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Gayban, A.J.B. (author), Souza, L.A.C. (author), Cooper, S.G. (author), Regalado, E. (author), Kleemann, R. (author), Earley, Y.F. (author)Non-alcoholic fatty liver disease (NAFLD) comprises a spectrum of liver damage directly related to diabetes, obesity, and metabolic syndrome. The (pro)renin receptor (PRR) has recently been demonstrated to play a role in glucose and lipid metabolism. Here, we test the hypothesis that the PRR regulates the development of diet-induced hepatic...article 2023
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van Gemert, Y. (author), Kruisbergen, N.N.L. (author), Blom, A.B. (author), van den Bosch, M.H.J. (author), van der Kraan, P.M. (author), Pieterman, E.J. (author), Princen, H.M.G. (author), van Lent, P.L.E.M. (author)Introduction: Both systemic inflammation and dyslipidemia contribute to osteoarthritis (OA) development and have been suggested as a possible link between metabolic disease and OA development. Recently, the CANTOS trial showed a reduction in knee and hip replacements after inhibition of IL-1β in patients with a history of cardiovascular disease...article 2023
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van Gemert, Y. (author), Blom, A.B. (author), Cegli I. Di, (author), Walgreen, B. (author), Helsen, M. (author), Sloetjes, A. (author), Vogl, T. (author), Kruisbergen, N.N.L. (author), Pieterman, E.J. (author), Princen, H.M.G. (author), van der Kraan, P.M. (author), van Lent, P.L.E.M. (author), van den Bosch, M.H.J. (author)Introduction: The association between metabolic syndrome (MetS) and osteoarthritis (OA) development has become increasingly recognized. In this context, the exact role of cholesterol and cholesterol-lowering therapies in OA development has remained elusive. Recently, we did not observe beneficial effects of intensive cholesterol-lowering...article 2023
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Wopereis, S. (author), Boorsma, A. (author)We are all getting older, but enjoying a long and healthy life is not a given. Our quality of life is declining. Although our lifespan continues to increase, our healthy years have declined. In short, we are mostly living longer but in poor health1. More and more people are developing chronic, lifestyle-related conditions, such as type 2...report 2023
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Wang, R. (author), Damanik, F. (author), Kuhnt, T. (author), Jaminon, A. (author), Hafeez, S. (author), Liu, H. (author), Ippel, H. (author), Dijkstra, P.J. (author), Bouvy, N. (author), Schurgers, L. (author), ten Cate, A.T. (author), Dias, A. (author), Moroni, L. (author), Baker, M.B. (author)Digital light processing (DLP) is an accurate and fast additive manufacturing technique to produce a variety of products, from patient-customized biomedical implants to consumer goods. However, DLP's use in tissue engineering has been hampered due to a lack of biodegradable resin development. Herein, a library of biodegradable poly(esters)...article 2023
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- Palumbo, M.C. (author), de Graaf, A.A. (author), Morettini, M. (author), Tieri, P. (author), Krishnan, S. (author), Castiglione, F. (author) article 2023
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Holmberg, A.A. (author), Weidolf, L. (author), Necander, S. (author), Bold, P. (author), Sidhu, S. (author), Pelay-Gimeno, M. (author), de Ligt, R.A.F. (author), Verheij, E.R. (author), Jauhiainen, A. (author), Psallidas, I. (author), Hamrén, U.W. (author), Prothon, S. (author)This open-label, single-period study describes the human absorption, distribution, metabolism, excretion, and pharmacokinetics of velsecorat (AZD7594). Healthy subjects received inhaled velsecorat (non-radiolabeled; 720 mg) followed by intravenous infusion of carbon 14 (14C)-velsecorat (30 mg). Plasma, urine, and feces were collected up to 168...article 2022
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Haman, F. (author), Souza, S.C.S. (author), Castellani, J.W. (author), Dupuis, M.P. (author), Friedl, K.E. (author), Sullivan-Kwantes, W. (author), Kingma, B.R.M. (author)Human tolerance to cold environments is extremely limited and responses between individuals is highly variable. Such physiological and morphological predispositions place them at high risk of developing cold weather injuries [CWI; including hypothermia and/or non-freezing (FCI) and freezing cold injuries (NFCI)]. The present manuscript...article 2022
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Perez‑Corral, I. (author), Gomez‑Delgado, F. (author), Ruissen, M.M. (author), Torres‑Peña1, J.D. (author), Larriva Arenas-de, A.P. (author), Sont, J.K. (author), de Graaf, A.A. (author), Uitbeijerse, B.S. (author), de Koning, E.J.P. (author), Delgado-Lista, J. (author)This study assesses the association between sleep duration and plasma lipid profiles in people with diabetes mellitus (DM). Sleep duration data were obtained in 91 patients from the POWER2DM study (NCT03588104). The patients were divided in tertiles, based on their sleep duration, and blood samples were obtained at the beginning and after 9...article 2022
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Suchowerska, A.K. (author), Stokman, G. (author), Palmer, J.T. (author), Coghlan, P.A. (author), Pieterman, E.J. (author), Keijzer, N. (author), Lambert, G. (author), Chemello, K. (author), Jaafar, A.K. (author), Parmar, J. (author), Yan, L. (author), Tong, Y. (author), Mu, L. (author), Princen, H.M.G. (author), Bonnar, J. (author), Evison, B.J. (author)Proprotein convertase subtilisin kexin type 9 (PCSK9) inhibits the clearance of low-density lipoprotein (LDL) cholesterol (LDL-C) from plasma by directly binding with the LDL receptor (LDLR) and sending the receptor for lysosomal degradation. As the interaction promotes elevated plasma LDL-C levels, and therefore a predisposition to...article 2022
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Olga, L. (author), Bobeldijk-Pastorova, I. (author), Bas R.C., (author), Seidel, F. (author), Snowden, S.G. (author), Furse, S. (author), Ong, K.K. (author), Kleemann, R. (author), Koulman, A. (author)This protocol outlines a translational lipidomic approach to discover lipid biomarkers that could predict morphometric body and histological organ measurements (e.g., weight and adiposity gains) during specific stages of life (e.g., early life). We describe procedures ranging from animal experimentation and histological analyses to downstream...article 2022
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van den Hoek, A.M. (author), Özsezen, S. (author), Caspers, M.P.M. (author), van Koppen, A. (author), Hanemaaijer, R. (author), Verschuren, L. (author)The prevalence of non-alcoholic steatohepatitis (NASH) is rapidly increasing and associated with cardiovascular disease (CVD), the major cause of mortality in NASH patients. Although sharing common risk factors, the mechanisms by which NASH may directly contribute to the development to CVD remain poorly understood. The aim of this study is to...article 2022
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Li, L. (author), Hoefsloot, H. (author), de Graaf, A.A. (author), Acar, E. (author), Smilde, A.K. (author)Background: Analysis of dynamic metabolomics data holds the promise to improve our understanding of underlying mechanisms in metabolism. For example, it may detect changes in metabolism due to the onset of a disease. Dynamic or time-resolved metabolomics data can be arranged as a three-way array with entries organized according to a subjects...article 2022
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Gart, E. (author), van Duyvenvoorde, W. (author), Caspers, M.P.M. (author), van Trigt, N. (author), Snabel, J. (author), Menke, A. (author), Keijer, J. (author), Salic, K. (author), Morrison, M.C. (author), Kleemann, R. (author)Non-alcoholic steatohepatitis (NASH) is associated with a disturbed metabolism in liver, insulin resistance, and excessive accumulation of ectopic fat. Branched-chain amino acids (BCAAs) may beneficially modulate hepatic lipids, however, it remains unclear whether individual BCAAs can attenuate already established NASH and associated oxidative...article 2022
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Fiamoncini, J. (author), Donado-Pestana, C.M. (author), Duarte, G.B.S. (author), Rundle, M. (author), Thomas, E.L. (author), Kiselova-Kaneva, Y. (author), Gundersen, T.E. (author), Bunzel, D. (author), Trezzi, J.P. (author), Kulling, S.E. (author), Hiller, K. (author), Sonntag, D. (author), Ivanova, D. (author), Brennan, L. (author), Wopereis, S. (author), van Ommen, B. (author), Frost, G. (author), Bell, J. (author), Drevon, C.A. (author), Daniel, H. (author)Insulin secretion following ingestion of a carbohydrate load affects a multitude of metabolic pathways that simultaneously change direction and quantity of interorgan fluxes of sugars, lipids and amino acids. In the present study, we aimed at identifying markers associated with differential responses to an OGTT a population of healthy adults. By...article 2022
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Cavill, R. (author), Bouwman, J. (author)Metabolic pathways are the foundation for understanding metabolomic data in its biochemical context. By mapping metabolomic results to these pathways and identifying those which are altered in the experiment, we can easily add biological interpretability to our experimental results. However, to perform these analyses in a robust, reproducible...bookPart 2022
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Schlunk, F. (author), Fisher, P. (author), Princen, H.M.G. (author), Rex, A. (author), Prinz, V. (author), Foddis, M. (author), Lütjohann, D. (author), Laufs, U. (author), Endres, M. (author)Monoclonal anti-proprotein convertase subtilisin/kexin type 9 (PSCK9) neutralizing antibodies effectively lower plasma cholesterol levels and decrease cardiovascular events but also raised some concern that cognitive function could worsen as a side effect. Here, we performed experiments in mice to characterize the effect of anti-PCSK9 antibodies...article 2021
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van der Haar, S. (author), Hoevenaars, F.P.M. (author), van den Brink, W.J. (author), van den Broek, T. (author), Timmer, M. (author), Boorsma, A. (author), Doets, E.L. (author)Background: Dietary quality plays an essential role in the prevention and management of metabolic syndrome (MetS). Objective: The aim of this pilot study is to organize personalized dietary advice in a real-life setting and to explore the effects on dietary intake, metabolic health, and perceived health. Methods: We followed a one-group pretest...article 2021
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Pieterman, E.J. (author), Princen, H.M.G. (author), Jarke, A. (author), Nilsson, R. (author), Cavallin, A. (author), Bergenholm, L. (author), Henricsson, M. (author), Gopaul, V.S. (author), Agrawal, R. (author), Nissen, S.E. (author), Hurt-Camejo, E. (author)We investigated the effects of chronic oral administration of mineral oil, versus corn oil as control, on intestinal permeability, inflammatory markers, and plasma lipids in APOE*3-Leiden.CETP mice. Mice received mineral oil or corn oil 15 or 30 μL/mouse/day for 16 weeks (15 mice/group). Intestinal permeability was increased with mineral versus...article 2021
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Fragki, S.S. (author), Dirven, H. (author), Fletcher, T. (author), Grasl-Kraupp, B. (author), Guetzkow, K.B. (author), Hoogenboom, R. (author), Kersten, S. (author), Lindeman, B. (author), Louisse, J. (author), Peijnenburg, A. (author), Aldert H., (author), Piersma, A.H. (author), Princen, H.M.G. (author), Uhl, M. (author), Westerhout, J. (author), Zeilmaker, M.J. (author), Luijten, M. (author)Associations between per- and polyfluoroalkyl substances (PFASs) and increased blood lipids have been repeatedly observed in humans, but a causal relation has been debated. Rodent studies show reverse effects, i.e. decreased blood cholesterol and triglycerides, occurring however at PFAS serum levels at least 100-fold higher than those in humans....article 2021