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Pronk, A. (author), Loh, M. (author), Kuijpers, E. (author), Albin, M. (author), Selander, J. (author), Godderis, L. (author), Ghosh, M. (author), Vermeulen, R. (author), Peters, S. (author), Sivesind Mehlum, I. (author), Turner, M. (author), Schlunssen, V. (author), Goldberg, M. (author), Kogevinas, M. (author), Harding, B. (author), Solovieva, S. (author), Garani-Papadatos, T. (author), van Tongeren, M. (author), Stierum, R. (author)Exposures at work have a major impact on noncommunicable diseases (NCDs). Current risk reduction policies and strategies are informed by existing scientific evidence, which is limited due to the challenges of studying the complex relationship between exposure at work and outside work and health. We define the working life exposome as all...article 2022
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van Bilsen, J.H.M. (author), van den Brink, W. (author), van den Hoek, A.M. (author), Dulos, R. (author), Caspers, M.P.M. (author), Kleeman, R. (author), Wopereis, S. (author), Verschuren, L. (author)Metabolic disorders, such as obesity and type 2 diabetes have a large impact on global health, especially in industrialized countries. Tissue-specific chronic low-grade inflammation is a key contributor to complications in metabolic disorders. To support therapeutic approaches to these complications, it is crucial to gain a deeper understanding...article 2021
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van Gool, A.J. (author), Bietrix, F. (author), Caldenhoven, E. (author), Zatloukal, K. (author), Scherer, A. (author), Litton, J.E. (author), Meijer, G. (author), Blomberg, N. (author), Smith, A. (author), Mons, B. (author), Heringa, J. (author), Koot, W.J. (author), Smit, M.J. (author), Hajduch, M. (author), Rijnders, T. (author), Ussi, A. (author)[No abstract available] Chemicals / CAS Biomarkers.article 2017
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Raiten, D.J. (author), Sakr Ashour, F.A. (author), Ross, A.C. (author), Meydani, S.N. (author), Dawson, H.D. (author), Stephensen, C.B. (author), Brabin, B.J. (author), Suchdev, P.S. (author), van Ommen, B. (author), Ahluwalia, N. (author), Ahmed, T. (author), Allen, L. (author), Beck, M. (author), Blanchard, H. (author), Brindle, E. (author), Brown, K. (author), Calder, P. (author), Checkley, W. (author), Claycombe, K. (author), Coles, C. (author), Esamai, F. (author), Friis, H. (author), Gardner, E. (author), Grinspoon, S. (author), Guerrant, R. (author), Hellerstein, M. (author), Hunt, J. (author), King, J. (author), Klasing, K. (author), Kramer, B. (author), Koski, K. (author), Northrop-Clewes, C. (author), Pfeiffer, C. (author), Prentice, A. (author), Ramirez-Zea, M. (author), van Rheenan, P. (author), Rink, L. (author), Srinivasa, S. (author), Benn, C.S. (author), Stephensen, C. (author), Suchdev, P. (author), Sullivan, K. (author), Thurnham, D. (author), Varadhan, R. (author), Van Der Ven, A. (author), Walston, J. (author), Xia, J. (author)An increasing recognition has emerged of the complexities of the global health agenda-specifically, the collision of infections and noncommunicable diseases and the dual burden of over- and undernutrition. Of particular practical concern are both 1) the need for a better understanding of the bidirectional relations between nutritional status and...article 2015
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Hegger, I. (author), Janssen, S.W.J. (author), Keijsers, J.F.E.M. (author), Schuit, A.J. (author), van Oers, H.A.M. (author)Background: It often remains unclear to investigators how their research contributes to the work of the commissioner. We initiated the 'Risk Model' case study to gain insight into how a Dutch National Institute for Public Health and the Environment (RIVM) project and its knowledge products contribute to the commissioner's work, the commissioner...article 2014
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Thurlings, M.E. (author), Brouwer, A.M. (author), van Erp, J.B.F. (author), Blankertz, B. (author), Werkhoven, P.J. (author)Event-related potential (ERP)-based brain–computer interfaces (BCIs) employ differences in brain responses to attended and ignored stimuli. Typically, visual stimuli are used. Tactile stimuli have recently been suggested as a gaze-independent alternative. Bimodal stimuli could evoke additional brain activity due to multisensory integration which...article 2012
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Berg, N. (author), de Wever, B. (author), Fuchs, H.W. (author), Gaca, M. (author), Krul, C.A.M. (author), Roggen, E.L. (author)In November 2009 the In Vitro Testing Industrial Platform (IVTIP) organized a meeting entitled '. Toxicology in the 21st century - working our way towards a visionary reality'. Participating delegates included scientists, key opinion leaders, developers and users of 3Rs-related tests and testing strategies. This paper summarizes the discussions...article 2011
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Mihaescu, R. (author), Detmar, S.B. (author), Cornel, M.C. (author), van der Flier, W.M. (author), Heutink, P. (author), Hol, E.M. (author), Rikkert, M.G.M.O. (author), van Duijn, C.M. (author), Janssens, A.C.J.W. (author), TNO Kwaliteit van leven (author)Alzheimer's disease (AD) is the most prevalent form of dementia and the number of cases is expected to increase exponentially worldwide. Three highly penetrant genes (AβPP, PSEN1, and PSEN2) explain only a small number of AD cases with a Mendelian transmission pattern. Many genes have been analyzed for association with non-Mendelian AD, but the...article 2010
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Vogel, I. (author), Brug, J. (author), van der Ploeg, C.P.B. (author), Raat, H. (author), TNO Kwaliteit van Leven (author)OBJECTIVE. To identify parties involved in the prevention of MP3-induced hearing loss among adolescents and potentially effective prevention strategies and interventions. METHODS. Thirty experts in fields such as scientific research, medical practice, community health professions, education, youth work, music entertainment, and enforcement...article 2009
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TNO Kwaliteit van Leven (author), Gaisser, S. (author), Vignola-Gagné, E. (author), Hüsing, B. (author), Enzing, C. (author), van der Valk, T. (author)Against the background of a number of first drug-diagnostic co-products developed and introduce into the European market, European decision-makers feel impelled to react and position themselves in the field of personalized medicine. Their reactions cover a broad range, from the analysis of knowledge requirements for market approval to the need...article 2009
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Senker, J. (author), Enzing, C. (author), Reiss, T. (author), TNO Kwaliteit van Leven (author)This paper assesses how far ten Central and Eastern European (CEE) countries have 'caught up' in biotechnology on the basis of information about the policies and funding for biotechnology research and commercialisation from 2002-2005 and on the research and commercialisation performance of these countries. The countries that are covered are...article 2008
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Vinken, M. (author), Doktorova, T. (author), Ellinger-Ziegelbauer, H. (author), Ahr, H.-J. (author), Lock, E. (author), Carmichael, P. (author), Roggen, E. (author), van Delft, J. (author), Kleinjans, J. (author), Castell, J. (author), Bort, R. (author), Donato, T. (author), Ryan, M. (author), Corvi, R. (author), Keun, H. (author), Ebbels, T. (author), Athersuch, T. (author), Sansone, S.-A. (author), Rocca-Serra, P. (author), Stierum, R. (author), Jennings, P. (author), Pfaller, W. (author), Gmuender, H. (author), Vanhaecke, T. (author), Rogiers, V. (author), TNO Kwaliteit van Leven (author)Recent changes in the European legislation of chemical-related substances have forced the scientific community to speed up the search for alternative methods that could partly or fully replace animal experimentation. The Sixth Framework Program project carcinoGENOMICS was specifically raised to develop omics-based in vitro screens for testing...article 2008
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Ashwell, M. (author), Lambert, J.P. (author), Alles, M.S. (author), Branca, F. (author), Bucchini, L. (author), Brzozowska, A. (author), de Groot, L.C.P.G.M. (author), Dhonukshe-Rutten, R.A.M. (author), Dwyer, J.T. (author), Fairweather-Tait, S. (author), Koletzko, B. (author), Pavlovic, M. (author), Raats, M.M. (author), Serra-Majem, L. (author), Smith, R. (author), van Ommen, B. (author), Veer, P.V. (author), Von Rosen, J. (author), Pijls, L.T.J. (author), TNO Kwaliteit van Leven (author)Background: There is considerable variation in the recommended micronutrient intakes used by countries within Europe, partly due to different methodologies and concepts used to determine requirements and different approaches used to express the recommendations. As populations become more mobile and multi-national, and more traditional foods...article 2008
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- Bottini, A.A. (author), Alepee, N. (author), Phillips, B. (author), Gribaldo, L. (author), de Silva, O. (author), Hartung, T. (author), Hendriksen, C. (author), Kuil, J. (author), Pazos, P. (author), Rhein, C. (author), Schiffelers, M.-J. (author), Stokes, W. (author), Theobald, A. (author), Vidal, J.-M. (author), van de Sandt, H. (author), Breier, S. (author), Sintes, J.R. (author), Blaauboer, B. (author), TNO Kwaliteit van Leven (author) article 2008
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- Bouvier D'Yvoire, M. (author), Prieto, P. (author), Blaauboer, B.J. (author), Bois, F.Y. (author), Boobis, A. (author), Brochot, C. (author), Coecke, S. (author), Freidig, A. (author), Gundert-Remy, U. (author), Hartung, T. (author), Jacobs, M.N. (author), Lavé, T. (author), Leahy, D.E. (author), Lennernäs, H. (author), Loizou, G.D. (author), Meek, B. (author), Pease, C. (author), Rowland, M. (author), Spendiff, M. (author), Yang, J. (author), Zeilmaker, M. (author), TNO Kwaliteit van Leven (author) article 2007
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Griffith, L.E. (author), Hogg-Johnson, S. (author), Cole, D.C. (author), Krause, N. (author), Hayden, J. (author), Burdorf, A. (author), Leclerc, A. (author), Coggon, D. (author), Bongers, P. (author), Walter, S.D. (author), Shannon, H.S. (author), TNO Kwaliteit van Leven (author)Objective: To determine which literature-based definitions of low back pain (LBP) could be combined to produce sufficiently similar sets for use in a meta-analysis. Study Design and Setting: A group of six international experts participated in an e-mail-administered Delphi process. Literature-based LBP definitions were preliminarily classified...article 2007
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TNO Kwaliteit van Leven (author), Verheijden, M.W. (author), Jans, M.P. (author), Hildebrandt, V.H. (author), Hopman-Rock, M. (author)Background: In recent years, many tailored lifestyle counseling programs have become available through the Internet. Previous research into such programs has shown selective enrollment of relatively healthy people. However, because of the known dose-response relationship between the intensity and frequency of counseling and the behavior change...article 2007
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Verloove-Vanhorick, S.P. (author), TNO Kwaliteit van Leven (author)Due to ever-improving medical technology over the course of the last century, the limit of viability has been lowered from around 32 weeks of gestation, first to 28 weeks and, in recent decades, to as low as less than 24 weeks. Long-term follow-up studies (Project on Preterm and Small-for- Gestational-Age Infants, Leiden Follow-up Project on...article 2006
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TNO Kwaliteit van Leven (author), IJmker, S. (author), Blatter, B.M. (author), van der Beek, A.J. (author), van Mechelen, W. (author), Bongers, P.M. (author)Background: This article describes the background and study design of the PROMO study (Prospective Research on Musculoskeletal disorders in Office workers). Few longitudinal studies have been performed to investigate the risk factors responsible for the incidence of hand, arm, shoulder and neck symptoms among office workers, given the...article 2006
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Verheijden, M.W. (author), Bakx, J.C. (author), van Weel, C. (author), van Staveren, W.A. (author), TNO Kwaliteit van Leven (author)This paper was based on collaborative research efforts from Wageningen University and the University Medical Centre St Radboud in The Netherlands and describes the rationale for web-based nutrition counselling applications in general practice as well as some of the frequently used models and theories (predominantly the Stages of Change Model)....article 2005
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