Searched for: subject:"kidney"
(1 - 20 of 100)

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Giordano, L. (author), Mihaila, S.M. (author), Eslami Amirabadi, H. (author), Masereeuw, R. (author)
Chronic kidney disease (CKD) typically appears alongside other comorbidities, highlighting an underlying complex pathophysiology that is thought to be vastly modulated by the bidirectional gut–kidney crosstalk. By combining advances in tissue engineering, biofabrication, microfluidics, and biosensors, microphysiological systems (MPSs) have...
article 2021
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van den Dries, M.A. (author), Lamballais, S. (author), El Marroun, H. (author), Pronk, A. (author), Spaan, S. (author), Ferguson, K.K. (author), Longnecker, M.P. (author), Tiemeier, H. (author), Guxens, M. (author)
Background: Prenatal exposure to organophosphate (OP) pesticides associate with impaired neurodevelopment in humans and animal models. However, much uncertainty exists about the brain structural alterations underlying these associations. The objective of this study was to determine whether maternal OP pesticide metabolite concentrations in urine...
article 2020
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Humalda, J.K. (author), Klaassen, G. (author), de Vries, H. (author), Meuleman, Y. (author), Verschuur, L.C. (author), Straathof, E.J.M. (author), Laverman, G.D. (author), Bos, W.J.W. (author), van der Boog, P.J.M. (author), Vermeulen, K.M. (author), Blanson Henkemans, O.A. (author), Otten, W. (author), de Borst, M.H. (author), van Dijk, S. (author), Navis, G.J. (author)
Rationale & objective: Patients with chronic kidney disease (CKD) are particularly sensitive to dietary sodium. We evaluated a self-management approach for dietary sodium restriction in patients with CKD. Study design: Randomized controlled trial. Setting & participants: Nephrology outpatient clinics in 4 Dutch hospitals. 99 adults with CKD...
article 2020
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de Kok, M.J. (author), McGuinness, D. (author), Shiels, P.G. (author), de Vries, D.K. (author), Nolthenius, J.B.T. (author), Wijermars, L.G. (author), Rabelink, T.J. (author), Verschuren, L. (author), Stevenson, K.S. (author), Kingsmore, D.B. (author), McBride, M. (author), Ploeg, R.J. (author), Bastiaannet, E. (author), Schaapherder, A.F. (author), Lindeman, J.H. (author)
Objective: To explore putative different impacts of delayed graft function (DGF) on long-term graft survival in kidneys donated after brain death (DBD) and circulatory death (DCD). Background: Despite a 3-fold higher incidence of DGF in DCD grafts, large studies show equivalent long-term graft survival for DBD and DCD grafts. This observation...
article 2019
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Carmany, D. (author), Walz, A.J. (author), Hsu, F.L. (author), Benton, B. (author), Burnett, D. (author), Gibbons, J. (author), Noort, D. (author), Glaros, T. (author), Sekowski, J.W. (author)
Organophosphorus (OP) nerve agents continue to be a threat at home and abroad during the war against terrorism. Human exposure to nerve agents such as VX results in a cascade of toxic effects relative to the exposure level including ocular miosis, excessive secretions, convulsions, seizures, and death. The primary mechanism behind these overt...
article 2017
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van Lint, C.L. (author), Wang, W. (author), van Dijk, S. (author), Brinkman, W.P. (author), Rövekamp, T.J.M. (author), Neerincx, M.A. (author), Rabelink, T.J. (author), van der Boog, P.J.M. (author)
Background: The high frequency of outpatient visits after kidney transplantation is burdensome to both the recovering patient and health care capacity. Self-monitoring kidney function offers a promising strategy to reduce the number of these outpatient visits. Objective: The objective of this study was to investigate whether it is safe to rely...
article 2017
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Wopereis, S. (author), Stroeve, J.H.M. (author), Stafleu, A. (author), Bakker, G.C.M. (author), Burggraaf, J. (author), van Erk, M.J. (author), Pellis, L. (author), Boessen, R. (author), Kardinaal, A.A.F. (author), van Ommen, B. (author)
Background: A key feature of metabolic health is the ability to adapt upon dietary perturbations. Recently, it was shown that metabolic challenge tests in combination with the new generation biomarkers allow the simultaneous quantification of major metabolic health processes. Currently, applied challenge tests are largely non-standardized. A...
article 2017
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Wang, W. (author), van Lint, C.L. (author), Brinkman, W.P. (author), Rövekamp, T.J.M. (author), van Dijk, S. (author), van der Boog, P.J.M. (author), Neerincx, M.A. (author)
Background: Self-management support systems (SMSS) have been proposed for renal transplant patients to increase their autonomy and reduce the number of hospital visits. For the design and implementation of such systems, it is important to understand factors influencing patients’ acceptance of a SMSS. This paper aims to identify these key factors...
article 2017
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Wijermars, L.G.M. (author), Schaapherder, A.F. (author), de Vries, D.K. (author), Verschuren, L. (author), Wüst, R.C.I. (author), Kostidis, S. (author), Mayboroda, O.A. (author), Prins, F. (author), Ringers, J. (author), Bierau, J. (author), Bakker, J.A. (author), Kooistra, T. (author), Lindeman, J.H.N. (author)
Delayed graft function (DGF) following kidney transplantation affects long-term graft function and survival and is considered a manifestation of ischemia reperfusion injury. Preclinical studies characterize metabolic defects resulting from mitochondrial damage as primary driver of ischemia reperfusion injury. In a comprehensive approach that...
article 2016
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Walczak, A.P. (author), Hendriksen, P.J.M. (author), Woutersen, R.A. (author), van der Zande, M. (author), Undas, A.K. (author), Helsdingen, R. (author), van den Berg, H.H.J. (author), Rietjens, I.M.C.M. (author), Bouwmeester, H. (author)
The likelihood of oral exposure to nanoparticles (NPs) is increasing, and it is necessary to evaluate the oral bioavailability of NPs. In vitro approaches could help reducing animal studies, but validation against in vivo studies is essential. Previously, we assessed the translocation of 50 nm polystyrene NPs of different charges (neutral,...
article 2015
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van Lint, C.L. (author), van der Boog, P.J.M. (author), Romijn, F.P.H.T.M. (author), Schenk, P.W. (author), van Dijk, S. (author), Rövekamp, T.J.M. (author), Kessler, A. (author), Siekmann, L. (author), Rabelink, T.J. (author), Cobbaert, C.M. (author)
Background: The StatSensor® Xpress-i™, a point-of-care system for blood creatinine measurement, offers patients the possibility of self-monitoring creatinine. In this study, the analytical performance of the StatSensor® for both detecting current renal function and monitoring renal (dys)function in kidney transplant patients was examined....
article 2015
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van Lint, C.L. (author), van der Boog, P.J.M. (author), Wang, W. (author), Brinkman, W.P. (author), Rövekamp, T.J.M. (author), Neerincx, M.A. (author), Rabelink, T.J. (author), van Dijk, S. (author)
Background: After a kidney transplantation, patients have to visit the hospital often to monitor for early signs of graft rejection. Self-monitoring of creatinine in addition to blood pressure at home could alleviate the burden of frequent outpatient visits, but only if patients are willing to self-monitor and if they adhere to the self...
article 2015
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Gozalpour, E. (author), Greupink, R. (author), Wortelboer, H.M. (author), Bilos, A. (author), Schreurs, M. (author), Russel, F.G.M. (author), Koenderink, J.B. (author)
Digitalis-like compounds (DLCs) such as digoxin, digitoxin, and ouabain, also known as cardiac glycosides, are among the oldest pharmacological treatments for heart failure. The compounds have a narrow therapeutic window, while at the same time, DLC pharmacokinetics is prone to drug-drug interactions at the transport level. Hepatic transporters...
article 2014
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van der Kloet, F.M. (author), Tempels, F.W.A. (author), Ismail, N. (author), van der Heijden, R. (author), Kasper, P.T. (author), Rojas-Cherto, M. (author), van Doorn, R. (author), Spijksma, G. (author), Koek, M. (author), van der Greef, J. (author), Mäkinen, V.P. (author), Forsblom, C. (author), Holthöfer, H. (author), Groop, P.H. (author), Reijmers, T.H. (author), Hankemeier, T. (author)
Diabetic kidney disease (DKD) is a devastating complication that affects an estimated third of patients with type 1 diabetes mellitus (DM). There is no cure once the disease is diagnosed, but early treatment at a sub-clinical stage can prevent or at least halt the progression. DKD is clinically diagnosed as abnormally high urinary albumin...
article 2012
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Wielinga, P.Y. (author), Yakala, G.K. (author), Heeringa, P. (author), Kleemann, R. (author), Kooistra, T. (author)
Background: Alternate day calorie restriction (CR) has been shown to be almost as beneficial as daily CR. The question arises whether this concept is also applicable to alternating dietary composition. Objective: To seek evidence that alternating high cholesterol (HC) - cholesterol-free (CON) Western diet can effectively diminish hepatic and...
article 2011
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Tonk, E.C.M. (author), de Groot, D.M.G. (author), Penninks, A.H. (author), Waalkens - Berendsen, I.D.H. (author), Wolterbeek, A.P.M. (author), Slob, W. (author), Piersma, A.H. (author), van Loveren, H. (author), TNO Kwaliteit van Leven (author)
Current developmental and reproductive toxicity protocols include only a limited set of parameters for effects on the developing immune system. In this study, a wide range of immunological parameters were included in a pre- and postnatal developmental toxicity study. Dose-response data were compared to determine the relative sensitivity of...
article 2010
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Smits, K.M. (author), Schouten, L.J. (author), Hudak, E. (author), Verhage, B. (author), van Dijk, B.A.C. (author), van de Hulsbergen - Kaa, C.A. (author), Goldbohm, R.A. (author), Oosterwijk, E. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)
Purpose: Body mass index (BMI) is an important risk factor for clear-cell renal cancer (cc-RCC). A common molecular alteration in cc-RCC is loss-of-function of the von Hippel-Lindau (VHL) gene. We evaluated the association between BMI and VHL mutations in cc-RCC by using data from the Netherlands Cohort Study (NLCS), a prospective study, which...
article 2010
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Hogervorst, J.G.F. (author), Schouten, L.J. (author), Konings, E.J.M. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)
Background: Acrylamide is a probable human carcinogen, which is present in several heat-treatedfood s. In epidemiologic studies, positive associations with endometrial, ovarian, and renal cell cancer risk have been observed. The incidence of central nervous system tumors was increased upon acrylamide administration in drinking water to rats. In...
article 2009
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Smits, K.M. (author), Schouten, L.J. (author), van Dijk, B.A.C. (author), van Houwelingen, K. (author), van de Hulsbergen-Kaa, C.A. (author), Kiemeney, L.A.L.M. (author), van Houwelingen, K. (author), Goldbohm, R.A. (author), Oosterwijk, E. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)
Metabolic gene polymorphisms have previously been suggested as risk factors for renal cell carcinoma (RCC). These polymorphisms are involved in activation or detoxification of carcinogens in cigarette smoke which is another RCC risk factor. We evaluated gene-environment interactions between CYP1A1, GSTμ1 and smoking in a large population-based...
article 2008
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Garre, F.G. (author), Zwinderman, A.H. (author), Geskus, R.B. (author), Sijpkens, Y.W.J. (author), TNO Kwaliteit van Leven (author)
The reciprocal of serum creatinine concentration, RC, is often used as a biomarker to monitor renal function. It has been observed that RC trajectories remain relatively stable after transplantation until a certain moment, when an irreversible decrease in the RC levels occurs. This decreasing trend commonly precedes failure of a graft. Two...
article 2008
Searched for: subject:"kidney"
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