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Chen, X. (author), Yuan, C.A. (author), Wong, C.K.Y. (author), Ye, H. (author), Leung, S.Y.Y. (author), Zhang, G. (author)We proposed a molecular modeling methodology to study the protonic acid doping of emeraldine base polyaniline which can used in gas detection. The commercial forcefield COMPASS was used for the polymer and protonic acid molecules. The molecular model, which is capable of representing the polyaniline doping with the aqueous hydrochloric acid, was...article 2012
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van der Greef, J. (author), Hankemeier, T. (author), McBurney, R.N. (author), TNO Kwaliteit van Leven (author)Personalized medicine - defined as customized medical care for each patient's unique condition - in the broader context of personalized health, will make significant strides forward when a systems approach is implemented to achieve the ultimate in disease phenotyping and to create novel therapeutics that address system-wide molecular...article 2006
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te Biesebeke, R. (author), van Biezen, N. (author), de Vos, W.M. (author), van den Hondel, C.A.M.J.J. (author), Punt, P.J. (author), TNO Kwaliteit van Leven (author)Solid-state fermentation (SSF) with Aspergillus oryzae results in high levels of secreted protein. However, control mechanisms of gene expression in SSF have been only poorly studied. In this study we show that both glucoamylase (glaB) and protease (alpA, nptB) genes are highly expressed during surface cultivation on wheat-based solid medium,...article 2005
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Zhu, Q. (author), de With, G. (author), Dortmans, L.J.M.G. (author), Feenstra, F. (author), TNO Industrie (author)Near net-shape fabrication of hydroxyapatite (HA) glass composites has been attempted by infiltrating a glass into porous HA performs. Main efforts were put to develop glasses that are chemically compatible with HA at elevated temperatures. After extensive investigations in the phosphate and borosilicate systems, glasses of (50-55)SiO2-(20-25...article 2004
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de Groot, J. (author)Accumulation of advanced glycation endproducts (AGEs) plays a crucial part in the development of age-related diseases and diabetic complications. AGEs are formed in vivo via the so-called Maillard reaction: a reducing sugar reacts with a protein to form a labile Amadori product that is subsequently stabilized, producing an irreversible, non...article 2004
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Valencia, J.V. (author), Weldon, S.C. (author), Quinn, D. (author), Kiers, G.H. (author), de Groot, J. (author), TeKoppele, J.M. (author), Hughes, T.E. (author), Gaubius instituut TNO (author)Advanced glycation end products (AGEs) accumulate with age and at an accelerated rate in diabetes. AGEs bind cell-surface receptors including the receptor for advanced glycation end products (RAGE). The dependence of RAGE binding on specific biochemical characteristics of AGEs is currently unknown. Using standardized procedures and a variety of...article 2004
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Technisch Physische Dienst TNO - TH (author), Antipov, E.M. (author), Barannikov, A.A. (author), Gerasin, V.A. (author), Shklyaruk, B.F. (author), Tsamalashvili, L.A. (author), Fischer, H.R. (author), Razumovskaya, I.V. (author)The effects of the type and concentration of a filler and the ratio of modifier components in the filler on the structure and deformation behavior of nanocomposites based on an isotactic PP and Na+ montmorillonite (a natural clay) modified by various substrates (modifiers) were studied. Upon crystallization of this system from the melt, part of...article 2003