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den Ouden, H. (author), Pellis, L. (author), Rutten, G.E.H.M. (author), Geerars-van Vonderen, I.K. (author), Rubingh, C.M. (author), van Ommen, B. (author), van Erk, M.J. (author), Beulens, J.W.J. (author)We aimed to identify metabolites to predict patients’ response to glucose lowering treatment during the first 5 years after detection of type 2 diabetes. Metabolites were measured by GC–MS in baseline samples from 346 screen-detected type 2 diabetes patients in the ADDITION-NL study. The response to treatment with metformin and/or sulphonylurea ...article 2016
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van Ommen, B. (author), Wopereis, S. (author)Current biomarkers used in health care and in nutrition and health research are based on quantifying disease onset and its progress. Yet, both health care and nutrition should focus on maintaining optimal health, where the related biology is essentially differing from biomedical science. Health is characterized by the ability to continuously...conference paper 2016
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Dols, J.A.M. (author), Molenaar, D. (author), van der Helm, J.J. (author), Caspers, M.P.M. (author), de Kat Angelino-Bart, A. (author), Schuren, F.H.J. (author), Speksnijder, A.G.C.L. (author), Westerhoff, H.V. (author), Richardus, J.H. (author), Boon, M.E. (author), Reid, G. (author), de Vries, H.J.C. (author), Kort, R. (author)Background: To date, women are most often diagnosed with bacterial vaginosis (BV) using microscopy based Nugent scoring or Amsel criteria. However, the accuracy is less than optimal. The aim of the present study was to confirm the identity of known BV-associated composition profiles and evaluate indicators for BV using three molecular methods....article 2016
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Erpelinck, E. (author)TNO’s intestinal screening model (TNO i-screen) helps to quickly identify pharmacological compounds that are metabolized by intestinal microbiota. For pharmaceutical companies, searching for novel pharmaceuticals is a complex and time-consuming process. When a novel drug has been selected, extensive in vitro and clinical studies are required to...other 2016
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Wijermars, L.G.M. (author), Schaapherder, A.F. (author), de Vries, D.K. (author), Verschuren, L. (author), Wüst, R.C.I. (author), Kostidis, S. (author), Mayboroda, O.A. (author), Prins, F. (author), Ringers, J. (author), Bierau, J. (author), Bakker, J.A. (author), Kooistra, T. (author), Lindeman, J.H.N. (author)Delayed graft function (DGF) following kidney transplantation affects long-term graft function and survival and is considered a manifestation of ischemia reperfusion injury. Preclinical studies characterize metabolic defects resulting from mitochondrial damage as primary driver of ischemia reperfusion injury. In a comprehensive approach that...article 2016
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Hossain, A.H. (author), Li, A. (author), Brickwedde, A. (author), Wilms, L. (author), Caspers, M. (author), Overkamp, K. (author), Punt, P.J. (author)Background: The industrially relevant filamentous fungus Aspergillus niger is widely used in industry for its secretion capabilities of enzymes and organic acids. Biotechnologically produced organic acids promise to be an attractive alternative for the chemical industry to replace petrochemicals. Itaconic acid (IA) has been identified as one of...article 2016
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Fallaize, R. (author), Celis-Morales, C. (author), MacReady, A.L. (author), Marsaux, C.F.M. (author), Forster, H. (author), O'Donovan, C. (author), Woolhead, C. (author), San-Cristobal, R. (author), Kolossa, S. (author), Hallmann, J. (author), Mavrogianni, C. (author), Surwillo, A. (author), Livingstone, K.M. (author), Moschonis, G. (author), Navas-Carretero, S. (author), Walsh, M.C. (author), Gibney, E.R. (author), Brennan, L. (author), Bouwman, J. (author), Grimaldi, K. (author), Manios, Y. (author), Traczyk, I. (author), Drevon, C.A. (author), Martinez, J.A. (author), Daniel, H. (author), Saris, W.H.M. (author), Gibney, M.J. (author), Mathers, J.C. (author), Lovegrove, J.A. (author)Background: The apolipoprotein E (APOE) risk allele (e4) is associated with higher total cholesterol (TC), amplified response to saturated fatty acid (SFA) reduction, and increased cardiovascular disease. Although knowledge of gene risk may enhance dietary change, it is unclear whether e4 carriers would benefit from gene-based personalized...article 2016
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Ripken, D. (author), van der Wielen, N. (author), Wortelboer, H.M. (author), Meijerink, J. (author), Witkamp, R.F. (author), Hendriks, H.F.J. (author)Glucagon like peptide-1 (GLP-1) and serotonin are both involved in food intake regulation. GLP-1 release is stimulated upon nutrient interaction with G-protein coupled receptors by enteroendocrine cells (EEC), whereas serotonin is released from enterochromaffin cells (ECC). The central hypothesis for the current study was that nutrient-induced...article 2016
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Schrieks, I.C. (author), Joosten, M.M. (author), Klöpping-Ketelaars, W.A.A. (author), Witkamp, R.F. (author), Hendriks, H.F.J. (author)Alcohol is often consumed to reduce tension and improve mood when exposed to stressful situations. Previous studies showed that moderate alcohol consumption may reduce stress when alcohol is consumed prior to a stressor, but data on the effect of alcohol consumption after a mental stressor is limited. Therefore, our objective was to study...article 2016
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Swart, P. (author), Lozac'h, F. (author), Simon, M. (author), van Duijn, E. (author), Vaes, W.H. (author)Modern accelerator mass spectrometry (AMS) methods enable the routine application of this technology in drug development. By the administration of a (14)C-labelled microdose or microtrace, pharmacokinetic (PK) data, such as mass balance, metabolite profiling, and absolute bioavailability (AB) data, can be generated easier, faster, and at lower...article 2016
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Rijkschroeff, P. (author), Jansen, I.D.C. (author), van der Weijden, F.A. (author), Keijser, B.J.F. (author), Loos, B.G. (author), Nicu, E.A. (author)Polymorphonuclear neutrophils (PMNs) have a major role in the innate immune system. However, little is known about PMN contribution in relation to oral health. The objective of this study was to investigate the numbers and functional characteristics of oral PMNs (oPMNs) compared with circulatory PMNs (cPMNs). Oral rinse and venous blood samples...article 2016
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van Nieuwenhuijzen, E.J. (author), Houbraken, J.A.M.P. (author), Meijer, M. (author), Adan, O.C.G. (author), Samson, R.A. (author)The genus Aureobasidium, which is known as a wood staining mould, has been detected on oil treated woods in the specific stain formation called biofinish. This biofinish is used to develop a new protective, self-healing and decorative biotreatment for wood. In order to understand and control biofinish formation on oil treated wood, the...article 2016
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- Wietmarschen, H.A. (author), Wortelboer, H.M. (author), van der Greef, J. (author) article 2016
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Prodan, A. (author), Imangaliyev, S. (author), Brand, H.S. (author), Rosema, M.N.A. (author), Levin, E. (author), Crielaard, W. (author), Keijser, B.J.F. (author), Veerman, E.C.I. (author)Introduction: Understanding the changes occurring in the oral ecosystem during development of gingivitis could help improve prevention and treatment strategies for oral health. Erythritol is a non-caloric polyol proposed to have beneficial effects on oral health. Objectives: To examine the effect of experimental gingivitis and the effect of...article 2016
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Aguirre, M. (author), de Souza, C.B. (author), Venema, K. (author)Background An aberrant metabolic activity or a compositional alteration of the gut microbiota has been proposed as a factor that makes us more prone to disease. Therefore, we explored the effect of two dietary fibers (arabinogalactan and inulin) on the microbiota from lean and obese subjects during 72 h in vitro fermentation experiments using...article 2016
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Summer, G. (author), Kelder, T. (author), Radonjic, M. (author), van Bilsen, M. (author), Wopereis, S. (author), Heymans, S. (author)Motivation: Much of the biological knowledge accumulated over the last decades is stored in different databases governed by various organizations and institutes. Integrating and connecting these vast knowledge repositories is an extremely useful method to support life sciences research and help formulate novel hypotheses. Results: We developed...article 2016
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Sun, M. (author), Li, L. (author), Wang, M. (author), Van Wijk, E. (author), He, M. (author), van Wijk, R. (author), Koval, S. (author), Hankemeier, T. (author), van der Greef, J. (author), Wei, S. (author)To improve the quality control of herbal drugs, there has been a major shift from evaluating individual chemicals to evaluating multiple-constituent chemicals, given the multi-pharmacology nature of herbal drugs. Therefore, rapid, systematic assays are needed in order to assess the quality of medicinal herbs using a comprehensive, integrated...article 2016
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Blanco-Rojo, R. (author), Alcala-Diaz, J.F. (author), Wopereis, S. (author), Perez-Martinez, P. (author), Quintana-Navarro, G.M. (author), Marin, C. (author), Ordovas, J.M. (author), van Ommen, B. (author), Perez-Jimenez, F. (author), Delgado-Lista, J. (author), Lopez-Miranda, J. (author)Aims/hypothesis: The aim of the study was to determine whether basal insulin resistance (IR) phenotype (muscle and/or liver) determines the effect of long-term consumption of a Mediterranean diet or a low-fat diet on tissue-specific IR and beta cell function. Methods: The study was performed in 642 patients included in The effect of an olive oil...article 2016
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He, M. (author), Sun, M. (author), van Wijk, E. (author), van Wietmarschen, H. (author), van Wijk, R. (author), Wang, Z. (author), Wang, M. (author), Hankemeier, T. (author), van der Greef, J. (author)To present the possibilities pertaining to linking ultra-weak photon emission (UPE) with Chinese medicine-based diagnostics principles, we conducted a review of Chinese literature regarding UPE with respect to a systems view of diagnostics. Data were summarized from human clinical studies and animal models published from 1979 through 1998. The...article 2016
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van der Veen, M.H. (author), Volgenant, C.M.C. (author), Keijser, B. (author), ten Cate, J.M. (author), Crielaard, W. (author)Objectives The dynamics of red fluorescent plaque (RFP) in comparison to clinical plaque and bleeding scores were studied during an experimental gingivitis protocol in a cohort of healthy participants. Methods Forty-one participants were monitored for RFP before (24 h plaque), during 14 days plaque accumulation (days 2, 5, 9, 14) and after 7...article 2016