Searched for: subject:"isotope"
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Cremer, H. (author), Bunnik, F.P.M. (author), Donders, T.H. (author), Hoek, W.Z. (author), Koolen-Eekhout, M. (author), Koolmees, H.H. (author), Lavooi, E. (author), TNO Bouw en Ondergrond (author)
A 400-year sediment record from an 18 m deep scour hole lake (Haarsteegse Wiel) near the Meuse River in the Netherlands was investigated for past changes in water quality, flooding frequency and landscape change using geophysical, geochemical and micropaleontological information. The results are highly significant for determining long-term...
article 2010
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Coulier, L. (author), Bradley, E.L. (author), Bas, R.C. (author), Verhoeckx, K.C.M. (author), Driffield, M. (author), Harmer, N. (author), Castle, L. (author), TNO Kwaliteit van Leven (author)
Bisphenol A diglycidyl ether (BADGE) is an epoxide that is used as a starting substance in the manufacture of can coatings for food-contact applications. Following migration from the can coating into food, BADGE levels decay and new reaction products are formed by reaction with food ingredients. The significant decay of BADGE was demonstrated by...
article 2010
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Venema, K. (author), TNO Kwaliteit van Leven (author)
Purpose of review: To describe the recent developments and insights gained in the role played by the colonic microbiota in energy and carbohydrate metabolism related to obesity in humans. Recent findings: Previous findings that the ratio of Firmicutes and Bacteriodetes is important in energy harvesting and obesity have not been confirmed in...
article 2010
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de Graaf, A.A. (author), Maathuis, A. (author), de Waard, P. (author), Deutz, N.E.P. (author), Dijkema, C. (author), de Vos, W.M. (author), Venema, K. (author), TNO Kwaliteit van Leven (author)
This study introduces a stable-isotope metabolic approach employing [U-13C]glucose that, as a novelty, allows selective profiling of the human intestinal microbial metabolic products of carbohydrate food components, as well as the measurement of the kinetics of their formation pathways, in a single experiment. A well-established, validated in...
article 2010
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Vos, P. (author), Intema, F. (author), van El, B. (author), de Groot, J. (author), Bijlsma, J.W.J. (author), Lafeber, F. (author), Mastbergen, S. (author), TNO Kwaliteit van Leven (author)
Many animal models are used to study osteoarthritis (OA). In these models the role of joint loading in the development of OA is not fully understood. We studied the effect of loading on the development of OA in the canine Groove-model. In ten female beagle dogs OA was induced in one knee according to the Groove-model. The animals were divided in...
article 2009
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van Schalkwijk, D.B. (author), de Graaf, A.A. (author), van Ommen, B. (author), van Bochove, K. (author), Rensen, P.C.N. (author), Havekes, L.M. (author), van de Pas, N.C.A. (author), Hoefsloot, H.C.J. (author), van der Greef, J. (author), Freidig, A.P. (author), TNO Kwaliteit van Leven (author)
Increased plasma cholesterol is a known risk factor for cardiovascular disease. Lipoprotein particles transport both cholesterol and triglycerides through the blood. It is thought that the size distribution of these particles codetermines cardiovascular disease risk. New types of measurements can determine the concentration of many lipoprotein...
article 2009
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Huisman, D.J. (author), de Groot, T. (author), Pols, S. (author), van Os, B.J.H. (author), Degryse, P. (author), TNO Bouw en Ondergrond (author)
We investigated the major and trace element composition and Pb and Sr isotope characteristics of a series of about 20 colourless glass objects from a single high-status Roman burial from the Netherlands (Bocholtz). The major elements show a relatively homogeneous group, with one outlier. This is corroborated by the Sr isotopes. Based on the Sb...
article 2009
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Crushell, P.H. (author), Smolders, A.J.P. (author), Schouten, M.G.C. (author), Roelofs, J.G.M. (author), van Wirdum, G. (author), TNO Bouw en Ondergrond (author)
The peat and pore-water biogeochemistry of an Irish oceanic raised bog are reported with a view to understanding the origin and development of a minerotrophic soak contained within an ombrotrophic bog. Depth profiles of electrical conductivity, pore-water chemistry and peat chemistry were recorded from the mire surface down to a maximum depth of...
article 2009
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Kovatcheva-Datchary, P. (author), Egert, M. (author), Maathuis, A. (author), Rajilić-Stojanović, M. (author), de Graaf, A.A. (author), Smidt, H. (author), de Vos, W.M. (author), Venema, K. (author), TNO Kwaliteit van Leven (author)
Summary Carbohydrates, including starches, are an important energy source for humans, and are known for their interactions with the microbiota in the digestive tract. Largely, those interactions are thought to promote human health. Using 16S ribosomal RNA (rRNA)-based stable isotope probing (SIP), we identified starch-fermenting bacteria under...
article 2009
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van den Heuvel, E.G.H.M. (author), Muijs, T. (author), Brouns, F. (author), Hendriks, H.F.J. (author), TNO Kwaliteit van Leven (author)
Consumption of fructo-oligosaccharides (FOS) has been shown to improve mineral absorption in the short term, but no long-term effects were studied in girls with a low calcium intake. Therefore, we hypothesized that short- and long-term consumption of short-chain FOS (sc-FOS) improves calcium and magnesium absorption in girls with a low habitual...
article 2009
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Frewer, L.J. (author), Davies, O.H. (author), van Rijswijk, W. (author), Lucas Luijckx, N.B. (author), Ward, S. (author), TNO Kwaliteit van Leven (author)
The modified European Food Law (General Food Law) has been emphasizing on the need to increase consumer confidence through implementation of regulatory measures focused on increased traceability in food chain. The implementation of effective traceability systems can provide the basis of communication between actors in the production chain, and...
article 2008
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de Graaf, A.A. (author), Venema, K. (author), TNO Kwaliteit van Leven (author)
The importance of the human large intestine for nutrition, health, and disease, is becoming increasingly realized. There are numerous indications of a distinct role for the gut in such important issues as immune disorders and obesity-linked diseases. Research on this long-neglected organ, which is colonized by a myriad of bacteria, is a rapidly...
conference paper 2008
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Busschers, F.S. (author), van Balen, R.T. (author), Cohen, K.M. (author), Kasse, C. (author), Weerts, H.J.T. (author), Wallinga, J. (author), Bunnik, F.P.M. (author), TNO Bouw en Ondergrond (author)
A new reconstruction of the interaction between the Saalian Drente glaciation ice margin and the Rhine-Meuse fluvial system is presented based on a sedimentary analysis of continuous core material, archived data and a section in an ice-pushed ridge. Optically Stimulated Luminescence (OSL) was applied to obtain independent age control on these...
article 2008
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Heiri, O. (author), Cremer, H. (author), Engels, S. (author), Hoek, W.Z. (author), Peeters, W. (author), Lotter, A.F. (author), TNO Bouw en Ondergrond (author)
Lateglacial environments at Hijkermeer, northwest Netherlands, were reconstructed by means of chironomid, diatom and pollen analyses. Diatom assemblages indicate that Hijkermeer was a shallow, oligo- to mesotrophic lake during this period. Pollen assemblages reflect the typical northwest European Lateglacial vegetation development and provide an...
article 2007
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Visser, A. (author), Broers, H.P. (author), Bierkens, M.F.P. (author), TNO Bouw en Ondergrond (author)
The production of gases in groundwater under contaminated locations by geochemical and biological processes is not uncommon. Degassing of these gases from groundwater and repartitioning of noble gases between water and gas phase distorts groundwater dating by 3H/3He. We observed noble gas concentrations below atmospheric equilibrium in 20 out of...
article 2007
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Houben, E. (author), Uchida, Y. (author), Nieuwenhuizen, W.F. (author), de Paepe, K. (author), Vanhaecke, T. (author), Holleran, W.M. (author), Rogiers, V. (author), TNO Kwaliteit van Leven (author)
It has recently become evident that at least five ceramidase (CDase) isoforms are present in human epidermis, and that specifically acidic CDase (aCDase) and alkaline CDase (alkCDase) activities increase during keratinocyte differentiation, and thus might play a pivotal role(s) in permeability barrier function. Prior to investigating their...
article 2007
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Visser, A. (author), Broers, H.P. (author), van der Grift, B. (author), Bierkens, M.F.P. (author), TNO Bouw en Ondergrond (author)
Recent EU legislation is directed to reverse the upward trends in the concentrations of agricultural pollutants in groundwater. However, uncertainty of the groundwater travel time towards the screens of the groundwater quality monitoring networks complicates the demonstration of trend reversal. We investigated whether trend reversal can be...
article 2007
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Cawello, W. (author), Wolff, H.M. (author), Meuling, W.J.A. (author), Horstmann, R. (author), Braun, M. (author), TNO Kwaliteit van Leven (author)
Background and objective: The dopamine agonist rotigotine has been formulated in a silicone-based transdermal system for once-daily administration. The objective of the present study was to characterise the mass balance of rotigotine in humans after administration of a single transdermal patch containing radiolabelled [14C]rotigotine and to...
article 2007
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Meesters, R.J.W. (author), van Eijk, H.M.H. (author), ten Have, G.A.M. (author), de Graaf, A.A. (author), Venema, K. (author), van Rossum, B.E.J. (author), Deutz, N.E.P. (author), TNO Kwaliteit van Leven (author)
A new method involving zinc sulphate deproteinization was developed to study short chain fatty acids (SCFA) production in the colon and subsequent occurrence of SCFA in blood. SCFA were baseline separated in a 30 min cycle using ion-exclusion chromatography and detected by mass spectrometry. Concentrations could be measured down to 10 μM and...
article 2007
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Egert, M. (author), de Graaf, A.A. (author), Maathuis, A. (author), de Waard, P. (author), Plugge, C.M. (author), Smidt, H. (author), Deutz, N.E.P. (author), Dijkema, C. (author), de Vos, W.M. (author), Venema, K. (author), TNO Kwaliteit van Leven (author)
16S rRNA-based stable isotope probing (SIP) and nuclear magnetic resonance (NMR) spectroscopy-based metabolic profiling were used to identify bacteria fermenting glucose under conditions simulating the human intestine. The TIM-2 in vitro model of the human intestine was inoculated with a GI tract microbiota resembling that of the small intestine...
article 2007
Searched for: subject:"isotope"
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