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Smilde, A.K. (author), Jansen, J.J. (author), Hoefsloot, H.C.J. (author), Lamers, R.J.A.N. (author), van der Greef, J. (author), Timmerman, M.E. (author), TNO Kwaliteit van Leven (author)Motivation: Datasets resulting from metabolomics or metabolic profiling experiments are becoming increasingly complex. Such datasets may contain underlying factors, such as time (time-resolved or longitudinal measurements), doses or combinations thereof. Currently used biostatistics methods do not take the structure of such complex datasets into...article 2005
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TNO Preventie en Gezondheid (author), Tchetverikov, I. (author), Lohmander, L.S. (author), Verzijl, N. (author), Huizinga, T.W.J. (author), TeKoppele, J.M. (author), Hanemaaijer, R. (author), de Groot, J. (author)Objective: To determine protein and activity levels of matrix metalloproteinases 1 and 3 (MMP-1 and MMP-3) in synovial fluid of patients with knee joint injury, primary osteoarthritis, and acute pyrophosphate arthritis (pseudogout). Methods: Measurements were done on knee synovial fluid obtained in a cross sectional study of cases of injury (n...article 2005
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van Rooij, L. (author), van Hoof, J. (author), Barbir, A. (author), van der Made, R. (author), Slaats, P.M.A. (author), McCann, M.J. (author), Ridella, S.A. (author), Rupp, J.D. (author), TNO Wegtransportmiddelen (author)Injuries to the knee-thigh-hip (KTH) complex in frontal motor vehicle crashes are of substantial concern because of their frequency and potential to result in long-term disability. Current frontal impact Anthropometric Test Dummies (ATDs) have been shown to respond differently than human cadavers under frontal knee impact loading and...conference paper 2004
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de Jong, O.R.W. (author), Hopman-Rock, M. (author), Tak, E.C.M.P. (author), Klazinga, N.S. (author), TNO Preventie en Gezondheid (author)Implementation studies are recommended to assess the feasibility and effectiveness in real-life of programmes which have been tested in randomized controlled trials (RCTs). We report on an implementation study of two evidence-based exercise and health education programmes for older adults with osteoarthritis (OA) of the knee of hip. Three types...article 2004
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Oudenhuijzen, A.J.K. (author), Tan, T.K. (author), Morsch, F. (author), TNO Technische Menskunde (author)With rising customer expectations, driver comfort will become more and more important for car manufacturers in distinguishing themselves from others. This creates a design challenge, since it is difficult to predict comfort, especially in early design stages. Today, comfort can only be assessed and tested very late during design and construction...conference paper 2004
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TNO Preventie en Gezondheid (author), Ha-Vinh, R. (author), Alanay, Y. (author), Bank, R.A. (author), Campos-Xavier, A.B. (author), Zankl, A. (author), Superti-Furga, A. (author), Bonafé, L. (author)Bruck syndrome (BS) is a recessively-inherited phenotypic disorder featuring the unusual combination of skeletal changes resembling osteogenesis imperfects (OI) with congenital contractures of the large joints. Clinical heterogeneity is apparent in cases reported thus far. While the genes coding for collagen 1 chains are unaffected in BS, there...article 2004
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Gaubius Instituut TNO (author), Tchetverikov, I. (author), Ronday, H.K. (author), van El, B. (author), Kiers, G.H. (author), Verzijl, N. (author), TeKoppele, J.M. (author), Huizinga, T.W.J. (author), de Groot, J. (author), Hanemaaijer, R. (author)Objective: To analyse matrix metalloproteinases (MMPs) and tissue inhibitor-1 of MMPs (TIMP-1) levels in the systemic circulation and synovial fluid (SF) of patients with RA and to compare these levels with inflammatory and collagen degradation markers. Methods: ProMMP-1, -2, -3, -8, -9, TIMP-1, levels of MMP/ α2-macroglobulin complexes, and...article 2004
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TNO Preventie en Gezondheid (author), Verkerke, G.J. (author), Lemmink, K.A.P.M. (author), Slagers, A.J. (author), Westhoff, M.H. (author), van Riet, G.A.J. (author), Rakhorst, G. (author)The mechanical performance, repeatability and comfort of the Quadrisotester, which assesses isometric knee extensor muscle strength, were examined. Twenty healthy subjects and 20 patients treated for unilateral anterior ligamenta cruciata insufficiency were tested. Intra-rater repeatability was determined by the testing and retesting of subjects...article 2003
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de Jong, A.M. (author), Vink, P. (author), TNO Arbeid (author)This paper evaluates a step-by-step participatory approach to better work, applied in reducing the musculoskeletal workload in installation work. To arrive at a reduction in workload, a steering group led the project through the following steps: Introduction: defining the goal and informing all 7000 employees. Analysis: finding major loading...article 2002
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Bank, R.A. (author), Verzijl, N. (author), Lafeber, F.P.J.G. (author), Tekoppele, J.M. (author), Gaubius instituut TNO TNO Preventie en Gezondheid (author)Objective: The collagen network in human articular cartilage experiences a large number of stress cycles during life as it shows hardly any turnover after adolescence. We hypothesized that, to withstand fatigue failure, the physical condition of the collagen network laid down at adolescence is of crucial importance for the age of onset of...article 2002
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Marijnissen, A.C.A. (author), van Roermund, P.M. (author), TeKoppele, J.M. (author), Bijlsma, J.W.J. (author), Lafeber, F.P.J.G. (author), TNO Preventie en Gezondheid (author)Objective: The frequently used anterior cruciate ligament transection (ACLT) model of osteoarthritis (OA) in the dog, makes use of a permanent trigger (joint instability) for inducing degenerative changes. The present study evaluates a canine model of degenerative cartilage damage, mimicking OA, which is induced without making use of permanent...article 2002
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Huebner, J.L. (author), Hanes, M.A. (author), Beekman, B. (author), TeKoppele, J.M. (author), Kraus, V.B. (author), Gaubius Instituut (author)Objective: To evaluate the interaction of bone and cartilage in knee osteoarthritis (OA) pathogenesis in two guinea-pig strains with appreciable differences in bone metabolism. Design: Two guinea-pig strains were evaluated for their susceptibilities to OA using semi-quantitative histological grading of knee joints and quantification of...article 2002
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Marijnissen, A.C.A. (author), van Roermund, P.M. (author), Verzijl, N. (author), Tekoppele, J.M. (author), Bijlsma, J.W.J. (author), Lafeber, F.P.J.G. (author), TNO Preventie en Gezondheid (author)Objective: Recently we described a canine model of osteoarthritis (OA), the groove model with features of OA at 10 weeks after induction, identical to those seen in the canine anterior cruciate ligament transection (ACLT) model. This new model depends on cartilage damage accompanied by transient intensified loading of the affected joint. The...article 2002
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de Groot, J. (author), Verzijl, N. (author), Wenting-Van Wijk, M.J.G. (author), Bank, R.A. (author), Lafeber, F.P.J.G. (author), Bijlsma, J.W.J. (author), Tekoppele, J.M. (author), Gaubius Instituut (author)Objective. Progressive destruction of articular cartilage is a hallmark of osteoarthritis (OA) and rheumatoid arthritis (RA). Age-related changes in cartilage may influence tissue destruction and thus progression of the disease. Therefore, the effect of age-related accumulation of advanced glycation end products (AGEs) on cartilage...article 2001
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Westhoff, M.H. (author), Stemmerik, L. (author), Boshuizen, H.C. (author), TNO Preventie en Gezondheid (author)This study's purpose was to investigate whether a 10-week low-intensity strength-training program could improve strength of the knee extensors and functional ability. Participants 65 years and older with low knee-extensor muscle strength were randomized into an exercise (n = 11) and a control group (n = 10). Knee-extensor strength and functional...article 2000
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Hopman-Rock, M. (author), Westhoff, M.H. (author), TNO Preventie en Gezondheid (author)Objective. Evaluation of a self-management program for patients with osteoarthritis (OA) of the hip or knee. The program, which consisted of 6 weekly sessions of 2 hours, included health education by a peer and physical exercises taught by a physical therapist. Methods. Randomized controlled trial. Inclusion criteria were diagnosis of OA of the...article 2000
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Hopman-Rock, M. (author), Kraaimaat, F.W. (author), Odding, E. (author), Bijlsma, J.W.J. (author), TNO Preventie en Gezondheid (author)Objective. To investigate the use of pain coping strategies by community-living older people with pain in the hip or knee and the mediating role of coping with pain in the relationship between the chronicity of pain and physical disability. Methods. A group of 157 people with pain 'in the last month' was identified. Coping with pain was assessed...article 1998
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Hopman-Rock, M. (author), de Bock, G.H. (author), Bijlsma, J.W.J. (author), Springer, M.P. (author), Hofman, A. (author), Kraaimaat, F.W. (author), TNO Preventie en Gezondheid (author)Objective: The aim of the study was to determine the pattern of health care utilization of people aged 55-74 years with arthritic pain in the knee or hip. Design: People with current pain were identified in a population- based study. A filter model was used to describe the pattern of health care utilization of people who presented as patients at...article 1997
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- van Valburg, A.A. (author), Wenting, M.J.G. (author), Beekman, B. (author), TeKoppele, J.M. (author), Lafeber, F.P.G.J. (author), Bijlsma, J.W.J. (author) article 1997
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Hopman-Rock, M. (author), Kraaimaat, F.W. (author), Bijlsma, J.W.J. (author), TNO Preventie en Gezondheid (author)This study examines the quality of life (QOL) of community living elderly people aged 55-74 with chronic, episodic or sporadic pain in the hip or knee and of a reference group without pain (total n = 306). Firstly, it was hypothesized that the experienced QOL is lower in people with more chronic pain. Secondly, the potential mediating and...article 1997