- document
-
Li, M. (author), de Graaf, I.A.M. (author), van de Steeg, E. (author), de Jager, M.H. (author), Groothuis, G.M.M. (author)Intestinal P-gp and CYP3A4 work coordinately to reduce the intracellular concentration of drugs, and drug-drug interactions (DDIs) based on this interplay are of clinical importance and require pre-clinical investigation. Using precision-cut intestinal slices (PCIS) of human jejunum, ileum and colon, we investigated the P-gp/CYP3A4 interplay and...article 2017
- document
-
Raaphorst, R.M. (author), Savolainen, H. (author), Cantore, M. (author), van de Steeg, E. (author), van Waarde, A. (author), Colabufo, N.A. (author), Elsinga, P.H. (author), Lammertsma, A.A. (author), Windhorst, A.D. (author), Luurtsema, G. (author)Positron emission tomography (PET) imaging of P-glycoprotein (P-gp) in the blood-brain barrier can be important in neurological diseases where P-gp is affected, such as Alzheimer’s disease. Radiotracers used in the imaging studies are present at very small, nanomolar, concentration, whereas in vitro assays where these tracers are characterized,...article 2017
- document
-
Pantophlet, A.J. (author), Wopereis, S. (author), Eelderink, C. (author), Vonk, R.J. (author), Stroeve, J.H. (author), Bijlsma, S. (author), van Stee, L. (author), Bobeldijk, I. (author), Priebe, M.G. (author)Background: The consumption of products rich in cereal fiber and with a low glycemic index is implicated in a lower risk of metabolic diseases. Previously, we showed that the consumption of fiber-rich pasta compared with bread resulted in a lower rate of appearance of exogenous glucose and a lower glucose clearance rate quantified with a dual...article 2017
- document
-
Kooter, I.M. (author), Grollers-Mulderij, M. (author), Duistermaat, E. (author), Kuper, C.F. (author)Mucilair 3D bronchial airway models, cultured at an air-liquid interface, were exposed to aerosols of copper oxide (CuO) nanoparticles in Vitrocell air exposure modules. Four cell donors, four exposure modules and four exposure concentrations were varied within four different exposure sessions using a statistical experimental design called a...article 2017
- document
- van Ommen, B. (author) public lecture 2017
- document
-
Wopereis, S. (author), Stroeve, J.H.M. (author), Stafleu, A. (author), Bakker, G.C.M. (author), Burggraaf, J. (author), van Erk, M.J. (author), Pellis, L. (author), Boessen, R. (author), Kardinaal, A.A.F. (author), van Ommen, B. (author)Background: A key feature of metabolic health is the ability to adapt upon dietary perturbations. Recently, it was shown that metabolic challenge tests in combination with the new generation biomarkers allow the simultaneous quantification of major metabolic health processes. Currently, applied challenge tests are largely non-standardized. A...article 2017
- document
-
van Ommen, B. (author), van den Broek, T. (author), de Hoogh, I. (author), van Erk, M. (author), van Someren, E. (author), Rouhani-Rankouhi, T. (author), Anthony, J.C. (author), Hogenelst, K. (author), Pasman, W. (author), Boorsma, A. (author), Wopereis, S. (author)Personalized nutrition is fast becoming a reality due to a number of technological, scientific, and societal developments that complement and extend current public health nutrition recommendations. Personalized nutrition tailors dietary recommendations to specific biological requirements on the basis of a person’s health status and goals. The...article 2017
- document
-
Erpelinck, S. (author), Meijers, T. (author), Ariga, K. (author)Transporter proteins are embedded in plasma membranes and actively transport their substrates (drugs, food components or endogenous compounds) into or out of the cell. Transporters play a significant role in the absorption, distribution and excretion of drugs. Drug-transporter interactions can cause unwanted drug-drug or drug-food interactions...other 2017
- document
-
Vaes, W. (author), Meijers, T. (author), Ariga, K. (author)The development of new medicines is a costly and time consuming process. One way to increase the effi ciency of drug development pipelines is by using microtracer dosing. Microtracing is an innovative technology in which very small quantities of substances are tested in humans at a very early stage of development. No more than 100 micrograms, or...other 2017
- document
-
Kallen, V.L. (author), Stubbe, J.H. (author), Zwolle, H.J. (author), Valk, P. (author)Background/aimIt is well known that physical strain is associated with increased cortisol production. And although mental stress elevates cortisol concentrations as well, little is known of the independent and/or combined effects of both on the secretion of cortisol. Aim of the study was to investigate the day-to-day cortisol dynamics associated...article 2017
- document
-
Ruehl-Fehlert, C. (author), Parker, G.A. (author), Elmore, S.A. (author), Kuper, C.F. (author)Cells of the immune system are found in every organ, from the classic lymphoid organs to tissues such as liver, mucosae, and omental adipose tissue. Toxicity to the immune system may be from a direct or indirect injury to lymphoid organs. The morphological responses range from lymphocyte depletion to proliferation, and may result in an increased...bookPart 2017
- document
- Imangaliyev, S. (author), van der Veen, M.H. (author), Volgenant, C.M.C. (author), Keijser, B.J.F. (author), Crielaard, W. (author), Levin, E. (author) conference paper 2016
- document
-
Sun, M. (author), van Wijk, R. (author), van Wijk, E. (author), Wang, M. (author), van Wietmarschen, H. (author), Hankemeier, T. (author), van der Greef, J. (author)In Chinese medicine, raw herbal materials are used in processed and unprocessed forms aiming to meet the different requirements of clinical practice. To assure the chemical quality and therapeutic properties of the herbs, fast and integrated systematic assays are required. So far, such assays have not been established. Delayed luminescence (DL)...article 2016
- document
-
Paillart, M.J.M. (author), van der Vossen, J.M.B.M. (author), Lommen, E. (author), Levin, E. (author), Otma, E.C. (author), Snels, J.C.M.A. (author), Woltering, E.J. (author)The shelf-life of fresh-cut lettuce packed in a modified atmosphere (MA) is determined by its "overall visual quality" (OVQ), being a measure of its general appearance based on colour and shape criteria. In addition to the OVQ, the development of off-flavour and acid off-smell reduces consumer acceptance of such products. Concomitant with these...conference paper 2016
- document
- Amaral Santos, P.L. (author), Imangaliyev, S. (author), Schutte, K. (author), Levin, E. (author) conference paper 2016
- document
- Spruit, M.A. (author), Franssen, F.M.E. (author), Rutten, E.P.A. (author), Wopereis, S. (author), Wouters, E.F.M. (author), Vanfleteren, L.E.G.W. (author) article 2016
- document
-
Burgos, R.C.R. (author), Cervinková, K. (author), van der Laan, T. (author), Ramautar, R. (author), van Wijk, E.P.A. (author), Cifra, M. (author), Koval, S. (author), Berger, R. (author), Hankemeier, T. (author), van der Greef, J. (author)Ultra-weak photon emission (UPE) is light emitted spontaneously by biological systems without the use of specific luminescent complexes. UPE is emitted in the near-UV/UV–Vis/near-IR spectra during oxidative metabolic reactions; however, the specific pathways involved in UPE remain poorly understood. Here, we used HL-60 cells, a human...article 2016
- document
- van Avesaat, M. (author), Troost, F.J. (author), Ripken, D. (author), Hendriks, H.F.J. (author), Masclee, A.A.M. (author) article 2016
- document
-
van der Wielen, P.W.J.J. (author), Bakker, G. (author), Atsma, A. (author), Lut, M. (author), Roeselers, G. (author), de Graaf, B. (author)The objective of our study was to explore microbiological parameters that are suitable as indicators for regrowth in distribution systems that receive unchlorinated drinking water in the Netherlands. Treated water and distributed water at two locations in the distribution system of 28 treatment plants were analyzed for a range of biological...article 2016
- document
-
Westerik, N. (author), Wacoo, A.P. (author), Sybesma1, W. (author), Kort, R. (author)A novel dried bacterial consortium of Lactobacillus rhamnosus yoba 2012 and Streptococcus thermophilus C106 is cultured in 1 L of milk. This fresh starter can be used for the production of fermented milk and other fermented foods either at home or at small-scale in rural settings. For the fresh starter, 1 L of milk is pasteurized in a pan that...article 2016