Searched for: subject:"non%5C%2Binsulin%5C%2Bdependent%5C%2Bdiabetes%5C%2Bmellitus"
(1 - 11 of 11)
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Wopereis, S. (author), Stroeve, J.H.M. (author), Stafleu, A. (author), Bakker, G.C.M. (author), Burggraaf, J. (author), van Erk, M.J. (author), Pellis, L. (author), Boessen, R. (author), Kardinaal, A.A.F. (author), van Ommen, B. (author)
Background: A key feature of metabolic health is the ability to adapt upon dietary perturbations. Recently, it was shown that metabolic challenge tests in combination with the new generation biomarkers allow the simultaneous quantification of major metabolic health processes. Currently, applied challenge tests are largely non-standardized. A...
article 2017
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Tsikas, D. (author), Pham, V.V. (author), Suchy, M.T. (author), van de Ree, M.A. (author), Huisman, M.V. (author), Frölich, J.C. (author), Princen, H.M.G. (author)
The present study describes the effects of atorvastatin on whole body synthesis of nitric oxide (NO), prostacyclin (PGI2), and thromboxane A2 (TxA2), on oxidative stress and nitrite/nitrate-related renal carbonic anhydrase (CA) activity in patients with type 2 diabetes mellitus (T2DM). A double-blind, randomized, placebo-controlled parallel...
article 2015
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Guigas, B. (author), de Leeuw van Weenen, J.E. (author), van Leeuwen, N. (author), Simonis-Bik, A.M. (author), van Haeften, T.W. (author), Nijpels, G. (author), Houwing-Duistermaat, J.J. (author), Beekman, M. (author), Deelen, J. (author), Havekes, L.M. (author), Penninx, B.W.J.H. (author), Vogelzangs, N. (author), van 't Riet, E. (author), Dehghan, A. (author), Hofman, A. (author), Witteman, J.C. (author), Uitterlinden, A.G. (author), Grarup, N. (author), Jørgensen, T. (author), Witte, D.R. (author), Lauritzen, T. (author), Hansen, T. (author), Pedersen, O. (author), Hottenga, J. (author), Romijn, J.A. (author), Diamant, M. (author), Kramer, M.H.H. (author), Heine, R.J. (author), Willemsen, G. (author), Dekker, J.M. (author), Eekhoff, E.M. (author), Pijl, H. (author), de Geus, E.J. (author), Slagboom, P.E. (author), 't Hart, L.M. (author)
Aims: Modulation of dopamine receptor D2 (DRD2) activity affects insulin secretion in both rodents and isolated pancreatic β-cells. We hypothesized that single nucleotide polymorphisms in the DRD2/ANKK1 locus may affect susceptibility to Type 2 diabetes in humans. Methods: Four potentially functional variants in the coding region of the DRD2...
article 2014
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Bakker, L.E.H. (author), Boon, M.R. (author), van der Linden, R.A.D. (author), Arias-Bouda, L.P. (author), van Klinken, J.B. (author), Smit, F. (author), Verberne, H.J. (author), Jukema, J.W. (author), Tamsma, J.T. (author), Havekes, L.M. (author), van Marken Lichtenbelt, W.D. (author), Jazet, I.M. (author), Rensen, P.C.N. (author)
Background: Individuals of south Asian origin have a very high risk of developing type 2 diabetes compared with white Caucasians. We aimed to assess volume and activity of brown adipose tissue (BAT), which is thought to have a role in energy metabolism by combusting fatty acids and glucose to produce heat and might contribute to the difference...
article 2014
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Beulens, J.W.J. (author), de Zoete, E.C. (author), Kok, F.J. (author), Schaafsma, G. (author), Hendriks, H.F.J. (author), TNO Kwaliteit van Leven (author)
Objective: Moderate alcohol consumption is associated with a decreased risk of type II diabetes. This study investigates the effect of moderate alcohol consumption on adipokines and insulin sensitivity. Subjects: Twenty healthy, lean (body mass index (BMI) 18.5-25 kg/m2; n=11) or overweight (BMI>27 kg/m2; n=9) men (18-25 years). Methods: Three...
article 2008
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Beulens, J.W.J. (author), Rimm, E.B. (author), Hu, F.B. (author), Hendriks, H.F.J. (author), Mukamal, K.J. (author), TNO Kwaliteit van Leven (author)
OBJECTIVE - The purpose of this study was to investigate whether adiponectin concentrations and biomarkers of inflammation, endothelial dysfunction, and insulin resistance mediate the association between alcohol consumption and diabetes. RESEARCH DESIGN AND METHODS - In a nested case-control study of 705 women with incident diabetes and 787...
article 2008
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Sierksma, A. (author), Patel, H. (author), Ouchi, N. (author), Kihara, S. (author), Funahashi, T. (author), Heine, R.J. (author), Grobbee, D.E. (author), Kluft, C. (author), Hendriks, H.F.J. (author), TNO Preventie en Gezondheid (author)
OBJECTIVE - Epidemiological studies suggest that moderate alcohol consumers have enhanced insulin sensitivity and a reduced risk of type 2 diabetes. Adiponectin, an adipocyte-derived plasma protein, has been found to be negatively associated with adiposity and positively associated with insulin sensitivity. Moderate alcohol consumption may...
article 2004
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van de Ree, M.A. (author), de Maat, M.P. (author), Kluft, C. (author), Meinders, A.E. (author), Princen, H.M. (author), Huisman, M.V. (author), Gaubius Instituut TNO (author)
BACKGROUND: Patients with Type 2 diabetes mellitus have increased levels of hemostatic risk variables for cardiovascular disease, such as fibrinogen, von Willebrand factor (VWF), factor (F)VIIa, d-dimer and plasminogen activator inhibitor-1 (PAI-1). OBJECTIVES: To evaluate the effect of aggressive vs. standard dose atorvastatin on hemostatic...
article 2003
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Rosendal, H. (author), Vondeling, H. (author), de Witte, L.P. (author), Hutubessy, R.C.W. (author), van Beekum, W.T. (author), Heine, R.J. (author)
Objective. Assessing whether the initiation of insulin therapy in patients with diabetes mellitus type 2 can be delivered as effectively in a structured transmural care model as in the more usual outpatients structure. Design. Retrospective comparative cohort study. Method. In 1997 data were collected from 52 patients with diabetes mellitus type...
article 2002
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Becker, A. (author), van Hinsbergh, V.W.M. (author), Kostense, P.J. (author), Jager, A. (author), Dekker, J.M. (author), Nijpels, G. (author), Heine, R.J. (author), Bouter, L.M. (author), Stehouwer, C.D.A. (author), TNO Preventie en Gezondheid (author)
Background: Hyperhomocysteinaemia may constitute an independent risk factor for cardiovascular disease, but it is still unclear by which pathophysiological mechanisms homocysteine (tHcy) may promote atherothrombosis. The aim of this study was firstly to examine whether tHcy is associated with endothelial dysfunction, increased adherence of...
article 2000
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Brussaard, H.E. (author), Leuven, J.A.G. (author), Kluft, C. (author), Krans, H.M.J. (author), van Duyvenvoorde, W. (author), Buytenhek, R. (author), van der Laarse, A. (author), Princen, H.M.G. (author), TNO Preventie en Gezondheid (author)
In type II diabetes mellitus the altered hormonal state after menopause may represent an additional cardiovascular risk factor. Estrogen replacement therapy (ERT) is associated with a decreased cardiovascular risk, at least in nondiabetic post-menopausal women. We studied the effect of ERT on plasma lipids and lipoproteins and on LDL oxidation...
article 1997
Searched for: subject:"non%5C%2Binsulin%5C%2Bdependent%5C%2Bdiabetes%5C%2Bmellitus"
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