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Cnubben, N.H.P. (author), Tel, S.L. (author), Hemmes, M.A. (author), Langenkamp-Brand, A. (author), Grossouw, D. (author), Jansen, H.T. (author), de Bie, B.T.H.J. (author)Background: Worldwide obesity has nearly doubled since 1980 and is a leading risk for global deaths, profoundly affecting morbidity, mortality, health-care costs, and professional and personal quality of life. Treatment of obesity and its consequences include lifestyle intervention, pharmacotherapy, and bariatric surgery. Polyglucosamines have...article 2016
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Aguirre, M. (author), Eck, A. (author), Koenen, M.E. (author), Savelkoul, P.H.M. (author), Budding, A.E. (author), Venema, K. (author)The aim of this study was to screen how rapidly the human gut microbiota responds to diet in an in vitro model of the proximal colon (TIM-system). Two experimental diets were provided to the gut bacteria: a high carbohydrate and a high protein diet. The metabolic response and the composition of the microbiota were compared to a control diet...article 2016
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Schrieks, I.C. (author), Wei, M.Y. (author), Rimm, E.B. (author), Okereke, O.I. (author), Kawachi, I. (author), Hendriks, H.F.J. (author), Mukamal, K.J. (author)Background: Evidence from cross-sectional studies has suggested a positive association between moderate alcohol consumption and health-related quality of life but prospective data remain scarce. Objectives: To examine the bidirectional relationships between alcohol consumption and health-related quality of life using a longitudinal study design....article 2016
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Berk, K.A. (author), Mulder, M.T. (author), Verhoeven, A.J.M. (author), van Wietmarschen, H. (author), Boessen, R. (author), Pellis, L.P. (author), van Spijker, A.T. (author), Timman, R. (author), Ozcan, B. (author), Sijbrands, E.J.G. (author)Aims A very low calorie diet improves the metabolic regulation of obesity related type 2 diabetes, but not for all patients, which leads to frustration in patients and professionals alike. The aim of this study was to develop a prediction model of diet-induced weight loss in type 2 diabetes. Methods 192 patients with type 2 diabetes and BMI>27...article 2016
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van Nieuwenhuijzen, E.J. (author), Miadlikowska, J.M. (author), Houbraken, J.A.M.P. (author), Adan, O.C.G. (author), Lutzoni, F.M. (author), Samson, R.A. (author)A culture-based survey of staining fungi on oil-treated timber after outdoor exposure in Australia and the Netherlands uncovered new taxa inPezizomycotina.Their taxonomic novelty was confirmed by phylogenetic analyses of multi-locus sequences (ITS, nrSSU, nrLSU, mitSSU,RPB1,RPB2, andEF-1alpha) using multiplereference data sets. These previously...article 2016
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Wilkinson, M.D. (author), Dumontier, M. (author), Aalbersberg, I.J. (author), Appleton, G. (author), Axton, M. (author), Baak, A. (author), Blomberg, N. (author), Boiten, J.W. (author), da Silva Santos, L.B. (author), Bourne, P.E. (author), Bouwman, J. (author), Brookes, A.J. (author), Clark, T. (author), Crosas, M. (author), Dillo, I. (author), Dumon, O. (author), Edmunds, S. (author), Evelo, C.T. (author), Finkers, R. (author), Gonzalez-Beltran, A. (author), Gray, A.J.G. (author), Groth, P. (author), Goble, C. (author), Grethe, J.S. (author), Heringa, J. (author), 't Hoen, P.A.C. (author), Hooft, R. (author), Kuhn, T. (author), Kok, R. (author), Kok, J. (author), Lusher, S.J. (author), Martone, M.E. (author), Mons, A. (author), Packer, A.L. (author), Persson, B. (author), Rocca-Serra, P. (author), Roos, M. (author), van Schaik, R. (author), Sansone, S.A. (author), Schultes, E. (author), Sengstag, T. (author), Slater, T. (author), Strawn, G. (author), Swertz, M.A. (author), Thompson, M. (author), van der Lei, J. (author), van Mulligen, E. (author), Velterop, J. (author), Waagmeester, A. (author), Wittenburg, P. (author), Wolstencroft, K. (author), Zhao, J. (author), Mons, B. (author)There is an urgent need to improve the infrastructure supporting the reuse of scholarly data. A diverse set of stakeholders-representing academia, industry, funding agencies, and scholarly publishers-have come together to design and jointly endorse a concise and measureable set of principles that we refer to as the FAIR Data Principles. The...article 2016
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Janus, M.M. (author), Crielaard, W. (author), Zaura, E. (author), Keijser, B.J. (author), Brandt, B.W. (author), Krom, B.P. (author)Objective: Dental caries is caused by prolonged episodes of low pH due to acid production by oral biofilms. Bacteria within such biofilms communicate via quorum sensing (QS). QS regulates several phenotypic biofilm parameters, such as biofilm formation and the production of virulence factors. In this study, we evaluated the effect of several QS...article 2016
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- Caspers, M.P.M. (author), Boekhorst, J. (author), Jong, A. (author), Kort, R. (author), Groot, M.N. (author), Abee, T. (author) article 2016
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Kortman, G.A.M. (author), Dutilh, B.E. (author), Maathuis, A.J.H. (author), Engelke, U.F. (author), Boekhorst, J. (author), Keegan, K.P. (author), Nielsen, F.G.G. (author), Betley, J. (author), Weir, J.C. (author), Kingsbury, Z. (author), Kluijtmans, L.A.J. (author), Swinkels, D.W. (author), Venema, K. (author), Tjalsma, H. (author)Oral iron administration in African children can increase the risk for infections. However, it remains unclear to what extent supplementary iron affects the intestinal microbiome. We here explored the impact of iron preparations on microbial growth and metabolism in the well-controlled TNO's in vitro model of the large intestine (TIM-2). The...article 2016
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Fu, J. (author), Cuppen, B.V.J. (author), Welsing, P.M. (author), van Wietmarschen, H. (author), Harms, A.C. (author), Berger, R. (author), Koval, S. (author), Fritsch-Stork, R.D. (author), Bijlsma, J.W. (author), Hankemeier, T. (author), van der Greef, J. (author), Lafeber, F.P. (author)Objective As there are pharmacological differences between males and females, and glucocorticoid (GC) treatment is associated with increased cardiovascular mortality rate in rheumatoid arthritis (RA) patients, it is important to study serum polar lipid profiles of male and female patients in response to GC therapy. Gender differences may require...article 2016
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Leon-Acuña, A. (author), Alcala-Diaz, J.F. (author), Delgado-Lista, J. (author), Torres-Peña, J.D. (author), Lopez-Moreno, J. (author), Camargo, A. (author), Garcia-Rios, A. (author), Marin, C. (author), Gomez-Delgado, F. (author), Caballero, J. (author), van Ommen, B. (author), Malagon, M.M. (author), Perez-Martinez, P. (author), Lopez-Miranda, J. (author)Background/aims: Previous evidences have shown the presence of a prolonged and exaggerated postprandial response in type 2 diabetes mellitus (T2DM) and its relation with an increase of cardiovascular risk. However, the response in prediabetes population has not been established. The objective was to analyze the degree of postprandial lipemia...article 2016
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Schoeman, J.C. (author), Harms, A.C. (author), van Wietmarschen, H.A. (author), Vreeken, R.J. (author), Berger, R. (author), Cuppen, B.V.J. (author), Lafeber, F.P.J.G. (author), van der Greef, J. (author), Hankemeier, T. (author)Oxidised lipids, covering enzymatic and auto-oxidation-synthesised mediators, are important signalling metabolites in inflammation while also providing a readout for oxidative stress, both of which are prominent physiological processes in a plethora of diseases. Excretion of these metabolites via urine is enhanced through the phase-II...article 2016
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- Bosch, A.A. (author), Levin, E. (author), van Houten, M.A. (author), Hasrat, R. (author), Kalkman, G. (author), Biesbroek, G. (author), de Steenhuijsen Piters, W.A. (author), de Groot, P.K. (author), Pernet, P. (author), Keijser, B.J. (author), Sanders, E.A. (author), Bogaert, D. (author) article 2016
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Cuppen, B.V.J. (author), Fu, J. (author), van Wietmarschen, H.A. (author), Harms, A.C. (author), Koval, S. (author), Marijnissen, A.C.A. (author), Peeters, J.J.W. (author), Bijlsma, J.W.J. (author), Tekstra, J. (author), van Laar, J.M. (author), Hankemeier, T. (author), Lafeber, F.P.J.G. (author), van der Greef, J. (author)In clinical practice, approximately one-Third of patients with rheumatoid arthritis(RA) respond insufficiently to TNF-alpha inhibitors (TNFis). The aim of the study was to explore the use of a metabolomics to identify predictors for the outcome of TNFi therapy, and study the metabolomic fingerprint in active RA irrespective of patients' response...article 2016
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Mooij, M.G. (author), van de Steeg, E. (author), van Rosmalen, J. (author), Windster, J.D. (author), de Koning, B.A.E. (author), Vaes, W.H.J. (author), van Groen, B.D. (author), Tibboel, D. (author), Wortelboer, H.M. (author), de Wildt, S.N. (author)Human hepatic membrane-embedded transporter proteins are involved in trafficking endogenous and exogenous substrates. Even though impact of transporters on pharmacokinetics is recognized, little is known on maturation of transporter protein expression levels, especially during early life. We aimed to study the protein expression of 10...article 2016
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Stroeve, J.H.M. (author), Saccenti, E. (author), Bouwman, J. (author), Dane, A. (author), Strassburg, K. (author), Vervoort, J. (author), Hankemeier, T. (author), Astrup, A. (author), Smilde, A.K. (author), van Ommen, B. (author), Saris, W.H.M. (author)Objective: Aim is to predict successful weight loss by metabolic signatures at baseline and to identify which differences in metabolic status may underlie variations in weight loss success. Methods: In DiOGenes, a randomized, controlled trial, weight loss was induced using a low calorie diet (800 kcal) for 8-weeks. Men (N5236) and women (N5431)...article 2016
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Matualatupauw, J.C. (author), Radonjic, M. (author), van de Rest, O. (author), de Groot, L.C.P.G.M. (author), Geleijnse, J.M. (author), Müller, M. (author), Afman, L.A. (author)Scope: People who carry the apolipoprotein E4 (APOE4) single nucleotide polymorphism have an increased risk of cardiovascular disease (CVD). Fish-oil supplementation may help in the prevention of CVD, though interindividual differences in the response to n-3 PUFAs have been observed. We aimed to assess the impact of APOE genotype on peripheral...article 2016
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Roeselers, G. (author), Bouwman, J. (author), Levin, E. (author)The gastro-intestinal microbiome has become the subject of intensive research, which is beginning to elucidate its roles in human health. It is becoming increasingly recognised that gut microbiota plays a part in regulating human immune homeostasis and metabolism, which gives rise to novel opportunities for preventative and treatment strategies....article 2016
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van Wietmarschen, H. (author), Hagels, H. (author), Peters, R. (author), Heistek, J. (author), van der Greef, J. (author), Wang, M. (author)Objective: Digoxin is a therapeutic cardenolide widely used to treat various heart conditions such as atrial flutter, atrial fibrillation and heart failure in both Western as well as Chinese medicine. Digoxin is extracted from cultivated Digitalis lanata Ehrh. plants, known as Mao Hua Yang Di Huang in Chinese medicine. This manuscript presents...article 2016
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- Salek, R.M. (author), Neumann, S. (author), Schober, D. (author), Hummel, J. (author), Billiau, K. (author), Kopka, J. (author), Correa, E. (author), Reijmers, T. (author), Rosato, A. (author), Tenori, L. (author), Turano, P. (author), Marin, S. (author), Deborde, C. (author), Jacob, D. (author), Rolin, D. (author), Dartigues, B. (author), Conesa, P. (author), Haug, K. (author), Rocca-Serra, P. (author), O’Hagan, S. (author), Hao, J. (author), van Vliet, M. (author), Sysi-Aho, M. (author), Ludwig, C. (author), Bouwman, J. (author), Cascante, M. (author), Ebbels, T. (author), Griffin, J.L. (author), Moing, A. (author), Nikolski, M. (author), Oresic, M. (author), Sansone, S.A. (author), Viant, M.R. (author), Goodacre, R. (author), Günther, U.L. (author), Hankemeier, T. (author), Luchinat, C. (author), Walther, D. (author), Steinbeck, C. (author) article 2015