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Proper, K.I. (author), van den Heuvel, S.G. (author), de Vroome, E.M. (author), Hildebrandt, V.H. (author), van der Beek, A.J. (author), TNO Kwaliteit van Leven (author)Objective: To investigate the dose-response relation between moderate and vigorous physical activity and sick leave in a working population. Methods: Data were used from three large Dutch databases: two continuous, cross sectional surveys among a representative sample of the Dutch population and one prospective cohort study. A distinction was...article 2006
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Reijneveld, S.A. (author), de Kleine, M.J.K. (author), van Baar, A.L. (author), Kollée, L.A.A. (author), Verhaak, C.M. (author), Verhulst, F.C. (author), Verloove-Vanhorick, S.P. (author), TNO Kwaliteit van Leven (author)Background: Children born very preterm (VP; <32 weeks' gestation) or with very low birth weight (VLBW, <1500 g; hereafter called VP/VLBW) are at risk for behavioural and emotional problems during school age and adolescence. At school entrance these problems may hamper academic functioning, but evidence on their occurrence at this age in VP/VLBW...article 2006
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TNO Kwaliteit van Leven (author), Kempers, M.J.E. (author), Lanting, C.I. (author), van Heijst, A.F.J. (author), van Trotsenburg, A.S.P. (author), Wiedijk, B.M. (author), de Vijlder, J.J.M. (author), Vulsma, T. (author)Context: The Dutch T4-TSH-TBG-based neonatal screening program detects patients with congenital hypothyroidism (CH) of thyroidal (CH-T) as well as central (CH-C) origin. The numbers and characteristics of true-positive and false-positive referrals will differ from other, predominantly TSH-based, screening methods. Objective: The present study...article 2006
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TNO Kwaliteit van Leven (author), van Wier, M.F. (author), Ariëns, G.A.M. (author), Dekkers, J.C. (author), Hendriksen, I.J.M. (author), Pronk, N.P. (author), Smid, T. (author), van Mechelen, W. (author)Background: The prevalence of overweight is increasing and its consequences will cause a major public health burden in the near future. Cost-effective interventions for weight control among the general population are therefore needed. The ALIFE@Work study is investigating a novel lifestyle intervention, aimed at the working population, with...article 2006
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TNO Kwaliteit van Leven (author), IJmker, S. (author), Blatter, B.M. (author), van der Beek, A.J. (author), van Mechelen, W. (author), Bongers, P.M. (author)Background: This article describes the background and study design of the PROMO study (Prospective Research on Musculoskeletal disorders in Office workers). Few longitudinal studies have been performed to investigate the risk factors responsible for the incidence of hand, arm, shoulder and neck symptoms among office workers, given the...article 2006
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TNO Kwaliteit van Leven (author), Bernaards, C.M. (author), Ariëns, G.A.M. (author), Hildebrandt, V.H. (author)Background: Neck and upper limb symptoms are frequently reported by computer workers. Work style interventions are most commonly used to reduce work-related neck and upper limb symptoms but lifestyle physical activity interventions are becoming more popular to enhance workers health and reduce work-related symptoms. A combined approach targeting...article 2006
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TNO Kwaliteit van Leven (author), Trion, A. (author), Maat, M.de (author), Jukema, W. (author), Maas, A. (author), Offerman, E. (author), Havekes, L. (author), Szalai, A. (author), Laarse, A.V.D. (author), Princen, H. (author), Emeis, J. (author)We investigated the pleiotropic effects of a calcium antagonist (amlodipine) on early atherosclerosis development in the presence and absence of an HMG-CoA-reductase inhibitor (atorvastatin) in apolipoprotein E*3-Leiden/human C-reactive protein (E3L/CRP) transgenic mice. Male E3L/CRP transgenic mice were fed a cholesterol-containing diet either...article 2006
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Lanting, C.I. (author), van Tijn, D.A. (author), Loeber, J.G. (author), Vulsma, T. (author), de Vijlder, J.J.M. (author), Verkerk, P.H. (author), TNO Preventie en Gezondheid (author)Context. Since the introduction of screening for congenital hypothyroidism (CH) in 1974, the optimal laboratory strategy has been the subject of debate. Objective. To assess the clinical effectiveness and cost-effectiveness of various types of thyroxine (T4)-based strategies to screen for CH. Design, Setting, and Participants. In the Netherlands...article 2005
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Wiefferink, C.H. (author), Poelman, J. (author), Linthorst, M. (author), Vanwesenbeeck, I. (author), van Wijngaarden, J.C.M. (author), Paulussen, T.G.W.M. (author), TNO Kwaliteit van Leven (author)This study examines the effects of a systematically designed innovation strategy on teachers' implementation of a sex education curriculum and its related determinants. A quasi-experimental group design was used to assess the effectiveness of the innovation strategy. Teachers filled in questionnaires on the determinants of curriculum...article 2005
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TNO Kwaliteit van Leven (author), van Sluijs, E.M.F. (author), van Poppel, M.N.M. (author), Twisk, J.W.R. (author), Brug, J. (author), van Mechelen, W. (author)PACE (Physician-based Assessment and Counseling for Exercise) is an individualized theory-based minimal intervention strategy aimed at the enhancement of regular physical activity. The aim of this study was to evaluate the effectiveness of a PACE intervention applied by general practitioners (GPs) on potential determinants of physical activity....article 2005
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Engels, Y. (author), Verheijen, N. (author), Fleuren, M. (author), Mokkink, H. (author), Grol, R. (author)Objective: To study the effects of small group continuous quality improvement (CQI) on the clinical practice of midwives in the Netherlands. Design: Randomised pre-/post-test (balanced block). Intervention: The CQI groups were assigned to either the set of peer review topics including 'perineal repair' and 'artificial rupture of the membranes ...article 2003
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van Straaten, H.L.M. (author), Hille, E.T.M. (author), Kok, J.H. (author), Verkerk, P.H. (author), Baerts, W. (author), Bunkers, C.M. (author), Smink, E.W.A. (author), van Elburg, R.M. (author), de Kleine, M.J.K. (author), Ilsen, A. (author), Maingay-Visser, A.P.G.F. (author), de Vries, L.S. (author), Weisglas-Kuperus, N. (author)Aim: As part of a future national neonatal hearing screening programme in the Netherlands, automated auditory brainstem response (AABR) hearing screening was implemented in seven neonatal intensive care units (NICUs). The objective was to evaluate key outcomes of this programme: participation rate, first stage success rate, pass/referral rates,...article 2003
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Peters, J.W.B. (author), Koot, H.M. (author), Grunau, R.E. (author), de Boer, J. (author), van Druenen, M.J. (author), Tibboel, D. (author), Duivenvoorden, H.J. (author), TNO Preventie en Gezondheid (author)Objective: The objectives of this study were to: (1) evaluate the validity of the Neonatal Facial Coding System (NFCS) for assessment of postoperative pain and (2) explore whether the number of NFCS facial actions could be reduced for assessing postoperative pain. Design: Prospective, observational study. Patients: Thirty-seven children (0-18...article 2003
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Rosendal, H. (author), Vondeling, H. (author), de Witte, L.P. (author), Hutubessy, R.C.W. (author), van Beekum, W.T. (author), Heine, R.J. (author)Objective. Assessing whether the initiation of insulin therapy in patients with diabetes mellitus type 2 can be delivered as effectively in a structured transmural care model as in the more usual outpatients structure. Design. Retrospective comparative cohort study. Method. In 1997 data were collected from 52 patients with diabetes mellitus type...article 2002
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TNO Arbeid (author), Proper, K.I. (author), Staal, B.J. (author), Hildebrandt, V.H. (author), van der Beek, A.J. (author), van Mechelen, W. (author)This paper systematically reviews the literature on the effectiveness of physical activity programs at worksites with respect to work-related outcomes. A computerized literature search, a reference search, and a manual search of personal databases were performed using the following inclusion criteria: randomized controlled or controlled trial,...article 2002
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Hopman-Rock, M. (author), Staats, P.G.M. (author), Tak, E.C.P.M. (author), Dröes, R.M. (author), TNO Preventie en Gezondheid (author)Objectives. To test the effects of the Psychomotor Activation Programme (PAP) on the behaviour and cognition of demented elderly people. Design. Randomized controlled trial with an experimental group and a control group. Post-test after 6 months. Setting. Group care projects for demented elderly people living in 11 different homes for the...article 1999
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TNO Preventie en Gezondheid NIA TNO (author), Miedema, H.S. (author), Chorus, A.M.J. (author), Wevers, C.W.J. (author), van der Linden, S. (author)Study Design. A follow-up study of a cohort of 444 patients aged 16 to 59 years who consulted with their general practitioners (GPs) in 1987-1988 for an incident episode of back pain. Objectives. To determine the proportion of patients with back pain in whom chronic back problems develop after a follow-up of 7 years, to compare health outcomes...article 1998
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TNO Preventie en Gezondheid (author), Verkerk, P.H. (author), van Spronsen, F.J. (author), van Houten, M. (author), Smit, G.P. (author), Sengers, R.C. (author)We studied the relationship between plasma phenylalanine level at first diagnostic visit, country of origin of the mother, birth cohort, child clinic, sex, and social class on the one hand and mean plasma phenylalanine levels in the first five years of life on the other hand in patients with phenylketonuria (PKU) who were treated early. The...article 1994
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Ens-Dokkum, M.H. (author), Schreuder, A.M. (author), Veen, S. (author), Verloove-Vanhorick, S.P. (author), Brand, R. (author), Ruys, J.H. (author), Nederlands Instituut voor Praeventieve Gezondheidszorg TNO (author)Since the introduction of neonatal intensive care in the 1960s, mortality in very preterm and very low birthweight infants has been decreasing steadily. Consequently, interest in the outcome of surviving infants is growing. Restriction of health care resources has stressed the need for information concerning the effect of individual treatment...article 1992
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Banta, H.D. (author), Engel, G.L. (author), Schersten, T. (author), TNO/WHO, Program on Health Tech. Assessment Centre for Medical Technology/TNO Instituut voor verouderings- en vaatziekten onderzoek TNO (author)In general, technically demanding medical procedures are associated with better outcomes when they are carried out in institutions and by physicians with higher volumes of practice. This paper examines the evidence for a volume-outcome relationship in the case of organ transplantation. Although few studies have been done on this subject,...article 1992