, Tibet) expedition, the influence of Actz and exercise (750 mg PO daily) on heart rate, peripheral and regional...article 2006
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Jellema, W.T. (author), Groeneveld, A.B.J. (author), Wesseling, K.H. (author), Thijs, L.G. (author), Westerhof, N. (author), van Lieshout, J.J. (author)OBJECTIVE: To establish the heterogeneity of hemodynamic responses to dobutamine in patients with septic shock and to identify the predictive factors of these hemodynamic responses. DESIGN: Prospective study. SETTING AND PATIENTS: A total of 12 patients with septic shock in a tertiary medical intensive care unit. INTERVENTIONS: A 20-min...article 2006
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Daanen, H.A.M. (author), van Es, E.M. (author), de Graaf, J.L. (author), TNO Defensie en Veiligheid (author)The maximal power that muscles can generate is reduced at low muscle temperatures. However, in prolonged heavy exercise in the heat, a high core temperature may be the factor limiting performance. Precooling has been shown to delay the attainment of hyperthermia. It is still unclear if the whole body should be cooled or if the active muscles...article 2006
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Influence of inspiratory resistance on performance during graded exercise tests on a cycle ergometerHeus, R. (author), den Hartog, E.A. (author), Kistemaker, L.J.A. (author), van Dijk, W.J. (author), Swenker, G. (author), TNO Technische Menskunde (author)Due to more stringent requirements to protect personnel against hazardous gasses, the inspiratory resistance of the present generation of respiratory protective devices tends to increase. Therefore an important question is to what extent inspiratory resistance may increase without giving problems during physical work. In this study the effects...article 2004
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den Hartog, E.A. (author), Heus, R. (author), TNO Technische Menskunde (author)The requirements to maintain a positive pressure with respiratory protection during heavy exercise and the effects on ventilation and feelings of discomfort were investigated. Eight male subjects participated, using the respirator system during rest and exercise at about 80% of their individual maximum power. A blower was used at maximum and...article 2003
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te Biesebeke, R. (author), Ruijter, G. (author), Rahardjo, Y.S.P. (author), Hoogschagen, M.J. (author), Heerikhuisen, M. (author), Levin, A. (author), van Driel, K.G.A. (author), Schutyser, M.A.I. (author), Dijksterhuis, J. (author), Zhu, Y. (author), Weber, F.J. (author), de Vos, W.M. (author), van den Hondel, K.A.M.J.J. (author), Rinzema, A. (author), Punt, P.J. (author)We report the progress of a multi-disciplinary research project on solid-state fermentation (SSF) of the filamentous fungus Aspergillus oryzae. The molecular and physiological aspects of the fungus in submerged fermentation (SmF) and SSF are compared and we observe a number of differences correlated with the different growth conditions. First,...article 2002
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Wertheim, A.H. (author), Kemper, H.C.G. (author), Heus, R. (author)In previous studies on physical fatigue during simulated ship movements, the apparent exhaustion of subjects after experimentation suggested that the traditional index of physical workload, oxygen consumption expressed as the percentage of peak oxygen consumption (VO2-peak) measured in a separate graded exercise test (GXT), underestimates...article 2002
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TNO Biomedical Instrumentation (author), van Lieshout, J.J. (author), Pott, F. (author), Madsen, P.L. (author), van Goudoever, J. (author), Secher, N.H. (author)Background and Purpose - When standing up causes dizziness, tensing of the leg muscles may alleviate the symptoms. We tested the hypothesis that leg tensing improves orthostatic tolerance via enhanced cerebral perfusion and oxygenation. Methods - In 10 healthy young adults, the effects of leg tensing on transcranial Doppler-determined middle...article 2001
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van Golde, J.M.C.G. (author), Mulder, T.A.L.M. (author), Scheve, E. (author), Prinzen, F.W. (author), Blanco, C.E. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)1. Hyperoxia can cause local vasoconstriction in adult animal organs as a protective mechanism against hyperoxia-induced toxicity. It is not known at what time during development this vasoconstrictor capacity is present. Therefore, we measured the cardiac output (GO) distribution in different organs during a period of acute hyperoxia (100% O2)...article 1999
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Bos, W.J.W. (author), Zietse, R. (author), Wesseling, K.H. (author), Westerhof, N. (author), TNO Biomedical Instrumentation (author)Background. Arteriovenous (AV) fistulas used for hemodialysis access may affect cardiac load by increasing the preload while decreasing the afterload. In dogs, AV fistulas have also been shown to affect coronary perfusion negatively. We investigated the net effect of AV fistulas on cardiac oxygen supply and demand. Methods. Aortic pressure waves...article 1999
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Smits, J.P. (author), Rinzema, A. (author), Tramper, J. (author), van Sonsbeek, H.M. (author), Hage, J.C. (author), Kaynak, A. (author), Knol, W. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)In this paper, correlations between temperature and kinetics of Trichoderma reesei QM9414 growing on wheat bran are described in terms of glucosamine production, oxygen consumption, and carbon dioxide production. Maximum growth temperature (T(max)) being approximately 314 K, is estimated by measuring the radial growth rate on wheat bran. The...article 1998
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Smits, J.P. (author), Rinzema, A. (author), Tramper, J. (author), van Sonsbeek, H.M. (author), Knol, W. (author)A description is given of the solid-state fermentation of wheat bran by Trichoderma reesei QM9414 at constant temperature and relative humidity. Glucosamine, the oxygen consumption rate (OCR), the carbon dioxide production rate (CPR), changes in wheat bran composition and the production of four enzymes were measured during 125 h of fermentation....article 1996
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Smits, J.P. (author), Rinzema, A. (author), Tramper, J. (author), Schlösser, E.E. (author), Knol, W. (author), TNO Voeding (author)The solid-state fermentation (SSF) method described enabled accurate determination of variables related to biological activity. Growth, respiratory activity and production of carboxymethyl-cellulose-hydrolysing enzyme (CMC-ase) activity by Trichoderma reesei QM9414 on wheat bran was used as a model SSF. The standard deviation (s) of measured...article 1996
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