Searched for: subject:"normal%5C+human"
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Siddiqui, A. (author), Cuttini, M. (author), Wood, R. (author), Velebil, P. (author), Delnord, M. (author), Zile, I. (author), Barros, H. (author), Gissler, M. (author), Hindori-Mohangoo, A.D. (author), Blondel, B. (author), Zeitlin, J. (author), Haidinger, G. (author), Alexander, S. (author), Pavlou, P. (author), Mortensen, L. (author), Sakkeus, L. (author), Lack, N. (author), Antsaklis, A. (author), Berbik, I. (author), Ólafsdóttir, H.S. (author), Bonham, S. (author), Misins, J. (author), Jaselioniene, J. (author), Wagener, Y. (author), Gatt, M. (author), Nijhuis, J. (author), Klungsøyr, K. (author), Szamotulska, K. (author), Horga, M. (author), Cap, J. (author), Mandić, N.T. (author), Bolúmar, F. (author), Gottvall, K. (author), Berrut, S. (author), Macfarlane, A. (author), Euro-Peristat Scientific Committee (author)
Background: The Apgar score has been shown to be predictive of neonatal mortality in clinical and population studies, but has not been used for international comparisons. We examined population-level distributions in Apgar scores and associations with neonatal mortality in Europe. Methods: Aggregate data on the 5 minute Apgar score for live...
article 2017
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van den Broek, T.J. (author), Bakker, G.C.M. (author), Rubingh, C.M. (author), Bijlsma, S. (author), Stroeve, J.H.M. (author), van Ommen, B. (author), van Erk, M.J. (author), Wopereis, S. (author)
Background: A key feature of metabolic health is the ability to adapt upon dietary perturbations. A systemic review defined an optimal nutritional challenge test, the "PhenFlex test" (PFT). Recently, it has been shown that the PFT enables the quantification of all relevant metabolic processes involved in maintaining or regaining homeostasis of...
article 2017
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Joustra, S.D. (author), van der Plas, E.M. (author), Goede, J. (author), Oostdijk, W. (author), Delemarre-van de Waal, H.A. (author), Hack, W.W.M. (author), van Buuren, S. (author), Wit, J.M. (author)
Aim Accurate calculations of testicular volume standard deviation (SD) scores are not currently available. We constructed LMS-smoothed age-reference charts for testicular volume in healthy boys. Methods The LMS method was used to calculate reference data, based on testicular volumes from ultrasonography and Prader orchidometer of 769 healthy...
article 2015
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van Avesaat, M. (author), Troost, F.J. (author), Ripken, D. (author), Hendriks, H.F. (author), Aam, M. (author)
BACKGROUND: Activation of the ileal brake, by infusing lipid directly into the distal part of the small intestine, alters gastrointestinal (GI) motility and inhibits food intake. The ileal brake effect on eating behavior of the other macronutrients is currently unknown. OBJECTIVE: The objective of this study was to investigate the effects of...
article 2015
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Ettwig, J.F. (author), Bronkhorst, A.W. (author)
In four experiments, we studied the time course of interference between detection of an oddball orientation target (OT) in an 8-item circular search display, and identification of a letter target (LT) in a central stream of distractor letters. Dual-task performance for different temporal lags between targets was compared to single-task...
article 2015
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Schmidt, S.C. (author), Sleddens, E.F.C. (author), de Vries, S.I. (author), Gubbels, J. (author), Thijs, C. (author)
Changes in the neighborhood environment may explain part of the rapid increase in childhood overweight and obesity during the last decades. To date few theory-driven rather than data-driven studies have explored longitudinal associations between multiple neighborhood characteristics and child body weight development. We aimed to assess the...
article 2015
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Schrieks, I.C. (author), Stafleu, A. (author), Griffioen-Roose, S. (author), de Graaf, C. (author), Witkamp, R.F. (author), Boerrigter-Rijneveld, R. (author), Hendriks, H.F.J. (author)
The aim of this study was to investigate whether food reward plays a role in the stimulating effect of moderate alcohol consumption on subsequent food intake. In addition, we explored the role of oral and gut sensory pathways in alcohol's effect on food reward by modified sham feeding (MSF) or consumption of a preload after alcohol intake.In a...
article 2015
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van Avesaat, M. (author), Troost, F.J. (author), Ripken, D. (author), Peters, J. (author), Hendriks, H.F.J. (author), Masclee, A.A.M. (author)
Background: Taste receptors are expressed not only in taste buds but also in the gastrointestinal tract. It has been hypothesized that these receptors may play a role in satiety and food intake. Objective: This study investigated the effect of intraduodenal tastant infusions (bitter, sweet, and umami) on food intake, hunger and fullness,...
article 2015
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Hendriksen, M.A.H. (author), Verkaik-Kloosterman, J. (author), Noort, M.W. (author), van Raaij, J.M.A. (author)
Background/objectives: Sodium intake in the Netherlands is substantially above the recommended intake of 2400 mg/day. This study aimed to estimate the effect of two sodium reduction strategies, that is, modification of the composition of industrially processed foods toward the technologically feasible minimum level or alteration of consumers’...
article 2015
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Hiemstra-van Mastrigt, S. (author), Kamp, I. (author), van Veen, S.A.T. (author), Vink, P. (author), Bosch, T. (author)
New technologies have led to an increasingly sedentary lifestyle. Sedentary behaviour is characterised by physical inactivity and is associated with several health risks. This excessive sitting does not only take place in the office or at home, but also during daily commute. Therefore, BMW AG developed an active seating system for the back seat...
article 2015
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Schrieks, I.C. (author), Ripken, D. (author), Stafleu, A. (author), Witkamp, R.F. (author), Hendriks, H.F.J. (author)
Background: The endocannabinoid system is suggested to play a regulatory role in mood. However, the response of circulating endocannabinoids (ECs) to mood changes has never been tested in humans. In the present study, we examined the effects of mood changes induced by ambiance and moderate alcohol consumption on plasma ECs 2-arachidonoylglycerol...
article 2015
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Aguirre, M. (author), Ramiro-Garcia, J. (author), Koenen, M.E. (author), Venema, K. (author)
This study investigated the stability and the activity of the microbiota from a single and a pool of donors in the TNO in vitro model of the colon (TIM-2 system). Our findings demonstrate the suitability of the preparation of a pool of fecal sample to be used for fermentation experiments. Chemicals/CAS: isobutyric acid, 5711-69-3, 79-31-2;...
article 2014
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Kaduk, M. (author), Hoefsloot, H.C.J. (author), Vis, D.J. (author), Reijmers, T. (author), van der Greef, J. (author), Smilde, A.K. (author), Hendriks, M.M.W.B. (author)
Modern chromatography-based metabolomics measurements generate large amounts of data in the form of abundances of metabolites. An increasingly popular way of representing and analyzing such data is by means of association networks. Ideally, such a network can be interpreted in terms of the underlying biology. A property of chromatography-based...
article 2014
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Ladirat, S.E. (author), Schoterman, M.H.C. (author), Rahaoui, H. (author), Mars, M. (author), Schuren, F.H.J. (author), Gruppen, H. (author), Nauta, A. (author), Schols, H.A. (author)
In the present double-blind, randomised, parallel intervention study, the effects of the intake of galacto-oligosaccharides (GOS) on the gut microbiota of twelve healthy adult subjects (aged 18-45 years with a normal BMI (18-25 kg/m2)) receiving amoxicillin (AMX) treatment were determined. All the subjects were treated with AMX (375 mg; three...
article 2014
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Risto, M. (author), Martens, M.H. (author)
With specific headway instructions drivers are not able to attain the exact headways as instructed. In this study, the effects of discrete headway feedback (and the direction of headway adjustment) on headway accuracy for drivers carrying out time headway instructions were assessed experimentally. Two groups of each 10 participants (one...
article 2014
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Neumann, A. (author), Berends, E.T.M. (author), Nerlich, A. (author), Molhoek, E.M. (author), Gallo, R.L. (author), Meerloo, T. (author), Nizet, V. (author), Naim, H.Y. (author), von Köckritz-Blickwede, M. (author)
NETs (neutrophil extracellular traps) have been described as a fundamental innate immune defence mechanism. Duringformation of NETs, the nuclear membrane is disrupted by an asyet unknown mechanism. In the present study we investigated the role of human cathelicidin LL-37 in nuclear membrane disruption and formation of NETs. Immunofluorescence...
article 2014
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Saccenti, E. (author), Tenori, L. (author), Verbruggen, P. (author), Timmerman, M.E. (author), Bouwman, J. (author), van der Greef, J. (author), Luchinat, C. (author), Smilde, A.K. (author)
Background: Metabolomics has attracted the interest of the medical community for its potential in predicting early derangements from a healthy to a diseased metabolic phenotype. One key issue is the diversity observed in metabolic profiles of different healthy individuals, commonly attributed to the variation of intrinsic (such as (epi)genetic...
article 2014
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Koopmans, L. (author), Bernaards, C.M. (author), Hildebrandt, V.H. (author), de Vet, H.C.W. (author), van der Beek, A.J. (author)
OBJECTIVE:: To examine the construct validity of the Individual Work Performance Questionnaire (IWPQ). METHODS:: A total of 1424 Dutch workers from three occupational sectors (blue, pink, and white collar) participated in the study. First, IWPQ scores were correlated with related constructs (convergent validity). Second, differences between...
article 2014
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Ellegast, R.P. (author), Kraft, K. (author), Groenesteijn, L. (author), Krause, F. (author), Berger, H. (author), Vink, P. (author)
Prolonged and static sitting postures provoke physical inactivity at VDU workplaces and are therefore discussed as risk factors for the musculoskeletal system. Manufacturers have designed specific dynamic office chairs featuring structural elements which promote dynamic sitting and therefore physical activity. The aim of the present study was to...
article 2012
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Thurlings, M.E. (author), Brouwer, A.M. (author), van Erp, J.B.F. (author), Blankertz, B. (author), Werkhoven, P.J. (author)
Event-related potential (ERP)-based brain–computer interfaces (BCIs) employ differences in brain responses to attended and ignored stimuli. Typically, visual stimuli are used. Tactile stimuli have recently been suggested as a gaze-independent alternative. Bimodal stimuli could evoke additional brain activity due to multisensory integration which...
article 2012
Searched for: subject:"normal%5C+human"
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