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Shankar, K. (author), Pivik, R.T. (author), Johnson, S.L. (author), van Ommen, B. (author), Demmer, E. (author), Murray, R. (author)Understanding health requires more than knowledge of the genome. Environmental factors regulate gene function through epigenetics. Collectively, environmental exposures have been called the "exposome." Caregivers are instrumental in shaping exposures in a child's initial years. Maternal dietary patterns, physical activity, degree of weight gain,...article 2018
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Celis-Morales, C. (author), Livingstone, K.M. (author), Woolhead, C. (author), Forster, H. (author), O’Donovan, C.B. (author), Macready, A.L. (author), Fallaize, R. (author), Marsaux, C.F.M. (author), Tsirigoti, L. (author), Efstathopoulou, E. (author), Moschonis, G. (author), Navas-Carretero, S. (author), San-Cristobal, R. (author), Kolossa, S. (author), Klein, U.L. (author), Hallmann, J. (author), Godlewska, M. (author), Surwiłło, A. (author), Drevon, C.A. (author), Bouwman, J. (author), Grimaldi, K. (author), Parnell, L.D. (author), Manios, Y. (author), Traczyk, I. (author), Gibney, E.R. (author), Brennan, L. (author), Walsh, M.C. (author), Lovegrove, J.A. (author), Martinez, J.A. (author), Daniel, H. (author), Saris, W.H.M. (author), Gibney, M. (author), Mathers, J.C. (author)In e-health intervention studies, there are concerns about the reliability of internet-based, self-reported (SR) data and about the potential for identity fraud. This study introduced and tested a novel procedure for assessing the validity of internet-based, SR identity and validated anthropometric and demographic data via measurements performed...article 2015
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TNO Kwaliteit van Leven (author), Stroeve, J.H.M. (author), van Wietmarschen, H. (author), Kremer, B.H.A. (author), van Ommen, B. (author), Wopereis, S. (author)Nutrition research is struggling to demonstrate beneficial health effects, since nutritional effects are often subtle and long term. Health has been redefined as the ability of our body to cope with daily-life challenges. Physiology acts as a well-orchestrated machinery to adapt to the continuously changing environment. We term this adaptive...article 2015
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de Jong, L. (author)The role of our intestinal microbiota reaches far beyond fermentation of indigestible food components. Apart from immunological functions, they have a major impact on our metabolic and perhaps even mental health. Dutch research organization TNO is exploring this exciting field, known as host-microbiota interactions, and is developing and...article 2013
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Schneider, T. (author), Brouwer, D.H. (author), Koponen, I.K. (author), Jensen, K.A. (author), Fransman, W. (author), van Duuren-Stuurman, B. (author), van Tongeren, M. (author), Tielemans, E. (author)As workplace air measurements of manufactured nanoparticles are relatively expensive to conduct, models can be helpful for a first tier assessment of exposure. A conceptual model was developed to give a framework for such models. The basis for the model is an analysis of the fate and underlying mechanisms of nanoparticles emitted by a source...article 2011
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van Eunen, K. (author), Rossell, S. (author), Bouwman, J. (author), Westerhoff, H.V. (author), Bakker, B.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Regulation analysis is a methodology that quantifies to what extent a change in the flux through a metabolic pathway is regulated by either gene expression or metabolism. Two extensions to regulation analysis were developed over the past years: (i) the regulation of Vmax can be dissected into the various levels of the gene-expression cascade,...conference paper 2011
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- Dutman, A.E. (author), Stafleu, A. (author), Kruizinga, A. (author), Brants, H.A. (author), Westerterp, K.R. (author), Kistemaker, C. (author), Meuling, W.J. (author), Goldbohm, R.A. (author) article 2011
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Joosten, M.M. (author), Chiuve, S.E. (author), Mukamal, K.J. (author), Hu, F.B. (author), Hendriks, H.F. (author), Rimm, E.B. (author)OBJECTIVE: The objective of this study was to investigate the association of 4-year changes in alcohol consumption with a subsequent risk of type 2 diabetes. RESEARCH DESIGN AND METHODS: We prospectively examined 38,031 men from the Health Professionals Follow-Up Study who were free of diagnosed diabetes or cancer in 1990. Alcohol consumption...article 2011
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- Blom, W.M. (author), Vlieg-Boerstra, B.J. (author), Spanjersberg, M.I.Q. (author), Kruizinga, A.G. (author), van der Heide, S. (author), Dubois, A.E.J. (author), Houben, G.F. (author), TNO Kwaliteit van Leven (author) conference paper 2010
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TNO Kwaliteit van Leven (author), van Ommen, B. (author), Bouwman, J. (author), Dragsted, L.O. (author), Drevon, C.A. (author), Elliott, R. (author), de Groot, P. (author), Kaput, J. (author), Mathers, J.C. (author), Müller, M. (author), Pepping, F. (author), Saito, J. (author), Scalbert, A. (author), Radonjic, M. (author), Rocca-Serra, P. (author), Travis, A. (author), Wopereis, S. (author), Evelo, C.T. (author)The challenge of modern nutrition and health research is to identify food-based strategies promoting life-long optimal health and well-being. This research is complex because it exploits a multitude of bioactive compounds acting on an extensive network of interacting processes. Whereas nutrition research can profit enormously from the revolution...article 2010
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- TNO Kwaliteit van Leven (author), van Ommen, B. (author) article 2007
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Verheijden, M.W. (author), Bakx, J.C. (author), van Weel, C. (author), van Staveren, W.A. (author), TNO Kwaliteit van Leven (author)This paper was based on collaborative research efforts from Wageningen University and the University Medical Centre St Radboud in The Netherlands and describes the rationale for web-based nutrition counselling applications in general practice as well as some of the frequently used models and theories (predominantly the Stages of Change Model)....article 2005
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Verheijden, M.W. (author), Kok, F.J. (author), TNO Kwaliteit van Leven (author)Community-based interventions have increasingly received attention since researchers and public health professionals have come to acknowledge the importance of an environment that makes the healthy choice the easy choice. All stakeholders including the target community are involved to achieve changes in legislation, in people's social and...article 2005
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Koster, F.R.T. (author), Verheijden, M.W. (author), Baartmans, J.A. (author), TNO Kwaliteit van Leven (author)Every year 7000 people die from obesity and another 13 000 people die by wrong diets in The Netherlands. Part of this problem can be solved when the communication between general practitioners (GPs) and patients about nutrition and diets improves. There are four activities that can contribute greatly to the communication between GPs and their...article 2005
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Terpstra, M.E.J. (author), Janssen, A.M. (author), Prinz, J.F. (author), de Wijk, R.A. (author), Weenen, H. (author), van der Linden, E. (author), TNO Kwaliteit van Leven (author)We investigated the relationship between orally perceived thickness and calculated shear stress on the tongue for mayonnaise and custard. To this end, the applicability of the models of Kokini et al. (1977), describing the mechanical breakdown in the mouth, have been tested. Within a limited range of shear stresses (mayonnaise < 150 Pa; custard ...article 2005
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TNO Kwaliteit van Leven (author), Kaput, J. (author), Ordovas, J.M. (author), Ferguson, L. (author), van Ommen, B. (author), Rodriguez, R.L. (author), Allen, L. (author), Ames, B.N. (author), Dawson, K. (author), German, B. (author), Krauss, R. (author), Malyj, W. (author), Archer, M.C. (author), Barnes, S. (author), Bortholomew, A. (author), Birk, R. (author), van Bladeren, P. (author), Bradford, K.J. (author), Brown, K.H. (author), Caetano, R. (author), Castle, D. (author), Chadwick, R. (author), Clarke, S. (author), Clemént, K. (author), Cooney, C.A. (author), Corella, D. (author), da Cruz, I.B.M. (author), Daniel, H. (author), Duster, T. (author), Ebbesson, S.O.E. (author), Elliott, R. (author), Fairweather-Tait, S. (author), Felton, J. (author), Fenech, M. (author), Finley, J.W. (author), Fogg-Johnson, N. (author), Gill-Garrison, R. (author), Gibney, M.J. (author), Gillies, P.J. (author), Gustafsson, J.A. (author), Hartman IV, J.L. (author), He, L. (author), Hwang, J.K. (author), Jais, J.P. (author), Jang, Y. (author), Joost, H. (author), Junien, C. (author), Kanter, M. (author), Kibbe, W.A. (author), Koletzko, B. (author), Korf, B.R. (author), Kornman, K. (author), Krempin, D.W. (author), Langin, D. (author), Lauren, D.R. (author), Lee, J.H. (author), Leveille, G.A. (author), Lin, S.J. (author), Mathers, J. (author), Mayne, M. (author), McNabb, W. (author), Milner, J.A. (author), Morgan, P. (author), Muller, M. (author), Nikolsky, Y. (author), van der Ouderaa, F. (author), Park, T. (author), Pensel, N. (author), Perez-Jimenez, F. (author), Poutanen, K. (author), Roberts, M. (author), Saris, W.H.M. (author), Schuster, G. (author), Shelling, A.N. (author), Simopoulos, A.P. (author), Southon, S. (author), Shyong Tai, E. (author), Towne, B. (author), Trayhurn, P. (author), Uauy, R. (author), Visek, W.J. (author), Warden, C. (author), Weiss, R. (author), Wiencke, J. (author), Winkler, J. (author), Wolff, G.L. (author), Zhao-Wilson, X. (author), Zucker, J.D. (author)Nutrigenomics is the study of how constituents of the diet interact with genes, and their products, to alter phenotype and, conversely, how genes and their products metabolise these constituents into nutrients, antinutrients, and bioactive compounds. Results from molecular and genetic epidemiological studies indicate that dietary unbalance can...article 2005
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- Marquart, L. (author), Asp, N.G. (author), Richardson, D.P. (author), TNO Voeding (author) bookPart 2004
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- Schaafsma, G. (author), TNO Voeding (author) article 2004
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Snoek, H.M. (author), Huntjens, L. (author), van Gemert, L.J. (author), de Graaf, C. (author), Weenen, H. (author), TNO Voeding (author)Background: Sensory-specific satiety has been found to play an important role in food choice and meal termination, and it might be a factor contributing to obesity. Objective: We hypothesized that obese and normal-weight people have different sensitivities to sensory-specific satiety for high-fat foods. Design: Sensory-specific satiety was...article 2004
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Hoek, A.C. (author), Luning, P.A. (author), Stafleu, A. (author), de Graaf, C. (author), TNO Voeding (author)The aim was to investigate socio-demographic characteristics, and attitudes to food and health of vegetarians, non-vegetarian consumers of meat substitutes, and meat consumers in the Netherlands. The sample used for this study (participants ≥18 years) was taken from the Dutch National Food Consumption Survey, 1997/1998. Vegetarians (n=63) and...article 2004