- document
-
Verhoeckx, K.C.M. (author), Bijlsma, S. (author), Jespersen, S. (author), Ramaker, R. (author), Verheij, E.R. (author), Witkamp, R.F. (author), van der Greef, J. (author), Rodenburg, R.J.T. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)The discovery of new anti-inflammatory drugs is often based on an interaction with a specific target, although other pathways often play a primary or secondary role. Anti-inflammatory drugs can be categorized into classes, based on their mechanism of action. In this article we investigate the possibility to characterize novel anti-inflammatory...article 2004
- document
-
Anthony, S. (author), Ouden, L.D. (author), Brand, R. (author), Verloove-Vanhorick, P. (author), Gravenhorst, J.B. (author)Objective: To evaluate changes in obstetrical and neonatal care for very preterm and extremely preterm infants between 1983 and 1995 in The Netherlands and to evaluate the effect of those changes. Study design: Data on all very preterm or VLBW infants from the linked national obstetrical and neonatal databases of 1995 (N=2066) were compared to...article 2004
- document
-
Boelsma, E. (author), Lamers, R.-J.A.N. (author), Hendriks, H.F.J. (author), van Nesselrooij, J.H.J. (author), Roza, L. (author), TNO Voeding (author)Ginkgo biloba extract has been advocated for the improvement of blood circulation in circulatory disorders. This study investigated the effect of the Gingko biloba extract EGb 761 on skin blood flow in healthy volunteers and accompanying changes in urinary metabolites. Twenty-seven healthy middle-aged subjects participated in a randomized,...article 2004
- document
-
van der Greef, J. (author), Stroobant, P. (author), van der Heijden, R. (author), TNO Voeding (author)Medical systems biology has generated widespread interest because of its bold conception and exciting potential, but the field is still in its infancy. Although there has been tremendous progress achieved recently in generating, integrating and analysing data in the medical and pharmaceutical field, many challenges remain, especially with...article 2004
- document
-
Zeegers, M.P.A. (author), Friesema, I.H.M. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Voeding (author)A wide variety of occupations has been associated with prostate cancer in previous retrospective studies. Most attention has been paid to farming, metal working, and the rubber industry. Today, these results cannot be affirmed with confidence, because many associations could be influenced by recall bias, have been inconsistent, or have not been...article 2004
- document
-
TNO Preventie en Gezondheid (author), Riese, H. (author), van Doornen, L.J.P. (author), Houtman, I.L.D. (author), de Geus, E.J.C. (author)Objective. This study examined the effects of exposure to job strain on independent predictors of cardiovascular disease (ambulatory blood pressure, heart rate, and heart rate variability). Methods. The participants comprised a homogeneous group of 159 healthy female nurses [mean age 35.9 (SD 8.5) years]. The choice of this population minimized...article 2004
- document
-
Identification of disease- and nutrient-related metabolic fingerprints in osteoarthritic guinea pigsLamers, R.-J.A.N. (author), de Groot, J. (author), Spies-Faber, E.J. (author), Jellema, R.H. (author), Kraus, V.B. (author), Verzijl, N. (author), te Koppele, J.M. (author), Spijksma, G.K. (author), Vogels, J.T.W.E. (author), van der Greef, J. (author), van Nesselrooij, J.H.J. (author)Osteoarthritis (OA), one of the most common diseases among the elderly, is characterized by the progressive destruction of joint tissues. Its etiology is largely unclear and no effective disease-modifying treatment is currently available. Metabolic fingerprinting provides a novel tool for the identification of biomarkers. A metabolic fingerprint...article 2003
- document
-
Smith-Warner, S.A. (author), Spiegelman, D. (author), Yaun, S.-S. (author), Albanes, D. (author), Beeson, W.L. (author), van den Brandt, P.A. (author), Feskanich, D. (author), Folsom, A.R. (author), Fraser, G.E. (author), Freudenheim, J.L. (author), Giovannucci, E. (author), Goldbohm, R.A. (author), Graham, S. (author), Kushi, L.H. (author), Miller, A.B. (author), Pietinen, P. (author), Rohan, T.E. (author), Speizer, F.E. (author), Willett, W.C. (author), Hunter, D.J. (author)Inverse associations between fruit and vegetable consumption and lung cancer risk have been consistently reported. However, identifying the specific fruits and vegetables associated with lung cancer is difficult because the food groups and foods evaluated have varied across studies. We analyzed fruit and vegetable groups using standardized...article 2003
- document
-
Dirx, M.J.M. (author), van den Brandt, P.A. (author), Goldbohm, R.A. (author), Lumey, L.H. (author)BACKGROUND. This study evaluated the effects of severe undernutrition during adolescence and subsequent colon carcinoma risk. METHODS. The authors evaluated The Netherlands Cohort Study on Diet and Cancer (NLCS) among 62,573 women and 58,279 men aged 55-69 years at baseline. Information on diet and risk factors was collected by questionnaire in...article 2003
- document
-
Lamers, R.-J.A.N. (author), Wessels, E.C.H.H. (author), van de Sandt, J.J.M. (author), Venema, K. (author), Schaafsma, G. (author), van der Greef, J. (author), van Nesselrooij, J.H.J. (author)Metabolic fingerprints are novel measurement tools to evaluate the biochemical status of a living organism by using 1H NMR and multivariate data analysis (MVDA). In this way, a quick evaluation of changes in health or diseased state can be made, reflected in alterations of metabolic patterns. Normally, metabolic finger-printing is based on in...article 2003
- document
-
Witte, D.R. (author), Broekmans, W.M.R. (author), Kardinaal, A.F.M. (author), Klöpping-Ketelaars, I.A.A. (author), van Poppel, G. (author), Bots, M.L. (author), Kluft, C. (author), Princen, J.M.G. (author), Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author)Background: Flow mediated dilatation (FMD) of the brachial artery and soluble intercellular adhesion molecule 1 (sICAM-1) are measures of distinct functions of the endothelium, reflecting nitric oxide (NO)-mediated and pro-inflammatory status, respectively. The comparative value of the two measures in relation to cardiovascular risk is unknown....article 2003
- document
-
van den Brandt, P.A. (author), Botterweck, A.A.M. (author), Goldbohm, R.A. (author), Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author)Objective: Many case-control studies have reported that salt and cured meat intake are positively, and refrigerator use is inversely, associated with stomach cancer risk. In the current prospective study these associations were evaluated. Methods: The Netherlands Cohort Study consisted of 120,852 men and women ages 55-69 years at baseline in...article 2003
- document
-
Schuller, A.A. (author), Willumsen, T. (author), Holst, D. (author)Epidemiological studies of the relationship between dental fear, use of dental services, and oral health in different age groups in a common population are scarce. Dental fear and its relationships are usually described in individuals with high dental fear only. The purposes of this study were to describe the prevalence of dental fear in the...article 2003
- document
-
't Hart, B.A. (author), Vogels, J.T.W.E. (author), Spijksma, G. (author), Brok, H.P.M. (author), Polman, C. (author), van der Greef, J. (author), Primatencentrum TNO (author)Proton nuclear magnetic resonance (1H-NMR) spectroscopy in combination with pattern recognition techniques were used to investigate the composition of organic compounds in urines from patients with multiple sclerosis (MS), patients with other neurological diseases (OND) and healthy controls (H). Using a valid animal model of MS, namely the...article 2003
- document
-
van den Brandt, P.A. (author), Zeegers, M.P.A. (author), Bode, P. (author), Goldbohm, R.A. (author)Results of a randomized controlled trial have suggested a protective effect of selenium against prostate cancer. Few other prospective studies have been conducted to confirm or refute this. The association between prostate cancer and baseline toenail selenium level was evaluated in the Netherlands Cohort Study, conducted among 58,279 men, aged...article 2003
- document
-
van der Meer, I.M. (author), de Maat, M.P.M. (author), Bots, M.L. (author), Breteler, M.M.B. (author), Meijer, J. (author), Kiliaan, A.J. (author), Hofman, A. (author), Witteman, J.C.M. (author), Gaubius Instituut TNO (author)Inflammatory mediators and soluble cell adhesion molecules predict cardiovascular events. It is not clear whether they reflect the severity of underlying atherosclerotic disease. Within the Rotterdam Study, we investigated the associations of C-reactive protein (CRP), interleukin-6 (IL-6), soluble intercellular adhesion molecule-1, and soluble...article 2002
- document
-
Schuurman, A.G. (author), Goldbohm, R.A. (author), Brants, H.A.M. (author), van den Brandt, P.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Objectives: The roles of retinol, vitamins C and E, and carotenoids as risk factors for prostate carcinoma are still questionable. We evaluated these in the Netherlands Cohort Study. Methods: The cohort study consisted of 58,279 men ages 55-69 years at baseline in 1986. After 6.3 years of follow-up, 642 incident prostate carcinoma cases were...article 2002
- document
-
Zeegers, M.P.A. (author), Dorant, E. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Objectives: Coffee, tea, and fluid consumption have been thought to influence bladder cancer incidence. In a large prospective study, these associations were investigated. Methods: In 1986, cohort members (55-69 years) completed a questionnaire on cancer risk factors. Follow-up was established by linkage to cancer registries until 1992. The...article 2001
- document
-
Smith-Warner, S.A. (author), Spiegelman, D. (author), Adami, H.O. (author), Beeson, W.L. (author), van den Brandt, P.A. (author), Folsom, A.R. (author), Fraser, G.E. (author), Freudenheim, J.L. (author), Goldbohm, R.A. (author), Graham, S. (author), Kushi, L.H. (author), Miller, A.B. (author), Rohan, T.E. (author), Speizer, F.E. (author), Toniolo, P. (author), Willett, W.C. (author), Wolk, A. (author), Zelenuch-Jacquotte, A. (author), Hunter, D.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Recently, there has been interest in whether intakes of specific types of fat are associated with breast cancer risk independently of other types of fat, but results have been inconsistent. We identified 8 prospective studies that met predefined criteria and analyzed their primary data using a standardized approach. Holding total energy intake...article 2001
- document
-
Ariëns, G.A.M. (author), Bongers, P.M. (author), Douwes, M. (author), Miedema, M.C. (author), Hoogendoorn, W.E. (author), van der Wal, G. (author), Bouter, L.M. (author), van Mechelen, W. (author)Objective: To study the relation between neck pain and work related neck flexion, neck rotation, and sitting. Methods: A prospective cohort study was performed with a follow up of 3 years among 1334 workers from 34 companies. Work related physical load was assessed by analysing objectively measured exposure data (video recordings) of neck...article 2001