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Vos, P.A.J.M. (author), Welsing, P.M.J. (author), de Groot, J. (author), Huisman, A.M. (author), Oostveen, J.C.M. (author), Reijman, M. (author), Damen, J. (author), Mastbergen, S.C. (author), Lafeber, F.P.J.G. (author)Age-related changes in articular cartilage are likely to play a role in the etiology of osteoarthritis (OA). One of the major age-related changes in cartilage is the accumulation of advanced glycation end products (AGEs). The present study evaluates whether pentosidine can predict radiographic progression and/or burden over 5 years follow-up in...article 2013
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de Lange-Brokaar, B.J.E. (author), Ioan-Facsinay, A. (author), van Osch, G.J.V.M. (author), Zuurmond, A.-M. (author), Schoones, J. (author), Toes, R.E.M. (author), Huizinga, T.W.J. (author), Kloppenburg, M. (author)Objective: Although osteoarthritis (OA) is considered a non-inflammatory condition, it is widely accepted that synovial inflammation is a feature of OA. However, the role of immune cells and their cytokines in OA is largely unknown. This narrative systematic review summarizes the knowledge of inflammatory properties, immune cells and their...article 2012
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Vos, P.A.J.M. (author), Mastbergen, S.C. (author), Huisman, A.M. (author), de Boer, T.N. (author), de Groot, J. (author), Polak, A.A. (author), Lafeber, F.P.J.G. (author)Objectives: Age is the most prominent predisposition for development of osteoarthritis (OA). Age-related changes of articular cartilage are likely to play a role. Advanced glycation endproducts (AGEs) accumulate in cartilage matrix with increasing age and adversely affect the biomechanical properties of the cartilage matrix and influence...article 2012
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Oosting, E. (author), Jans, M.P. (author), Dronkers, J.J. (author), Naber, R.H. (author), Dronkers-Landman, C.M. (author), Appelman-De Vries, S.M. (author), van Meeteren, N.L. (author)Preoperative home-based physical therapy versus usual care to improve functional health of frail older adults scheduled for elective total hip arthroplasty: a pilot randomized controlled trial. Objective: To investigate the feasibility and preliminary effectiveness of a home-based intensive exercise program to improve physical health of frail...article 2012
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Vos, P.A.J.M. (author), Degroot, J. (author), Barten-Van Rijbroek, A.D. (author), Zuurmond, A.-M. (author), Bijlsma, J.W.J. (author), Mastbergen, S.C. (author), Lafeber, F.P.J.G. (author)Osteoarthritis is a highly prevalent disease, age being the main risk factor. The age-related accumulation of advanced-glycation-endproducts (AGEs) adversely affects the mechanical and biochemical properties of cartilage. The hypothesis that accumulation of cartilage AGEs in combination with surgically induced damage predisposes to the...article 2012
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van Spil, W.E. (author), Jansen, N.W.D. (author), Bijlsma, J.W.J. (author), Reijman, M. (author), de Groot, J. (author), Welsing, P.M.J. (author), Lafeber, F.P.J.G. (author)Objective: To assess a wide spectrum of biochemical markers (biomarkers) in a large cohort of individuals with (very) early symptomatic knee and/or hip osteoarthritis (OA). Secondly, to investigate associations between biomarkers and between biomarkers and demographics to demonstrate validity of the obtained dataset and further investigate the...article 2012
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Vlaskamp, F. (author), Cremers, G. (author), Pas, R. (author), Arts, C. (author), Bonroy, B. (author), Gransier, R. (author), Kalisvaart, S.H. (author), Kerkhofs, V. (author), Koomen, P. (author), van Lummel, R. (author), Meijer, K. (author), Sauren, H. (author), Swinkels, M. (author), Vanrumste, B. (author), Verschuren, G. (author), de Witte, L. (author)Objective. People use pedometers and sport watches to measure calorie use and training performance. Knowing "how you move" is often more important than knowing "how much you move". Measuring "how you move" and feedback to the user is the objective of the BioSensing project. Patients with osteoarthritis of the knee and patients with acute knee...bookPart 2011
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Jans, M.P. (author), Slootweg, V.C. (author), Boot, C.R. (author), de Morton, N.A. (author), van der Sluis, G. (author), van Meeteren, N.L. (author)Objective: To examine the reproducibility, construct validity, and unidimensionality of the Dutch translation of the de Morton Mobility Index (DEMMI), a performance-based measure of mobility for older patients. Design: Cross-sectional study. Setting: Rehabilitation center (reproducibility study) and hospital (validity study). Participants:...article 2011
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Klein-Wieringa, I.R. (author), Kloppenburg, M. (author), Bastiaansen-Jenniskens, Y.M. (author), Yusuf, E. (author), Kwekkeboom, J.C. (author), El-Bannoudi, H. (author), Nelissen, R.G.H.H. (author), Zuurmond, A. (author), Stojanovic-Susulic, V. (author), van Osch, G.J.V.M. (author), Toes, R.E.M. (author), Ioan-Facsinay, A. (author)Objectives: Obesity is a risk factor for the development of osteoarthritis (OA) in hands and knees. Adipose tissue can secrete different adipokines with powerful immunomodulatory effects. The infrapatellar fat pad (IFP) is an intra-articular organ in the vicinity of the synovium and cartilage. It is hypothesised that IFP-derived soluble factors...article 2011
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Castro-Perez, J.M. (author), Kamphorst, J. (author), de Groot, J. (author), Lafeber, F. (author), Goshawk, J. (author), Yu, K. (author), Shockcor, J.P. (author), Vreeken, R.J. (author), Hankemeier, T. (author), TNO Kwaliteit van Leven (author)A fast and robust method for lipid profiling utilizing liquid chromatography coupled with mass spectrometry has been demonstrated and validated for the analysis of human plasma. This method allowed quantification and identification of lipids in human plasma using parallel alternating low energy and high energy collision spectral acquisition...article 2010
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Intema, F. (author), Sniekers, Y.H. (author), Weinans, H. (author), Vianen, M.E. (author), Yocum, S.A. (author), Zuurmond, A.-M.M. (author), de Groot, J. (author), Lafeber, F.P. (author), Mastbergen, S.C. (author), TNO Kwaliteit van Leven (author)In osteoarthritis (OA), cartilage degradation is accompanied by subchondral bone changes. The pathogenesis and physiology of bone changes in OA are still unclear. The changes in subchondral bone architecture and cartilage damage were compared in differently induced experimental models of OA. Experimental OA was induced bilaterally by anterior...article 2010
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Vos, P.A.J.M. (author), de Groot, J. (author), Huisman, A.M. (author), Oostveen, J.C.M. (author), Marijnissen, A.C.A. (author), Bijlsma, J.W.J. (author), van El, B. (author), Zuurmond, A.M. (author), Lafeber, F.P.J.G. (author), TNO Kwaliteit van Leven (author)Objectives: Age-related changes in articular cartilage are likely to play a role in the aetiology of osteoarthritis (OA). One of the major age-related changes in cartilage is the accumulation of advanced-glycation-endproducts (AGEs). Since, cartilage tissue is not readily available from patients for studying AGE levels, alternative approaches...article 2010
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van Spil, W.E. (author), de Groot, J. (author), Lems, W.F. (author), Oostveen, J.C.M. (author), Lafeber, F.P.J.G. (author), TNO Kwaliteit van Leven (author)Context: Molecules that are released into biological fluids during matrix metabolism of articular cartilage, subchondral bone, and synovial tissue could serve as biochemical markers of the process of osteoarthritis (OA). Unfortunately, actual breakthroughs in the biochemical OA marker field are limited so far. Objective: By reviewing the status...article 2010
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Vos, P. (author), Intema, F. (author), van El, B. (author), de Groot, J. (author), Bijlsma, J.W.J. (author), Lafeber, F. (author), Mastbergen, S. (author), TNO Kwaliteit van Leven (author)Many animal models are used to study osteoarthritis (OA). In these models the role of joint loading in the development of OA is not fully understood. We studied the effect of loading on the development of OA in the canine Groove-model. In ten female beagle dogs OA was induced in one knee according to the Groove-model. The animals were divided in...article 2009
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The impact of waiting for total joint replacement on pain and functional status: A systematic reviewHoogeboom, T.J. (author), van den Ende, C.H.M. (author), van der Sluis, G. (author), Elings, J. (author), Dronkers, J.J. (author), Aiken, A.B. (author), van Meeteren, N.L.U. (author), TNO Kwaliteit van Leven (author)Objective: To systematically describe changes in pain and functioning in patients with osteoarthritis (OA) awaiting total joint replacement (TJR), and to assess determinants of this change. Methods: MEDLINE®, EMBASE, CINAHL® and Cochrane Database were searched through June 2008. The reference lists of eligible publications were reviewed. Studies...article 2009
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Bastiaansen-Jenniskens, Y.M. (author), Koevoet, W. (author), de Bart, A.C.W. (author), van der Linden, J.C. (author), Zuurmond, A.M. (author), Weinans, H. (author), Verhaar, J.A.N. (author), van Osch, G.J.V.M. (author), de Groot, J. (author), TNO Kwaliteit van Leven (author)Background: Damage to articular cartilage is one of the features of osteoarthritis (OA). Cartilage damage is characterised by a net loss of collagen and proteoglycans. The collagen network is considered highly important for cartilage function but little is known about processes that control composition and function of the cartilage collagen...article 2008
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Frost-Christensen, L.N. (author), Mastbergen, S.C. (author), Vianen, M.E. (author), Hartog, A. (author), de Groot, J. (author), Voorhout, G. (author), van Wees, A.M.C. (author), Lafeber, F.P.J.G. (author), Hazewinkel, H.A.W. (author), TNO Kwaliteit van Leven (author)Objective: The most used model for joint instability is the canine anterior cruciate ligament transection (ACLT)-model. The ACLT-model can be extended with a medial meniscectomy (MX) (i.e., ACLT-MX-model) to avoid unintentional, and with that variable, meniscal damage. The present study compares the ACLT-MX-model with the more recently...article 2008
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Intema, F. (author), de Groot, J. (author), Elshof, B. (author), Vianen, M.E. (author), Yocum, S. (author), Zuurmond, A. (author), Mastbergen, S.C. (author), Lafeber, F.P. (author), TNO Kwaliteit van Leven (author)In studies aimed at local treatment of experimental osteoarthritis (OA) it is optimal to have an internal (untreated) OA control. Such an approach excludes interanimal variation, and allows paired statistical evaluation of treatment efficacy. For this purpose, we developed and characterized a bilateral version of the canine Groove model. We...article 2008
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TNO Kwaliteit van Leven (author), Hunter, D.J. (author), LaValley, M. (author), Li, J. (author), Bauer, D.C. (author), Nevitt, M. (author), de Groot, J. (author), Poole, R. (author), Eyre, D. (author), Guermazi, A. (author), Gale, D. (author), Totterman, S. (author), Felson, D.T. (author)Introduction: Our objective was to determine whether markers of bone resorption and formation could serve as markers for the presence of bone marrow lesions (BMLs). Methods: We conducted an analysis of data from the Boston Osteoarthritis of the Knee Study (BOKS). Knee magnetic resonance images were scored for BMLs using a semiquantitative...article 2008
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TNO Kwaliteit van Leven (author), Jansen, N.W.D. (author), Roosendaal, G. (author), Bijlsma, J.W.J. (author), de Groot, J. (author), Theobald, M. (author), Lafeber, F.P.J.G. (author)Background: Joint bleeds have a direct adverse effect on joint cartilage, leading to joint deterioration and, ultimately, to disability. Objective: To examine the hypothesis that because degenerated cartilage has a limited repair capacity, it is more susceptible than healthy cartilage to blood-induced cartilage damage. Methods: Healthy,...article 2008