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Chen, C.-T. (author), Burton-Wurster, N. (author), Lust, G. (author), Bank, R.A. (author), Tekoppele, J.M. (author)The first objective of this study was to determine if the cumulative effects of impact or smoothly arising compression would damage the matrix of articular cartilage. Canine cartilage explants were subjected to repeated impacts or to smoothly arising compressions of as much as 20 MPa at 0.3 Hz for as long as 120 minutes. An increase in the water...article 1999
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de Groot, J. (author), Verzijl, N. (author), Bank, R.A. (author), Lafeber, F.P.J.G. (author), Bijlsma, J.W.J. (author), TeKoppele, J.M. (author)Objective. To examine the effect of nonenzymatic glycation of cartilage extracellular matrix on the synthetic activity of chondrocytes. Methods. The proteoglycan-synthesis rate (35SO42- incorporation) and levels of advanced nonenzymatic glycation (determined by high-performance liquid chromatography measurement of pentosidine) were evaluated in...article 1999
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Hopman-Rock, M. (author), Kraaimaat, F.W. (author), Odding, E. (author), Bijlsma, J.W.J. (author), TNO Preventie en Gezondheid (author)Objective. To investigate the use of pain coping strategies by community-living older people with pain in the hip or knee and the mediating role of coping with pain in the relationship between the chronicity of pain and physical disability. Methods. A group of 157 people with pain 'in the last month' was identified. Coping with pain was assessed...article 1998
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Basser, P.J. (author), Schneiderman, R. (author), Bank, R.A. (author), Wachtel, E. (author), Maroudas, A. (author), TNO Preventie en Gezondheid (author)We have used an isotropic osmotic stress technique to assess the swelling pressures of human articular cartilage over a wide range of hydrations in order to determine from these measurements, for the first time, the tensile stress in the collagen network, P(c), as a function of hydration. Osmotic stress was applied by means of calibrated...article 1998
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Bank, R.A. (author), Bayliss, M.T. (author), Lafeber, F.P.J.G. (author), Maroudas, A. (author), Tekoppele, J.M. (author), Gaubius Instituut TNO (author)A biomechanical failure of the collagen network is postulated in many hypotheses of the development of osteoarthritis with advancing age. Here we investigate the accumulation of non-enzymatic glycation (NEG) products in healthy human articular cartilage, its relation to tissue remodelling and its role in tissue stiffening. Pentosidine levels...article 1998
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TeKoppele, J.M. (author), Beekman, B. (author), Verzijl, N. (author), Koopman, J.L. (author), de Groot, J. (author), Bank, R.A. (author), Gaubius Instituut TNO (author)Doxycycline (DOX) profoundly inhibited collagen synthesis by differentiated articular chondrocytes. At 25 microM, the rate of collagen synthesis was suppressed by more than 50% without affecting cell proliferation (DNA levels) and general protein synthesis (35S-Met and 35S-Cys incorporation). Steady-state mRNA levels of type II collagen were...article 1998
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Gaubius Instituut TNO (author), Meulenbelt, I. (author), Bijkerk, C. (author), Miedema, H.S. (author), Breedveld, F.C. (author), Hofman, A. (author), Valkenburg, H.A. (author), Pols, H.A.P. (author), Slagboom, P.E. (author), van Duijn, C.M. (author)Objective - A genetic association study was performed to investigate whether radiographical osteoarthritis (ROA) was associated with specific genotypes of the insulin-like growth factor I (IGF-1) gene. Methods - Subjects aged 55-65 years were selected from a population-based study of which ROA at the knee, hip, spine, and hand was assessed....article 1998
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Gaubius Instituut TNO (author), Brama, P.A.J. (author), TeKoppele, J.M. (author), Beekman, B. (author), van Weeren, P.R. (author), Barneveld, A. (author)Objective - To investigate the influence of age, osteoarthritis (OA), and osteochondrosis (OC) on the matrix metalloproteinase (MMP) activity in the synovial fluid (SF) of equine joints. Methods - SF was collected from normal and osteoarthritic metacarpophalangeal joints (normal: 14 adult, 28 juvenile; OA: 22 adult). And from normal and...article 1998
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Hopman-Rock, M. (author), de Bock, G.H. (author), Bijlsma, J.W.J. (author), Springer, M.P. (author), Hofman, A. (author), Kraaimaat, F.W. (author), TNO Preventie en Gezondheid (author)Objective: The aim of the study was to determine the pattern of health care utilization of people aged 55-74 years with arthritic pain in the knee or hip. Design: People with current pain were identified in a population- based study. A filter model was used to describe the pattern of health care utilization of people who presented as patients at...article 1997
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- van Valburg, A.A. (author), Wenting, M.J.G. (author), Beekman, B. (author), TeKoppele, J.M. (author), Lafeber, F.P.G.J. (author), Bijlsma, J.W.J. (author) article 1997
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Hopman-Rock, M. (author), Kraaimaat, F.W. (author), Bijlsma, J.W.J. (author), TNO Preventie en Gezondheid (author)This study examines the quality of life (QOL) of community living elderly people aged 55-74 with chronic, episodic or sporadic pain in the hip or knee and of a reference group without pain (total n = 306). Firstly, it was hypothesized that the experienced QOL is lower in people with more chronic pain. Secondly, the potential mediating and...article 1997
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Hopman-Rock, M. (author), Odding, E. (author), Hofman, A. (author), Kraaimaat, F.W. (author), Bijlsma, J.W.J. (author), TNO Preventie en Gezondheid (author)Objective. To determine differences in health status of people aged 55 to 74 years with pain in the hip or knee only and with additional mobility restricting conditions. Methods. A subsample from a community based study on pain, disability, comorbidity, and radio-logical osteoarthritis (OA) was used to identify a group with current pain in the...article 1997
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Beekman, B. (author), Verzijl, N. (author), de Roos, J.A.D.M. (author), Koopman, J.L. (author), Tekoppele, J.M. (author), Leiden, Netherlands Gaubius Instituut TNO (author)Doxycycline is known for its ability to inhibit matrix metalloproteinases (MMPs), a family of enzymes that play a role in cartilage breakdown in arthritides. Its prophylactic effect in reducing joint degradation in osteoarthritis is mainly attributed to this property. In this study, we show that doxycycline exhibits a profound inhibition of...article 1997
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Meulenbelt, I. (author), Bijkerk, C. (author), de Wildt, S.C.M. (author), Miedema, H.S. (author), Valkenburg, H.A. (author), Breedveld, F.C. (author), Pols, H.A.P. (author), TeKoppele, J.M. (author), Sloos, V.F.G. (author), Hofman, A. (author), Slagboom, P.E. (author), van Duijn, C.M. (author)Objective. To investigate whether radiographically evident osteoarthritis (ROA) in 55-65-year-old men and women is associated with specific alleles or genotypes of the cartilage matrix protein (CRTM) and cartilage link protein (CRTL1) genes. Methods. Cases were selected from a population-based study on the presence of ROA of the knee or hip....article 1997
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Dolhain, R.J.E.M. (author), ter Haar, N.T. (author), Hoefakker, S. (author), Tak, P.P. (author), de Ley, M. (author), Claassen, E. (author), Breedveld, F.C. (author), Miltenburg, A.M.M. (author), TNO Preventie en Gezondheid (author)Data concerning the presence of T-cell-derived cytokines in the rheumatic joint are conflicting, challenging the hypothesis that rheumatoid arthritis (RA) is a T-cell-mediated disease. In this study synovial tissue specimens of 11 patients with RA and eight patients with osteoarthritis (OA) were stained for interferon-gamma IFN-γ) and its...article 1996
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Hopman-Rock, M. (author), Odding, E. (author), Hofman, A. (author), Kraaimaat, F.W. (author), Bijlsma, J.W.J. (author), TNO Preventie en Gezondheid (author)Objective. To determine physical and psychosocial disability in subjects aged 55 to 74 years living in the community, in relation to pain in the hip and/or knee, and to explore the relationships between pain, physical and psychosocial disability, and selected background variables. Methods. A subsample from a community based study on pain,...article 1996
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Hopman-Rock, M. (author), Kraaimaat, F.W. (author), Bijlsma, J.W.J. (author), TNO Preventie en Gezondheid (author)The relationship between the frequency (chronic, episodic, and sporadic) of arthritic pain in the hip and/or knee, other illness-related variables, physical disability, and a physically active lifestyle was analyzed in community-living subjects aged 55 to 74 years (N = 306). We tested the hypothesis that a physically active lifestyle is a...article 1996
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Meulenbelt, I. (author), Williams, G.J. (author), Koppele, J.M.T.E. (author), van Giessen, G.C.D.E. (author), Slagboom, P.E. (author), TNO Preventie en Gezondheid (author), PG (author)We have determined the allele frequencies mad pairwise linkage disequilibria of restriction fragment length polymorphisms (RFLPs) distributed over the entire COL2A1 gene (spanning 23 · 6 kb) in a population of unrelated Dutch Caucasians. Pairwise linkage disequilibrium analysis of RFLP sites between exon 5B and 51 indicated a high degree of...article 1996
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Ronday, H.K. (author), Smits, H.H. (author), van Muijen, G.N.P. (author), Pruszczynski, M.S.M. (author), Dolhain, R.J.E.M. (author), van Langelaan, E.J. (author), Breedveld, F.C. (author), Verheijen, J.H. (author), Gaubius Instituut TNO (author)Proteolytic joint destruction in inflammatory and non-inflammatory arthropathy is believed to be mediated, at least in part, by the plasminogen activation (PA) system. To further investigate possible involvement of the PA system, we quantified immunoreactive urokinase-type plasminogen activator (u-PA), tissue-type plasminogen activator (t-PA),...article 1996
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- te Koppele, J.M. (author), Beekman, B. (author), Bloemhoff, W. (author), Drijfhout, J.W. (author), TNO Preventie en Gezondheid (author) article 1995