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Loerbroks, A. (author), Schouten, L.J. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)Objective: To examine the association between alcohol consumption, cigarette smoking, and endometrial cancer. Methods: In 1986, the Netherlands Cohort Study was initiated. A self-administered questionnaire on dietary habits and other cancer risk factors was completed by 62,573 women. Follow-up for cancer was established by record linkage to the...article 2007
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Kubben, F.J.G.M. (author), Sier, C.F.M. (author), Hawinkels, L.J.A.C. (author), Tschesche, H. (author), van Duijn, W. (author), Zuidwijk, K. (author), van der Reijden, J.J. (author), Hanemaaijer, R. (author), Griffioen, G. (author), Lamers, C.B.H.W. (author), Verspaget, H.W. (author), TNO Kwaliteit van Leven (author)Recently, complexes of matrix metalloproteinase matrix metalloproteinase-9 (MMP-9) with lipocalin-2 (neutrophil gelatinase-associated lipocalin) were found in the urine obtained from breast cancer patients, while these were completely absent in that obtained from healthy controls. In vitro data suggested a possible role for lipocalin-2 in the...article 2007
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Oomens, S. (author), Geurts, S. (author), Scheepers, P. (author), TNO Kwaliteit van Leven (author)In this article we study which characteristics of combining work and family put people at risk for mental illness. Two alternative perspectives on the impact of multiple social roles on mental health are tested: the role accumulation perspective and the role strain perspective. Both perspectives are studied with data from a cross-sectional...article 2007
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Vis, D.J. (author), Westerhuis, J.A. (author), Smilde, A.K. (author), van der Greef, J. (author), TNO Kwaliteit van Leven (author)Background: Innovative extensions of (M) ANOVA gain common ground for the analysis of designed metabolomics experiments. ASCA is such a multivariate analysis method; it has successfully estimated effects in megavariate metabolomics data from biological experiments. However, rigorous statistical validation of megavariate effects is still...article 2007
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de Kleine, M.J.K. (author), den Ouden, A.L. (author), Kollée, L.A.A. (author), Ilsen, A. (author), van Wassenaer, A.G. (author), Brand, R. (author), Verloove-Vanhorick, S.P. (author), TNO Kwaliteit van Leven (author)Better perinatal care has led to better survival of very preterm children, but may or may not have increased the number of children with cerebral and pulmonary morbidity. We therefore investigated the relationship between changes in perinatal care during one decade, and short-term outcome in very preterm infants. Perinatal risk factors and their...article 2007
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TNO Kwaliteit van Leven (author), Steevens, J. (author), Schouten, L.J. (author), Verhage, B.A.J. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author)In a cohort study, ovarian cancer (280 cases) showed no significant association with tea or coffee, the multivariable rate ratios being 0.94 (95% confidence interval (CI): 0.89, 1.00) and 1.04 (95% CI: 0.97, 1.12) per cup per day, respectively. A meta-analysis also produced no significant findings overall, though the cohort studies showed a...article 2007
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TNO Kwaliteit van Leven (author), van den Stomp-Berg, S.G.M. (author), van Poppel, M.N.M. (author), Hendriksen, I.J.M. (author), Bruinvels, D.J. (author), Uegaki, K. (author), de Bruijne, M.C. (author), van Mechelen, W. (author)Background. Many women suffer from health problems after giving birth, which can lead to sick leave. About 30% of Dutch workers are on sick leave after maternity leave. Structural contact of supervisors with employees on maternity leave, supported by early medical advice of occupational physicians, may increase the chances of return-to-work...article 2007
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van Hamberg - Reenen, H.H. (author), Ariëns, G.A.M. (author), Blatter, B.M. (author), Twisk, J.W.R. (author), van Mechelen, W. (author), Bongers, P.M. (author), TNO Kwaliteit van Leven (author)Aims: To investigate the longitudinal relation between physical capacity (isokinetic lifting strength, static endurance of the back, neck, and shoulder muscles, and mobility of the spine) and low back, neck, and shoulder pain. Methods: In this prospective cohort study, 1789 Dutch workers participated. At baseline, isokinetic lifting strength,...article 2006
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van der Werf, M.J. (author), Pieterse, B. (author), van Luijk, N. (author), Schuren, F. (author), van der Werff van der - Vat, B. (author), Overkamp, K. (author), Jellema, R.H. (author), TNO Kwaliteit van Leven (author)The value of the multivariate data analysis tools principal component analysis (PCA) and principal component discriminant analysis (PCDA) for prioritizing leads generated by microarrays was evaluated. To this end, Pseudomonas putida S12 was grown in independent triplicate fermentations on four different carbon sources, i.e. fructose, glucose,...article 2006
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Zeegers, M.P. (author), Selen, R.F.M. (author), Kleinjans, J.C.S. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)Objectives: N-nitroso compounds, endogenously formed from nitrate-derived nitrite, are suspected to be important bladder carcinogens. However, the association between nitrate exposure from food or drinking water and bladder cancer has not been substantially investigated in epidemiologic studies. Methods: We evaluated the associations between...article 2006
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Cho, E. (author), Hunter, D.J. (author), Spiegelman, D. (author), Albanes, D. (author), Beeson, W.L. (author), van den Brandt, P.A. (author), Colditz, G.A. (author), Feskanich, D. (author), Folsom, A.R. (author), Fraser, G.E. (author), Freudenheim, J.L. (author), Giovannucci, E. (author), Goldbohm, R.A. (author), Graham, S. (author), Miller, A.B. (author), Rohan, T.E. (author), Sellers, T.A. (author), Virtamo, J. (author), Willett, W.C. (author), Smith-Warner, S.A. (author), TNO Kwaliteit van Leven (author)Intakes of vitamins A, C and E and folate have been hypothesized to reduce lung cancer risk. We examined these associations in a pooled analysis of the primary data from 8 prospective studies from North America and Europe. Baseline vitamin intake was assessed using a validated food-frequency questionnaire, in each study. We calculated study...article 2006
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- Wiefferink, C.H. (author), Reijneveld, S.A. (author), de Wijs, J. (author), Swagerman, M. (author), Campman, D. (author), Paulussen, T.G.W.M. (author), TNO Kwaliteit van Leven (author) article 2006
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Gaspari, M. (author), Verhoeckx, K.C.M. (author), Verheij, E.R. (author), van der Greef, J. (author), TNO Kwaliteit van Leven (author)LC-MS-based proteomics requires methods with high peak capacity and a high degree of automation, integrated with data-handling tools able to cope with the massive data produced and able to quantitatively compare them. This paper describes an off-line two-dimensional (2D) LC-MS method and its integration with software tools for data preprocessing...article 2006
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Genkinger, J.M. (author), Hunter, D.J. (author), Spiegelman, D. (author), Anderson, K.E. (author), Arslan, A. (author), Beeson, W.L. (author), Buring, J.E. (author), Fraser, G.E. (author), Freudenheim, J.L. (author), Goldbohm, R.A. (author), Hankinson, S.E. (author), Jacobs Jr., D.R. (author), Koushik, A. (author), Lacey Jr., J.V. (author), Larsson, S.C. (author), Leitzmann, M. (author), McCullough, M.L. (author), Miller, A.B. (author), Rodriguez, C. (author), Rohan, T.E. (author), Scheuten, L.J. (author), Shore, R. (author), Smit, E. (author), Wolk, A. (author), Zhang, S.M. (author), Smith-Warner, S.A. (author), TNO Kwaliteit van Leven (author)Background: Dairy foods and their constituents (lactose and calcium) have been hypothesized to promote ovarian carcinogenesis. Although case-control studies have reported conflicting results for dairy foods and lactose, several cohort studies have shown positive associations between skim milk, lactose, and ovarian cancer. Methods: A pooled...article 2006
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Biesma, R.G. (author), Schouten, L.J. (author), Dirx, M.J.M. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven TNO Voeding (author)Objective: To investigate the association between nonoccupational physical activity and the risk of ovarian cancer among post-menopausal women. Methods: The Netherlands Cohort Study on Diet and Cancer consists of 62,573 women aged 55-69 years at baseline. Information regarding baseline nonoccupational physical activity and history of sports...article 2006
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Coulier, L. (author), Kaal, E. (author), Hankemeier, T. (author), TNO Kwaliteit van Leven (author)Hyphenation of infrared spectroscopy (IR) to liquid chromatography (LC) has been applied to study chemical changes in poly(bisphenol A)carbonate (PC) as a result of degradation. Especially coupling of LC to FTIR through solvent elimination is a sensitive approach to identify changes in functionality observed in the LC chromatograms as has been...article 2006
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van Dellen, Q.M. (author), Stronks, K. (author), Bindels, P.J.E. (author), Öry, F.G. (author), van Aalderen, W.M.C. (author), TNO Kwaliteit van Leven (author)Poor adherence to inhaled corticosteroids (ICSs) may contribute to the recent rise in asthma morbidity. In general, appropriate adherence to ICSs is a complex process that is influenced by various determinants. The purpose of this study was to identify factors that were associated with adherence to ICSs in children with asthma and their parents...article 2006
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TNO Kwaliteit van Leven (author), van Dijk, B.A.C. (author), Schouten, L.J. (author), Oosterwijk, E. (author), Hulsbergen van de, (author), Kaa, C.A. (author), Kiemeney, L.A.L.M. (author), Goldbohm, R.A. (author), Schalken, J.A. (author), van den Brandt, P.A. (author)We investigated whether smoking is associated with mutations in the Von Hippel-Lindau (VHL) gene in 337 cases of sporadic renal cell carcinoma (RCC) among 120 852 people followed for 11.3 years; the findings suggest that smoking causes RCC independently of VHL gene mutations. © 2006 Cancer Research. Chemicals / CAS: adenine, 22177-51-1, 2922-28...article 2006
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van Mispelaar, V.G. (author), Janssen, H.G. (author), Tas, A.C. (author), Schoenmakers, P.J. (author), TNO Kwaliteit van Leven (author)For practical chromatographers it is extremely difficult to judge the merits and limitations of new technological developments. On the other hand, it is nearly impossible for those at the forefront of technology to judge the implications of their efforts for all specific applications of chromatography. Both chromatographers and researchers can...article 2005
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Park, Y. (author), Hunter, D.J. (author), Spiegelman, D. (author), Bergkvist, L. (author), Berrino, F. (author), van den Brandt, P.A. (author), Buring, J.E. (author), Colditz, G.A. (author), Freudenheim, J.L. (author), Fuchs, C.S. (author), Giovannucci, E. (author), Goldbohm, R.A. (author), Graham, S. (author), Harnack, L. (author), Hartman, A.M. (author), Jacobs, D.R. (author), Kato, I. (author), Krogh, V. (author), Leitzmann, M.F. (author), McCullough, M.L. (author), Miller, A.B. (author), Pietinen, P. (author), Rohan, T.E. (author), Schatzkin, A. (author), Willett, W.C. (author), Wolk, A. (author), Zeleniuch-Jacquotte, A. (author), Zhang, S.M. (author), Smith-Warner, S.A. (author), TNO Kwaliteit van Leven (author)Context: Inconsistent findings from observational studies have continued the controversy over the effects of dietary fiber on colorectal cancer. Objective: To evaluate the association between dietary fiber intake and risk of colorectal cancer. Design, Setting, and Participants: From 13 prospective cohort studies included in the Pooling Project...article 2005