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Overcoming Mass Transport Limitations in Electrochemical Reactors with a Pulsating Flow ElectrolyzerPérez Gallent, E. (author), Sánchez Martínez, C. (author), Geers, L.F.G. (author), Turk, S. (author), Latsuzbaia, R. (author), Goetheer, E.L.V. (author)Electrochemical processes are a promising technology for industrial production of chemicals. One of the major drawbacks of electrochemical systems is the low mass transfer of reactants toward the active surface area of the electrode. In this paper, an approach is presented to enhance the mass transfer and increase the overall performance of the...article 2020
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- Wacoo, A.P. (author), Atukunda, P. (author), Muhoozi, G. (author), Braster, M. (author), Wagner, M. (author), van den Broek, T.J. (author), Sybesma, W. (author), Westerberg, A.C. (author), Iversen, P.O (author), Kort, R. (author) article 2020
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Collins, S.L. (author), McMillan, A. (author), Seney, S. (author), van der Veer, C. (author), Kort, R. (author), Sumarah, M.W. (author), Reid, G. (author)Perturbations to the vaginal microbiota can lead to dysbiosis, including bacterial vaginosis (BV), which affects a large portion of the female population. In a healthy state, the vaginal microbiota is characterized by low diversity and colonization by Lactobacillus spp., whereas in BV, these species are displaced by a highly diverse population...article 2018
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Paillart, M.J.M. (author), van der Vossen, J.M.B.M. (author), Lommen, E. (author), Levin, E. (author), Otma, E.C. (author), Snels, J.C.M.A. (author), Woltering, E.J. (author)The shelf-life of fresh-cut lettuce packed in a modified atmosphere (MA) is determined by its "overall visual quality" (OVQ), being a measure of its general appearance based on colour and shape criteria. In addition to the OVQ, the development of off-flavour and acid off-smell reduces consumer acceptance of such products. Concomitant with these...conference paper 2016
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Stroeve, J.H.M. (author), Saccenti, E. (author), Bouwman, J. (author), Dane, A. (author), Strassburg, K. (author), Vervoort, J. (author), Hankemeier, T. (author), Astrup, A. (author), Smilde, A.K. (author), van Ommen, B. (author), Saris, W.H.M. (author)Objective: Aim is to predict successful weight loss by metabolic signatures at baseline and to identify which differences in metabolic status may underlie variations in weight loss success. Methods: In DiOGenes, a randomized, controlled trial, weight loss was induced using a low calorie diet (800 kcal) for 8-weeks. Men (N5236) and women (N5431)...article 2016
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Aguirre, M. (author), Jonkers, D.M.A.E. (author), Troost, F.J. (author), Roeselers, G. (author), Venema, K. (author)The aim of this study was to investigate the effect of galacto-oligosaccharides, lactulose, apple fiber and sugar beet pectin on the composition and activity of human colonic microbiota of lean and obese healthy subjects using an in vitro model of the proximal colon: TIM-2. Substrate fermentation was assessed by measuring the production of short...article 2014
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Biesbroek, G. (author), Bosch, A.A.T.M. (author), Wang, X. (author), Keijser, B.J.F. (author), Veenhoven, R.H. (author), Sanders, E.A.M. (author), Bogaert, D. (author)Rationale: Breastfeeding elicits significant protection against respiratory tract infections in infancy. Modulation of respiratory microbiota might be part of the natural mechanisms of protection against respiratory diseases induced by breastfeeding. Objectives: To study the association between breastfeeding and nasopharyngeal microbial...article 2014
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van den Berg, C. (author), Boon, F. (author), Roelands, C.P.M. (author), Bussmann, P.J.Th. (author), Goetheer, E.L.V. (author), Verdoes, D. (author), Wielen, L.A.M. (author)Most fermentation products have a feedback inhibiting effect on the host organism. In situ product recovery (ISPR) can be a means to overcome this product inhibition in fermentations. Particles such as solvent impregnated resins or capsules can be valuable tools for product recovery based on extraction. To evaluate, which kind of particle will...article 2010
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van de Briel, R.J. (author), Pennings, J.L.A. (author), Baken, K.A. (author), Pronk, T.E. (author), Boorsma, A. (author), Gottschalk, R. (author), van Loveren, H. (author), TNO Kwaliteit van Leven (author)Many chemicals can induce allergic contact dermatitis. Because evaluation of skin sensitizing potential by animal testing is prohibited for cosmetics, and screening of many chemicals is required within Registration, Evaluation, Authorisation and Restriction of Chemicals, urgent need exists for predictive in vitro assays to identify contact...article 2010
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Oudshoorn, A. (author), van den Berg, C. (author), Roelands, C.P.M. (author), Straathof, A.J.J. (author), van der Wielen, L.A.M. (author), TNO Industrie en Techniek (author)Microorganisms are generally sensitive to high concentrations of products that they excrete. Such product inhibition and toxicity effects can significantly be reduced by the integration of fermentations with separation technologies to remove the products continuously. Cost-calculations are required to select the preferred integration method....article 2010
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van Groenestijn, J.W. (author), Geelhoed, J.S. (author), Goorissen, H.P. (author), Meesters, K.P.M. (author), Stams, A.J.M. (author), Claassen, P.A.M. (author), TNO Kwaliteit van Leven (author)Non-axenic operation of a 400 L trickle bed reactor inoculated with the thermophile Caldicellulosiruptor saccharolyticus, yielded 2.8 molH 2mol hexose converted. The reactor was fed with a complex medium with sucrose as the main substrate, continuously flushed with nitrogen gas, and operated at 73°C. The volumetric productivity was 22 mmolH2(L...article 2009
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He, T. (author), Venema, K. (author), Priebe, M.G. (author), Welling, G.W. (author), Brummer, R.J.M. (author), Vonk, R.J. (author), TNO Kwaliteit van Leven (author), KvL (author)Lactose maldigestion and intolerance affect a large part of the world population. The underlying factors of lactose intolerance are not fully understood. In this review, the role of colonic metabolism is discussed, i.e. fermentation of lactose by the colonic microbiota, colonic processing of the fermentation metabolites and how these processes...article 2008
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Plaque formation and lactic acid production after use of amine fluoride/stannous fluoride mouthrinseGerardu, V.A.M. (author), Buijs, M. (author), van Loveren, C. (author), ten Cate, J.M. (author), TNO Kwaliteit van Leven (author)The aim of this study was lo determine the effects of 3 wk of daily rinsing with amine fluoride/stannous fluoride (AmF/SnF2) mouthrinse on plaque formation at buccal and interproximal sites, and on the acid production in plaque. in a randomized clinical trial with 30 participants. The amount of plaque was scored according to Turesky's...article 2007
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Egert, M. (author), de Graaf, A.A. (author), Maathuis, A. (author), de Waard, P. (author), Plugge, C.M. (author), Smidt, H. (author), Deutz, N.E.P. (author), Dijkema, C. (author), de Vos, W.M. (author), Venema, K. (author), TNO Kwaliteit van Leven (author)16S rRNA-based stable isotope probing (SIP) and nuclear magnetic resonance (NMR) spectroscopy-based metabolic profiling were used to identify bacteria fermenting glucose under conditions simulating the human intestine. The TIM-2 in vitro model of the human intestine was inoculated with a GI tract microbiota resembling that of the small intestine...article 2007
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van Hijum, S.A.F.T. (author), Kralj, S. (author), Ozimek, L.K. (author), Dijkhuizen, L. (author), van Geel-Schutten, G.H. (author), TNO Kwaliteit van Leven (author)Lactic acid bacteria (LAB) employ sucrase-type enzymes to convert sucrose into homopolysaccharides consisting of either glucosyl units (glucans) or fructosyl units (fructans). The enzymes involved are labeled glucansucrases (GS) and fructansucrases (FS), respectively. The available molecular, biochemical, and structural information on sucrase...article 2006
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Pasman, W. (author), Wils, D. (author), Saniez, M.H. (author), Kardinaal, A. (author), TNO Kwaliteit van Leven TNO Voeding (author)Objective: To determine the gastrointestinal (GI) tolerance of NUTRIOSE®FB in men. Design: A randomized, placebo-contro lled, parallel, double-blind study. Setting: The metabolic ward of TNO Quality of Life. Subjects: Forty-eight subjects started the study: 16 men participated in one of the three treatments. Subjects consumed either 22.5 g of...article 2006
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Kralj, S. (author), van Geel-Schutten, G.H. (author), Faber, E.J. (author), van der Maarel, M.J.E.C. (author), Dijkhuizen, L. (author), TNO Kwaliteit van Leven (author)Glucansucrase or glucosyltransferase (GTF) enzymes of lactic acid bacteria display high sequence similarity but catalyze synthesis of different α-glucans (e.g., dextran, mutan, alternan, and reuteran) from sucrose. The variations in glucosidic linkage specificity observed in products of different glucansucrase enzymes appear to be based on...article 2005
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Heijne, W.H.M. (author), Lamers, R.J.A.N. (author), van Bladeren, P.J. (author), Groten, J.P. (author), van Nesselrooij, J.H.J. (author), van Ommen, B. (author), TNO Kwaliteit van Leven (author)This study investigated whether integrated analysis of transcriptomics and metabolomics data increased the sensitivity of detection and provided new insight in the mechanisms of hepatotoxicity. Metabolite levels in plasma or urine were analyzed in relation to changes in hepatic gene expression in rats that received bromobenzene to induce acute...article 2005
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Pieterse, B. (author), Leer, R.J. (author), Schuren, F.H.J. (author), van der Werf, M.J. (author), TNO Kwaliteit van Leven (author)The organic acid lactate is the predominant fermentation product of Lactobacillus plantarum. The undissociated form of this organic acid is a strong growth inhibitor for the organism. Different theories have been postulated to explain the inhibitory effects of lactic acid: (i) toxicity arising from the dissipation of the membrane potential, (ii)...article 2005
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van Nuenen, M.H.M.C. (author), Venema, K. (author), van der Woude, J.C.J. (author), Kuipers, E.J. (author), TNO Voeding (author)The hypothesis was studied that intestinal microbial metabolites play a role in the pathogenesis of inflammatory bowel disease. For that purpose, an in vitro model of the colon was inoculated with fresh feces of six healthy individuals and eight inflammatory bowel disease patients. Samples were taken from the model over time to analyze...article 2004