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Kaan, A.M. (author), Brandt, B.W. (author), Buijs, M.J. (author), Crielaard, W. (author), Keijser, B.J.F. (author), Zaura, E. (author)In general, saliva is used for microbiota analysis in longitudinal studies, and several collection methods are being used. Using a robust sample collection procedure is important, as it may influence salivary composition. This study explored the comparability of the microbiota of swabbed and spit saliva. Twenty-two females participated in this...article 2022
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Selberherr, E. (author), Grau, J.H. (author), Meixner, M. (author), Liere, K. (author), Ercolini, D. (author), de Filippo, C. (author), Caderni, G. (author), Brigidi, P. (author), Turroni, S. (author)The core microbiome, which refers to a set of consistent microbial features across populations, is of major interest in microbiome research and has been addressed by numerous studies. Understanding the core microbiome can help identify elements that lead to dysbiosis, and lead to treatments for microbiome-related health states. However, defining...article 2022
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Derksen, G.C.H. (author), Holthoon, F.L. (author), Willemen, H.M. (author), Krul, C.A.M. (author), Franssen, M.C.R. (author), van Beek, T.A. (author)Madder, used as a red dye, contains anthraquinones, and some of these can react with DNA possibly causing mutagenic effects. This is especially true for 1,3-dihydroxyanthraquinones with a hydroxymethyl (e.g., lucidin 6, ibericin 10) or methyl group (e.g., rubiadin 9) at C-2. In this research, a new process was developed through which the...article 2021
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Jagadeesan, B. (author), Gerner-Smidt, P. (author), Allard, M.W. (author), Leuillet, S. (author), Winkler, A. (author), Xiao, Y. (author), Chaffron, S. (author), Chaffron, S. (author), Tang, S. (author), Katase, M. (author), McClure, P. (author), Kimura, B. (author), Chai, L. Ching (author), Chapman, J. (author), Grant, K. (author)Next Generation Sequencing (NGS) combined with powerful bioinformatic approaches are revolutionising food microbiology. Whole genome sequencing (WGS) of single isolates allows the most detailed comparison possible hitherto of individual strains. The two principle approaches for strain discrimination, single nucleotide polymorphism (SNP) analysis...article 2019
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Tans, R. (author), Verschuren, L. (author), Wessels, H.J.C.T. (author), Bakker, S.J.L. (author), Tack, C.J. (author), Gloerich, J. (author), van Gool, A.J. (author)Introduction: The onset of type 2 diabetes mellitus (T2DM) is strongly associated with obesity and subsequent perturbations in immuno-metabolic responses. To understand the complexity of these systemic changes and better monitor the health status of people at risk, validated clinical biomarkers are needed. Omics technologies are increasingly...article 2019
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Tans, R. (author), van Diepen, J.A. (author), Bijlsma, S. (author), Verschuren, L. (author), Suppers, A. (author), Stienstra, R. (author), Wevers, R.A. (author), Tack, C.J. (author), Gloerich, J. (author), van Gool, A.J. (author)Background: Overweight and obesity can lead to adipose tissue inflammation, which causes insulin resistance and on the long-term type 2 diabetes mellitus (T2D). The inflammatory changes of obese-adipose tissue are characterized by macrophage infiltration and activation, but validated circulating biomarkers for adipose tissue inflammation for...article 2019
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Abe, N. (author), Kato, S. (author), Tsuchida, T. (author), Sugimoto, K. (author), Saito, R. (author), Verschuren, L. (author), Kleemann, R. (author), Oka, K. (author)Non-alcoholic steatohepatitis (NASH) is a fast-growing liver disease in the Western world. Currently, only a few animal models show both the metabolic and histological features of human NASH. We aimed to explore murine NASH models in a time dependent manner that exhibit metabolic, histological and transcriptomic hallmarks of human NASH. For this...article 2019
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Agamennone, V. (author), Krul, C.A.M. (author), Rijkers, G. (author), Kort, R. (author)BACKGROUND Antibiotic-associated diarrhea (AAD) is a side-effect frequently associated with the use of broad spectrum antibiotics. Although a number of clinical studies show that co-administration of specific probiotics reduces the risk for AAD, there is still unclarity among healthcare professionals on the recommendation of probiotic products....article 2019
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Agamennone, V. (author), van Straalen, J. (author), Brouwer, A. (author), de Boer, T.E. (author), Hensbergen, P.J. (author), Zaagman, N. (author), Braster, M. (author), van Straalen, N.M. (author), Roelofs, D. (author), Janssens, T.K.S. (author)Antibiotic resistance necessitates the search for new bioactive compounds with novel mechanisms of action. Natural products derived from bacteria and fungi are widely used in the field of medicine and new environments can be explored as sources of antimicrobials. Bacteria associated with springtails have shown high inhibitory activity against...article 2019
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- Wilkinson, M.D. (author), Dumontier, M. (author), Aalbersberg, I.J. (author), Appleton, G. (author), Axton, M. (author), Baak, A. (author), Blomberg, N. (author), Boiten, J.W. (author), da Silva Santos, L.B. (author), Bourne, P.E. (author), Bouwman, J. (author), Brookes, A.J. (author), Clark, T. (author), Crosas, M. (author), Dillo, I. (author), Dumon, O. (author), Edmunds, S. (author), Evelo, C.T. (author), Finkers, R. (author), Gonzalez-Beltran, A. (author), Gray, A.J.G. (author), Groth, P. (author), Goble, C. (author), Grethe, J.S. (author), Heringa, J. (author), 't Hoen, P.A.C. (author), Hooft, R. (author), Kuhn, T. (author), Kok, R. (author), Kok, J. (author), Lusher, S.J. (author), Martone, M.E. (author), Mons, A. (author), Packer, A.L. (author), Persson, B. (author), Rocca-Serra, P. (author), Roos, M. (author), van Schaik, R. (author), Sansone, S.A. (author), Schultes, E. (author), Sengstag, T. (author), Slater, T. (author), Strawn, G. (author), Swertz, M.A. (author), Thompson, M. (author), van der Lei, J. (author), van Mulligen, E. (author), Velterop, J. (author), Waagmeester, A. (author), Wittenburg, P. (author), Wolstencroft, K. (author), Zhao, J. (author), Mons, B. (author) article 2019
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He, M. (author), Harms, A.C. (author), van Wijk, E. (author), Wang, M. (author), Berger, R. (author), Koval. S., (author), Hankemeier, T. (author), van der Greef, J. (author)Background. Rheumatoid arthritis (RA) is a complex, chronic autoimmune disease characterized by various inflammatory symptoms, including joint swelling, joint pain, and both structural and functional joint damage. The most commonly used animal model for studying RA is mice with collagen‐induced arthritis (CIA); the wide use of this model is due...article 2019
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Jurburg, S.D. (author), Cornelissen, J.J.B.W.J. (author), de Boer, P. (author), Smits, M.A. (author), Rebel, J.M.J. (author)Clostridium difficile infections (CDI) are a major cause of antibiotic-associated diarrhea. It is hypothesized that CDI develops due to the antibiotic-induced disruption of the intestinal microbial community structure, which allows C. difficile to flourish. Here, we pre-treated weaned pigs with the antibiotics Clindamycin or Ciprofloxacin for 1...article 2019
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Erpelinck, E. (author), Meijers, T. (author), Ariga, K. (author)The TNO InTESTine™ system is developed to study the absorption and translocation of pharmaceutical, biological and nutritional compounds across the intestinal wall in a physiologically relevant model. In this medium-throughput system, fresh ex vivo intestinal tissue from human or animal origin is mounted into a two compartment model with an...other 2019
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Hogenelst, K. (author), Soeter, M. (author), Kallen, V. (author)Accumulating evidence supports the harmful effects of stress on health, including the development and progress of psychopathology (e.g. anxiety disorders), metabolic disorders (e.g. diabetes type II), inflammatory disturbances, and cardiovascular disease. These harmful effects are often expressed as disturbances in cortisol levels, patterns, or...article 2019
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- Reijmer, D. (author) other 2019
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Fu, J. (author), van Wietmarschen, H.A. (author), van der Kooij, A. (author), Cuppen, B.V.J. (author), Schroën, Y. (author), Marijnissen, A.K. (author), Meulman, J.J. (author), Lafeber, F.P.J.G. (author), van der Greef, J. (author)Introduction: Biological therapies have greatly improved the treatment efficacy in rheumatoid arthritis (RA). However, in clinical practice a significant proportion of patients experience an inadequate response to treatment. The aim of this study is to classify responding and non-responding rheumatoid arthritis patients treated with biological...article 2018
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Schutte, S. (author), Esser, D. (author), Hoevenaars, F.P.M. (author), Hooiveld, G.J.E.J. (author), Priebe, M.G. (author), Vonk, R.J. (author), Wopereis, S. (author), Afman, L.A. (author)Background: Whole-grain wheat (WGW) is described as nutritionally superior to refined wheat (RW) and thus advocated as the healthy choice, although evidence from intervention studies is often inconsistent. The liver, as the central organ in energy metabolism, might be an important target organ for WGW interventions. Objective: The aim of this...article 2018
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de Ligt, R. (author), van Duijn, E. (author), Grossouw, D. (author), Bosgra, S. (author), Burggraaf, J. (author), Windhorst, A. (author), Peeters, P.A.M. (author), van der Luijt, G.A. (author), Alexander-White, C. (author), Vaes, W.H.J. (author)A clinical pharmacokinetic study was performed in 12 healthy women to evaluate systemic exposure to aluminum following topical application of a representative antiperspirant formulation under real-life use conditions. A simple roll-on formulation containing an extremely rare isotope of aluminum (26 Al) chlorohydrate (ACH) was prepared to...article 2018
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Remels, A.H.V. (author), Derks, W.J.A. (author), Cillero-Pastor, B. (author), Verhees, K.J.P. (author), Kelders, M.C. (author), Heggermont, W. (author), Carai, P. (author), Summer, G. (author), Ellis, S.R. (author), de Theije, C.C. (author), Heeren, R.M.A. (author), Heymans, S. (author), Papageorgiou, A.P. (author), van Bilsen, M. (author)Acute viral myocarditis (VM), characterised by leukocyte infiltration and dysfunction of the heart, is an important cause of sudden cardiac death in young adults. Unfortunately, to date, the pathological mechanisms underlying cardiac failure in VM remain incompletely understood. In the current study, we investigated if acute VM leads to cardiac...article 2018
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Aldi, S. (author), Matic, L.P. (author), Hamm, G. (author), van Keulen, D. (author), Tempel, D. (author), Holmstrøm, K. (author), Szwajda, A. (author), Nielsen, B. (author), Emilsson, V. (author), Ait-Belkacem, R. (author), Lengquist, M. (author), Paulsson-Berne, G. (author), Eriksson, P. (author), Lindeman, J.H.N. (author), Gool, A.J. (author), Stauber, J. (author), Hedin, U. (author), Hurt-Camejo, E. (author)Variants in the PLPP3 gene encoding for lipid phosphate phosphohydrolase 3 have been associated with susceptibility to atherosclerosis independently of classical risk factors. PLPP3 inactivates lysophosphatidic acid (LPA), a pro-inflammatory, pro-thrombotic product of phospholipase activity. Here we performed the first exploratory analysis of...article 2018