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Notenboom, S. (author), Weigand, K.M. (author), Proost, J.H. (author), van Lipzig, M.M. (author), van de Steeg, E. (author), van den Broek, P.H.H. (author), Greupink, R. (author), Russel, F.G.M. (author), Groothuis, G.M.M. (author)The authors regret the molar unit is incorrectly displayed on the x-axis in Fig. 4A and 4C and on the y-axis in Fig. 4B, 4D and Fig. 5. The correct versions of the figures are displayed below together with the unchanged legends. The authors would like to apologise for any inconvenience caused. DOI of original article: 10.1016/j.ejps.2018.01.007 ...article 2018
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Collins, S.L. (author), McMillan, A. (author), Seney, S. (author), van der Veer, C. (author), Kort, R. (author), Sumarah, M.W. (author), Reid, G. (author)Perturbations to the vaginal microbiota can lead to dysbiosis, including bacterial vaginosis (BV), which affects a large portion of the female population. In a healthy state, the vaginal microbiota is characterized by low diversity and colonization by Lactobacillus spp., whereas in BV, these species are displaced by a highly diverse population...article 2018
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van der Does, A.M. (author), Amatngalim, G.D. (author), Keijser, B.J.F. (author), Hiemstra, P.S. (author), Villenave, R. (author)The respiratory tract harbours a variety of microorganisms, collectively called the respiratory microbiota. Over the past few years, alterations in respiratory and gut microbiota composition have been associated with chronic inflammatory diseases of the lungs. How these changes influence disease development and progression is an active field of...article 2018
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Notenboom, S. (author), Weigand, K.M. (author), Proost, J.H. (author), van Lipzig, M.M.H. (author), van de Steeg, E. (author), van den Broek, P.H.H. (author), Greupink, R. (author), Russel, F.G.M. (author), Groothuis, G.M.M. (author)Drug-induced liver injury (DILI) is a common reason for drug withdrawal from the market. An important cause of DILI is drug-induced cholestasis. One of the major players involved in drug-induced cholestasis is the bile salt efflux pump (BSEP; ABCB11). Inhibition of BSEP by drugs potentially leads to cholestasis due to increased (toxic)...article 2018
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van Ommen, B. (author), Wopereis, S. (author), van Empelen, P. (author), van Keulen, H.M. (author), Otten, W. (author), Kasteleyn, M. (author), Molema, J.J.W. (author), de Hoogh, I.M. (author), Chavannes, N.H. (author), Numans, M.E. (author), Evers, A.W.M. (author), Pijl, H. (author)From a biological view, most of the processes involved in insulin resistance, which drives the pathobiology of type 2 diabetes, are reversible. This theoretically makes the disease reversible and curable by changing dietary habits and physical activity, particularly when adopted early in the disease process. Yet, this is not fully implemented...article 2018
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Pouwer, M.G. (author), Pieterman, E.J. (author), Verschuren, L. (author), Caspers, M.P.M. (author), Kluft, C. (author), Garcia, R.A. (author), Aman, J. (author), Jukema, J.W. (author), Princen, H.M.G. (author)Treatment with the second and third generation BCR-ABL1 tyrosine kinase inhibitors (TKIs) increases cardiovascular risk in chronic myeloid leukemia (CML) patients. We investigated the vascular adverse effects of three generations of TKIs in a translational model for atherosclerosis, the APOE*3Leiden.CETP mouse. Mice were treated for sixteen...article 2018
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Fallaize, R. (author), Livingstone, K.M. (author), Celis-Morales, C. (author), Macready, A.L. (author), San-Cristobal, R. (author), Navas-Carretero, S. (author), Marsaux, C.F.M. (author), O’Donovan, C.B. (author), Kolossa, S. (author), Moschonis, G. (author), Walsh, M.C. (author), Gibney, E.R. (author), Brennan, L. (author), Bouwman, J. (author), Manios, Y. (author), Jarosz, M. (author), Martinez, J.A. (author), Daniel, H. (author), Saris, W.H.M. (author), Gundersen, T.E. (author), Drevon, C.A. (author), Gibney, M.J. (author), Mathers, J.C. (author), Lovegrove, J.A. (author)Diet-quality scores (DQS), which are developed across the globe, are used to define adherence to specific eating patterns and have been associated with risk of coronary heart disease and type-II diabetes. We explored the association between five diet-quality scores (Healthy Eating Index, HEI; Alternate Healthy Eating Index, AHEI; MedDietScore,...article 2018
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Keijser, B.J.F. (author), van den Broek, T.J. (author), Slot, D.E. (author), van Twillert, L. (author), Kool, J. (author), Thabuis, C. (author), Ossendrijver, M. (author), van der Weijden, F.A. (author), Montijn, R.C. (author)Background: The oral cavity harbors a complex microbial ecosystem, intimately related to oral health and disease. The use of polyol-sweetened gum is believed to benefit oral health through stimulation of salivary flow and impacting oral pathogenic bacteria. Maltitol is often used as sweetener in food products. This study aimed to establish the...article 2018
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Zhao, Y. (author), Kumar, M. (author), Caspers, M.P.M. (author), Nierop Groot, M.N. (author), van der Vossen, J.M.B.M. (author), Abee, T. (author)Thermophilic bacilli such as Anoxybacillus and Geobacillus are important contaminants in dairy powder products. Remarkably, one of the common contaminants, Geobacillus thermoglucosidans, showed poor growth in skim milk, whereas significant growth of G. thermoglucosidans was observed in the presence of an Anoxybacillus flavithermus dairy isolate....article 2018
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Schaudien, D. (author), Harleman, J.H. (author), Bouallala, F. (author), Kuper, C.F. (author)Toxicologic pathology plays a crucial role in the identification and interpretation of substance-induced health effects. Histology of lymphoid organs is quite sensitive, although it does not flag every model immunotoxic substance. Subtle interferences of toxic compounds, like transmembrane signaling and cell activation, are often not detectable...bookPart 2018
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Sun, M. (author), Chang, W.T. (author), van Wijk, E. (author), He, M. (author), Koval, S. (author), Lin, M.K. (author), Van Wijk, R. (author), Hankemeier, T. (author), van der Greef, J. (author), Wang, M. (author)Based on the traditional Chinese medicine theory, the Chinese pharmacopeia assigns a therapeutic description of “taste” to all herbs; thus, an herb's “taste” is valued in traditional Chinese medicine as a major ethnopharmacological category and reflects the herb's therapeutic properties. These properties guide the practitioner with respect to...article 2017
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Sun, M. (author), van Wijk, E. (author), Koval, S. (author), van Wijk, R. (author), He, M. (author), Wang, M. (author), Hankemeier, T. (author), van der Greef, J. (author)The global prevalence of type 2 diabetes is estimated to reach 4.4% by 2030, placing a significant burden on our healthcare system. Therefore, the ability to identify patients in early stages of the disease is essential for both prevention and effective management, and diagnostic methods based on traditional Chinese medicine (TCM) may be...article 2017
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Celis-Morales, C. (author), Marsaux, C.F.M. (author), Livingstone, K.M. (author), Navas-Carretero, S. (author), San-Cristobal, R. (author), Fallaize, R. (author), Macready, A.L. (author), O'Donovan, C. (author), Woolhead, C. (author), Forster, H. (author), Kolossa, S. (author), Daniel, H. (author), Moschonis, G. (author), Mavrogianni, C. (author), Manios, Y. (author), Surwillo, A. (author), Traczyk, I. (author), Drevon, C.A. (author), Grimaldi, K. (author), Bouwman, J. (author), Gibney, M.J. (author), Walsh, M.C. (author), Gibney, E.R. (author), Brennan, L. (author), Lovegrove, J.A. (author), Martinez, J.A. (author), Saris, W.H.M. (author), Mathers, J.C. (author)Background: There has been limited evidence about whether genotype-tailored advice provides extra benefits in reducing obesityrelated traits compared with the benefits of conventional one-size-fitsall advice. Objective: We determined whether the disclosure of information on fat-mass and obesity-associated (FTO) genotype risk had a greater effect...article 2017
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Paillart, M.J.M. (author), van der Vossen, J.M.B.M. (author), Levin, E. (author), Lommen, E. (author), Otma, E.C. (author), Snels, J.C.M.A. (author), Woltering, E.J. (author)The end of shelf life of fresh-cut iceberg lettuce packed in modified atmosphere (MA) is determined by its visual quality and by its microbial load. The total microbial load should not exceed 6–7 log CFU g−1 mesophilic counting and be free of human pathogens. Not much is known about specific interactions between the levels of specific spoilage...article 2017
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Botschuijver, S. (author), Roeselers, G. (author), Levin, E. (author), Jonkers, D.M. (author), Welting, O. (author), Heinsbroek, S.E.M. (author), de Weerd, H.H. (author), Boekhout, T. (author), Fornai, M. (author), Masclee, A.A. (author), Schuren, F.H.J. (author), de Jonge, W.J. (author), Seppen, J. (author), van den Wijngaard, R.M. (author)Background & Aims Visceral hypersensitivity is one feature of irritable bowel syndrome (IBS). Bacterial dysbiosis might be involved in the activation of nociceptive sensory pathways, but there have been few studies of the role of the mycobiome (the fungal microbiome) in the development of IBS. We analyzed intestinal mycobiomes of patients with...article 2017
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Fiamoncini, J. (author), Yiorkas, A.M. (author), Gedrich, K. (author), Rundle, M. (author), Alsters, S.I. (author), Roeselers, G. (author), van den Broek, T.J. (author), Clavel, T. (author), Lagkouvardos, I. (author), Wopereis, S. (author), Frost, G. (author), van Ommen, B. (author), Blakemore, A.I. (author), Daniel, H. (author)Bile acids (BA) are signaling molecules with a wide range of biological effects, also identified among the most responsive plasma metabolites in the postprandial state. We here describe this response to different dietary challenges and report on key determinants linked to its interindividual variability. Healthy men and women (n = 72, 62 ± 8 yr,...article 2017
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van de Steeg, E. (author), Läppchen, T. (author), Aguilera, B. (author), Jansen, H.T. (author), Muilwijk, D. (author), Vermue, R. (author), van der Hoorn, J.W. (author), Donato, K. (author), Rossin, R. (author), de Visser, P.C. (author), Vlaming, M.L.H. (author)Antisense oligonucleotides (AONs) are promising candidates for treatment of Duchenne muscular dystrophy (DMD), a severe and progressive disease resulting in premature death. However, more knowledge on the pharmacokinetics of new AON drug candidates is desired for effective application in the clinic. We assessed the feasibility of using...article 2017
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Goverse, G. (author), Molenaar, R. (author), MacIa, L. (author), Tan, J. (author), Erkelens, M.N. (author), Konijn, T. (author), Knippenberg, M. (author), Cook, E.C.L. (author), Hanekamp, D. (author), Veldhoen, M. (author), Hartog, A. (author), Roeselers, G. (author), MacKay, C.R. (author), Mebius, R.E. (author)The gastrointestinal tract is continuously exposed to many environmental factors that influence intestinal epithelial cells and the underlying mucosal immune system. In this article, we demonstrate that dietary fiber and short chain fatty acids (SCFAs) induced the expression of the Vitamin A-converting enzyme RALDH1 in intestinal epithelial...article 2017
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Matualatupauw, J.C. (author), Bohl, M. (author), Gregersen, S. (author), Hermansen, K. (author), Afman, L.A. (author)Background:Dietary medium-chain saturated fatty acids (MC-SFAs) have been shown to reduce total body fat. Previously, we showed that MC-SFAs prevent body fat accumulation, despite weight gain. Here, we aim to explore potential molecular mechanisms underlying the protective effect of MC-SFAs on body fat gain.Methods:The DairyHealth study examined...article 2017
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Wegler, C. (author), Gaugaz, F.Z. (author), Andersson, T.B. (author), Wiśniewski, J.R. (author), Busch, D. (author), Gröer, C. (author), Oswald, S. (author), Norén, A. (author), Weiss, F. (author), Hammer, H.S. (author), Joos, T.O. (author), Poetz, O. (author), Achour, B. (author), Rostami-Hodjegan, A. (author), van de Steeg, E. (author), Wortelboer, H.M. (author), Artursson, P. (author)Many different methods are used for mass-spectrometry-based protein quantification in pharmacokinetics and systems pharmacology. It has not been established to what extent the results from these various methods are comparable. Here, we compared six different mass spectrometry-based proteomics methods by measuring the expression of clinically...article 2017