Searched for: subject%3A%22insulin%255C%2Bdependent%255C%2Bdiabetes%255C%2Bmellitus%22
(41 - 60 of 67)

Pages

document
Sierksma, A. (author), Patel, H. (author), Ouchi, N. (author), Kihara, S. (author), Funahashi, T. (author), Heine, R.J. (author), Grobbee, D.E. (author), Kluft, C. (author), Hendriks, H.F.J. (author), TNO Preventie en Gezondheid (author)
OBJECTIVE - Epidemiological studies suggest that moderate alcohol consumers have enhanced insulin sensitivity and a reduced risk of type 2 diabetes. Adiponectin, an adipocyte-derived plasma protein, has been found to be negatively associated with adiposity and positively associated with insulin sensitivity. Moderate alcohol consumption may...
article 2004
document
den Boer, M. (author), Voshol, P.J. (author), Kuipers, F. (author), Havekes, L.M. (author), Romijn, J.A. (author), TNO Preventie en Gezondheid (author)
Epidemiological studies in humans, as well as experimental studies in animal models, have shown an association between visceral obesity and dyslipidemia, insulin resistance, and type 2 diabetes mellitus. Recently, attention has been focused on the excessive accumulation of triglycerides (TG) in the liver as part of this syndrome. In this review,...
article 2004
document
van Wouwe, J.P. (author), Mattiazzo, G.F. (author), El Mokadem, N. (author), Reeser, H.M. (author), Hirasing, R.A. (author)
Objective. To determine the incidence and characteristics of type-1 diabetes mellitus (DM) in children aged 0-14 years during the period 1996-1999 and to compare this with previous measurements of the incidence. Design. Descriptive. Method. Data were collected via reports from all practicing paediatricians to the Dutch Paediatric Surveillance...
article 2004
document
van de Ree, M.A. (author), de Maat, M.P. (author), Kluft, C. (author), Meinders, A.E. (author), Princen, H.M. (author), Huisman, M.V. (author), Gaubius Instituut TNO (author)
BACKGROUND: Patients with Type 2 diabetes mellitus have increased levels of hemostatic risk variables for cardiovascular disease, such as fibrinogen, von Willebrand factor (VWF), factor (F)VIIa, d-dimer and plasminogen activator inhibitor-1 (PAI-1). OBJECTIVES: To evaluate the effect of aggressive vs. standard dose atorvastatin on hemostatic...
article 2003
document
Renders, C.M. (author), Delemarre-van De Waal, H.A. (author), Dekker, J.M. (author), Hirasing, R.A. (author)
The prevalence of overweight and obesity in children is increasing significantly. This increase is attended by an increase in diabetes type 2 in children and adolescents. The most important risk factor for the rise of insulin resistance amongst young people is overweight. The diagnostic criteria for diabetes mellitus in young people are: (a)...
article 2003
document
Rosendal, H. (author), Vondeling, H. (author), de Witte, L.P. (author), Hutubessy, R.C.W. (author), van Beekum, W.T. (author), Heine, R.J. (author)
Objective. Assessing whether the initiation of insulin therapy in patients with diabetes mellitus type 2 can be delivered as effectively in a structured transmural care model as in the more usual outpatients structure. Design. Retrospective comparative cohort study. Method. In 1997 data were collected from 52 patients with diabetes mellitus type...
article 2002
document
Muurling, M. (author), Jong, M.C. (author), Mensink, R.P. (author), Hornstra, G. (author), Dahlmans, V.E.H. (author), Pijl, H. (author), Voshol, P.J. (author), Havekes, L.M. (author), Gaubius Instituut TNO (author)
Previous studies have shown that energy restriction (ER) or low-fat (LF) diets have beneficial effects on high-fat (HF) diet-induced obesity and non-insulin-dependent diabetes. However, comparison between ER and low-fat diet regarding the effect on insulin resistance and lipid metabolism has not been reported. After inducing insulin resistance...
article 2002
document
van Wouwe, J.P. (author), Verkerk, P.H. (author), Mattiazzo, G.F. (author), El Mokadem, N. (author), Hirasing, R.A. (author)
article 2002
document
Becker, A. (author), van Hinsbergh, V.W.M. (author), Kostense, P.J. (author), Jager, A. (author), Dekker, J.M. (author), Nijpels, G. (author), Heine, R.J. (author), Bouter, L.M. (author), Stehouwer, C.D.A. (author), TNO Preventie en Gezondheid (author)
Background: Hyperhomocysteinaemia may constitute an independent risk factor for cardiovascular disease, but it is still unclear by which pathophysiological mechanisms homocysteine (tHcy) may promote atherothrombosis. The aim of this study was firstly to examine whether tHcy is associated with endothelial dysfunction, increased adherence of...
article 2000
document
TNO Preventie en Gezondheid (author), van Maanen, J.M.S. (author), Albering, H.J. (author), de Kok, T.M.C.M. (author), van Breda, S.G.J. (author), Curfs, D.M.J. (author), Vermeer, I.T.M. (author), Ambergen, A.W. (author), Wolffenbuttel, B.H.R. (author), Kleinjans, J.C.S. (author), Reeser, H.M. (author)
In recent years, several studies have addressed a possible relationship between nitrate exposure and childhood type 1 insulin-dependent diabetes mellitus. The present ecologic study describes a possible relation between the incidence of type 1 diabetes and nitrate levels in drinking water in The Netherlands, and evaluates whether the World...
article 2000
document
Schalkwijk, C.G. (author), Poland, D.C.W. (author), van Dijk, W. (author), Kok, A. (author), Emeis, J.J. (author), Dräger, A.M. (author), Doni, A. (author), van Hinsbergh, V.W.M. (author), Stehouwer, C.D.A. (author), Gaubius instituut TNO (author)
Moderately increased plasma concentrations of C-reactive protein are associated with an increased risk of cardiovascular disease, C-reactive protein, its relation to a low degree of inflammatory activation and its association with activation of the endothelium have not been systematically investigated in Type I (insulin-dependent) diabetes...
article 1999
document
Myrup, B. (author), Rossing, P. (author), Jensen, T. (author), Gram, J. (author), Kluft, C. (author), Jespersen, J. (author), Gaubius instituut TNO (author)
Objective: To investigate protein concentration changes during venous occlusion of proteins with reported affinity for extracellular matrix (plasminogen activator inhibitor type 1, antithrombin III, fibronectin and von Willebrand factor) in comparison with proteins with no reported affinity (albumin, tissue-type plasminogen activator,...
article 1999
document
Jager, A. (author), van Hinsbergh, V.W.M. (author), Kostense, P.J. (author), Emeis, J.J. (author), Yudkin, J.S. (author), Nijpels, G. (author), Dekker, J.M. (author), Heine, R.J. (author), Bouter, L.M. (author), Stehouwer, C.D.A. (author), Gaubius instituut TNO (author)
Increased levels of von Willebrand factor (vWf) and C-reactive protein (CRP) predict cardiovascular mortality in selected populations. It is uncertain whether vWf and CRP predict mortality in a general population and whether vWf and CRP predict mortality through similar pathways. This study investigated the association of vWf and CRP with...
article 1999
document
Princen, H.M.G. (author), Gaubius instituut TNO (author)
article 1999
document
Fioretto, P. (author), Stehouwer, C.D.A. (author), Mauer, M. (author), Chiesura-Corona, M. (author), Brocco, E. (author), Carraro, A. (author), Bortoloso, E. (author), van Hinsbergh, V.W.M. (author), Crepaldi, G. (author), Nosadini, R. (author), Gaubius Instituut TNO (author)
Microalbuminuria (MA) is associated with microangiopathy (renal and retinal lesions) in insulin-dependent diabetic (IDDM) patients. In contrast MA does not reflect microvascular damage in a substantial number of non- insulin-dependent diabetic (NIDDM) patients. MA predicts cardiovascular disease in NIDDM patients with increased von Willebrand...
article 1998
document
Smulders, R.A. (author), Stehouwer, C.D.A. (author), Schalkwijk, C.G. (author), Donker, A.J.M. (author), van Hinsbergh, V.W.M. (author), TeKoppele, J.M. (author), TNO Preventie en Gezondheid (author)
Dysfunction of the vascular endothelium is considered an early step in the development of diabetic angiopathy. Hyperglycaemia results in endothelial dysfunction, both through direct effects of glucose and through formation of advanced glycosylation end-products (AGEs). We hypothesized that the effects of glucose and AGEs on endothelial function...
article 1998
document
Myrup, B. (author), Jensen, T. (author), Gram, J. (author), Kluft, C. (author), Jespersen, J. (author), Deckert, T. (author), Gaubius Instituut TNO (author)
OBJECTIVE - The high risk for cardiovascular disease in IDDM patients with nephropathy may be mediated by abnormal function of the vascular wall. We investigated whether heparin was able to modulate markers of vascular wall and hemostatic function in patients with incipient nephropathy. RESEARCH DESIGN AND METHODS - Thirty-five IDDM patients...
article 1997
document
Brussaard, H.E. (author), Gevers Leuven, J.A. (author), Frölich, M. (author), Kluft, C. (author), Krans, H.M.J. (author), Gaubius Instituut TNO (author)
Oestrogen replacement therapy is associated with a decreased risk of cardiovascular disease in postmenopausal women. Patients with non-insulin- dependent diabetes mellitus (NIDDM) have an increased cardiovascular risk. However, oestrogen replacement therapy is only reluctantly prescribed for patients with NIDDM. In a double blind randomized...
article 1997
document
Brussaard, H.E. (author), Leuven, J.A.G. (author), Kluft, C. (author), Krans, H.M.J. (author), van Duyvenvoorde, W. (author), Buytenhek, R. (author), van der Laarse, A. (author), Princen, H.M.G. (author), TNO Preventie en Gezondheid (author)
In type II diabetes mellitus the altered hormonal state after menopause may represent an additional cardiovascular risk factor. Estrogen replacement therapy (ERT) is associated with a decreased cardiovascular risk, at least in nondiabetic post-menopausal women. We studied the effect of ERT on plasma lipids and lipoproteins and on LDL oxidation...
article 1997
document
Böhm, F.J. (author), Hirasing, R.A. (author), Vaandrager, G.J. (author), Reeser, H.M. (author), Bijlsma, F. (author), de Groot, R.M. (author), TNO Preventie en Gezondheid (author)
Objective. To determine the mortality of insulin-dependent diabetes mellitus in the age group of 0-19 year over the period 1988-1990 and to compare these data with those of ten years ago. Design. Retrospective. Setting. The Netherlands. Method. The number of deaths was obtained by using the data of the death certificate registers of the Central...
article 1996
Searched for: subject%3A%22insulin%255C%2Bdependent%255C%2Bdiabetes%255C%2Bmellitus%22
(41 - 60 of 67)

Pages