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de Jong, O.R.W. (author), Hopman-Rock, M. (author), Tak, E.C.M.P. (author), Klazinga, N.S. (author), TNO Preventie en Gezondheid (author)Implementation studies are recommended to assess the feasibility and effectiveness in real-life of programmes which have been tested in randomized controlled trials (RCTs). We report on an implementation study of two evidence-based exercise and health education programmes for older adults with osteoarthritis (OA) of the knee of hip. Three types...article 2004
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Day, J.S. (author), van der Linden, J.C. (author), Bank, R.A. (author), Ding, M. (author), Hvid, I. (author), Sumner, D.R. (author), Weinans, H. (author), TNO Preventie en Gezondheid (author)Osteoarthritis is a chronic joint disease with pathological changes in the articulating cartilage and all other tissues that occupy the joint. Radin and coworkers have suggested the involvement of subchondral bone in the disease process. However, evidence for an essential role in the etiology has never been proven. Recent studies showing reduced...article 2004
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Gaubius Instituut TNO (author), Tchetverikov, I. (author), Ronday, H.K. (author), van El, B. (author), Kiers, G.H. (author), Verzijl, N. (author), TeKoppele, J.M. (author), Huizinga, T.W.J. (author), de Groot, J. (author), Hanemaaijer, R. (author)Objective: To analyse matrix metalloproteinases (MMPs) and tissue inhibitor-1 of MMPs (TIMP-1) levels in the systemic circulation and synovial fluid (SF) of patients with RA and to compare these levels with inflammatory and collagen degradation markers. Methods: ProMMP-1, -2, -3, -8, -9, TIMP-1, levels of MMP/ α2-macroglobulin complexes, and...article 2004
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TNO Preventie en Gezondheid (author), van den Boom, R. (author), Brama, P.A.J. (author), Kiers, G.H. (author), de Groot, J. (author), van Weeren, P.R. (author)Objective - To assess the effects of age and joint disease on hydroxyproline and glycosaminoglycan (GAG) concentrations in synovial fluid from the metacarpophalangeal joint of horses and evaluate the association of those concentrations with severity of osteoarthritis and general matrix metalloproteinase (MMP) activity. Sample Population -...article 2004
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Identification of disease- and nutrient-related metabolic fingerprints in osteoarthritic guinea pigsLamers, R.-J.A.N. (author), de Groot, J. (author), Spies-Faber, E.J. (author), Jellema, R.H. (author), Kraus, V.B. (author), Verzijl, N. (author), te Koppele, J.M. (author), Spijksma, G.K. (author), Vogels, J.T.W.E. (author), van der Greef, J. (author), van Nesselrooij, J.H.J. (author)Osteoarthritis (OA), one of the most common diseases among the elderly, is characterized by the progressive destruction of joint tissues. Its etiology is largely unclear and no effective disease-modifying treatment is currently available. Metabolic fingerprinting provides a novel tool for the identification of biomarkers. A metabolic fingerprint...article 2003
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Verzijl, N. (author), Bank, R.A. (author), TeKoppele, J.M. (author), de Groot, J. (author), TNO Preventie en Gezondheid Gaubius instituut TNO (author)Purpose of review: Across the world, osteoarthritis is the most commonly occurring musculoskeletal disease of the elderly, affecting more than 25% of the population older than 60 years of age. By far the single greatest risk factor for the development of osteoarthritis is age, but a mechanism to explain this relation has not yet been identified....article 2003
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Bank, R.A. (author), Verzijl, N. (author), Lafeber, F.P.J.G. (author), Tekoppele, J.M. (author), Gaubius instituut TNO TNO Preventie en Gezondheid (author)Objective: The collagen network in human articular cartilage experiences a large number of stress cycles during life as it shows hardly any turnover after adolescence. We hypothesized that, to withstand fatigue failure, the physical condition of the collagen network laid down at adolescence is of crucial importance for the age of onset of...article 2002
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Verzijl, N. (author), de Groot, J. (author), Zaken, C.B. (author), Braun-Benjamin, O. (author), Maroudas, A. (author), Bank, R.A. (author), Mizrahi, J. (author), Schalkwijk, C.G. (author), Thorpe, S.R. (author), Baynes, J.W. (author), Bijlsma, J.W.J. (author), Lafeber, F.P.J.G. (author), TeKoppele, J.M. (author), Gaubius Instituut TNO (author)Objective. Age is an important risk factor for osteoarthritis (OA). During aging, nonenzymatic glycation results in the accumulation of advanced glycation end products (AGEs) in cartilage collagen. We studied the effect of AGE crosslinking on the stiffness of the collagen network in human articular cartilage. Methods. To increase AGE levels,...article 2002
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Marijnissen, A.C.A. (author), van Roermund, P.M. (author), TeKoppele, J.M. (author), Bijlsma, J.W.J. (author), Lafeber, F.P.J.G. (author), TNO Preventie en Gezondheid (author)Objective: The frequently used anterior cruciate ligament transection (ACLT) model of osteoarthritis (OA) in the dog, makes use of a permanent trigger (joint instability) for inducing degenerative changes. The present study evaluates a canine model of degenerative cartilage damage, mimicking OA, which is induced without making use of permanent...article 2002
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Huebner, J.L. (author), Hanes, M.A. (author), Beekman, B. (author), TeKoppele, J.M. (author), Kraus, V.B. (author), Gaubius Instituut (author)Objective: To evaluate the interaction of bone and cartilage in knee osteoarthritis (OA) pathogenesis in two guinea-pig strains with appreciable differences in bone metabolism. Design: Two guinea-pig strains were evaluated for their susceptibilities to OA using semi-quantitative histological grading of knee joints and quantification of...article 2002
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de Groot, J. (author), Bank, R.A. (author), Tchetverikov, I. (author), Verzijl, N. (author), TeKoppele, J.M. (author), Gaubius Instituut (author)Osteoarthritis is a disabling joint disease that is characterized by the progressive destruction of articular cartilage. Diagnosis is based on clinical symptoms in combination with radiography, which is relatively insensitive and provides only an indication of accumulated damage. Alternative methods, such as molecular markers, are therefore...article 2002
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Marijnissen, A.C.A. (author), van Roermund, P.M. (author), Verzijl, N. (author), Tekoppele, J.M. (author), Bijlsma, J.W.J. (author), Lafeber, F.P.J.G. (author), TNO Preventie en Gezondheid (author)Objective: Recently we described a canine model of osteoarthritis (OA), the groove model with features of OA at 10 weeks after induction, identical to those seen in the canine anterior cruciate ligament transection (ACLT) model. This new model depends on cartilage damage accompanied by transient intensified loading of the affected joint. The...article 2002
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TNO Preventie en Gezondheid (author), Tolboom, T.C.A. (author), Pieterman, E. (author), van der Laan, W.H. (author), Toes, R.E.M. (author), Huidekoper, A.L. (author), Nelissen, R.G.H.H. (author), Breedveld, F.C. (author), Huizinga, T.W.J. (author)Background: Matrix metalloproteinases (MMPs) have a pivotal role in the destruction of cartilage in rheumatoid arthritis (RA), which is mediated by the fibroblast-like synoviocytes (FLS). Objective: To examine the in vitro invasiveness of synoviocytes obtained from inflamed joints of patients with arthritis in relation to the expression of MMP 1...article 2002
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Verzijl, N. (author), de Groot, J. (author), Bank, R.A. (author), Bayliss, M.T. (author), Bijlsma, J.W.J. (author), Lafeber, F.P.J.G. (author), Maroudas, A. (author), TeKoppele, J.M. (author), Gaubius Instituut (author)During aging, non-enzymatic glycation results in the formation and accumulation of the advanced glycation endproduct pentosidine in long-lived proteins, such as articular cartilage collagen. In the present study, we investigated whether pentosidine accumulation also occurs in cartilage aggrecan. Furthermore, pentosidine levels in aggrecan...article 2001
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de Groot, J. (author), Verzijl, N. (author), Wenting-Van Wijk, M.J.G. (author), Bank, R.A. (author), Lafeber, F.P.J.G. (author), Bijlsma, J.W.J. (author), Tekoppele, J.M. (author), Gaubius Instituut (author)Objective. Progressive destruction of articular cartilage is a hallmark of osteoarthritis (OA) and rheumatoid arthritis (RA). Age-related changes in cartilage may influence tissue destruction and thus progression of the disease. Therefore, the effect of age-related accumulation of advanced glycation end products (AGEs) on cartilage...article 2001
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Okma-Keulen, P. (author), Hopman-Rock, M. (author)Objective. This qualitative study aims to investigate which factors are possibly associated with the onset of generalized osteoarthritis (OA) in older women. Methods. The study population was recruited from participants of a group course, "Coping With Osteoarthritis of the Hip or Knee." Twenty-three women with generalized OA were identified, 20...article 2001
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de Groot, J. (author), Verzijl, N. (author), Budde, M. (author), Bijlsma, J.W.J. (author), Lafeber, F.P.J.G. (author), TeKoppele, J.M. (author), Gaubius Instituut (author)The integrity of the collagen network is essential for articular cartilage to fulfill its function in load support and distribution. Damage to the collagen network is one of the first characteristics of osteoarthritis. Since extensive collagen damage is considered irreversible, it is crucial that chondrocytes maintain a functional collagen...article 2001
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Hopman-Rock, M. (author), Westhoff, M.H. (author), TNO Preventie en Gezondheid (author)Objective. Evaluation of a self-management program for patients with osteoarthritis (OA) of the hip or knee. The program, which consisted of 6 weekly sessions of 2 hours, included health education by a peer and physical exercises taught by a physical therapist. Methods. Randomized controlled trial. Inclusion criteria were diagnosis of OA of the...article 2000
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Influence of development and joint pathology on stromelysin enzyme activity in equine synovial fluidTNO Preventie en Gezondheid (author), Brama, P.A.J. (author), TeKoppele, J.M. (author), Beekman, B. (author), van El, B. (author), Barneveld, A. (author), van Weeren, P.R. (author)Objective - To investigate the role of stromelysin (MMP-3) activity in synovial fluid (SF) at different stages of development and in common joint disorders in the horse. Methods - Stromelysin activity was determined with a fluorogenic enzyme activity assay in SF of normal joints of fetal, juvenile and adult horses, and in SF of horses suffering...article 2000
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Gaubius Instituut TNO (author), Braat, E.A.M. (author), Jie, A.F.H. (author), Ronday, H.K. (author), Beekman, B. (author), Rijken, D.C. (author)Background - Excessive fibrin deposition within the inflamed joints of rheumatoid arthritis (RA) patients suggests that local fibrinolysis is inefficient, which seems to be in contrast with the observed increased levels of urokinase type plasminogen activator (u-PA). Thrombin-mediated inactivation of single chain u-PA (scu-PA) into an inactive...article 2000