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Wiel, L. (author), Heskes, T. (author), Levin, E. (author)We propose a kernel-based online semi-supervised algorithm that is applicable for large scale learning tasks. In particular, we use a multi-view learning framework and a co-agreement strategy to take into account unlabelled data and to improve classification performance of the algorithm. Unlike the standard online methods our algorithm is...bookPart 2015
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The binding of drugs to plasma proteins has major consequences for its pharmacokinetic properties. Only the unbound fraction of the drug in plasma is available for excretion, for metabolism or for exerting its pharmacological effect. Factors that influence the extent of plasma protein binding can therefore have important implications on the...other 2015
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Schrieks, I.C. (author), Heil, A.L. (author), Hendriks, H.F. (author), Mukamal, K.J. (author), Beulens, J.W. (author)OBJECTIVE: Moderate alcohol consumption is associated with a reduced risk of type 2 diabetes. This reduced risk might be explained by improved insulin sensitivity or improved glycemic status, but results of intervention studies on this relation are inconsistent. The purpose of this study was to conduct a systematic review and meta-analysis of...article 2015
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van Nieuwenhuijzen, E.J. (author), Sailer, M.F. (author), Gobakken, L.R. (author), Adan, O.C.G. (author), Punt, P.J. (author), Samson, R.A. (author)Stains on wood are often unwanted in outdoor applications, dark stain formation however is essential to the development of a new protective, self-healing and decorative biotreatment for wood. The biotreatment is based on the formation of surface covering mould staining on linseed oil treated pine sapwood during outdoor exposure. This specific...article 2015
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Barlow, S.M. (author), Boobis, A.R. (author), Bridges, J. (author), Cockburn, A. (author), Dekant, W. (author), Hepburn, P. (author), Houben, G.F. (author), König, J. (author), Nauta, M.J. (author), Schuermans, J. (author), Bánáti, D. (author)Background: Food legislation in the European Union and elsewhere includes both hazard- and risk-based approaches for ensuring safety. In hazard-based approaches, simply the presence of a potentially harmful agent at a detectable level in food is used as a basis for legislation and/or risk management action. Risk-based approaches allow...article 2015
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Zaura, E. (author), Brandt, B.W. (author), de Mattos, M.J.T. (author), Buijs, M.J. (author), Caspers, M.P.M. (author), Rashid, M.U. (author), Weintraub, A. (author), Nord, C.E. (author), Savell, A. (author), Hu, Y. (author), Coates, A.R. (author), Hubank, M. (author), Spratt, D.A. (author), Wilson, M. (author), Keijser, B.J.F. (author), Crielaard, W. (author)Due to the spread of resistance, antibiotic exposure receives increasing attention. Ecological consequences for the different niches of individual microbiomes are, however, largely ignored. Here, we report the effects of widely used antibiotics (clindamycin, ciprofloxacin, amoxicillin, and minocycline) with different modes of action on the...article 2015
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Ripken, D. (author), Hendriks, H.F.J. (author)This chapter describes the use of the porcine ex vivo intestinal segment model. This includes the advantages and disadvantages of the segment model and a detailed description of the isolation and culture as well as the applications of the porcine ex vivo intestinal segment model in practice. Compared to the Ussing chamber (Chap. 24) the porcine...bookPart 2015
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- de Souza, C.B. (author), Roeselers, G. (author), Troost, F. (author), Jonkers, D. (author), Koenen, M.E. (author), Venema, K. (author) article 2015
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Broekman, H. (author), Knulst, A. (author), den Hartog Jager, S. (author), Monteleone, F. (author), Gaspari, M. (author), de Jong, G. (author), Houben, G. (author), Verhoeckx, K. (author)Scope: The growing world population requires the exploration of new sustainable protein sources to ensure food security. Insects such as mealworm are promising candidates. For safety reasons, a risk assessment, including allergy risks, is needed. Since allergenicity can be influenced by thermal processing, it is highly important to take this...article 2015
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- Verhoeckx, K. (author), Cotter, P.D. (author) bookPart 2015
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Vlaming, M.L. (author), van Duijn, E. (author), Dillingh, M.R. (author), Brands, R. (author), Windhorst, A.D. (author), Hendrikse, N.H. (author), Bosgra, S. (author), Burggraaf, J. (author), de Koning, M.C. (author), Fidder, A. (author), Mocking, J.A. (author), Sandman, H. (author), de Ligt, R.A. (author), Fabriek, B.O. (author), Pasman, W.J. (author), Seinen, W. (author), Alves, T. (author), Carrondo, M. (author), Peixoto, C. (author), Peeters, P.A. (author), Vaes, W.H. (author)Preclinical development of new biological entities (NBEs), such as human protein therapeutics, requires considerable expenditure of time and costs. Poor prediction of pharmacokinetics in humans further reduces net efficiency. In this study, we show for the first time that pharmacokinetic data of NBEs in humans can be successfully obtained early...article 2015
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van der Greef, J. (author), Wietmarschen, H. (author), Schroën, Y. (author), Babouraj, N. (author), Trousselard, M. (author)Background: The current health care system faces increasing costs and demands while the presence of chronic conditions in the general populations is rising. A shift from disease fighting toward health promotion is needed to prevent these conditions and empower people to work on their own health. In the Military setting, health promotion is...article 2015
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Nohynek, G.J. (author), Skare, J.A. (author), Meuling, W.J.A. (author), Wehmeyer, K.R. (author), de Bie, A.T.H.J. (author), Vaes, W.H.J. (author), Dufour, E.K. (author), Fautz, R. (author), Steiling, W. (author), Bramante, M. (author), Toutain, H. (author)Systemic exposure was measured in humans after hair dyeing with oxidative hair dyes containing 2.0% (A) or 1.0% (B) [14C]-p-phenylenediamine (PPD). Hair was dyed, rinsed, dried, clipped and shaved; blood and urine samples were collected for 48 hours after application. [14C] was measured in all materials, rinsing water, hair, plasma, urine and...article 2015
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Ripken, D. (author), van der Wielen, N. (author), van der Meulen, J. (author), Schuurman, T. (author), Witkamp, R.F. (author), Hendriks, H.F.J. (author), Koopmans, S.J. (author)The vagal nerve and gut hormones CCK and GLP-1 play important roles in the control of food intake. However, it is not clear to what extent CCK and GLP-1 increase satiation by stimulating receptors located on abdominal vagal nerve endings or via receptors located elsewhere. This study aimed to further explore the relative contribution of the...article 2015
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van Avesaat, M. (author), Troost, F.J. (author), Ripken, D. (author), Hendriks, H.F. (author), Aam, M. (author)BACKGROUND: Activation of the ileal brake, by infusing lipid directly into the distal part of the small intestine, alters gastrointestinal (GI) motility and inhibits food intake. The ileal brake effect on eating behavior of the other macronutrients is currently unknown. OBJECTIVE: The objective of this study was to investigate the effects of...article 2015
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Lukovac, S. (author), Roeselers, G. (author)When it comes to studying the effect of food bioactives on gut health, one of the essential steps that needs to be assessed is characterizing specific effects of the bioactives on the physical barrier of the lumen, the gastrointestinal tissue. In addition to studying the effects on transport function (e.g. by using Ussing chambers or cell...bookPart 2015
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- Punt, P.J. (author), Roa Engel, C. (author) article 2015
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Prodan, A. (author), Brand, H.S. (author), Ligtenberg, A.J.M. (author), Imangaliyev, S. (author), Tsivtsivadze, E. (author), van der Weijden, F. (author), Crielaard, W. (author), Keijser, B.J.F. (author), Veerman, E.C.I. (author)A cross-sectional observational study was conducted to evaluate interindividual biochemical variation in unstimulated whole saliva in a population of 268 systemically healthy young students, 18-30 yr of age, with no apparent caries lesions or periodontal disease. Salivary flow rate, protein content, pH, buffering capacity, mucins MUC5B and MUC7,...article 2015
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Jacobs, D.M. (author), Mihaleva, V.V. (author), van Schalkwijk, D.B. (author), de Graaf, A.A. (author), Vervoort, J. (author), van Dorsten, F.A. (author), Ras, R.T. (author), Demonty, I. (author), Trautwein, E.A. (author), van Duynhoven, J. (author)Scope: Consumption of a low-fat spread enriched with plant sterols (PS) and different low doses (<2 g/day) of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) from fish oil reduces serum triglycerides (TGs) and low-density lipoprotein-cholesterol (LDL-Chol) and thus beneficially affects two blood lipid risk factors. Yet, their combined...article 2015
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Westerhout, J. (author), Wortelboer, H. (author), Verhoeckx, K. (author)The Ussing chamber system is named after the Danish zoologist Hans Ussing, who invented the device in the 1950s to measure the short-circuit current as an indicator of net ion transport taking place across frog skin (Ussing and Zerahn, Acta Physiol Scand 23:110-127, 1951). Ussing chambers are increasingly being used to measure ion transport in...bookPart 2015