Searched for: subject:"isotope"
(1 - 19 of 19)
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van den Heuvel, E.G.H.M. (author), Muijs, T. (author), Brouns, F. (author), Hendriks, H.F.J. (author), TNO Kwaliteit van Leven (author)
Consumption of fructo-oligosaccharides (FOS) has been shown to improve mineral absorption in the short term, but no long-term effects were studied in girls with a low calcium intake. Therefore, we hypothesized that short- and long-term consumption of short-chain FOS (sc-FOS) improves calcium and magnesium absorption in girls with a low habitual...
article 2009
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de Graaf, A.A. (author), Venema, K. (author), TNO Kwaliteit van Leven (author)
The importance of the human large intestine for nutrition, health, and disease, is becoming increasingly realized. There are numerous indications of a distinct role for the gut in such important issues as immune disorders and obesity-linked diseases. Research on this long-neglected organ, which is colonized by a myriad of bacteria, is a rapidly...
conference paper 2008
document
Houben, E. (author), Uchida, Y. (author), Nieuwenhuizen, W.F. (author), de Paepe, K. (author), Vanhaecke, T. (author), Holleran, W.M. (author), Rogiers, V. (author), TNO Kwaliteit van Leven (author)
It has recently become evident that at least five ceramidase (CDase) isoforms are present in human epidermis, and that specifically acidic CDase (aCDase) and alkaline CDase (alkCDase) activities increase during keratinocyte differentiation, and thus might play a pivotal role(s) in permeability barrier function. Prior to investigating their...
article 2007
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Cawello, W. (author), Wolff, H.M. (author), Meuling, W.J.A. (author), Horstmann, R. (author), Braun, M. (author), TNO Kwaliteit van Leven (author)
Background and objective: The dopamine agonist rotigotine has been formulated in a silicone-based transdermal system for once-daily administration. The objective of the present study was to characterise the mass balance of rotigotine in humans after administration of a single transdermal patch containing radiolabelled [14C]rotigotine and to...
article 2007
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Egert, M. (author), de Graaf, A.A. (author), Maathuis, A. (author), de Waard, P. (author), Plugge, C.M. (author), Smidt, H. (author), Deutz, N.E.P. (author), Dijkema, C. (author), de Vos, W.M. (author), Venema, K. (author), TNO Kwaliteit van Leven (author)
16S rRNA-based stable isotope probing (SIP) and nuclear magnetic resonance (NMR) spectroscopy-based metabolic profiling were used to identify bacteria fermenting glucose under conditions simulating the human intestine. The TIM-2 in vitro model of the human intestine was inoculated with a GI tract microbiota resembling that of the small intestine...
article 2007
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Ullmann, U. (author), Haller, J. (author), Bakker, G.C.M. (author), Brink, E.J. (author), Weber, P. (author), TNO Kwaliteit van Leven (author)
A number of studies have shown that tea catechins can inhibit intestinal iron absorption, mostly iron in the nonhaem form. This randomized, double-blind, placebo-controlled, 3-periods cross-over study examined the degree of inhibition of nonhaem iron absorption by pure crystalline epigallocatechin gallate (EGCG). The study was designed to show...
article 2005
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Fox, T.E. (author), van den Heuvel, E.G.H.M. (author), Atherton, C.A. (author), Dainty, J.R. (author), Lewis, D.J. (author), Langford, N.J. (author), Crews, H.M. (author), Luten, J.B. (author), Lorentzen, M. (author), Sieling, F.W. (author), van Aken-Schneyder, P. (author), Hoek, M. (author), Kotterman, M.J.J. (author), van Dael, P. (author), Firweather-Tail, S.J. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)
Objective: To measure the bioavailability of selenium from cooked and raw fish in humans by estimating and comparing apparent absorption and retention of selenium in biosynthetically labelled fish with labelled selenate and biosynthetically labelled selenium in brewers yeast. Design: The intervention study was a parallel, randomised, reference...
article 2004
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van der Greef, J. (author), Stroobant, P. (author), van der Heijden, R. (author), TNO Voeding (author)
Medical systems biology has generated widespread interest because of its bold conception and exciting potential, but the field is still in its infancy. Although there has been tremendous progress achieved recently in generating, integrating and analysing data in the medical and pharmaceutical field, many challenges remain, especially with...
article 2004
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Ronday, H.K. (author), van der Laan, W.H. (author), Tak, P.P. (author), de Roos, J.A.D.M. (author), Bank, R.A. (author), Tekoppele, J.M. (author), Froelich, C.J. (author), Hack, C.E. (author), Hogendoorn, P.C.W. (author), Breedveld, F.C. (author), Verheijen, J.H. (author), Gaubius Instituut (author)
Objective. To investigate the cartilage-degrading capacity of granzyme B and the presence of granzyme B-positive cells at sites of erosion in the rheumatoid synovium. Methods. Granzyme B was added to [3H]proline/[35S]sulphate-labelled cartilage matrices and to cartilage explants. Proteoglycan degradation was assessed by the release of 35S and...
article 2001
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van de Sandt, J.J.M. (author), Meuling, W.J.A. (author), Elliott, G.R. (author), Cnubben, N.H.P. (author), Hakkert, B.C. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
In vitro and in vivo skin absorption of the pesticide propoxur (2-isopropoxyphenyl N-methyl carbamate, commercially Baygon(TM) and Unden(TM); log Po/w 1.56, MW 209.2) was investigated. In vivo studies were performed in rats and human volunteers, applying the test compound to the dorsal skin and the volar aspect of the forearm, respectively. In...
article 2000
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van den Heuvel, E.G.H.M. (author), Schoterman, M.H.C. (author), Muijs, T. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The aim of this study was to investigate whether a product rich in transgalactooligosaccharides (TOS, Elix'or) stimulates true Ca absorption in postmenopausal women. The study was a double-blind, randomized crossover study, consisting of two 9-d treatment periods separated by a 19-d washout period. During the treatment periods, 12 subjects drank...
article 2000
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van den Heuvel, E.G.H.M. (author), Muijs, T. (author), van Dokkum, W. (author), Schaafsma, G. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Animal studies have indicated that calcium absorption is increased by lactulose, a synthetic disaccharide. Therefore, the influence of lactulose on calcium absorption was measured in postmenopausal women who may benefit from the possible enhancing effect of lactulose on calcium absorption. Twelve postmenopausal women drank 100 ml of water...
article 1999
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van den Heuvel, E.G.H.M. (author), Muys, T. (author), van Dokkum, W. (author), Schaafsma, G. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Background: In rats, nondigestible oligosaccharides stimulate calcium absorption. Recently, this effect was also found in human subjects. Objective: The objective of the study was to investigate whether consumption of 15 g oligofructose/d stimulates calcium absorption in male adolescents. Design: Twelve healthy, male adolescents aged 14-16 y...
article 1999
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van den Heuvel, E.G.H.M. (author), Schaafsma, G. (author), Muys, T. (author), van Dokkum, W. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The effect of inulin, fructooligosaccharides, and galactooligosaccharides on true intestinal absorption of iron and calcium was measured in men by using double stable-isotope techniques (oral 57Fe and 44Ca and intravenous 58Fe and 48Ca). The incorporation of iron isotopes into erythrocytes and the urinary excretion of calcium isotopes was...
article 1998
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van den Heuvel, E.G.H.M. (author), Muys, T. (author), Pellegrom, H. (author), Bruyntjes, J.P. (author), van Dokkum, W. (author), Spanhaak, S. (author), Schaafsma, G. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Iron absorption can be measured by the incorporation of stable iron isotopes into erythrocytes, 14 days after isotope administration. The disadvantage of this method is the high dose of isotopes needed to obtain a sufficient enrichment. Therefore, in this study cell fractions rich in young erythroid cells were prepared by using a density...
article 1998
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Schalkwijk, C.G. (author), Vermeer, M.A. (author), Stehouwer, C.D.A. (author), te Koppele, J. (author), Princen, H.M.G. (author), van Hinsbergh, V.W.M. (author), Gaubius Instituut TNO (author)
In patients with diabetes, non-enzymatic glycation of low-density lipoprotein (LDL) has been suggested to be involved in the development of atherosclerosis. α-Dicarbonyl compounds were identified as intermediates in the non-enzymatic glycation and increased levels were reported in patients with diabetes. We studied the effect of the α-dicarbonyl...
article 1998
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Schaafsma, G. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)
Chemicals/CAS: Calcium, 7440-70-2; Magnesium, 7439-95-4
article 1997
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Lansink, M. (author), van Bennekum, A.M. (author), Blaner, W.S. (author), Kooistra, T. (author), TNO Preventie en Gezondheid (author)
Retinoic acid stimulates the expression of tissue-type plasminogen activator (t-PA) in vascular endothelial cells in vitro and enhances t-PA levels in plasma and tissues in vivo. Compared with the in vivo situation, high retinoic acid concentrations are required to induce optimally t-PA expression in vitro. These findings led us to study...
article 1997
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van Dokkum, W. (author), de la Guéronnière, V. (author), Schaafsma, G. (author), Bouley, C. (author), Luten, J. (author), Latgé, C. (author), TNO Voeding (author)
True fractional Ca absorption from six foods was measured in twelve normal healthy women, aged 20-29 years. The tested foods were commercially available fresh cheese, fresh cheese prepared by new technology and rich in Ca, similar cheese with added Fe, enteral food, mineral water alone and combined with a spaghetti meal. The aim of the study was...
article 1996
Searched for: subject:"isotope"
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