Searched for: subject:"kaempferol"
(1 - 4 of 4)
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Boerboom, A.M.J.F. (author), Vermeulen, M. (author), van der Woude, H. (author), Bremer, B.I. (author), Lee-Hilz, Y.Y. (author), Kampman, E. (author), van Bladeren, P.J. (author), Rietjens, I.M.C.M. (author), Aarts, J.M.M.J.G. (author), TNO Kwaliteit van Leven (author)
The electrophile-responsive element (EpRE) is a transcriptional enhancer involved in cancer-chemoprotective gene expression modulation by certain food components. Two stably transfected luciferase reporter cell lines were developed, EpRE(hNQO1)-LUX and EpRE(mGST-Ya)-LUX, based on EpRE sequences from the human NAD(P)H:quinone oxidoreductase ...
article 2006
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Schutte, M.E. (author), Freidig, A.P. (author), van de Sandt, J.J.M. (author), Alink, G.M. (author), Rietjens, I.M.C.M. (author), Groten, J.P. (author), TNO Kwaliteit van Leven (author)
The present study describes the effect of different flavonoids on the absorption of the pro-carcinogen PhIP through Caco-2 monolayers and the development of an in silico model describing this process taking into account passive diffusion and active transport of PhIP. Various flavonoids stimulated the apical to basolateral PhIP transport. Using...
article 2006
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van Zanden, J.J. (author), Wortelboer, H.M. (author), Bijlsma, S. (author), Punt, A. (author), Usta, M. (author), Bladeren, P.J.V. (author), Rietjens, I.M.C.M. (author), Cnubben, N.H.P. (author), TNO Kwaliteit van Leven (author)
In the present study, the effects of a large series of flavonoids on multidrug resistance proteins (MRPs) were studied in MRP1 and MRP2 transfected MDCKII cells. The results were used to define the structural requirements of flavonoids necessary for potent inhibition of MRP1- and MRP2-mediated calcein transport in a cellular model. Several of...
article 2005
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van Zanden, J.J. (author), Geraets, L. (author), Wortelboer, H.M. (author), van Bladeren, P.J. (author), Rietjens, I.M.C.M. (author), Cnubben, N.H.P. (author), TNO Voeding (author)
The objective of this study was to investigate the structural requirements necessary for inhibition of glutathione S-transferase P1-1 (GSTP1-1) and GS-X pump (MRP1 and MRP2) activity by structurally related flavonoids, in GSTP1-1 transfected MCF7 cells (pMTG5). The results reveal that GSTP1-1 activity in MCF7 pMTG5 cells can be inhibited by some...
article 2004
Searched for: subject:"kaempferol"
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