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de Bruin-Hoegée, J.M. (author), Lamriti, L. (author), Langenberg, J.P. (author), Olivier, R.C.M. (author), Chau, L.F. (author), van der Schans, M.J. (author), Noort, D. (author), van Asten, A.C. (author)The continuing threats of military conflicts and terrorism may involve the misuse of chemical weapons. The present study aims to use environmental samples to find evidence of the release of such agents at an incident scene. A novel approach was developed for identifying protein adducts in plants. Basil (Ocimum basilicum), bay laurel leaf (Laurus...article 2023
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Holmgren, K.H. (author), Hakulinen, H. (author), Norlin, R. (author), de Bruin-Hoegée, J.M. (author), Spiandore, M. (author), See, S.Q.S. (author), Webster, R. (author), Jacques, K.L. (author), Mauravaara, L. (author), Ang, L.H. (author), Evans, C.P. (author), Ovenden, S. (author), Noort, D. (author), Delaporte, G. (author), Dahlén, J. (author), Fraga, C.G. (author), Vanninen, P. (author), Åstot, C. (author)An interlaboratory evaluation of a chemical profiling method for a nerve agent precursor was performed by eight chemical analytical laboratories with a wide global distribution. A set of chemical attribution signatures (i.e. impurities) present in methylphosphonic dichloride (DC) were analysed by gas chromatography-mass spectrometry (GC/MS). The...article 2023
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Malvar, O. (author), Gil-Santos, E. (author), Ruz, J.J. (author), Sentre-Arribas, E. (author), Sanz-Jimenez, A. (author), Kosaka, P.M. (author), Garcia-Lopez, S. (author), Paulo, A.S. (author), Sbarra, S. (author), Waquier, L. (author), Favero, I. (author), Van Der Heiden, M. (author), Altmann, R.K. (author), Papanastasiou, D. (author), Kounadis, D. (author), Panagiotopoulos, I. (author), Mingorance, J. (author), Rodriguez-Tejedor, M. (author), Delgado, R. (author), Calleja, M. (author), Tamayo, J. (author)Nanomechanical mass spectrometry allows characterization of analytes with broad mass range, from small proteins to bacterial cells, and with unprecedented mass sensitivity. In this work, we show a novel multifrequency nanomechanical mass spectrometer prototype designed for focusing, guiding and soft-landing of nanoparticles and viral particles...conference paper 2023
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Bhattacharya, C. (author), Sandinge, A.S. (author), Bragg, R.A. (author), Heijer, M. (author), Yan, J. (author), Andersson, L.C. (author), Jurva, U. (author), Pelay-Gimeno, M. (author), Vaes, W.H.J. (author), de Ligt, R.A.F. (author), Gränfors, M. (author), Amilon, C. (author), Lindstedt, E.L. (author), Menakuru, S.R. (author), Garkaviy, P. (author), Weidolf, L. (author), Gopaul, V.S. (author)This study evaluated the mass balance and disposition of AZD4831, a novel myeloperoxidase inhibitor, in six healthy participants using a 14C-labeled microtracer coupled with analysis by accelerator mass spectrometry (AMS). A single oral dose of 10 mg 14C-AZD4831 (14.8 kBq) was administered as a solution, and 14C levels were quantified by AMS in...article 2023
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Balvers, M. (author), Gordijn, I.F. (author), Voskamp-Visser, A.I. (author), Schelling M.F.A., (author), Schuurman, R. (author), Heikens, E. (author), Braakman, R. (author), Stingl, C. (author), van Leeuwen, H.C. (author), Luider, T.M. (author), Dekker, L.J. (author), Levin, E. (author), Paauw, A. (author)Objectives: Shotgun proteomics is a generic method enabling detection of multiple viral species in one assay. The reliable and accurate identification of these viral species by analyzing peptides from MS-spectra is a challenging task. The aim of this study was to develop an easy accessible proteome analysis approach for the identification of...article 2023
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Olga, L. (author), Bobeldijk-Pastorova, I. (author), Bas R.C., (author), Seidel, F. (author), Snowden, S.G. (author), Furse, S. (author), Ong, K.K. (author), Kleemann, R. (author), Koulman, A. (author)This protocol outlines a translational lipidomic approach to discover lipid biomarkers that could predict morphometric body and histological organ measurements (e.g., weight and adiposity gains) during specific stages of life (e.g., early life). We describe procedures ranging from animal experimentation and histological analyses to downstream...article 2022
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de Ligt, R. (author), Westerhout, J. (author), Grossouw, D. (author), Buters, T.P. (author), Rissman, R. (author), Burggraaf, J. (author), Windhorst, A.D. (author), Tozer, S. (author), Pappa, G. (author), Wal, B. (author), Bury, D. (author), Mason, D.R. (author), Vaes, W.H.J. (author)A follow-up study was performed in 12 healthy women to evaluate systemic exposure to aluminium following topical application of a representative antiperspirant formulation under real-life use conditions (part A) and to assess the local fate of topically applied aluminium by taking additional tape strips and skin biopsies (Part B). A simple roll...article 2022
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Hemme, M. (author), Fidder, A. (author), van der Riet-van Oeveren, D. (author), van der Schans, M.J. (author), Noort, D. (author)The primary aim of this study was to identify biomarkers of exposure to some so-called Schedule 1 sulfur mustard (HD) analogues, in order to facilitate and expedite their retrospective analysis in case of alleged use of such compounds. Since these HD analogues can be regarded as model compounds for possible impurities of HD formed during...article 2021
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Wang, X. (author), Vaes, W.H.J. (author), van Duijn, E. (author), Nooijen, I. (author), Tong, Z. (author), Lopes de Menezes, D. (author), Maxwell, S.E. (author)We report an accelerator mass spectrometry (AMS) assay to quantify azacitidine (Aza) incorporation into DNA and RNA from human acute myeloid leukemia (AML) cells, mouse bone marrow (BM) and peripheral blood mononuclear cells (PBMCs). Aza, a cytidine nucleoside analogue, is a disease modifying pharmacological agent used for treatment of...article 2021
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Streekstra, E.J. (author), Russel, F.G.M. (author), van de Steeg, E. (author), de Wildt, S.N. (author)Drug disposition in children is different compared to adults. Growth and developmental change the processes involved in drug disposition and efficacy, including membrane transporters and drug metabolizing enzymes, but for many of these proteins, the exact changes have not been fully elucidated to date. Quantitative proteomics offers a solution...article 2021
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Onder, S. (author), van Grol, M. (author), Fidder, A. (author), Xiao, G. (author), Noort, D. (author), Yerramalla, U. (author), Tacal, O. (author), Schopfer, L.M. (author), Lockridge, O. (author)Chronic low-dose exposure to organophosphorus pesticides is associated with the risk of neurodegenerative disease. The mechanism of neurotoxicity is independent of acetylcholinesterase inhibition. Adducts on tyrosine, lysine, threonine, and serine can occur after exposure to organophosphorus pesticides, the most stable being adducts on tyrosine....article 2021
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Bezemer, K. (author), McLennan, L. (author), van Duin, L. (author), Kuijpers, C.J. (author), Koeberg, M. (author), van den Elshout, J.J.M.H. (author), van der Heijden, A.E.D.M. (author), Busby, T. (author), Yevdokimov, A. (author), Schoenmakers, P. (author), Smith, J. (author), Oxley, J. (author), van Asten, A. (author)Erythritol tetranitrate (ETN) was prepared independently by two research groups from the USA and the Netherlands. The partially nitrated impurities present in ETN were studied using liquid chromatography-mass spectrometry to address the ultimate challenge in forensic explosives investigations, i.e., providing chemical and tactical information on...article 2020
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van der Schans, M.J. (author)Chemical warfare agents (CWAs) are the most toxic compounds that have ever been produced. In order to develop medical countermeasures against the effects of these agents, analytical procedures to analyze these agents in their intact form in biological matrices are essential for a better understanding of the toxicological process. Although the...bookPart 2020
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van den Dries, M.A. (author), Guxens, M. (author), Spaan, S. (author), Ferguson, K.K. (author), Philips, E. (author), Santos, S. (author), Jaddoe, V.W.V. (author), Ghassabian, A. (author), Trasande, L. (author), Tiemeier, H. (author), Pronk, A. (author)BACKGROUND: Prenatal exposures to phthalates and bisphenols are associated with impaired brain development in animals. However, epidemiological studies investigating the association between prenatal phthalate or bisphenol exposure and cognition have produced mixed findings and mostly had modest sample sizes and measured the exposure during the...article 2020
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Kelly, J.M. (author), Matuszek, G. (author), van den Broek, T.J. (author), Huggins, G.S. (author), Smith, C.E. (author), Ordovas, J.M. (author), Wopereis, S. (author), Booth, S.L. (author)Inconsistent associations between lipids and circulating markers of fat-soluble vitamin and carotenoid status have been reported. The aim of this hypothesis-generating study was to examine the contribution of the LC-MS-based lipidome, characterized by lipid class, carbon count, and the number of unsaturated bonds, to the interindividual...article 2020
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Bezemer, K. (author), McLennan, L. (author), Hessels, R. (author), Schoorl, J. (author), van den Elshout, J.J.M.H. (author), van der Heijden, A.E.D.M. (author), Hulsbergen, A. (author), Koeberg, M. (author), Busby, T. (author), Yevdokimov, A. (author), Rijke, E. (author), Schoenmakers, P. (author), Smith, J. (author), Oxley, J. (author), van Asten, A. (author)In this follow-up study the collaboration between two research groups from the USA and the Netherlands was continued to expand the framework of chemical attribution for the homemade explosive erythritol tetranitrate (ETN). Isotope ratio mass spectrometry (IRMS) analysis was performed to predict possible links between ETN samples and its...article 2020
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Miermans, C.J.H. (author), Dijkmans, E. (author), Krystek, P.W. (author)The ability to track & trace materials is a key feature in the entire chain, and it ensures circularity principles. Examples from plastic recycling show the enormous added value that analytical technology can have for the circular economy. During polymer production and recycling processes, pigments can be added for different purposes; e.g. as...article 2020
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Pali-Scholl, I. (author), Verhoeckx, K. (author), Mafra, I. (author), Bavaro, S.L. (author), Mills, E.N.C. (author), Monaci, L. (author)Background. There is an increasing demand for animal-derived products in the developing countries. This poses major concerns for the sustainable production of safe and nutritious food. Consequently, to address these needs alternative sustainable sources of valuable dietary proteins are sought for. Scope and approach. In this review, we discuss...article 2019
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de Jong, G.A.H. (author), Jayasena, S. (author), Johnson, P. (author), Marsh, J. (author), Apostolovic, D. (author), van Hage, M. (author), Nordlee, J. (author), Baumert, J. (author), Taylor, S.L. (author), Roucairol, C. (author), de Jongh, H. (author), Koppelman, S.J. (author)The 2S albumin Ara h 6 is one of the most important peanut allergens. A post-translationally cleaved Ara h 6 (pAra h 6) was purified from Virginia type peanuts, and the cleavage site was mapped using high-resolution mass spectrometry. Compared to intact Ara h 6, pAra h 6 lacks a 5-amino acid stretch, resembling amino acids 43-47 (UniProt...article 2018
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Remels, A.H.V. (author), Derks, W.J.A. (author), Cillero-Pastor, B. (author), Verhees, K.J.P. (author), Kelders, M.C. (author), Heggermont, W. (author), Carai, P. (author), Summer, G. (author), Ellis, S.R. (author), de Theije, C.C. (author), Heeren, R.M.A. (author), Heymans, S. (author), Papageorgiou, A.P. (author), van Bilsen, M. (author)Acute viral myocarditis (VM), characterised by leukocyte infiltration and dysfunction of the heart, is an important cause of sudden cardiac death in young adults. Unfortunately, to date, the pathological mechanisms underlying cardiac failure in VM remain incompletely understood. In the current study, we investigated if acute VM leads to cardiac...article 2018