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Hopman-Rock, M. (author), Tak, E.C.P.M. (author), Staats, P.G.M. (author)Objective: Development and validation of a short Observation List of possible early signs of Dementia (OLD) for use in general practice. Design: Stepwise development using reviews of publications and expert consensus. Field study for evaluation of reliability. Validation study (interviews, family forms) using existing valid and reliable measures...article 2001
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Walther, F.J. (author), den Ouden, A.L. (author), Verloove-Vanhorick, S.P. (author)In 1983, Dutch pediatricians collaborated on a national level and collected perinatal data on 1338 liveborn infants with a gestational age <32 weeks and/or a birthweight <1500 g (project on preterm and small for gestational age infants, POPS). Their outcome was assessed at 2 years of age by their pediatricians, at 5 years by a team of...article 2000
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van Gijzen, M.B. (author), van Walree, P.A. (author), TNO Physics and Electronics Lab, Hague, Netherlands (author)BPSK signals have been defined for transmission through a shallow-water acoustic communication channel. The signals were accompanied by two displaced carriers to facilitate carrier recovery. To correct for the adverse effects of time spreading, a pseudo-random learning sequence was transmitted ahead of the communication signal. The signal...conference paper 2000
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den Ouden, A.L. (author), Drijkoningen, C.E.M. (author), van der Spee-Wekke, J. (author), de Sigmond-Bruin, E.M. (author), Verloove-Vanhorick, S.P. (author), TNO Preventie en Gezondheid (author)Objective. To determine health and disabilities of preterm infants at age 10. Design. Prospective follow-up study. Setting. TNO Preventie en Gezondheid, sector Jeugd, Leiden, the Netherlands. Method. A questionnaire on medical consumption and physical disabilities was sent to the parents of a Dutch cohort of infants born alive in 1983 with a...article 1998
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Prins Maurits Laboratorium TNO (author), Philippens, I.H.C.H.M. (author), Busker, R.W. (author), Wolthuis, O.L. (author), Olivier, B. (author), Bruijnzeel, P.L.B. (author), Melchers, B.P.C. (author)The behavioral and neurophysiological effects of the subchronically administered cholinesterase-inhibitor physostigmine (PHY) (0.025 mg/kg/h) either with or without the muscarinergic antagonist scopolamine (SCO) (0.018 mg/kg/h) were determined in guinea pigs. In contrast to a single injection of PHY, subchronic application by osmotic minipumps...article 1998
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Oitzl, M.S. (author), Mulder, M. (author), Lucassen, P.J. (author), Havekes, L.M. (author), Grootendorst, J. (author), de Kloet, E.R. (author), Gaubius Instituut TNO (author)Recent studies on apolipoprotein E (apoE) have stressed the importance of this protein in neuronal viability, especially in the hippocampal area. In the present study, we used the Morris water maze to assess spatial learning and memory in 6-month-old homozygous apoE-deficient and heterozygous control mice. The apoE status was checked by...article 1997
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TNO Technische Menskunde (author)Prof.drs. J. Moraal (Ten geleide) Van iemand die 25 jaar bij een werkgever heeft doorgebracht mag je verwachten dat hij of zij in die periode groei heeft doorgemaakt. Maar wat is groei? Bij groei denken we aan verandering, aan vermeerdering, aan rijping. Soms zijn deze grootheden meetbaar, soms ook niet. En waar groei in maat of getal kan worden...conference paper 1996
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- van der Hulst, A.H. (author) doctoral thesis 1996
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Theeuwes, J. (author), TNO Technische Menskunde (author)The present studies investigated whether an isoluminant color change pops out, indicating that it can be detected preattentively in parallel. The results of Experi-ment 1 show that an abrupt color change presented on an equiluminant back-ground does not pop out. However, when the color change is accompanied by a small luminance change, it does...article 1995
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Essens, P.J.M.D. (author), TNO Technische Menskunde (author)Two stages for structuring tone sequences have been distinguished by Povel and Essens (1985). In the first, a mental clock segments a sequence into equal time units (clock model); in the second, intervals are specified in terms of subdivisions of these units. The present findings support the clock model in that it predicts human performance...article 1995
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Papp, Z. (author), Driessen, B.J.F. (author), Technisch Physische Dienst TNO - TH (author)The paper presents an adaptive nonlinear (state-) feedback control structure, where the nonlinearities are implemented as smooth fuzzy mappings defined as rule sets. The fine tuning and adaption of the controller is realized by an indirect adaptive scheme, which modifies the parameters of the fuzzy mapping. The performance index gradients are...conference paper 1995
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- Verloove-Vanhorick, S.P. (author), TNO Preventie en Gezondheid (author) article 1993
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Philippens, I.H.C.H.M. (author), Melchers, B.P.C. (author), de Groot, D.M.G. (author), Wolthuis, O.L. (author)It is known that rats poisoned with near-lethal doses of pinacolyl methylphosphonofluoridate (soman) develop brain lesions, particularly when convulsions are induced. When rats were intoxicated with a LD50 of soman and treated immediately thereafter with a combination of low doses of atropine and diazepam (LOW AS/DZ treatment), large decrements...article 1992
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Philippens, I.H.C.H.M. (author), Melchers, B.P.C. (author), Wolthuis, O.L. (author)Behavioral training of guinea pigs by conventional methods, such as used for rats and mice, appears difficult. Hence, only a few behavioral experiments with guinea pigs have been described in the literature. An active avoidance technique in an automated two-way shuttlebox is described using sound as a conditioned (CS) and a tactile stimulus (a...article 1992
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Theeuwes, J. (author)Two experiments were carried out to investigate the relation between exogenous and endogenous control of visual attention. Subjects searched for a target letter among three nontarget letters that were positioned on an imaginary circle around a fixation point. At different cue-display intervals, a centrally located arrowhead cue reliably...article 1991
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Wertheim, A.H. (author), van Gelder, P. (author)When the eyes pursue a fixation point that sweeps across a moving background pattern, and the fixation point is suddenly made to stop, the ongoing motion of the background pattern seems to accelerate to a higher velocity. Experiment I showed that this acceleration illusion is not caused by the sudden change in (i) the relative velocity between...article 1990
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Odink, J. (author), Kramer, F.M. (author), van der Beek, E.J. (author), Thissen, J.T.N.M. (author), Kempen, H.J.M. (author), van den Berg, H. (author), Egger, R.J. (author), Wientjes, C.J.E. (author), CIVO-TNO Nederlands instituut voor praeventieve gezondheidszorg TNO, NIPG-TNO Gaubius instituut TNO, GI-TNO Instituut voor zintuigfysiologie TNO, IZF-TNO (author)This study was designed to investigate the relation between fatty acid consumption, total plama cholesterol and neuroendocrine response to exposure to stress, factors thought to play a role in the development of coronary heart disease. For this purpose 32 apparently healthy male volunteers were classified on the basis of their plasma cholesterol...article 1989
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- Kulig, B.M. (author) article 1989
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Wolthuis, O.L. (author), Medisch Biologisch Laboratorium TNO (author)The effects of etiracetam, a structural analogue or piracetam, were investigated in rats on Y-maze discrimination acquisition, on open field behavior, on one-trial passive avoidance learning and on shuttlebox acquisition and extinction. The results indicate that this drug significantly enhances acquisition and may improve retention without...article 1981
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Noble, M.E. (author), Sanders, A.F. (author), Instituut voor Zintuigfysiologie TNO (author)An experiment is described in which subjects were required to search for familiar traffic signals. Half the time this was done while also engaged in a manual compensatory tracking task. The experimental variables of the visual search task were color, total number of signals exposed, the number of relevant signals, and the density of the signals....article 1980