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Koopman, J.E. (author), Hoogenkamp, M.A. (author), Buijs, M.J. (author), Brandt, B.W. (author), Keijser, B.J.F. (author), Crielaard, W. (author), ten Cate, J.M. (author), Zaura, E. (author)Objective Bacterial metabolism of arginine in the oral cavity has a pH-raising and thus, potential anti-caries effect. However, the influence of arginine on the oral microbial ecosystem remains largely unresolved. Design In this pilot study, nine healthy individuals used toothpaste containing 8% arginine for eight weeks. Saliva was collected to...article 2017
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He, M. (author), van Wijk, E. (author), van Wietmarschen, H. (author), Wang, M. (author), Sun, M. (author), Koval, S. (author), van Wijk, R. (author), Hankemeier, T. (author), van der Greef, J. (author)The increasing prevalence of rheumatoid arthritis has driven the development of new approaches and technologies for investigating the pathophysiology of this devastating, chronic disease. From the perspective of systems biology, combining comprehensive personal data such as metabolomics profiling with ultra-weak photon emission (UPE) data may...article 2017
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Ibarra, A. (author), Olli, K. (author), Pasman, W. (author), Hendriks, H. (author), Alhoniemi, E. (author), Raza, G.S. (author), Herzig, K.H. (author), Tiihonen, K. (author)Polydextrose (PDX) reduces subsequent energy intake (EI) when administered at midmorning in single-blind trials of primarily normal-weight men. However, it is unclear if this effect also occurs when PDX is given at breakfast time. Furthermore, for ecological validity, it is desirable to study a female population, including those at risk for...article 2017
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van den Broek, T.J. (author), Kremer, B.H.A. (author), marcondes Rezende, M. (author), Hoevenaars, F.P.M. (author), Weber, P. (author), Hoeller, U. (author), van Ommen, B. (author), Wopereis, S. (author)Background. Vitamins and carotenoids are key micronutrients facilitating the maintenance of health, as evidenced by the increased risk of disease with low intake. Optimal phenotypic flexibility, i.e., the ability to respond to a physiological challenge, is an essential indicator of health status. Therefore, health can be measured by applying a...article 2017
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Brouwer-Brolsma, E.M. (author), Brennan, L. (author), Drevon, C.A. (author), van Kranen, H. (author), Manach, C. (author), Dragsted, L.O. (author), Roche, H.M. (author), Andres-Lacueva, C. (author), Bakker, S.J.L. (author), Bouwman, J. (author), Capozzi, F. (author), de Saeger, S. (author), Gundersen, T.E. (author), Kolehmainen, M. (author), Kulling, S.E. (author), Landberg, R. (author), Linseisen, J. (author), Mattivi, F. (author), Mensink, R.P. (author), Scaccini, C. (author), Skurk, T. (author), Tetens, I. (author), Vergeres, G. (author), Wishart, D.S. (author), Scalbert, A. (author), Feskens, E.J.M. (author)FFQ, food diaries and 24 h recall methods represent the most commonly used dietary assessment tools in human studies on nutrition and health, but food intake biomarkers are assumed to provide a more objective reflection of intake. Unfortunately, very few of these biomarkers are sufficiently validated. This review provides an overview of food...article 2017
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Zaura, E. (author), Brandt, B.W. (author), Prodan, A. (author), de Mattos, T. (author), Imangaliyev, S. (author), Buijs, M.J. (author), Jagers, F.L. (author), Hennequin-Hoenderbos, N.L. (author), Slot, D.E. (author), Nicu, D.E. (author), Lagerweij, M.D. (author), Janus, M.M. (author), Fernandez-Gutierrez, M.M. (author), Levin, E. (author), Krom, B.P. (author), Brand, H.S. (author), Veerman, E.C. (author), Kleerebezem, M. (author), Loos, B.G. (author), van der Weijden, G.A. (author), Crielaard, W. (author), Keijser, B.J. (author)A dysbiotic state is believed to be a key factor in the onset of oral disease. Although oral diseases have been studied for decades, our understanding of oral health, the boundaries of a healthy oral ecosystem and ecological shift toward dysbiosis is still limited. Here, we present the ecobiological heterogeneity of the salivary ecosystem and...article 2017
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Yang, C. (author), Pinart, M. (author), Kolsteren, P. (author), van Camp, J. (author), de Cock, N. (author), Nimptsch, K. (author), Pischon, T. (author), Laird, E. (author), Perozzi, G. (author), Canali, R. (author), Hoge, A. (author), Stelmach-Mardas, M. (author), Dragsted, L.O. (author), Palombi, S.M. (author), Dobre, I. (author), Bouwman, J. (author), Clarys, P. (author), Minervini, F. (author), de Angelis, M. (author), Gobbetti, M. (author), Tafforeau, J. (author), Coltell, O. (author), Corella, D. (author), de Ruyck, H. (author), Walton, J. (author), Kehoe, L. (author), Matthys, C. (author), de Baets, B. (author), de Tré, G. (author), Bronselaer, A. (author), Rivellese, A. (author), Giacco, R. (author), Lombardo, R. (author), de Clercq, S. (author), Hulstaert, N. (author), Lachat, C. (author)Pooled analysis of secondary data increases the power of research and enables scientific discovery in nutritional epidemiology. Information on study characteristics that determine data quality is needed to enable correct reuse and interpretation of data. This study aims to define essential quality characteristics for data from observational...article 2017
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Prolonged high-fat diet induces gradual and fat depot-specific DNA methylation changes in adult miceSlieker, R.C. (author), Mulder, P.C.A. (author), Zoetemelk, I. (author), Verschuren, L. (author), Suchiman, H.E.D. (author), Toet, K.H. (author), Droog, S. (author), Slagboom, P.E. (author), Kooistra, T. (author), Kleemann, R. (author), Heijmans, B.T. (author)High-fat diets (HFD) are thought to contribute to the development of metabolism-related diseases. The long-term impact of HFD may be mediated by epigenetic mechanisms, and indeed, HFD has been reported to induce DNA methylation changes in white adipose tissue (WAT) near metabolism related genes. However, previous studies were limited to a single...article 2017
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Fluitman, K.S. (author), de Clercq, N.C. (author), Keijser, B.J.F. (author), Visser, M. (author), Nieuwdorp, M. (author), Ijzerman, R.G. (author)Introduction: Malnutrition refers to both over- and undernutrition and results from a disruption in energy balance. It affects one in three people worldwide and is associated with increased morbidity and mortality. The intestinal microbiota represents a newly identified factor that might contribute to the development of malnutrition, as it...article 2017
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van Koppen, A. (author), Verschuren, L. (author), van den Hoek, A.M. (author), Verheij, J. (author), Morrison, M.C. (author), Li, K. (author), Nagabukuro, H. (author), Costessi, A. (author), Caspers, M.P.M. (author), van den Broek, T.J. (author), Sagartz, J. (author), Kluft, C. (author), Beysen, C. (author), Emson, C. (author), van Gool, A.J. (author), Goldschmeding, R. (author), Stoop, R. (author), Bobeldijk-Pastorova, I. (author), Turner, S.M. (author), Hanauer, G. (author), Hanemaaijer, R. (author)Background & Aims: The incidence of nonalcoholic steatohepatitis (NASH) is increasing. The pathophysiological mechanisms of NASH and the sequence of events leading to hepatic fibrosis are incompletely understood. The aim of this study was to gain insight into the dynamics of key molecular processes involved in NASH and to rank early markers for...article 2017
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van den Broek, T.J. (author), Bakker, G.C.M. (author), Rubingh, C.M. (author), Bijlsma, S. (author), Stroeve, J.H.M. (author), van Ommen, B. (author), van Erk, M.J. (author), Wopereis, S. (author)Background: A key feature of metabolic health is the ability to adapt upon dietary perturbations. A systemic review defined an optimal nutritional challenge test, the "PhenFlex test" (PFT). Recently, it has been shown that the PFT enables the quantification of all relevant metabolic processes involved in maintaining or regaining homeostasis of...article 2017
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Blanco-Rojo, R. (author), Perez-Martinez, P. (author), Lopez-Moreno, J. (author), Martinez-Botas, J. (author), Delgado-Lista, J. (author), van Ommen, B. (author), Yubero-Serrano, E. (author), Camargo, A. (author), Ordovas, J.M. (author), Perez-Jimenez, F. (author), Gomez-Coronado, D. (author), Lopez-Miranda, J. (author)This prospective study evaluated whether baseline cholesterol efflux is associated with future development of type 2 diabetes (T2DM) in cardiovascular patients. We measured cholesterol efflux in all CORDIOPREV study (NCT00924937) participants free of T2DM at baseline (n = 462) and assessed its relationship with T2DM incidence during a 4.5 years...article 2017
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Fernandez-Gutierrez, M.M. (author), Roosjen, P.P.J. (author), Ultee, E. (author), Agelink, M. (author), Vervoort, J.J.M. (author), Keijser, B. (author), Wells, J.M. (author), Kleerebezem, M. (author)Gingival re-epithelialization represents an essential phase of oral wound healing in which epithelial integrity is re-establish. We developed an automated high-throughput re-epithelialization kinetic model, using the gingival epithelial cell line Ca9-22. The model was employed to screen 39 lactic acid bacteria, predominantly including oral...article 2017
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Bosch, A.A.T.M. (author), de Steenhuijsen Piters, W.A.A. (author), van Houten, M.A. (author), Chu, M.L.J.N. (author), Biesbroek, G. (author), Kool, J. (author), Pernet, P. (author), de Groot, P.C.M. (author), Eijkemans, M.J.C. (author), Keijser, B.J.F.5. (author), Sanders, E.A.M. (author), Bogaert, D. (author)RATIONALE: Perinatal and postnatal influences are presumed important drivers of the early-life respiratory microbiota composition. We hypothesized that the respiratory microbiota composition and development in infancy is affecting microbiota stability and thereby resistance against respiratory tract infections (RTIs) over time. OBJECTIVES: To...article 2017
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Bothe, M.K. (author), Maathuis, A.J.H. (author), Bellmann, S. (author), van der Vossen, J.M.B.M. (author), Berressem, D. (author), Koehler, A. (author), Schwejda-Guettes, S. (author), Gaigg, B. (author), Kuchinka-Koch, A. (author), Stover, J.F. (author)Lactulose, a disaccharide of galactose and fructose, used as a laxative or ammonia-lowering drug and as a functional food ingredient, enhances growth of Bifidobacterium and Lactobacillus at clinically relevant dosages. The prebiotic effect of subclinical dosages of Lactulose, however, remains to be elucidated. This study analyses changes in the...article 2017
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Grimaldi, K.A. (author), van Ommen, B. (author), Ordovas, J.M. (author), Parnell, L.D. (author), Mathers, J.C. (author), Bendik, I. (author), Brennan, L. (author), Celis-Morales, C. (author), Cirillo, E. (author), Daniel, H. (author), de Kok, B. (author), El-Sohemy, A. (author), Fairweather-Tait, S.J. (author), Fallaize, R. (author), Fenech, M. (author), Ferguson, L.R. (author), Gibney, E.R. (author), Gibney, M. (author), Gjelstad, I.M.F. (author), Kaput, J. (author), Karlsen, A.S. (author), Kolossa, S. (author), Lovegrove, J. (author), Macready, A.L. (author), Marsaux, C.F.M. (author), Alfredo Martinez, J. (author), Milagro, F. (author), Navas-Carretero, S. (author), Roche, H.M. (author), Saris, W.H.M. (author), Traczyk, I. (author), van Kranen, H. (author), Verschuren, L. (author), Virgili, F. (author), Weber, P. (author), Bouwman, J. (author)Nutrigenetic research examines the effects of inter-individual differences in genotype on responses to nutrients and other food components, in the context of health and of nutrient requirements. A practical application of nutrigenetics is the use of personal genetic information to guide recommendations for dietary choices that are more...article 2017
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Totté, J. (author), de Wit, J. (author), Pardo, L. (author), Schuren, F. (author), van Doorn, M. (author), Pasmans, S. (author)Background: Atopic dermatitis (AD) is associated with reduced skin microbial diversity and overgrowth of Staphylococcus (S.) aureus. However, the importance of S. aureus colonisation in the complex pathogenesis remains unclear and studies on the effect of anti-staphylococcal therapy in non-infected AD show contradictory results. Long-term...article 2017
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San-Cristobal, R. (author), Navas-Carretero, S. (author), Livingstone, K.M. (author), Celis-Morales, C. (author), Macready, A.L. (author), Fallaize, R. (author), O’Donovan, C.B. (author), Lambrinou, C.P. (author), Moschonis, G. (author), Marsaux, C.F.M. (author), Manios, Y. (author), Jarosz, M. (author), Daniel, H. (author), Gibney, E.R. (author), Brennan, L. (author), Drevon, C.A. (author), Gundersen, T.E. (author), Gibney, M. (author), Saris, W.H.M. (author), Lovegrove, J.A. (author), Grimaldi, K. (author), Parnell, L.D. (author), Bouwman, J. (author), Ommen, B. (author), Mathers, J.C. (author), Alfredo Martinez, J. (author)Mediterranean Diet (MedDiet) adherence has been proven to produce numerous health benefits. In addition, nutrigenetic studies have explained some individual variations in the response to specific dietary patterns. The present research aimed to explore associations and potential interactions between MedDiet adherence and genetic background...article 2017
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Aguirre, M. (author), Venema, K. (author)There is an elevated incidence of cases of obesity worldwide. Therefore, the development of strategies to tackle this condition is of vital importance. This review focuses on the necessity of optimising in vitro systems to model human colonic fermentation in obese subjects. This may allow to increase the resolution and the physiological...article 2017
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Marco, M.L. (author), Heeney, D. (author)Fermented foods and beverages were among the first processed food products consumed by humans. The production of foods such as yogurt and cultured milk, wine and beer, sauerkraut and kimchi, and fermented sausage were initially valued because of their improved shelf life, safety, and organoleptic properties. It is increasingly understood that...article 2017